Publications



Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro.
Toxicology 2016 Aug 30;370:94-105. Epub 2016 Sep 30.
University of Tübingen, Dept. of Experimental and Clinical Pharmacology and Toxicology, Wilhelmstr. 56, 72074 Tübingen, Germany; Federal Institute for Risk Assessment, Dept. Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address:



Antibiotic resistance marker genes as environmental pollutants in GMO-pristine agricultural soils in Austria.
Environ Pollut 2015 Nov 30;206:342-51. Epub 2015 Jul 30.
Division for Data, Statistics and Risk Assessment, Austrian Agency for Health and Food Safety (AGES - Österreichische Agentur für Gesundheit und Ernährungssicherheit), Vienna and Graz, Austria.

Application of HC-AFW1 Hepatocarcinoma Cells for Mechanistic Studies: Regulation of Cytochrome P450 2B6 Expression by Dimethyl Sulfoxide and Early Growth Response 1.
Drug Metab Dispos 2015 Nov 25;43(11):1727-33. Epub 2015 Aug 25.
University of Tübingen, Department of Toxicology, Tübingen (B.P., M.S., A.B.), Natural and Medical Sciences Institute, Reutlingen (N.G.), and Federal Institute for Risk Assessment, Department of Food Safety, Berlin (A.B.), Germany

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.
Drug Metab Dispos 2015 Nov 26;43(11):1781-7. Epub 2015 Aug 26.
Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany (A.B.); Dr.-Margarethe-Fischer-Bosch-Institute for Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (M.T., U.H., J.J., W.S., U.M.Z.); Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Tübingen, Germany (A.B., S.V., E.Z., B.P., M.S.); Regensburg University Hospital, Regensburg, Germany (T.S.W.).


Cervical Discitis in Children.
Pediatr Infect Dis J 2015 Jul;34(7):794-5
From the *Department of Pediatrics B, †Pediatric Infectious Disease Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; ‡Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; §Department of Imaging, and ¶Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.
Mol Pharmacol 2015 Jun 30;87(6):1013-20. Epub 2015 Mar 30.
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Tuebingen, Germany (M.T., C.B., U.H., U.M.Z.); Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Tübingen, Germany (S.V., M.S.); and Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany (A.B.).

Relevance of the mouse skin initiation-promotion model for the classification of carcinogenic substances encountered at the workplace.
Regul Toxicol Pharmacol 2015 Jun 3;72(1):150-7. Epub 2015 Apr 3.
Ruhr University Bochum, Institute for Prevention and Occupational Medicine of the DGUV, Department for Clinical and Experimental Occupational Dermatology, Bürkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany.

Signal integration by the CYP1A1 promoter--a quantitative study.
Nucleic Acids Res 2015 Jun 1;43(11):5318-30. Epub 2015 May 1.
Institute for Pathology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany Integrative Research Institute for the Life Sciences and Institute for Theoretical Biology, Humboldt University of Berlin, Philippstr. 13, 10115 Berlin, Germany

Real-time markerless lung tumor tracking in fluoroscopic video: Handling overlapping of projected structures.
Med Phys 2015 May;42(5):2540-9
Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg D-69120, Germany and Faculty of Medical Informatics, Heilbronn University, Max-Planck-Strasse 39, Heilbronn D-74081, Germany.



Ha-ras and β-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors.
Int J Cancer 2014 Oct 3;135(7):1574-85. Epub 2014 Mar 3.
Institute of Experimental and Clinical Pharmacology and Toxicology Department of Toxicology, Eberhard Karls University of Tübingen, Tübingen, 72074, Germany.



T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice.
Hepatology 2014 Jun 14;59(6):2344-57. Epub 2014 Apr 14.
Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (CNRS), UMR8104, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1016, Paris, France.


Parallel responses of bees to Pleistocene climate change in three isolated archipelagos of the southwestern Pacific.
Proc Biol Sci 2014 Jun 7;281(1785):20133293. Epub 2014 May 7.
School of Biological Sciences, Flinders University, , GPO Box 2100, Adelaide, South Australia 5001, Australia, South Australian Museum, , GPO Box 234, Adelaide, South Australia 5000, Australia, School of Pharmacy and Medical Sciences, University of South Australia, , Adelaide, South Australia 5000, Australia.

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.
Nucleic Acids Res 2014 Apr 23;42(7):4180-95. Epub 2014 Jan 23.
Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, 4057 Basel, Switzerland, Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, 72074 Tübingen, Germany, Department of Pharmacology and Toxicology, Michigan State University, MI 48824, USA and Biozentrum, University of Basel and Swiss Institute of Bioinformatics, 4056 Basel, Switzerland.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.
Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.



Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice.
J Mol Histol 2011 Oct 6;42(5):393-400. Epub 2011 Aug 6.
Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Wilhelmstr. 56, 72074 Tübingen, Germany.


Inclusive fitness theory and eusociality.
Nature 2011 Mar;471(7339):E1-4; author reply E9-10




Coordinate regulation of Cyp2e1 by β-catenin- and hepatocyte nuclear factor 1α-dependent signaling.
Toxicology 2016 03 3;350-352:40-8. Epub 2016 May 3.
University of Tübingen, Dept. of Toxicology, Wilhelmstr. 56, 72074 Tübingen, Germany; Federal Institute for Risk Assessment, Dept. Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address:


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