Michael W Pennington

Michael W Pennington

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Michael W Pennington

Michael W Pennington

Publications by authors named "Michael W Pennington"

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Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine.

mBio 2019 11 5;10(6). Epub 2019 Nov 5.

Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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http://dx.doi.org/10.1128/mBio.02552-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831779PMC
November 2019

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold.

Toxicon 2018 Aug 19;150:50-59. Epub 2018 May 19.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2018.05.006DOI Listing
August 2018

Peptide therapeutics from venom: Current status and potential.

Bioorg Med Chem 2018 06 23;26(10):2738-2758. Epub 2017 Sep 23.

Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Monash University, Parkville, 3052, Australia.

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http://dx.doi.org/10.1016/j.bmc.2017.09.029DOI Listing
June 2018

Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis.

J Pharmacol Exp Ther 2018 05 16;365(2):227-236. Epub 2018 Feb 16.

Department of Molecular Physiology and Biophysics (M.R.T., B.H.C., R.H., E.J.G., C.B.), Interdepartmental Graduate Program in Translational Biology and Molecular Medicine (M.R.T.), and Biology of Inflammation Center and Center for Drug Discovery (C.B.), Baylor College of Medicine, Houston, Texas; Peptides International Inc., Louisville, Kentucky (M.W.P.); and Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York (T.L., P.S.G.)

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http://dx.doi.org/10.1124/jpet.117.245118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878672PMC
May 2018

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK.

Peptides 2018 01 6;99:169-178. Epub 2017 Oct 6.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.10.001DOI Listing
January 2018

KCa1.1 channels regulate β-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.

FASEB J 2017 08 20;31(8):3309-3320. Epub 2017 Apr 20.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA;

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http://dx.doi.org/10.1096/fj.201601097RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503717PMC
August 2017

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.

Clin Immunol 2017 07 4;180:45-57. Epub 2017 Apr 4.

Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Biology of Inflammation Center and Center for Drug Discovery, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484050PMC
July 2017

Reinvestigation of the biological activity of d-allo-ShK protein.

J Biol Chem 2017 07 8;292(30):12599-12605. Epub 2017 Jun 8.

From the Department of Chemistry, University of Chicago, Chicago, Illinois 60637.

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http://dx.doi.org/10.1074/jbc.M117.793943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535034PMC
July 2017

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.

Sci Rep 2017 06 16;7(1):3756. Epub 2017 Jun 16.

Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, D-01328, Germany.

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http://dx.doi.org/10.1038/s41598-017-03998-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473807PMC
June 2017

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering.

Biochemistry 2017 05 2;56(19):2455-2466. Epub 2017 May 2.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/acs.biochem.7b00120DOI Listing
May 2017

Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa.

J Pharm Sci 2016 07 13;105(7):2173-9. Epub 2016 Jun 13.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.05.008DOI Listing
July 2016

Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

J Pharm Sci 2016 Feb 12;105(2):650-656. Epub 2016 Jan 12.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2015.10.025DOI Listing
February 2016

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases.

J Control Release 2015 Feb 4;199:37-44. Epub 2014 Dec 4.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.12.001DOI Listing
February 2015

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

Mar Drugs 2015 Jan 16;13(1):529-42. Epub 2015 Jan 16.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.3390/md13010529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306950PMC
January 2015

Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.

Angew Chem Int Ed Engl 2014 Mar 7;53(11):2931-4. Epub 2014 Feb 7.

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4072 (Australia).

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http://dx.doi.org/10.1002/anie.201310103DOI Listing
March 2014

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.

Toxicon 2012 Oct 31;60(5):840-50. Epub 2012 May 31.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.toxicon.2012.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411878PMC
October 2012

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.

Inflamm Allergy Drug Targets 2011 Oct;10(5):313-21

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398462PMC
http://dx.doi.org/10.2174/187152811797200641DOI Listing
October 2011

Potassium channel modulation by a toxin domain in matrix metalloprotease 23.

J Biol Chem 2010 Mar 4;285(12):9124-36. Epub 2009 Dec 4.

Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1074/jbc.M109.071266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838332PMC
March 2010

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.

Expert Opin Ther Targets 2009 Aug;13(8):909-24

University of California, Department of Physiology and Biophysics, Irvine, California 92697, USA.

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http://dx.doi.org/10.1517/14728220903018957DOI Listing
August 2009

Efficient synthesis of protected L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase synthesis.

Adv Exp Med Biol 2009 ;611:191-2

BACHEM Bioscience Inc., 3700 Horizon Drive, King of Prussia, PA 19406, USA.

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http://dx.doi.org/10.1007/978-0-387-73657-0_88DOI Listing
June 2009

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.

J Biol Chem 2008 Jan 5;283(2):988-97. Epub 2007 Nov 5.

Department of Physiology & Biophysics, University of California, California, Irvine, 92697-4560, USA.

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http://dx.doi.org/10.1074/jbc.M706008200DOI Listing
January 2008

Targeted tyrosine iodination in a multi-tyrosine vasopressin analog.

J Pept Sci 2007 Nov;13(11):756-61

Bay Pines VA Health Care System, Bay Pines, Florida 33744, USA.

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http://dx.doi.org/10.1002/psc.890DOI Listing
November 2007

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Mol Pharmacol 2005 Apr 21;67(4):1369-81. Epub 2005 Jan 21.

Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California-Irvine, Irvine, CA 92697-4561, USA.

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http://dx.doi.org/10.1124/mol.104.008193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275123PMC
April 2005

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

J Biol Chem 2005 Mar 16;280(10):9272-82. Epub 2004 Nov 16.

Department of Pediatrics, University of California San Diego, School of Medicine, San Diego, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M411154200DOI Listing
March 2005

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.

Curr Med Chem 2004 Dec;11(23):3041-52

Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia.

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http://dx.doi.org/10.2174/0929867043363947DOI Listing
December 2004

Efficient asymmetric synthesis of (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine using camphorsultam as a chiral auxiliary.

J Org Chem 2004 Jun;69(13):4551-4

Bachem Bioscience Inc, 3700 Horizon Drive, King of Prussia, Pennsylvania 19406, USA.

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http://dx.doi.org/10.1021/jo049622jDOI Listing
June 2004

Rational design and synthesis of selective BACE-1 inhibitors.

Bioorg Med Chem Lett 2004 Feb;14(3):601-4

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.bmcl.2003.11.061DOI Listing
February 2004