Publications by authors named "Michael Willem"

51Publications

The β-Secretase BACE1 in Alzheimer's Disease.

Biol Psychiatry 2020 Feb 13. Epub 2020 Feb 13.

From the Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France; Brain & Spine Institute, INSERM U 1127, CNRS UMR 7225, Paris, France. Electronic address:

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February 2020

Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.

Neurobiol Aging 2019 12 20;84:241.e5-241.e11. Epub 2019 Sep 20.

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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December 2019

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Neuron 2019 02;101(4):557-559

Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.

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February 2019

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Acta Neuropathol 2018 07 23;136(1):19-40. Epub 2018 Apr 23.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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July 2018

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein.

Elife 2017 07 6;6. Epub 2017 Jul 6.

Team Molecular Mechanisms of neuronal plasticity in health and disease, Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice Sophia Antipolis, Nice, France.

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July 2017

Young microglia restore amyloid plaque clearance of aged microglia.

EMBO J 2017 03 21;36(5):583-603. Epub 2016 Dec 21.

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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March 2017

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.

Biochim Biophys Acta Mol Cell Res 2017 Jan 3;1864(1):217-230. Epub 2016 Nov 3.

Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. Electronic address:

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January 2017

Proteolytic processing of Neuregulin-1.

Authors:
Michael Willem

Brain Res Bull 2016 09 5;126(Pt 2):178-182. Epub 2016 Jul 5.

BioMedical Center, Biochemistry, Ludwig-Maximilians-University, Feodor-Lynen Strasse 17, 81377 Munich, Germany. Electronic address:

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September 2016

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.

Cell Rep 2016 Mar 25;14(9):2127-2141. Epub 2016 Feb 25.

Systems and Cell Biology of Neurodegeneration, Institute of Regenerative Medicine, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland; Graduate Program in Neuroscience, Neuroscience Center Zurich, 8057 Zurich, Switzerland; Graduate Program of the Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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March 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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January 2016