Publications by authors named "Michael Wigler"

67Publications

Damaging de novo mutations diminish motor skills in children on the autism spectrum.

Proc Natl Acad Sci U S A 2018 02 6;115(8):E1859-E1866. Epub 2018 Feb 6.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.

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http://dx.doi.org/10.1073/pnas.1715427115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828599PMC
February 2018

Partial bisulfite conversion for unique template sequencing.

Nucleic Acids Res 2018 01;46(2):e10

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724 USA.

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http://dx.doi.org/10.1093/nar/gkx1054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778454PMC
January 2018

Measuring shared variants in cohorts of discordant siblings with applications to autism.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7073-7076. Epub 2017 Jun 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;

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http://dx.doi.org/10.1073/pnas.1700439114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502605PMC
July 2017

Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal.

Trends Mol Med 2017 07 3;23(7):594-603. Epub 2017 Jun 3.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502711PMC
July 2017

Low load for disruptive mutations in autism genes and their biased transmission.

Proc Natl Acad Sci U S A 2015 Oct 23;112(41):E5600-7. Epub 2015 Sep 23.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724; New York Genome Center, New York, NY 10013;

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http://dx.doi.org/10.1073/pnas.1516376112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611648PMC
October 2015

Interactive analysis and assessment of single-cell copy-number variations.

Nat Methods 2015 Nov 7;12(11):1058-60. Epub 2015 Sep 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/nmeth.3578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775251PMC
November 2015

Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors.

Genes Chromosomes Cancer 2015 Apr 26;54(4):235-48. Epub 2014 Dec 26.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0424, Oslo, 0310, Norway; The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.22237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369137PMC
April 2015

Facilitated sequence counting and assembly by template mutagenesis.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):E4632-7. Epub 2014 Oct 13.

Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

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http://dx.doi.org/10.1073/pnas.1416204111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217440PMC
October 2014

Accurate de novo and transmitted indel detection in exome-capture data using microassembly.

Nat Methods 2014 Oct 17;11(10):1033-6. Epub 2014 Aug 17.

Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/nmeth.3069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180789PMC
October 2014

The role of de novo mutations in the genetics of autism spectrum disorders.

Nat Rev Genet 2014 Feb 16;15(2):133-41. Epub 2014 Jan 16.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nrg3585DOI Listing
February 2014

Target inference from collections of genomic intervals.

Proc Natl Acad Sci U S A 2013 Jun 6;110(25):E2271-8. Epub 2013 Jun 6.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.1306909110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690846PMC
June 2013

Broad applications of single-cell nucleic acid analysis in biomedical research.

Authors:
Michael Wigler

Genome Med 2012 30;4(10):79. Epub 2012 Oct 30.

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY, 11724, USA.

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http://dx.doi.org/10.1186/gm380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580448PMC
May 2014

The cancer stem cell: cell type or cell state?

Cytometry A 2013 Jan 18;83(1):5-7. Epub 2012 Oct 18.

University of Pittsburgh Cancer Center, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1002/cyto.a.22208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154500PMC
January 2013

Reducing system noise in copy number data using principal components of self-self hybridizations.

Proc Natl Acad Sci U S A 2012 Jan 29;109(3):E103-10. Epub 2011 Dec 29.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.1106233109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271883PMC
January 2012

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses.

Neuron 2011 Jun;70(5):898-907

Center for Computational Biology and Bioinformatics and Department of Biomedical Informatics, Columbia University, 1130 St. Nicolas Ave, New York, NY 10032, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08966273110043
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http://dx.doi.org/10.1016/j.neuron.2011.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607702PMC
June 2011

Recurrent DNA copy number variation in the laboratory mouse.

Nat Genet 2007 Nov 28;39(11):1384-9. Epub 2007 Oct 28.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/ng.2007.19DOI Listing
November 2007

A unified genetic theory for sporadic and inherited autism.

Proc Natl Acad Sci U S A 2007 Jul 25;104(31):12831-6. Epub 2007 Jul 25.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0705803104
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http://dx.doi.org/10.1073/pnas.0705803104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933261PMC
July 2007

Identification of alterations in DNA copy number in host stromal cells during tumor progression.

Proc Natl Acad Sci U S A 2006 Dec 13;103(52):19848-53. Epub 2006 Dec 13.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1073/pnas.0609635104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698871PMC
December 2006

PROBER: oligonucleotide FISH probe design software.

Bioinformatics 2006 Oct 1;22(19):2437-8. Epub 2006 Jun 1.

Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btl273DOI Listing
October 2006

Validation of S. pombe sequence assembly by microarray hybridization.

J Comput Biol 2006 Jan-Feb;13(1):1-20

Cold Spring Harbor Laboratory, 1 Bungtown Road, P.O. Box 100, NY 11724, USA.

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http://www.cs.nyu.edu/mishra/PUBLICATIONS/05.arraymap.pdf
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http://www.liebertonline.com/doi/abs/10.1089/cmb.2006.13.1
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http://dx.doi.org/10.1089/cmb.2006.13.1DOI Listing
February 2009

Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements.

Genet Med 2005 Feb;7(2):111-8

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1097/01.gim.0000153661.11110.fbDOI Listing
February 2005

A versatile statistical analysis algorithm to detect genome copy number variation.

Proc Natl Acad Sci U S A 2004 Nov 8;101(46):16292-7. Epub 2004 Nov 8.

Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA.

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http://dx.doi.org/10.1073/pnas.0407247101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528962PMC
November 2004

Circular binary segmentation for the analysis of array-based DNA copy number data.

Biostatistics 2004 Oct;5(4):557-72

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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https://academic.oup.com/biostatistics/article-lookup/doi/10
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http://dx.doi.org/10.1093/biostatistics/kxh008DOI Listing
October 2004

Distribution of short paired duplications in mammalian genomes.

Proc Natl Acad Sci U S A 2004 Jul 6;101(28):10349-54. Epub 2004 Jul 6.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.0403727101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478600PMC
July 2004

Annotating large genomes with exact word matches.

Genome Res 2003 Oct 15;13(10):2306-15. Epub 2003 Sep 15.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1101/gr.1350803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403711PMC
October 2003

DBC2, a candidate for a tumor suppressor gene involved in breast cancer.

Proc Natl Acad Sci U S A 2002 Oct 7;99(21):13647-52. Epub 2002 Oct 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.212516099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129730PMC
October 2002

Genetics. Wild by nature.

Science 2002 May;296(5572):1407-8

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1126/science.1072445DOI Listing
May 2002