Michael Simons

Michael Simons

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Michael Simons

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FRS2α-dependent cell fate transition during endocardial cushion morphogenesis.

Dev Biol 2019 Oct 25. Epub 2019 Oct 25.

Department of Internal Medicine and Department of Cell Biology, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.10.022DOI Listing
October 2019

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

J Exp Med 2019 Aug 13;216(8):1874-1890. Epub 2019 Jun 13.

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT

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http://dx.doi.org/10.1084/jem.20182151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683988PMC
August 2019

Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis.

Nat Commun 2019 Aug 15;10(1):3679. Epub 2019 Aug 15.

Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, 10 Amistad St., New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1038/s41467-019-11659-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695411PMC
August 2019

Metabolic Analysis of Lymphatic Endothelial Cells.

Methods Mol Biol 2018 ;1846:325-334

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA.

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http://link.springer.com/10.1007/978-1-4939-8712-2_22
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http://dx.doi.org/10.1007/978-1-4939-8712-2_22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693514PMC
May 2019

Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization.

Nat Commun 2019 05 7;10(1):2124. Epub 2019 May 7.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

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http://www.nature.com/articles/s41467-019-10205-0
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http://dx.doi.org/10.1038/s41467-019-10205-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504881PMC
May 2019

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization.

Nat Commun 2019 04 5;10(1):1562. Epub 2019 Apr 5.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1038/s41467-019-09605-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450910PMC
April 2019

Metacognitive Therapy for Posttraumatic Stress Disorder in Youth: A Feasibility Study.

Front Psychol 2019 19;10:264. Epub 2019 Feb 19.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.3389/fpsyg.2019.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389642PMC
February 2019

Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis.

Curr Opin Lipidol 2018 10;29(5):397-403

Yale Cardiovascular Research Center, Department of Internal Medicine.

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http://dx.doi.org/10.1097/MOL.0000000000000542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290915PMC
October 2018

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis.

Nat Commun 2018 08 17;9(1):3303. Epub 2018 Aug 17.

Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, 10 Amistad St., New Haven, CT, 06520, USA.

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http://www.nature.com/articles/s41467-018-05812-2
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http://dx.doi.org/10.1038/s41467-018-05812-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098000PMC
August 2018

Recent advances in understanding lymphangiogenesis and metabolism.

F1000Res 2018 20;7. Epub 2018 Jul 20.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.12688/f1000research.14803.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058463PMC
July 2018

Endothelial Metabolic Control of Lymphangiogenesis.

Bioessays 2018 06 11;40(6):e1700245. Epub 2018 May 11.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, 06511, USA.

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http://doi.wiley.com/10.1002/bies.201700245
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http://dx.doi.org/10.1002/bies.201700245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237195PMC
June 2018

Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Arterioscler Thromb Vasc Biol 2018 04 15;38(4):870-879. Epub 2018 Feb 15.

From the Vascular Biology and Therapeutics Program, Department of Pharmacology (M.Y.L., A.G.-M., J.K., W.C.S.), Vascular Biology and Therapeutics Program, Department of Pathology (T.R.K.), and Department of Cell Biology (M.S.), Yale University School of Medicine, New Haven, CT; Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT (J.Z., Z.Z., M.S.); Department of Chemistry, Yale University, New Haven, CT (D.J.V., G.W.B.); and Department of Internal Medicine, VA Connecticut Healthcare System, West Haven, CT (H.V.).

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http://dx.doi.org/10.1161/ATVBAHA.118.310748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503971PMC
April 2018

A unifying concept in vascular health and disease.

Science 2018 Apr;360(6386):270-271

Yale Cardiovascular Research Center, 300 George Street, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1126/science.aat3470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295341PMC
April 2018

The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.

J Biol Chem 2018 03 7;293(13):4805-4817. Epub 2018 Feb 7.

From the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, and

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http://dx.doi.org/10.1074/jbc.M117.812172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880142PMC
March 2018

Reprogramming the Endocardium: Trials and Tribulations.

Circ Res 2018 03;122(7):913-915

From the Department of Internal Medicine and Department of Cell Biology, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880288PMC
March 2018

Emetophobia - A Metacognitive Therapeutic Approach for an Overlooked Disorder.

Z Kinder Jugendpsychiatr Psychother 2018 Jan 29;46(1):57-66. Epub 2016 Sep 29.

1 Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, RWTH Aachen University, Germany.

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http://dx.doi.org/10.1024/1422-4917/a000464DOI Listing
January 2018

SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.

Circ Res 2017 Sep 31;121(6):636-649. Epub 2017 Jul 31.

From the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581236PMC
September 2017

Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition.

Curr Drug Targets 2016 ;17(15):1707-1713

Yale Cardiovascular Research Center, 300 George St New Haven, CT 06511, USA.

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http://dx.doi.org/10.2174/1389450117666160502151308DOI Listing
August 2017

[Metacognitive Therapy and Pharmacotherapy - Adapted to Unaccompanied Refugee Minors].

Prax Kinderpsychol Kinderpsychiatr 2017 Apr;66(4):287-303

Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters Uniklinik RWTH Aachen Neuenhofer Weg 21 52074 Aachen Deutschland Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen.

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http://www.vr-elibrary.de/doi/10.13109/prkk.2017.66.4.287
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http://dx.doi.org/10.13109/prkk.2017.66.4.287DOI Listing
April 2017

The molecular basis of endothelial cell plasticity.

Nat Commun 2017 02 9;8:14361. Epub 2017 Feb 9.

Yale Cardiovascular Research Center, Department of Internal Medicine and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut CT06511, USA.

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http://dx.doi.org/10.1038/ncomms14361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309780PMC
February 2017

[New developments in the psychotherapeutic and pharmacological treatment of pediatric obsessivecompulsive disorder].

Z Kinder Jugendpsychiatr Psychother 2017 01 13;45(1):9-22. Epub 2016 Jun 13.

1 Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Universitätsklinikum der RWTH Aachen.

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http://dx.doi.org/10.1024/1422-4917/a000445DOI Listing
January 2017

Modulation of VEGF receptor 2 signaling by protein phosphatases.

Pharmacol Res 2017 01 23;115:107-123. Epub 2016 Nov 23.

Yale Cardiovascular Research Center, Department of Internal Medicine and Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5205541PMC
January 2017

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.

Development 2016 12 27;143(23):4441-4451. Epub 2016 Oct 27.

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA

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http://dx.doi.org/10.1242/dev.140129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201046PMC
December 2016

[The powerlessness of thoughts – metacognitive therapy for children and adolescents].

Authors:
Michael Simons

Z Kinder Jugendpsychiatr Psychother 2016 11 13;44(6):423-431. Epub 2016 Jun 13.

1 Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Uniklinik der RWTH Aachen.

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http://dx.doi.org/10.1024/1422-4917/a000438DOI Listing
November 2016

Mechanisms and regulation of endothelial VEGF receptor signalling.

Nat Rev Mol Cell Biol 2016 10 27;17(10):611-25. Epub 2016 Jul 27.

Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory and Science for Life Laboratory, Dag Hammarskjöldsv 20, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1038/nrm.2016.87DOI Listing
October 2016

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation.

Sci Rep 2016 09 16;6:33407. Epub 2016 Sep 16.

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/srep33407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025753PMC
September 2016

Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity.

Circ Res 2016 Aug 27;119(5):607-20. Epub 2016 Jun 27.

From the INSERM U970, Paris Center for Cardiovascular Research (PARCC), Paris, France (L.P., L.P.-F., T.M., A.E.); Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (A.D., M.S., A.E.); and INSERM U1050, Collège de France, Centre Interdisciplinaire de Recherche en Biologie (CIRB), Paris, France (I.E., I.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308473DOI Listing
August 2016

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression.

EMBO Mol Med 2016 07 1;8(7):712-28. Epub 2016 Jul 1.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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http://dx.doi.org/10.15252/emmm.201506181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931287PMC
July 2016

The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature.

Curr Opin Hematol 2016 May;23(3):260-7

aDepartment of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center bDepartment of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA.

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https://insights.ovid.com/crossref?an=00062752-201605000-000
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http://dx.doi.org/10.1097/MOH.0000000000000233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957701PMC
May 2016

When endothelial cells go rogue.

EMBO Mol Med 2016 Jan;8(1):1-2

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.15252/emmm.201505943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718160PMC
January 2016

[Diagnoses and treatment of (unaccompanied) refugee minors - a major challenge for child and adolescent psychiatry in Germany].

Z Kinder Jugendpsychiatr Psychother 2015 Nov;43(6):381-3

5 Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie, Universitätsklinikum Ulm.

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http://dx.doi.org/10.1024/1422-4917/a000380DOI Listing
November 2015

Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):12812-7. Epub 2015 Sep 28.

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1507094112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611600PMC
October 2015

Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.

Cytoskeleton (Hoboken) 2015 Aug;72(8):373-87

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1002/cm.21236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600664PMC
August 2015

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

Arterioscler Thromb Vasc Biol 2015 Jun 16;35(6):1401-12. Epub 2015 Apr 16.

From the Department of Biochemistry and Molecular Biology (Y.W., Y.C., S.B., A.K.S., E.W., L.H.H., S.K.D., E.B.L., D.M.), Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics (S.Y., A.T.), Department of Anesthesiology (V.N., J.C.-P., E.N.C.), Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Health Science Program (K.S., J.-P.A.K.), Department of Gastroenterology (V.S.), and Thoracic Diseases Research Unit, Department of Biochemistry and Molecular Biology (E.B.L.), Mayo Clinic, Rochester, MN; Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery (M.T., M.J., M.T.R., J.A.S., N.M.) and Department of Cell Biology, Center for Vascular Biology (K.P.C.), University of Connecticut Health Center, Farmington; Department of Surgery, Saint Mary's Hospital, Waterbury, CT (M.J., M.T.R., J.A.S.); and Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (M.S.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441604PMC
June 2015

Molecular controls of arterial morphogenesis.

Circ Res 2015 May;116(10):1712-24

From the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (M.S., A.E.) and Departments of Cell Biology (M.S.) and Molecular Physiology (A.E.), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.302953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509635PMC
May 2015

When it is better to regress: dynamics of vascular pruning.

PLoS Biol 2015 May 15;13(5):e1002148. Epub 2015 May 15.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433099PMC
May 2015

Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling.

F1000Prime Rep 2015 3;7:26. Epub 2015 Mar 3.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine 300 George Street, New Haven, CT 06520 USA ; Department of Cell Biology, Yale University School of Medicine 300 George Street, New Haven, CT 06520 USA.

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http://www.f1000.com/prime/reports/b/7/26
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http://dx.doi.org/10.12703/P7-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371373PMC
April 2015

Endothelial cell metabolism in normal and diseased vasculature.

Circ Res 2015 Mar;116(7):1231-44

From the Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven, Belgium (G.E., P.d.Z., P.C.); Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven, Belgium (G.E., P.d.Z., P.C.); Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT (M.S.); and Department of Cell Biology, Yale University School of Medicine, New Haven, CT (M.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.302855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380230PMC
March 2015

Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis.

PLoS One 2014 6;9(6):e90736. Epub 2014 Mar 6.

Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America; Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090736PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946293PMC
February 2015

Molecular controls of lymphatic VEGFR3 signaling.

Arterioscler Thromb Vasc Biol 2015 Feb 18;35(2):421-9. Epub 2014 Dec 18.

From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (Y.D., X.Z., M.S.) and Department of Cell Biology (X.Z., M.S.), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/ATVBAHA.114.304881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304921PMC
February 2015

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

J Biol Chem 2015 Jan 11;290(1):409-22. Epub 2014 Nov 11.

From the Departments of Pathology, the Program of Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, Connecticut 06520 Biomedical Engineering and

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http://dx.doi.org/10.1074/jbc.M114.618421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281743PMC
January 2015

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):17308-13. Epub 2014 Nov 17.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University, New Haven, CT 06520; Department of Biomedical Engineering, Yale University, New Haven, CT 06520; and Department of Cell Biology, Yale University, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1413725111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260558PMC
December 2014

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Proc Natl Acad Sci U S A 2014 Dec 24;111(51):18309-14. Epub 2014 Nov 24.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, and

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http://dx.doi.org/10.1073/pnas.1412172111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280608PMC
December 2014

Lymphatic fate specification: an ERK-controlled transcriptional program.

Microvasc Res 2014 Nov 15;96:10-5. Epub 2014 Aug 15.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT 06520, United States; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mvr.2014.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268409PMC
November 2014

Long-term symptoms and posttraumatic growth in traumatised adolescents: findings from a specialised outpatient clinic.

J Trauma Stress 2014 Oct 30;27(5):622-5. Epub 2014 Sep 30.

Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Medical Faculty, RWTH Aachen University, Germany.

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http://dx.doi.org/10.1002/jts.21955DOI Listing
October 2014

Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.

Arterioscler Thromb Vasc Biol 2014 Sep 12;34(9):1831-7. Epub 2014 Jun 12.

From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.303217
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http://dx.doi.org/10.1161/ATVBAHA.114.303217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141018PMC
September 2014

PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.

Circulation 2014 Sep 30;130(11):902-9. Epub 2014 Jun 30.

From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (A.A.L., D.L., A.D., J.Z., Z.W.Z., A.E., M.S.) and the Department of Cell Biology (M.S.), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.009683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060619PMC
September 2014

A brief etymology of the collateral circulation.

Arterioscler Thromb Vasc Biol 2014 Sep 10;34(9):1854-9. Epub 2014 Jul 10.

From the Departments of Cell Biology and Physiology, University of North Carolina, Chapel Hill (J.E.F.); Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown (W.M.C.), Walter-Brendel-Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany (E.D.); Division of Cardiology, VU University Medical Center, Amsterdam, The Netherlands (N.V.R.); and Departments of Internal Medicine and Cell Biology, Yale Cardiovascular Research Center, New Haven, CT (M.S.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140974PMC
September 2014

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):12865-70. Epub 2014 Aug 18.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1408472111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156707PMC
September 2014

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.

J Exp Med 2014 Sep 1;211(10):1957-68. Epub 2014 Sep 1.

Section of Cardiovascular Medicine, Department of Internal Medicine and the Yale Cardiovascular Research Center, Department of Immunobiology, Department of Cell Biology, and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University School of Medicine, New Haven, CT 06511 Section of Cardiovascular Medicine, Department of Internal Medicine and the Yale Cardiovascular Research Center, Department of Immunobiology, Department of Cell Biology, and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University School of Medicine, New Haven, CT 06511 Section of Cardiovascular Medicine, Department of Internal Medicine and the Yale Cardiovascular Research Center, Department of Immunobiology, Department of Cell Biology, and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University School of Medicine, New Haven, CT 06511

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http://dx.doi.org/10.1084/jem.20132130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172219PMC
September 2014

Brain radiation-related black dots on susceptibility-weighted imaging.

Neuroradiol J 2014 Sep 29;27(4):445-51. Epub 2014 Aug 29.

Department of Radiology, Neuroradiology Division, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236872PMC
http://dx.doi.org/10.15274/NRJ-2014-10071DOI Listing
September 2014

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

Sci Signal 2014 Sep 23;7(344):ra90. Epub 2014 Sep 23.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/scisignal.2005504DOI Listing
September 2014

Fox(y) regulators of VEGF receptors.

Circ Res 2014 Sep;115(8):683-5

From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181365PMC
September 2014

Flow-regulated lymphatic vasculature development and signaling.

Vasc Cell 2014 9;6:14. Epub 2014 Jul 9.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA ; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://vascularcell.com/index.php/vc/article/view/10.1186-20
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http://dx.doi.org/10.1186/2045-824X-6-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105398PMC
July 2014

Vasa vasorum in normal and diseased arteries.

Circulation 2014 Jun;129(24):2557-66

From the Department of Surgery, Vascular Section, Geisel School of Medicine at Dartmouth, Lebanon, NH (M.J.M.-K.); and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (M.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007189DOI Listing
June 2014

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Proc Natl Acad Sci U S A 2014 Apr 2;111(15):5514-9. Epub 2014 Apr 2.

Yale Cardiovascular Research Center, Department of Internal Medicine, and Departments of Surgery, Pharmacology, and Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

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http://dx.doi.org/10.1073/pnas.1404545111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992672PMC
April 2014

Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.

Cancer Cell 2014 Mar;25(3):350-65

Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017921PMC
March 2014

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

Nature 2014 Jan 20;505(7481):97-102. Epub 2013 Nov 20.

Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature12681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142699PMC
January 2014

Endothelial cell-dependent regulation of arteriogenesis.

Circ Res 2013 Oct 29;113(9):1076-86. Epub 2013 Jul 29.

From the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, New Haven, CT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865810PMC
October 2013

Need glucose to sprout: local metabolic control of angiogenesis.

EMBO Mol Med 2013 10 27;5(10):1459-61. Epub 2013 Aug 27.

Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA; CIRB, Collège de France, Inserm 1050, Paris, France.

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http://dx.doi.org/10.1002/emmm.201303174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799572PMC
October 2013

Syndecan-4 signaling at a glance.

J Cell Sci 2013 Sep 22;126(Pt 17):3799-804. Epub 2013 Aug 22.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.124636
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757327PMC
September 2013

Endothelial signaling and the molecular basis of arteriovenous malformation.

Cell Mol Life Sci 2013 Sep 28. Epub 2013 Sep 28.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.

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http://link.springer.com/10.1007/s00018-013-1475-1
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969452PMC
September 2013

Physiology. Lymphatics are in my veins.

Science 2013 Aug;341(6146):622-4

Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/science.1243452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241765PMC
August 2013

Lymphatics in health and disease: a new thematic series in vascular cell.

Vasc Cell 2013 Jul 25;5(1):14. Epub 2013 Jul 25.

Pathology, Columbia University Medical Center, NY, NY, 10032, USA.

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http://vascularcell.com/index.php/vc/article/view/10.1186-20
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http://dx.doi.org/10.1186/2045-824X-5-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734013PMC
July 2013

The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo.

J Biol Chem 2013 May 22;288(18):12712-21. Epub 2013 Mar 22.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.452383
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642317PMC
May 2013

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

Blood 2013 May 25;121(19):3988-96, S1-9. Epub 2013 Mar 25.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1182/blood-2012-12-474601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650709PMC
May 2013

Effects of cell grafting on coronary remodeling after myocardial infarction.

J Am Heart Assoc 2013 May 30;2(3):e000202. Epub 2013 May 30.

Department of Pathology, Center for Cardiovascular Biology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1161/JAHA.113.000202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698786PMC
May 2013

NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.

J Clin Invest 2013 Apr;123(4):1718-31

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, USA.

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http://www.jci.org/articles/view/65112
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http://dx.doi.org/10.1172/JCI65112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613910PMC
April 2013

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis.

Dev Cell 2013 Apr;25(2):156-68

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1016/j.devcel.2013.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774154PMC
April 2013

Endothelial ERK signaling controls lymphatic fate specification.

J Clin Invest 2013 Mar 8;123(3):1202-15. Epub 2013 Feb 8.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1172/JCI63034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582116PMC
March 2013

Syndecan 4 regulation of PDK1-dependent Akt activation.

Cell Signal 2013 Jan 10;25(1):101-5. Epub 2012 Sep 10.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.cellsig.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508137PMC
January 2013

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

PLoS One 2012 22;7(5):e37600. Epub 2012 May 22.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037600PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358251PMC
December 2012

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Cell Rep 2012 Dec 29;2(6):1684-96. Epub 2012 Nov 29.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534912PMC
December 2012

Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice.

Arterioscler Thromb Vasc Biol 2012 Nov 13;32(11):2644-51. Epub 2012 Sep 13.

Departments of Surgery, Vascular Section (J.I.M., A.J.-H.P., J.K., T.Z.W., M.J.M.-K.), Immunology and Microbiology (S.K.), Medicine, Cardiology Section (S.L.S.), and Thayer School of Engineering (L.G.Z.), Dartmouth Medical School, Lebanon, NH; and Department of Internal Medicine, Cardiovascular Medicine Section, Yale University School of Medicine, New Haven, CT (M.S.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.252544
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http://dx.doi.org/10.1161/ATVBAHA.112.252544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819102PMC
November 2012

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.

Circulation 2012 Nov 22;126(22):2589-600. Epub 2012 Oct 22.

Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520-8017, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.119321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514045PMC
November 2012

Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency.

Angiogenesis 2012 Sep 5;15(3):469-80. Epub 2012 May 5.

Department of Medical Cell Biology, Uppsala University, Box 571, Husargatan 3, 75123, Uppsala, Sweden.

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http://link.springer.com/10.1007/s10456-012-9275-z
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059510PMC
September 2012

An inside view: VEGF receptor trafficking and signaling.

Authors:
Michael Simons

Physiology (Bethesda) 2012 Aug;27(4):213-22

Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1152/physiol.00016.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037811PMC
August 2012

Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.

Sci Signal 2012 May 8;5(223):ra36. Epub 2012 May 8.

Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1126/scisignal.2002495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827948PMC
May 2012

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

Dev Cell 2012 Mar;22(3):489-500

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511-6664, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047762PMC
March 2012