Publications by authors named "Michael T Lewis"

83Publications

Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9.

J Mammary Gland Biol Neoplasia 2020 06 23;25(2):145-162. Epub 2020 Jul 23.

Department of Molecular and Cellular Biology, Lester and Sue Smith Breast Center, Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Room N1210; BCM600, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10911-020-09454-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392944PMC
June 2020

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer.

J Vis Exp 2020 05 18(159). Epub 2020 May 18.

Department of Molecular and Cellular Biology, Baylor College of Medicine; Lester and Sue Smith Breast Center, Baylor College of Medicine; Dan L. Duncan Cancer Center, Baylor College of Medicine;

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http://dx.doi.org/10.3791/61173DOI Listing
May 2020

Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.

Proc Natl Acad Sci U S A 2020 05 22;117(18):9912-9921. Epub 2020 Apr 22.

UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232;

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http://dx.doi.org/10.1073/pnas.1921333117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211963PMC
May 2020

C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes.

Oncogene 2019 05 27;38(20):3765-3780. Epub 2018 Sep 27.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1038/s41388-018-0516-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437025PMC
May 2019

The chick chorioallantoic membrane (CAM) as a versatile patient-derived xenograft (PDX) platform for precision medicine and preclinical research.

Am J Cancer Res 2018 1;8(8):1642-1660. Epub 2018 Aug 1.

Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129484PMC
August 2018

New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 15;1868(1):315-332. Epub 2017 Jun 15.

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567999PMC
August 2017

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.

Nat Commun 2017 06 12;8:15773. Epub 2017 Jun 12.

Department of Pharmacology, University of Colorado-Denver, 12800 East 19th Avenue, Room P18-6115, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/ncomms15773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472791PMC
June 2017

Carbon nanotube capsules enhance the in vivo efficacy of cisplatin.

Acta Biomater 2017 08 2;58:466-478. Epub 2017 May 2.

Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2017.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344128PMC
August 2017

Epithelial and non-epithelial play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland.

Development 2017 04 8;144(7):1317-1327. Epub 2017 Mar 8.

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dev.140434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399619PMC
April 2017

The Terminal End Bud: the Little Engine that Could.

J Mammary Gland Biol Neoplasia 2017 06 6;22(2):93-108. Epub 2017 Feb 6.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10911-017-9372-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488158PMC
June 2017

The Pursuit of Truth in the Company of Friends : In Memorium: Charles W. Daniel.

J Mammary Gland Biol Neoplasia 2016 12;21(3-4):77-79

Breast Center, Baylor College of Medicine, One Baylor Plaza, Rm. N-1230.1;MS:BCM600, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10911-016-9367-2DOI Listing
December 2016

A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud.

PLoS Comput Biol 2016 Apr 26;12(4):e1004839. Epub 2016 Apr 26.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845990PMC
April 2016

An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

Sci Signal 2015 Sep 15;8(394):ra92. Epub 2015 Sep 15.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA. Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aaa7
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http://dx.doi.org/10.1126/scisignal.aaa7355DOI Listing
September 2015

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.

Cell Rep 2015 Jul 9;12(3):511-24. Epub 2015 Jul 9.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512851PMC
July 2015

Identifying and targeting tumor-initiating cells in the treatment of breast cancer.

Endocr Relat Cancer 2015 Jun 15;22(3):R135-55. Epub 2015 Apr 15.

Baylor College of MedicineLester and Sue Smith Breast Center, Houston, Texas, USADepartments of Molecular and Cellular BiologyRadiologyBaylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, Texas 77030, USA Baylor College of MedicineLester and Sue Smith Breast Center, Houston, Texas, USADepartments of Molecular and Cellular BiologyRadiologyBaylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, Texas 77030, USA Baylor College of MedicineLester and Sue Smith Breast Center, Houston, Texas, USADepartments of Molecular and Cellular BiologyRadiologyBaylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, Texas 77030, USA

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http://erc.endocrinology-journals.org/content/22/3/R135.full
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http://erc.endocrinology-journals.org/cgi/doi/10.1530/ERC-14
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http://dx.doi.org/10.1530/ERC-14-0447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447610PMC
June 2015

STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer.

Stem Cells 2014 Oct;32(10):2571-82

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1002/stem.1752DOI Listing
October 2014

Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer.

Stem Cells Transl Med 2014 Jul 5;3(7):857-66. Epub 2014 May 5.

Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, Texas, USA; Department of Developmental Biology, Pittsburgh, Pennsylvania, USA; Women's Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.5966/sctm.2013-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073819PMC
July 2014

Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.

J Biomol Screen 2014 Jul 13;19(6):878-89. Epub 2014 Feb 13.

Texas Children's Cancer Center, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

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http://dx.doi.org/10.1177/1087057114520972DOI Listing
July 2014

Three-dimensional vasculature reconstruction of tumour microenvironment via local clustering and classification.

Interface Focus 2013 Aug;3(4):20130015

Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute , Weill Cornell Medical College , Houston, TX 77030 , USA ; Department of Molecular and Cellular Biology , Baylor College of Medicine , One Baylor Plaza, Houston, TX 77030 , USA.

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http://dx.doi.org/10.1098/rsfs.2013.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915834PMC
August 2013

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Proc Natl Acad Sci U S A 2013 Apr 4;110(17):6991-6. Epub 2013 Apr 4.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1303671110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637696PMC
April 2013

Separation by cell size enriches for mammary stem cell repopulation activity.

Stem Cells Transl Med 2013 Mar 13;2(3):199-203. Epub 2013 Feb 13.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.5966/sctm.2012-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659766PMC
March 2013

Establishment of Patient-Derived Xenograft (PDX) Models of Human Breast Cancer.

Curr Protoc Mouse Biol 2013 Mar 1;3(1):21-9. Epub 2013 Mar 1.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/9780470942390.mo120140DOI Listing
March 2013

A mystery wrapped in an enigma: Matrigel enhancement of mammary cell growth and morphogenesis.

J Mammary Gland Biol Neoplasia 2012 Jun 13;17(2):99-101. Epub 2012 May 13.

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10911-012-9249-1DOI Listing
June 2012

Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes.

Cancer Res 2012 Jun 30;72(11):2705-13. Epub 2012 Mar 30.

Department of Anatomy & Cellular Biology, Sackler School of Biomedical Research, Tufts Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3287DOI Listing
June 2012

Integrative physical oncology.

Wiley Interdiscip Rev Syst Biol Med 2012 Jan-Feb;4(1):1-14. Epub 2011 Aug 18.

Department of Pathology, University of New Mexico, Albuquerque, NM, USA.

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http://dx.doi.org/10.1002/wsbm.158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622087PMC
April 2012

Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.

Dev Biol 2011 Apr 27;352(1):116-27. Epub 2011 Jan 27.

Program in Developmental Biology Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057274PMC
April 2011

Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study.

J Theor Biol 2011 Jan 20;269(1):138-49. Epub 2010 Oct 20.

Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00225193100054
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http://dx.doi.org/10.1016/j.jtbi.2010.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153880PMC
January 2011

Hedgehog signaling in the normal and neoplastic mammary gland.

Curr Drug Targets 2010 Sep;11(9):1103-11

The Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM600, Room N1210, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499530PMC
http://dx.doi.org/10.2174/138945010792006753DOI Listing
September 2010

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling.

Int J Biochem Cell Biol 2010 Sep 6;42(9):1462-71. Epub 2010 May 6.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S135727251000167
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http://dx.doi.org/10.1016/j.biocel.2010.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038129PMC
September 2010

Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.

Biol Reprod 2010 May 3;82(5):991-9. Epub 2010 Feb 3.

Department of Molecular and Cellular Biology, Department of Molecular and Human Genetics, The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1095/biolreprod.109.081513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857637PMC
May 2010

Methods in mammary gland biology and breast cancer research: an update.

J Mammary Gland Biol Neoplasia 2009 Dec 2;14(4):365. Epub 2009 Dec 2.

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http://dx.doi.org/10.1007/s10911-009-9162-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233414PMC
December 2009

Methods for preparing fluorescent and neutral red-stained whole mounts of mouse mammary glands.

J Mammary Gland Biol Neoplasia 2009 Dec 24;14(4):411-5. Epub 2009 Nov 24.

The Lester and Sue Smith Breast Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10911-009-9155-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038127PMC
December 2009

Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.

Development 2009 May 18;136(9):1423-32. Epub 2009 Mar 18.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/dev.023994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675781PMC
May 2009

Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis.

Mol Cancer 2009 Mar 6;8:15. Epub 2009 Mar 6.

Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1186/1476-4598-8-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669049PMC
March 2009

Tumor-initiating cells and treatment resistance: how goes the war?

J Mammary Gland Biol Neoplasia 2009 Mar 24;14(1):1-2. Epub 2009 Feb 24.

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http://dx.doi.org/10.1007/s10911-009-9112-1DOI Listing
March 2009

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

Breast Cancer Res Treat 2009 Jun 19;115(3):505-21. Epub 2008 Jun 19.

Lester and Sue Smith Breast Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10549-008-0093-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300001PMC
June 2009

Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia.

Development 2007 Mar 7;134(6):1231-42. Epub 2007 Feb 7.

Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210; MS:BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/dev.02797DOI Listing
March 2007

Next stop, the twilight zone: hedgehog network regulation of mammary gland development.

J Mammary Gland Biol Neoplasia 2004 Apr;9(2):165-81

Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1023/B:JOMG.0000037160.24731.35DOI Listing
April 2004

Embryogenesis and oncogenesis: Dr Jekyll and Mr Hyde.

J Mammary Gland Biol Neoplasia 2004 Apr;9(2):105-7

Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1023/B:JOMG.0000037155.93520.4aDOI Listing
April 2004