Michael W Jakowec

Michael W Jakowec

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Michael W Jakowec

Michael W Jakowec

Publications by authors named "Michael W Jakowec"

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Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease.

Int J Geriatr Psychiatry 2020 Jan 1. Epub 2020 Jan 1.

Department of Neurology, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1002/gps.5255DOI Listing
January 2020

Treadmill exercise rescues mitochondrial function and motor behavior in the CAG knock-in mouse model of Huntington's disease.

Chem Biol Interact 2019 Nov 26;315:108907. Epub 2019 Nov 26.

Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.108907DOI Listing
November 2019

Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice.

J Neurosci Res 2019 Sep 7;97(9):1081-1094. Epub 2019 Jun 7.

Department of Neurology, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/jnr.24430DOI Listing
September 2019

Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms.

Front Cell Neurosci 2019 23;13:331. Epub 2019 Jul 23.

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fncel.2019.00331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664007PMC
July 2019

Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.

Psychopharmacology (Berl) 2018 06 2;235(6):1697-1709. Epub 2018 Mar 2.

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA, 90089, USA.

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http://dx.doi.org/10.1007/s00213-018-4869-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949264PMC
June 2018

Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.

Alcohol 2018 05 30;68:63-70. Epub 2017 Sep 30.

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:

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http://dx.doi.org/10.1016/j.alcohol.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878121PMC
May 2018

Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease.

Neuroreport 2017 Oct;28(15):987-995

Departments of aNeurology, The George and MaryLou Boone Center for Parkinson's Disease Research bBiokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/WNR.0000000000000865DOI Listing
October 2017

Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.

Neuropharmacology 2017 02 15;113(Pt A):60-70. Epub 2016 Sep 15.

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148646PMC
February 2017

Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors.

J Neurochem 2016 10 15;139(1):134-48. Epub 2016 Aug 15.

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1111/jnc.13734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037001PMC
October 2016

Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality.

J Hum Kinet 2016 Sep 10;52:35-51. Epub 2016 Sep 10.

Department of Neurology, University of Southern California, Los Angeles, California, United States of America.

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http://content.sciendo.com/view/journals/hukin/52/1/article-
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http://dx.doi.org/10.1515/hukin-2015-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260516PMC
September 2016

Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease.

Neuroreport 2016 06;27(9):632-9

Departments of aPsychiatry and Behavioral Sciences bNeurology cCell and Neurobiology, Biomedical Engineering, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/WNR.0000000000000587DOI Listing
June 2016

Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.

PLoS One 2013 21;8(11):e80058. Epub 2013 Nov 21.

Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080058PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836982PMC
September 2014

P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders.

Front Neurosci 2014 24;8:176. Epub 2014 Jun 24.

Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fnins.2014.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068020PMC
July 2014

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

Neurobiol Dis 2014 Mar 5;63:201-9. Epub 2013 Dec 5.

The George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA; The George and MaryLou Boone Center for Parkinson's Disease Research, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.nbd.2013.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940446PMC
March 2014

The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease.

Front Neurol 2013 12;4:134. Epub 2013 Sep 12.

Department of Psychology, Queens College, City University of New York , New York, NY , USA.

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http://dx.doi.org/10.3389/fneur.2013.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770942PMC
November 2013

Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice.

Neuropsychopharmacology 2013 Sep 19;38(10):1993-2002. Epub 2013 Apr 19.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/npp.2013.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746707PMC
September 2013

Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease.

Neuroreport 2013 Jul;24(10):509-14

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1097/WNR.0b013e328361dc13DOI Listing
July 2013

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse.

Parkinsons Dis 2011 8;2011:138471. Epub 2011 Jun 8.

Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.4061/2011/138471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134993PMC
November 2011

The role of exercise in facilitating basal ganglia function in Parkinson's disease.

Neurodegener Dis Manag 2011 Apr;1(2):157-170

The George & MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, MCA-241, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA ; Division of Biokinesiology & Physical Therapy, University of Southern California, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691073PMC
http://dx.doi.org/10.2217/nmt.11.16DOI Listing
April 2011

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.

Behav Brain Res 2010 Dec 21;213(2):253-62. Epub 2010 May 21.

Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.bbr.2010.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902645PMC
December 2010

Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease.

Mov Disord 2010 ;25 Suppl 1:S141-5

The George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/mds.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111643PMC
June 2010

Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease.

Pharmacol Biochem Behav 2010 Jun 27;95(4):466-72. Epub 2010 Mar 27.

University of Southern California, Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.pbb.2010.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866026PMC
June 2010

Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.

J Neurosci Res 2010 Feb;88(3):650-68

Department of Neurology, The George and MaryLou Boone Center for Parkinson's Disease Research, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/jnr.22216DOI Listing
February 2010

Association of MBP peptides with Hsp70 in normal appearing human white matter.

J Neurol Sci 2006 Nov 13;249(2):122-34. Epub 2006 Jul 13.

Department of Neurology, Keck School of Medicine, University of Southern California, McKibben Annex, Room 246, 1333 San Pablo Street, Los Angeles, California 90033, United States.

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http://dx.doi.org/10.1016/j.jns.2006.05.066DOI Listing
November 2006

Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins.

J Neurosci Res 2006 Feb;83(2):332-47

George and MaryLou Boone Parkinson's Disease and Movement Disorders Research Center, Department of Neurology, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/jnr.20730DOI Listing
February 2006

High and low responders to novelty show differential effects in striatal glutamate.

Synapse 2005 Dec;58(3):200-7

Research Services, Neurocytology Lab, V.A. Medical Center, Portland, OR 97239.

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http://doi.wiley.com/10.1002/syn.20198
Publisher Site
http://dx.doi.org/10.1002/syn.20198DOI Listing
December 2005

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates.

Comp Med 2004 Oct;54(5):497-513

The George and MaryLou Boone Parkinson's Disease and Movement Disorders Research Center Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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October 2004

Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia.

J Neurosci Res 2004 Aug;77(3):378-90

Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/jnr.20162DOI Listing
August 2004

Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway.

J Neurosci Res 2004 May;76(4):539-50

Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/jnr.20114DOI Listing
May 2004

Human neural stem cell transplantation in the MPTP-lesioned mouse.

Brain Res 2003 May;971(2):168-77

Department of Neurosurgery, Keck School of Medicine of the University of Southern California, Los Angeles CA 90033, USA.

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http://dx.doi.org/10.1016/s0006-8993(03)02337-0DOI Listing
May 2003