Publications by authors named "Michael T McCabe"

40Publications

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.

Authors:
Aidan G Gilmartin Arthur Groy Elizabeth R Gore Charity Atkins Edward R Long Monica N Montoute Zining Wu Wendy Halsey Dean E McNulty Daniela Ennulat Lourdes Rueda Melissa Pappalardi Ryan G Kruger Michael T McCabe Ali Raoof Roger Butlin Alexandra Stowell Mark Cockerill Ian Waddell Donald Ogilvie Juan Luengo Allan Jordan Andrew B Benowitz

Haematologica 2020 06 25. Epub 2020 Jun 25.

GlaxoSmithKline, Collegeville, Pennsylvania, USA.

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June 2020

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer.

Authors:
Marian L Burr Christina E Sparbier Kah Lok Chan Yih-Chih Chan Ariena Kersbergen Enid Y N Lam Elizabeth Azidis-Yates Dane Vassiliadis Charles C Bell Omer Gilan Susan Jackson Lavinia Tan Stephen Q Wong Sebastian Hollizeck Ewa M Michalak Hannah V Siddle Michael T McCabe Rab K Prinjha Glen R Guerra Benjamin J Solomon Shahneen Sandhu Sarah-Jane Dawson Paul A Beavis Richard W Tothill Carleen Cullinane Paul J Lehner Kate D Sutherland Mark A Dawson

Cancer Cell 2019 10 26;36(4):385-401.e8. Epub 2019 Sep 26.

Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia; Centre for Cancer Research, University of Melbourne, Parkville, Australia. Electronic address:

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October 2019

Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors.

Authors:
Timothy A Yap Jane N Winter Lisa Giulino-Roth Jemma Longley Juanita Lopez Jean-Marie Michot John P Leonard Vincent Ribrag Michael T McCabe Caretha L Creasy Melissa Stern Teodora Pene Dumitrescu Xiaowei Wang Steve Frey Jennifer Carver Thierry Horner Choon Oh Ahmed Khaled Arindam Dhar Peter W M Johnson

Clin Cancer Res 2019 12 30;25(24):7331-7339. Epub 2019 Aug 30.

Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom.

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December 2019

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Authors:
Andrew Fedoriw Satyajit R Rajapurkar Shane O'Brien Sarah V Gerhart Lorna H Mitchell Nicholas D Adams Nathalie Rioux Trupti Lingaraj Scott A Ribich Melissa B Pappalardi Niyant Shah Jenny Laraio Yan Liu Michael Butticello Chris L Carpenter Caretha Creasy Susan Korenchuk Michael T McCabe Charles F McHugh Raman Nagarajan Craig Wagner Francesca Zappacosta Roland Annan Nestor O Concha Roberta A Thomas Timothy K Hart Jesse J Smith Robert A Copeland Mikel P Moyer John Campbell Kim Stickland James Mills Suzanne Jacques-O'Hagan Christina Allain Danielle Johnston Alejandra Raimondi Margaret Porter Scott Nigel Waters Kerren Swinger Ann Boriack-Sjodin Tom Riera Gideon Shapiro Richard Chesworth Rabinder K Prinjha Ryan G Kruger Olena Barbash Helai P Mohammad

Cancer Cell 2019 07 27;36(1):100-114.e25. Epub 2019 Jun 27.

Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address:

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July 2019

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Authors:
Sarah M Greenblatt Na Man Pierre-Jacques Hamard Takashi Asai Daniel Karl Concepcion Martinez Daniel Bilbao Vasileios Stathias Anna M Jermakowicz Stephanie Duffort Madhavi Tadi Ezra Blumenthal Samantha Newman Ly Vu Ye Xu Fan Liu Stephan C Schurer Michael T McCabe Ryan G Kruger Mingjiang Xu Feng-Chun Yang Daniel G Tenen Justin Watts Francisco Vega Stephen D Nimer

Cancer Cell 2019 Jan;35(1):156

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January 2019

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- retinoic acid in acute myeloid leukemia across subtypes.

Authors:
Kimberly N Smitheman Tesa M Severson Satyajit R Rajapurkar Michael T McCabe Natalie Karpinich James Foley Melissa B Pappalardi Ashley Hughes Wendy Halsey Elizabeth Thomas Christopher Traini Kelly E Federowicz Jenny Laraio Fredrick Mobegi Geraldine Ferron-Brady Rabinder K Prinjha Christopher L Carpenter Ryan G Kruger Lodewyk Wessels Helai P Mohammad

Haematologica 2019 06 4;104(6):1156-1167. Epub 2018 Dec 4.

Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA

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June 2019

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Authors:
Sarah M Greenblatt Na Man Pierre-Jacques Hamard Takashi Asai Daniel Karl Concepcion Martinez Daniel Bilbao Vasileios Stathias Anna McGrew-Jermacowicz Stephanie Duffort Madhavi Tadi Ezra Blumenthal Samantha Newman Ly Vu Ye Xu Fan Liu Stephan C Schurer Michael T McCabe Ryan G Kruger Mingjiang Xu Feng-Chun Yang Daniel Tenen Justin Watts Francisco Vega Stephen D Nimer

Cancer Cell 2018 11;34(5):868

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November 2018

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.

Authors:
Sarah V Gerhart Wendy A Kellner Christine Thompson Melissa B Pappalardi Xi-Ping Zhang Rocio Montes de Oca Elayne Penebre Kenneth Duncan Ann Boriack-Sjodin BaoChau Le Christina Majer Michael T McCabe Chris Carpenter Neil Johnson Ryan G Kruger Olena Barbash

Sci Rep 2018 06 26;8(1):9711. Epub 2018 Jun 26.

Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.

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June 2018

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Authors:
Sarah M Greenblatt Na Man Pierre-Jacques Hamard Takashi Asai Daniel Karl Concepcion Martinez Daniel Bilbao Vasileios Stathias Anna M Jermakowicz Stephanie Duffort Madhavi Tadi Ezra Blumenthal Samantha Newman Ly Vu Ye Xu Fan Liu Stephan C Schurer Michael T McCabe Ryan G Kruger Mingjiang Xu Feng-Chun Yang Daniel G Tenen Justin Watts Francisco Vega Stephen D Nimer

Cancer Cell 2018 06;33(6):1111-1127.e5

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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June 2018

MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.

Authors:
Anastasia Wyce Jeanne J Matteo Shawn W Foley Daniel J Felitsky Satyajit R Rajapurkar Xi-Ping Zhang Melissa C Musso Susan Korenchuk Natalie O Karpinich Kathryn M Keenan Melissa Stern Lijoy K Mathew Charles F McHugh Michael T McCabe Peter J Tummino Ryan G Kruger Christopher Carpenter Olena Barbash

Oncogenesis 2018 Apr 20;7(4):35. Epub 2018 Apr 20.

Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.

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April 2018

Signaling function of PRC2 is essential for TCR-driven T cell responses.

Authors:
Marc-Werner Dobenecker Joon Seok Park Jonas Marcello Michael T McCabe Richard Gregory Steven D Knight Inmaculada Rioja Anna K Bassil Rabinder K Prinjha Alexander Tarakhovsky

J Exp Med 2018 04 9;215(4):1101-1113. Epub 2018 Mar 9.

Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, NY

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April 2018

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.

Authors:
Allison E Drew Oscar Moradei Suzanne L Jacques Nathalie Rioux Ann P Boriack-Sjodin Christina Allain Margaret Porter Scott Lei Jin Alejandra Raimondi Jessica L Handler Heidi M Ott Ryan G Kruger Michael T McCabe Christopher Sneeringer Thomas Riera Gideon Shapiro Nigel J Waters Lorna H Mitchell Kenneth W Duncan Mikel P Moyer Robert A Copeland Jesse Smith Richard Chesworth Scott A Ribich

Sci Rep 2017 12 21;7(1):17993. Epub 2017 Dec 21.

Epizyme, Inc., Cambridge, Massachusetts, USA.

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December 2017

Targeting Histone Methylation in Cancer.

Authors:
Michael T McCabe Helai P Mohammad Olena Barbash Ryan G Kruger

Cancer J 2017 Sep/Oct;23(5):292-301

From the Cancer Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA.

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May 2018

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

Authors:
Lian Dee Ler Sujoy Ghosh Xiaoran Chai Aye Aye Thike Hong Lee Heng Ee Yan Siew Sucharita Dey Liang Kai Koh Jing Quan Lim Weng Khong Lim Swe Swe Myint Jia Liang Loh Pauline Ong Xin Xiu Sam Dachuan Huang Tony Lim Puay Hoon Tan Sanjanaa Nagarajan Christopher Wai Sam Cheng Henry Ho Lay Guat Ng John Yuen Po-Hung Lin Cheng-Keng Chuang Ying-Hsu Chang Wen-Hui Weng Steven G Rozen Patrick Tan Caretha L Creasy See-Tong Pang Michael T McCabe Song Ling Poon Bin Tean Teh

Sci Transl Med 2017 02;9(378)

Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.

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February 2017

Factors affecting the persistence of drug-induced reprogramming of the cancer methylome.

Authors:
Joshua S K Bell Jacob D Kagey Benjamin G Barwick Bhakti Dwivedi Michael T McCabe Jeanne Kowalski Paula M Vertino

Epigenetics 2016 04 15;11(4):273-87. Epub 2016 Apr 15.

b Winship Cancer Institute , Emory University , Atlanta , GA , USA.

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April 2016

Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Authors:
Lei Jiang Alexander A Shestov Pamela Swain Chendong Yang Seth J Parker Qiong A Wang Lance S Terada Nicholas D Adams Michael T McCabe Beth Pietrak Stan Schmidt Christian M Metallo Brian P Dranka Benjamin Schwartz Ralph J DeBerardinis

Nature 2016 Apr 6;532(7598):255-8. Epub 2016 Apr 6.

Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390-8502, USA.

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April 2016

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.

Authors:
Ujunwa C Okoye-Okafor Boris Bartholdy Jessy Cartier Enoch N Gao Beth Pietrak Alan R Rendina Cynthia Rominger Chad Quinn Angela Smallwood Kenneth J Wiggall Alexander J Reif Stanley J Schmidt Hongwei Qi Huizhen Zhao Gerard Joberty Maria Faelth-Savitski Marcus Bantscheff Gerard Drewes Chaya Duraiswami Pat Brady Arthur Groy Swathi-Rao Narayanagari Iléana Antony-Debre Kelly Mitchell Heng Rui Wang Yun-Ruei Kao Maximilian Christopeit Luis Carvajal Laura Barreyro Elisabeth Paietta Hideki Makishima Britta Will Nestor Concha Nicholas D Adams Benjamin Schwartz Michael T McCabe Jaroslav Maciejewski Amit Verma Ulrich Steidl

Nat Chem Biol 2015 Nov 5;11(11):878-86. Epub 2015 Oct 5.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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November 2015

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

Authors:
Helai P Mohammad Kimberly N Smitheman Chandrashekhar D Kamat David Soong Kelly E Federowicz Glenn S Van Aller Jess L Schneck Jeffrey D Carson Yan Liu Michael Butticello William G Bonnette Shelby A Gorman Yan Degenhardt Yuchen Bai Michael T McCabe Melissa B Pappalardi Jiri Kasparec Xinrong Tian Kenneth C McNulty Meagan Rouse Patrick McDevitt Thau Ho Michelle Crouthamel Timothy K Hart Nestor O Concha Charles F McHugh William H Miller Dashyant Dhanak Peter J Tummino Christopher L Carpenter Neil W Johnson Christine L Hann Ryan G Kruger

Cancer Cell 2015 Jul;28(1):57-69

Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address:

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July 2015

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

Authors:
Daniel Zingg Julien Debbache Simon M Schaefer Eylul Tuncer Sandra C Frommel Phil Cheng Natalia Arenas-Ramirez Jessica Haeusel Yudong Zhang Mario Bonalli Michael T McCabe Caretha L Creasy Mitchell P Levesque Onur Boyman Raffaella Santoro Olga Shakhova Reinhard Dummer Lukas Sommer

Nat Commun 2015 Jan 22;6:6051. Epub 2015 Jan 22.

Cell and Developmental Biology, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

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January 2015

A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.

Authors:
Heidi M Ott Alan P Graves Melissa B Pappalardi Michael Huddleston Wendy S Halsey Ashley M Hughes Arthur Groy Edward Dul Yong Jiang Yuchen Bai Roland Annan Sharad K Verma Steven D Knight Ryan G Kruger Dashyant Dhanak Benjamin Schwartz Peter J Tummino Caretha L Creasy Michael T McCabe

Mol Cancer Ther 2014 Dec 24;13(12):3062-73. Epub 2014 Sep 24.

Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania.

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December 2014