Michael Tymianski

Michael Tymianski

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Michael Tymianski

Publications by authors named "Michael Tymianski"

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Spinal and Paraspinal Arteriovenous Lesions.

Stroke 2019 08 10;50(8):2259-2269. Epub 2019 Jun 10.

From the Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, University Health Network and University of Toronto (S.L., P.N., C.H., T.K., V.M.P.), University Health Network, ON, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.118.012783DOI Listing
August 2019

Deep Brain Stimulation Rescues Memory and Synaptic Activity in a Rat Model of Global Ischemia.

J Neurosci 2019 Mar 29;39(13):2430-2440. Epub 2019 Jan 29.

Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada,

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1222-1
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http://dx.doi.org/10.1523/JNEUROSCI.1222-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435818PMC
March 2019

The endoscopic transpterional port approach: anatomy, technique, and initial clinical experience.

J Neurosurg 2019 Feb 22:1-11. Epub 2019 Feb 22.

1Division of Neurosurgery, Toronto Western Hospital, Krembil Brain Institute, University Health Network, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2018.10.JNS171898DOI Listing
February 2019

Management of Residual Brain Arteriovenous Malformations After Stereotactic Radiosurgery.

World Neurosurg 2018 Aug 1;116:e1105-e1113. Epub 2018 Jun 1.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Neuroscience Center, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.05.180DOI Listing
August 2018

Interval angioarchitectural evolution of brain arteriovenous malformations following rupture.

J Neurosurg 2018 Jul;131(1):96-103

5Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada; and.

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http://dx.doi.org/10.3171/2018.2.JNS18128DOI Listing
July 2018

PHASES and ELAPSS Scores Are Associated with Aneurysm Growth: A Study of 431 Unruptured Intracranial Aneurysms.

World Neurosurg 2018 Jun 10;114:e425-e432. Epub 2018 Mar 10.

Department of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183046
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http://dx.doi.org/10.1016/j.wneu.2018.03.003DOI Listing
June 2018

Neurotransmitters in the mediation of cerebral ischemic injury.

Neuropharmacology 2018 05 2;134(Pt B):178-188. Epub 2017 Dec 2.

Division of Fundamental Neurobiology, Krembil Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Department of Neurosurgery, University of Toronto, Toronto, Ontario, M5G 1LG, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.11.050DOI Listing
May 2018

Discovery and development of NA-1 for the treatment of acute ischemic stroke.

Acta Pharmacol Sin 2018 May 22;39(5):661-668. Epub 2018 Mar 22.

Division of Neurosurgery, Institute of Medical Science Toronto Western Research Institute, University of Toronto, University Health Network 60 Leonard avenue, 8KD-406, Toronto, Ontario M5T 2R1, Canada.

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http://dx.doi.org/10.1038/aps.2018.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943917PMC
May 2018

Application of PHASES and ELAPSS scores to ruptured cerebral aneurysms: how many would have been conservatively managed?

J Neurosurg Sci 2018 May 28. Epub 2018 May 28.

Division of Neuroradiology, Joint Division of Medical Imaging, University Health Network, University of Toronto, Toronto ON, Canada.

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https://www.minervamedica.it/index2.php?show=R38Y9999N00A180
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http://dx.doi.org/10.23736/S0390-5616.18.04498-3DOI Listing
May 2018

Targeting NMDA receptors in stroke: new hope in neuroprotection.

Mol Brain 2018 03 13;11(1):15. Epub 2018 Mar 13.

Krembil Research Institute, University Health Network, 60 Leonard St, Toronto, ON, M5T2S8, Canada.

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http://dx.doi.org/10.1186/s13041-018-0357-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851248PMC
March 2018

Translational Stroke Research: Vision and Opportunities.

Stroke 2017 09 27;48(9):2632-2637. Epub 2017 Jul 27.

From the National Institute of Neurological Disorders and Stroke, National Institutes of Health (F.B., J.I.K., R.A.C., L.B.J., S.J., L.M.M., C.S.M., I.R., W.K.); Department of Neurology, Massachusetts General Hospital, Boston (C.A., E.H.L., L.H.S.); Oregon Health & Science University, Portland (S.A.B., M.P.S.-P.); Department of Neurology and Neurological Surgery, University of Washington, Seattle (K.B.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (J.P.B.); Department of Neurology, University of California, Los Angeles (S.T.C.); Brain Mind Research Institute, Weill Cornell Medicine, New York, NY (S.C., C.I.); Department of Neurological Sciences, University of Vermont, Burlington (M.J. C.); Brain and Mind Research Institute, University of Ottawa, Ontario (D.C.); Department of Neurology, University of California, Irvine, Orange (S.C.C.); Department of Neurological Surgery, University of California, San Francisco (A.R.F.); Stemetix, Inc, Needham, MA (S.F.); Division of Biomedical Sciences, University of California, Riverside (B.D.F.); Department of Neurology, Brown University, Providence, RI (K.L.F.); Department of Neurology, University of California, San Diego (T.M.H.); Department of Emergency Medicine, Medical University of South Carolina, Charleston (E.C.J.); Department of Neurology, University of Virginia, Charlottesville (K.C.J.); Department of Critical Care Medicine (P.M.K.) and Department of Neurology (L.R.W.), University of Pittsburgh, PA; School of Pharmacy, University of North Carolina, Chapel Hill (H.K.); Cedars-Sinai Medical Center, Los Angeles, CA (P.D.L.); University of Gothenburg, Sweden (C.M.); Department of Neurology, University of Texas Health Science Center, Houston (L.D.M., S.I.S.); Mayo Clinic, Jacksonville, FL (J.F.M.); Department of Neurology, University of Miami Miller School, FL (M.A.P.-P.); Department of Neurosurgery, Stanford University, CA (G.K.S.); Division of Fundamental Neurobiology, Krembil Research Institute, Toronto, ON (M.T.); Department of Neurology, University of Texas, Austin (S.W.); and Department of Neurosurgery and Anesthesiology, Loma Linda University, CA (J.H.Z.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599159PMC
September 2017

Combining Neuroprotection With Endovascular Treatment of Acute Stroke: Is There Hope?

Stroke 2017 06 9;48(6):1700-1705. Epub 2017 May 9.

From the Division of Neurosurgery (M.T.) and Krembil Research Institute (M.T.), Toronto Western Hospital, University Health Network, Ontario, Canada; and Department of Surgery, University of Toronto, Ontario, Canada (M.T.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017040DOI Listing
June 2017

The Extended Lateral Supraorbital Approach and Extradural Anterior Clinoidectomy Through a Frontopterio-Orbital Window: Technical Note and Pilot Surgical Series.

World Neurosurg 2017 Apr 29;100:159-166. Epub 2016 Dec 29.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.wneu.2016.12.087DOI Listing
April 2017

Gamma Knife radiosurgery for the treatment of intracranial dural arteriovenous fistulas.

Interv Neuroradiol 2017 Apr 16;23(2):211-220. Epub 2016 Dec 16.

1 Department of Medical Imaging, Division of Neuroradiology, Toronto Western Hospital, University Health Network & University of Toronto, Canada.

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http://journals.sagepub.com/doi/10.1177/1591019916683689
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http://dx.doi.org/10.1177/1591019916683689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433606PMC
April 2017

Microsurgery for ARUBA Trial (A Randomized Trial of Unruptured Brain Arteriovenous Malformation)-Eligible Unruptured Brain Arteriovenous Malformations.

Stroke 2017 01 17;48(1):136-144. Epub 2016 Nov 17.

From the Division of Neurosurgery, Toronto Western Hospital, University Health Network, Ontario, Canada (J.W., A.S., G.I., I.R., M.T.) and Department of Surgery, University of Toronto, Ontario, Canada (J.W., G.I., I.R., M.T.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014660DOI Listing
January 2017

Neuroprotective Effects of a PSD-95 Inhibitor in Neonatal Hypoxic-Ischemic Brain Injury.

Mol Neurobiol 2016 11 31;53(9):5962-5970. Epub 2015 Oct 31.

Department of Surgery, Faculty of Medicine, University of Toronto, 1132 Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8.

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http://link.springer.com/10.1007/s12035-015-9488-4
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http://dx.doi.org/10.1007/s12035-015-9488-4DOI Listing
November 2016

Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species.

J Cereb Blood Flow Metab 2016 Mar 19;36(3):555-61. Epub 2015 Oct 19.

Toronto Western Hospital Research Institute, Toronto, Ontario, Canada Department of Physiology, University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Department of Surgery, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1177/0271678X15612099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794097PMC
March 2016

Safety, efficacy, and cost of surgery for patients with unruptured aneurysms deemed unsuitable for endovascular therapy.

Acta Neurochir (Wien) 2015 Dec 24;157(12):2061-70; discussion 2070. Epub 2015 Oct 24.

Division of Neurosurgery, Toronto Western Hospital, University Health Network, 4W-435, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s00701-015-2606-2
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http://dx.doi.org/10.1007/s00701-015-2606-2DOI Listing
December 2015

Minimally Invasive Microsurgery for Cerebral Aneurysms.

Stroke 2015 Sep 30;46(9):2699-706. Epub 2015 Jul 30.

From the Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada (J.H.Y.W., R.T., I.R., M.T.); and Department of Surgery, University of Toronto, Toronto, Ontario, Canada (J.H.Y.W., I.R., M.T.).

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http://dx.doi.org/10.1161/STROKEAHA.115.008221DOI Listing
September 2015

Neuroprotective therapies: Preclinical reproducibility is only part of the problem.

Sci Transl Med 2015 Aug 5;7(299):299fs32. Epub 2015 Aug 5.

Toronto Western Hospital Research Institute, Toronto, Ontario M5T 2S8, Canada. Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1126/scitranslmed.aac9412DOI Listing
August 2015

Natural history and management of basilar trunk artery aneurysms.

Stroke 2015 Apr 24;46(4):948-53. Epub 2015 Feb 24.

From the Department of Neuroradiology, Hôpital Bicêtre, Le Kremlin Bicetre, France (G.S.); and Division of Neuroradiology, Department of Medical Imaging (G.S., R.H.S., S.P., A.K., R.A.W., K.G.t., S.R., T.K.) and Division of Neurosurgery (M.T.), Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.114.006909DOI Listing
April 2015

Early identification of brain tissue at risk for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Acta Neurochir Suppl 2015 ;120:105-9

Division of Neurosurgery, Department of Surgery, Sunnybrook Hospital, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room A1-37, Toronto, ON, Canada,

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http://dx.doi.org/10.1007/978-3-319-04981-6_18DOI Listing
March 2015

Impaired cerebrovascular reactivity in the early phase of subarachnoid hemorrhage in good clinical grade patients does not predict vasospasm.

Acta Neurochir Suppl 2015 ;120:249-53

Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room A1-37, Toronto, ON, M4N 3M5, Canada,

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http://dx.doi.org/10.1007/978-3-319-04981-6_42DOI Listing
March 2015

Assessing the effect of unilateral cerebral revascularisation on the vascular reactivity of the non-intervened hemisphere: a retrospective observational study.

BMJ Open 2015 Feb 11;5(2):e006014. Epub 2015 Feb 11.

Division of Neuroradiology, Joint Department of Medical Imaging of the University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/bmjopen-2014-006014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325130PMC
February 2015

Natural history and outcome after treatment of unruptured intradural fusiform aneurysms.

Stroke 2014 Nov 9;45(11):3251-6. Epub 2014 Sep 9.

From the Departments of Interventional Neuroradiology (R.H.S., G.S., A.K., R.M., T.K., K.T., R.W.) and Neurosurgery (R.H.S., M.T., I.R.), University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada; and Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands (G.J.E.R.).

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http://dx.doi.org/10.1161/STROKEAHA.114.006292DOI Listing
November 2014

BOLD MRI and early impairment of cerebrovascular reserve after aneurysmal subarachnoid hemorrhage.

J Magn Reson Imaging 2014 Oct 15;40(4):972-9. Epub 2013 Nov 15.

Division of Neurosurgery, Sunnybrook Hospital, University of Toronto, Ontario, Canada; Department of Medical Imaging, Toronto Western Hospital and University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jmri.24474DOI Listing
October 2014

Postoperative visual loss following cerebral arteriovenous malformation surgery: a case report.

F1000Res 2014 27;3:27. Epub 2014 Jan 27.

Department of Anesthesia, University Health Network, Toronto Western Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.12688/f1000research.3-27.v2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945764PMC
April 2014

A safety, length of stay, and cost analysis of minimally invasive microsurgery for anterior circulation aneurysms.

Acta Neurochir (Wien) 2014 Mar 7;156(3):493-503. Epub 2014 Jan 7.

Division of Neurosurgery, Toronto Western Hospital, University Health Network and University of Toronto, 399 Bathurst Street, Toronto, M5T2S8 ON, Canada.

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http://dx.doi.org/10.1007/s00701-013-1980-xDOI Listing
March 2014

Novel EEG pattern associated with impaired cerebrovascular reserve in Moyamoya disease.

Clin Neurophysiol 2014 Feb 18;125(2):422-5. Epub 2013 Jul 18.

Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2013.06.026DOI Listing
February 2014

Stroke in 2013: disappointments and advances in acute stroke intervention.

Nat Rev Neurol 2014 Feb 7;10(2):66-8. Epub 2014 Jan 7.

Toronto Western Hospital, Division of Neurosurgery, 4W-435, 399 Bathurst Street, Toronto, ON M5T-2S8, Canada.

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http://dx.doi.org/10.1038/nrneurol.2013.271DOI Listing
February 2014

Day surgery craniotomy for unruptured cerebral aneurysms: a single center experience.

J Neurosurg Anesthesiol 2014 Jan;26(1):60-4

*Department of Anesthesia †Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/ANA.0b013e3182991d8bDOI Listing
January 2014

Novel approaches to neuroprotection trials in acute ischemic stroke.

Stroke 2013 Oct 10;44(10):2942-50. Epub 2013 Sep 10.

From the Toronto Western Hospital Research Institute, University Health Network, Toronto, ON, Canada; and Departments of Surgery and Physiology, University of Toronto, Toronto, ON, Canada.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.113.000731
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http://dx.doi.org/10.1161/STROKEAHA.113.000731DOI Listing
October 2013

Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death.

J Neurosci 2013 Oct;33(44):17264-77

Toronto Western Hospital Research Institute, Toronto, Ontario M5T 2S8, Canada, Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Department of Surgery (Neurosurgery), University of Toronto, Toronto, Ontario M5S 1A8, Canada, and Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1729-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.1729-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618359PMC
October 2013

Priority setting in neurosurgery as exemplified by an everyday challenge.

Can J Neurol Sci 2013 May;40(3):378-83

Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/s0317167100014347DOI Listing
May 2013

Advances in stroke: vascular neurosurgery.

Stroke 2013 Feb 15;44(2):316-7. Epub 2013 Jan 15.

Department of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

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http://dx.doi.org/10.1161/STROKEAHA.111.000385DOI Listing
February 2013

A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic nonhuman primates.

Sci Transl Med 2012 Oct;4(154):154ra133

Toronto Western Hospital Research Institute, Department of Physiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3003824DOI Listing
October 2012

Nonhuman primate models of stroke for translational neuroprotection research.

Neurotherapeutics 2012 Apr;9(2):371-9

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto Western Hospital Division of Neurosurgery, Toronto, Ontario M5T 2S8, Canada.

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http://dx.doi.org/10.1007/s13311-012-0115-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337022PMC
April 2012

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain.

Nature 2012 Feb 29;483(7388):213-7. Epub 2012 Feb 29.

Toronto Western Hospital Research Institute, Toronto, Ontario, M5T 2S8, Canada.

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http://dx.doi.org/10.1038/nature10841DOI Listing
February 2012

Challenges in the management of ruptured and unruptured brainstem arteriovenous malformations: outcome after conservative, single-modality, or multimodality treatments.

Neurosurgery 2012 Jan;70(1):155-61; discussion 161

Department of Neurosurgery, Division of Neurosciences and Locomotive System, Lille University Hospital, Lille, France.

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http://dx.doi.org/10.1227/NEU.0b013e31822670acDOI Listing
January 2012

Microsurgical glue embolectomy of the middle cerebral artery following embolization of a maxillofacial arteriovenous malformation.

J Clin Neurosci 2011 Dec 8;18(12):1733-6. Epub 2011 Oct 8.

Division of Neurosurgery and Interventional Neuroradiology, Toronto Western Hospital, 399 Bathurst Street, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jocn.2011.04.020DOI Listing
December 2011

Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses.

Mol Brain 2011 Dec 21;4:44. Epub 2011 Dec 21.

Robarts Research Institute, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1186/1756-6606-4-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298512PMC
December 2011

Impact of extracranial-intracranial bypass on cerebrovascular reactivity and clinical outcome in patients with symptomatic moyamoya vasculopathy.

Stroke 2011 Nov 8;42(11):3047-54. Epub 2011 Sep 8.

Department of Anesthesia, University of Toronto and University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.111.615955DOI Listing
November 2011

Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor.

Stroke 2011 Nov 8;42(11):3265-70. Epub 2011 Sep 8.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1161/STROKEAHA.111.618801DOI Listing
November 2011

Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture.

Stroke 2011 Nov 6;42(11):3003-4. Epub 2011 Oct 6.

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http://dx.doi.org/10.1161/STROKEAHA.111.626762DOI Listing
November 2011

Emerging mechanisms of disrupted cellular signaling in brain ischemia.

Nat Neurosci 2011 Oct 26;14(11):1369-73. Epub 2011 Oct 26.

Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nn.2951DOI Listing
October 2011

Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy.

J Neurosurg Pediatr 2011 Sep;8(3):310-5

Division of Neurosurgery, University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2011.6.PEDS1170DOI Listing
September 2011

Intracranial aneurysms: from vessel wall pathology to therapeutic approach.

Nat Rev Neurol 2011 Sep 20;7(10):547-59. Epub 2011 Sep 20.

Division of Neuroradiology, Toronto Western Hospital, University Health Network, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1038/nrneurol.2011.136DOI Listing
September 2011

Impact of individual intracranial arterial aneurysm morphology on initial obliteration and recurrence rates of endovascular treatments: a multivariate analysis.

J Neurosurg 2011 Apr 8;114(4):994-1002. Epub 2010 Oct 8.

Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2010.8.JNS10241DOI Listing
April 2011

Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography.

Neurosurgery 2011 Apr;68(4):1077-83

Division of Neurosurgery, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1227/NEU.0b013e31820c6cbeDOI Listing
April 2011

Translating promising preclinical neuroprotective therapies to human stroke trials.

Expert Rev Cardiovasc Ther 2011 Apr;9(4):433-49

University of Toronto, Department of Surgery, Division of Neurosurgery, Toronto Western Research Institute Neuroprotection Laboratory, 11-414 MCl 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.

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http://dx.doi.org/10.1586/erc.11.34DOI Listing
April 2011

Advances in vascular neurosurgery 2010.

Stroke 2011 Feb 13;42(2):288-90. Epub 2011 Jan 13.

Department of Neurologic Surgery and Radiology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1161/STROKEAHA.110.605105DOI Listing
February 2011

Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations.

Brain 2011 Jan 24;134(Pt 1):100-9. Epub 2010 Nov 24.

Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, The University of Toronto, Toronto, ON M5T 2S8, Canada.

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awq286DOI Listing
January 2011

Multidisciplinary care of occipital arteriovenous malformations: effect on nonhemorrhagic headache, vision, and outcome in a series of 135 patients. Clinical article.

J Neurosurg 2010 Oct;113(4):742-8

Division of Neurosurgery, Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2009.11.JNS09884DOI Listing
October 2010

Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before.

Stroke 2010 Oct;41(10 Suppl):S87-90

Toronto Western Hospital Research Institute, Toronto, Ontario, Canada.

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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.110.
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October 2010

Glutamate receptors, neurotoxicity and neurodegeneration.

Pflugers Arch 2010 Jul 14;460(2):525-42. Epub 2010 Mar 14.

Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8.

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http://dx.doi.org/10.1007/s00424-010-0809-1DOI Listing
July 2010

Steal physiology is spatially associated with cortical thinning.

J Neurol Neurosurg Psychiatry 2010 Mar;81(3):290-3

University Health Network, Toronto Western Hospital, Department of Medical Imaging, 399 Bathurst St, Toronto, M5T 2S8 ON, Canada.

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http://dx.doi.org/10.1136/jnnp.2009.188078DOI Listing
March 2010

Calcium, ischemia and excitotoxicity.

Cell Calcium 2010 Feb 18;47(2):122-9. Epub 2010 Feb 18.

Toronto Western Hospital Research Institute, MC11-414, 399 Bathurst Street, Toronto, Ontario, Canada M5T2S8.

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http://dx.doi.org/10.1016/j.ceca.2010.01.003DOI Listing
February 2010

Symptomatic enlargement of an occluded giant carotido-ophthalmic aneurysm after endovascular treatment: the vasa vasorum theory.

Acta Neurochir (Wien) 2009 Sep 3;151(9):1153-8. Epub 2009 Apr 3.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.

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September 2009

Assessment of extracranial-intracranial bypass patency with 64-slice multidetector computerized tomography angiography.

Neuroradiology 2009 Aug 24;51(8):505-15. Epub 2009 Mar 24.

Department of Neurosurgery, Lille University Hospital, Lille, France.

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http://dx.doi.org/10.1007/s00234-009-0522-yDOI Listing
August 2009

Intraoperative biplanar rotational angiography during neurovascular surgery. Technical note.

J Neurosurg 2009 Jul;111(1):188-92

Division of Neurosurgery, Toronto Western Hospital, and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2008.12.JNS081018DOI Listing
July 2009

Cellular schwannoma of the abducens nerve: case report and review of the literature.

Clin Neurol Neurosurg 2009 Jun 5;111(5):467-71. Epub 2009 Feb 5.

Department of Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.clineuro.2009.01.001DOI Listing
June 2009

The contribution of imaging in diagnosis, preoperative assessment, and follow-up of moyamoya disease: a review.

Neurosurg Focus 2009 Apr;26(4):E3

Division of Neurosurgery, University Health Network, Toronto Western Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2009.01.FOCUS08296DOI Listing
April 2009

International Stroke Conference 2009. Translation of high impact targets into clinical trials. 17-20 February 2009, San Diego, CA, USA.

IDrugs 2009 Apr;12(4):217-9

Toronto Western Hospital Research Institute, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

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April 2009

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons.

J Physiol 2009 Mar 5;587(Pt 5):965-79. Epub 2009 Jan 5.

Robarts Research Institute, Molecular Brain Research Group, University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8.

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http://dx.doi.org/10.1113/jphysiol.2008.162289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673769PMC
March 2009

The natural history and predictive features of hemorrhage from brain arteriovenous malformations.

Stroke 2009 Jan 13;40(1):100-5. Epub 2008 Nov 13.

Toronto Western Hospital, Division of Neurosurgery, Suite 4W-435, 399 Bathurst St, Toronto, Ontario, Canada.

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January 2009

Overview of the current role of endovascular and surgical treatment in spinal dural arteriovenous fistulas.

Neurosurg Focus 2009 Jan;26(1):E8

Division of Neurosurgery, Toronto Brain Vascular Malformation Study Group, University of Toronto, Canada.

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http://dx.doi.org/10.3171/FOC.2009.26.1.E8DOI Listing
January 2009

Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.

Stroke 2008 Sep 10;39(9):2544-53. Epub 2008 Jul 10.

Toronto Western Hospital Research Institute, Suite 4W-435, 399 Bathurst Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/STROKEAHA.107.506048DOI Listing
September 2008

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.

Trends Pharmacol Sci 2008 May 1;29(5):268-75. Epub 2008 Apr 1.

Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.tips.2008.02.003DOI Listing
May 2008

The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures.

Methods Mol Biol 2007 ;399:15-29

Toronto Western Research Institute, Division of Applied and International Research, Torornto, ON.

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http://link.springer.com/10.1007/978-1-59745-504-6_2
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March 2008

TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations.

Proc Natl Acad Sci U S A 2007 Oct 3;104(41):16323-8. Epub 2007 Oct 3.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1073/pnas.0701149104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042205PMC
October 2007

Pituitary adenoma associated with intraventricular meningioma: case report.

Skull Base 2007 Sep;17(5):347-51

Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1055/s-2007-986440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095121PMC
September 2007

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.

J Neurosci 2007 Mar;27(11):2846-57

Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5.

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http://dx.doi.org/10.1523/JNEUROSCI.0116-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672582PMC
March 2007

Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.

J Neurosci 2006 Nov;26(45):11540-53

Division of Applied and Interventional Research, Toronto Western Research Institute, Toronto, Ontario, Canada M5T 2S8.

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http://dx.doi.org/10.1523/JNEUROSCI.3507-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674768PMC
November 2006

Symptomatic non-atherosclerotic bilateral extracranial vertebral artery occlusion treated with extracranial to intracranial bypass: case report.

Arq Neuropsiquiatr 2006 Sep;64(3A):664-7

Toronto Western Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1590/s0004-282x2006000400028DOI Listing
September 2006

A discriminative prediction model of neurological outcome for patients undergoing surgery of brain arteriovenous malformations.

Stroke 2006 Jun 11;37(6):1457-64. Epub 2006 May 11.

University of Toronto Brain Vascular Malformation Study Group, Toronto Western Hospital, Ontario, Canada.

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http://dx.doi.org/10.1161/01.STR.0000222937.30216.13DOI Listing
June 2006

TRPMs and neuronal cell death.

Pflugers Arch 2005 Oct 26;451(1):243-9. Epub 2005 Jul 26.

Applied and Interventional Research and Division of Neurosurgery, Toronto Western Research Institute, W4-325, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada.

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http://dx.doi.org/10.1007/s00424-005-1439-xDOI Listing
October 2005

Preoperative and postoperative mapping of cerebrovascular reactivity in moyamoya disease by using blood oxygen level-dependent magnetic resonance imaging.

J Neurosurg 2005 Aug;103(2):347-55

Department of Medical Imaging (Division of Neuroradiology), The Toronto Western Hospital of the University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3171/jns.2005.103.2.0347DOI Listing
August 2005

Analysis of cost related to clinical and angiographic outcomes of aneurysm patients enrolled in the international subarachnoid aneurysm trial in a North American setting.

Neurosurgery 2005 May;56(5):886-94; discussion 886-94

University of Toronto Brain Vascular Malformation Study Group, Toronto Western Hospital, Toronto, Ontario, Canada.

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May 2005

TRPM7 and ischemic CNS injury.

Neuroscientist 2005 Apr;11(2):116-23

Applied and Interventional Research and Division of Neurosurgery, Toronto Western Research Institute, 399 BathurstStreet, Toronto, Ontario M5T 2S8, Canada.

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http://dx.doi.org/10.1177/1073858404272966DOI Listing
April 2005

Molecular mechanisms underlying specificity of excitotoxic signaling in neurons.

Curr Mol Med 2004 Mar;4(2):137-47

Toronto Western Research Institute, McPav 11-416, 399 Bathurst Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2174/1566524043479202DOI Listing
March 2004

A key role for TRPM7 channels in anoxic neuronal death.

Cell 2003 Dec;115(7):863-77

Toronto Western Hospital Research Institute, 11-416 MC-PAV, 399 Bathurst Street, Toronto, Ontario M5T-2S8 Canada.

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http://dx.doi.org/10.1016/s0092-8674(03)01017-1DOI Listing
December 2003

Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro.

J Neurotrauma 2003 Dec;20(12):1377-95

Toronto Western Hospital Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/089771503322686166DOI Listing
December 2003

Novel concepts in excitotoxic neurodegeneration after stroke.

Expert Rev Mol Med 2003 Dec 16;5(30):1-22. Epub 2003 Dec 16.

Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, Suite 4W-435, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

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https://www.cambridge.org/core/product/identifier/S146239940
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http://dx.doi.org/10.1017/S1462399403007087DOI Listing
December 2003

Peptide action in stroke therapy.

Expert Opin Biol Ther 2003 Oct;3(7):1093-104

Toronto Western Hospital, Suite 4W-435, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada.

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http://dx.doi.org/10.1517/14712598.3.7.1093DOI Listing
October 2003