Publications by authors named "Michael Scharl"

100Publications

Malignancies in Inflammatory Bowel Disease.

Digestion 2020 14;101 Suppl 1:136-145. Epub 2020 Aug 14.

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000509544DOI Listing
August 2020

The Role of Protein Tyrosine Phosphatases in Inflammasome Activation.

Int J Mol Sci 2020 Jul 31;21(15). Epub 2020 Jul 31.

Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.3390/ijms21155481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432435PMC
July 2020

PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.

Gastroenterology 2020 Jul 9. Epub 2020 Jul 9.

Division of Biomedical Sciences, University of California Riverside, Riverside, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.07.004DOI Listing
July 2020

Novel Strategies to Prevent Total Parenteral Nutrition-Induced Gut and Liver Inflammation, and Adverse Metabolic Outcomes.

Mol Nutr Food Res 2020 May 2:e1901270. Epub 2020 May 2.

Department of Anesthesiology and Pain Medicine and Cardiovascular Research Centre, University of Alberta, Edmonton, T6G 2R3, Canada.

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http://dx.doi.org/10.1002/mnfr.201901270DOI Listing
May 2020

Effect of distance to specialist care for the diagnosis and disease outcome of inflammatory bowel disease in the Swiss inflammatory bowel disease cohort study.

Therap Adv Gastroenterol 2020 24;13:1756284819895217. Epub 2020 Jan 24.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.

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http://dx.doi.org/10.1177/1756284819895217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984432PMC
January 2020

Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine.

Inflamm Bowel Dis 2020 Jun;26(7):1038-1049

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/ibd/izaa013DOI Listing
June 2020

Lower Risk of B1-to-pB3-Stage Migration in Crohn's Disease Upon Immunosuppressive and Anti-TNF Treatment in the Swiss IBD Cohort Study.

Dig Dis Sci 2020 Sep 3;65(9):2654-2663. Epub 2019 Dec 3.

Division of Gastroenterology and Hepatology, Department of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10620-019-05978-9DOI Listing
September 2020

Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells.

Inflamm Intest Dis 2019 Oct 17;4(4):161-173. Epub 2019 Sep 17.

Department of Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000502861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873011PMC
October 2019

Intestinal microbiota and colorectal carcinoma: Implications for pathogenesis, diagnosis, and therapy.

EBioMedicine 2019 Oct 17;48:648-655. Epub 2019 Oct 17.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838386PMC
October 2019

Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission.

Clin Gastroenterol Hepatol 2020 Aug 20;18(9):2019-2029.e11. Epub 2019 Sep 20.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.09.022DOI Listing
August 2020

Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

Therap Adv Gastroenterol 2019 13;12:1756284819865142. Epub 2019 Aug 13.

Department of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Rämistrasse 100, 8091 Zürich, Switzerland.

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http://dx.doi.org/10.1177/1756284819865142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693019PMC
August 2019

Response to Al Sulais et al.

Am J Gastroenterol 2019 08;114(8):1346-1347

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.14309/ajg.0000000000000318DOI Listing
August 2019

Stepwise Development of an Continuous Fermentation Model for the Murine Caecal Microbiota.

Front Microbiol 2019 29;10:1166. Epub 2019 May 29.

Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.3389/fmicb.2019.01166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548829PMC
May 2019

AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species.

Am J Physiol Gastrointest Liver Physiol 2019 08 9;317(2):G171-G181. Epub 2019 May 9.

Division of Biomedical Sciences, University of California, Riverside, Riverside, California.

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http://dx.doi.org/10.1152/ajpgi.00317.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734373PMC
August 2019

The appearance of joint manifestations in the Swiss inflammatory bowel disease cohort.

PLoS One 2019 30;14(4):e0211554. Epub 2019 Apr 30.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211554PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490952PMC
December 2019

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.

Stem Cell Res 2019 03 7;35:101383. Epub 2019 Feb 7.

Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Translational Research Center, 91054 Erlangen, Germany; Optical Imaging Centre Erlangen (OICE), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91052 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.scr.2019.101383DOI Listing
March 2019

[Perianal fistulas in CED: from mouse model to clinic].

Authors:
Michael Scharl

Ther Umsch 2019 Jan;75(5):287-294

1 Klinik für Gastroenterologie und Hepatologie, UniversitätsSpital Zurich.

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http://dx.doi.org/10.1024/0040-5930/a001000DOI Listing
January 2019

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

PLoS One 2019 25;14(1):e0210436. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347222PMC
November 2019

Tofacitinib for the Treatment of Pyoderma Gangrenosum.

Clin Gastroenterol Hepatol 2019 04 4;17(5):991-993. Epub 2018 Nov 4.

Multidisciplinary Center for Inflammatory Bowel Disease, University of North Carolina, Chapel Hill, North Carolina; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183121
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http://dx.doi.org/10.1016/j.cgh.2018.10.047DOI Listing
April 2019

Genetics and epigenetics of inflammatory bowel disease.

Swiss Med Wkly 2018 09 23;148:w14671. Epub 2018 Sep 23.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2018.14671DOI Listing
September 2018

PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.

Mol Cell Oncol 2018 6;5(4):e1465013. Epub 2018 Jun 6.

Department for Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

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https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1
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http://dx.doi.org/10.1080/23723556.2018.1465013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149699PMC
June 2018

Eribulin Does Not Prevent Epithelial-to-Mesenchymal Transition in HT-29 Intestinal Epithelial Cells.

Inflamm Intest Dis 2018 Jul 10;2(4):211-218. Epub 2018 Jul 10.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000490052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135225PMC
July 2018

The Efficacy and Safety of Golimumab as Third- or Fourth-Line Anti-TNF Therapy in Patients with Refractory Crohn's Disease: A Case Series.

Inflamm Intest Dis 2017 Nov 19;2(2):131-138. Epub 2017 Oct 19.

Department of Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000481400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988172PMC
November 2017

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort.

Inflamm Bowel Dis 2018 07;24(8):1768-1779

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/ibd/izy054DOI Listing
July 2018

New insights into the pathophysiology of inflammatory bowel disease: microbiota, epigenetics and common signalling pathways.

Swiss Med Wkly 2018 22;148:w14599. Epub 2018 Mar 22.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Switzerland.

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http://doi.emh.ch/smw.2018.14599
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http://dx.doi.org/10.4414/smw.2018.14599DOI Listing
October 2018

Clinical manifestations, pathophysiology, treatment and outcome of inflammatory bowel diseases in older people.

Maturitas 2018 Apr 31;110:71-78. Epub 2018 Jan 31.

Division of Gastroenterology and Hepatology, University Hospital Zurich (USZ) and Zurich University, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.maturitas.2018.01.015DOI Listing
April 2018

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.

Cell Rep 2018 02;22(7):1835-1848

Clinic for Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636824PMC
February 2018

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Autophagy 2017 Sep 8;13(9):1590-1601. Epub 2017 Aug 8.

a Division of Gastroenterology and Hepatology , University Hospital Zurich, University of Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.1080/15548627.2017.1341453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612532PMC
September 2017

Fistulizing Crohn's Disease.

Clin Transl Gastroenterol 2017 Jul 13;8(7):e106. Epub 2017 Jul 13.

Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/ctg.2017.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539341PMC
July 2017

A Symptomatic Coffee Bean: Acute Sigmoid Volvulus.

Case Rep Gastroenterol 2017 May-Aug;11(2):348-351. Epub 2017 May 22.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000475918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471756PMC
May 2017

Widely differing screening and treatment practice for osteoporosis in patients with inflammatory bowel diseases in the Swiss IBD cohort study.

Medicine (Baltimore) 2017 Jun;96(22):e6788

aDivision of Gastroenterology and Hepatology, University Hospital Zurich and University of Zurich, Zurich bInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne cDivision of Rheumatology, University Hospital Zurich and University of Zurich dDepartment of Medicine, Division of Gastroenterology, Triemli Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1097/MD.0000000000006788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459696PMC
June 2017

Anti-TNF Treatment for Extraintestinal Manifestations of Inflammatory Bowel Disease in the Swiss IBD Cohort Study.

Inflamm Bowel Dis 2017 07;23(7):1174-1181

1Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland; 2Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; 3Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland; 4Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne, Switzerland; 5Division of Gastroenterology, Lindenhof Spital, Bern, Switzerland; 6Division of Gastroenterology and Hepatology, Spital Tiefenau, Bern, Switzerland; 7Crohn and Colitis Center, Clinique La Source-Beaulieu, Lausanne, Switzerland; 8Praxis Römerhof, Olten, Switzerland; 9Institute of Social and Preventive Medicine (IUMSP), University of Lausanne, Lausanne, Switzerland; 10Department of Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland; 11Department of Gastroenterology, See Spital, Horgen, Switzerland; 12Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; and 13Division of Gastroenterology, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1097/MIB.0000000000001109DOI Listing
July 2017

Anti-Cytokine Strategies beyond Anti-Tumour Necrosis Factor-α Therapy: Pathophysiology and Clinical Implications.

Dig Dis 2017 1;35(1-2):5-12. Epub 2017 Feb 1.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

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https://www.karger.com/Article/FullText/449076
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http://dx.doi.org/10.1159/000449076DOI Listing
February 2017

The perspective of celiac disease patients on emerging treatment options and non-celiac gluten sensitivity.

Dig Liver Dis 2017 Mar 7;49(3):268-272. Epub 2016 Dec 7.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2016.11.016DOI Listing
March 2017

Patients' views on fecal microbiota transplantation: an acceptable therapeutic option in inflammatory bowel disease?

Eur J Gastroenterol Hepatol 2017 Mar;29(3):322-330

aDepartment of Gastroenterology and Hepatology bDepartment of Hematology, University Hospital Zurich, University of Zurich cDepartment of Gastroenterology, Triemli Hospital dDepartment of Gastroenterology, Hospital Bethanien, Zurich, Switzerland eDepartment of Gastroenterology, Robert-Bosch-Hospital, Stuttgart, Germany.

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http://dx.doi.org/10.1097/MEG.0000000000000783DOI Listing
March 2017

Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease: Prevalence, Presentation, and Anti-TNF Treatment.

J Pediatr Gastroenterol Nutr 2017 08;65(2):200-206

*Division of Gastroenterology and Hepatology, University Hospital Zurich †Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich ‡Praxis Römerhof, Olten §Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland ||Division of Gastroenterology, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia ¶Division of Gastroenterology and Nutrition and Children's Research Center, University Children's Hospital Zurich, Zurich #Department of Pediatrics, Kantonsspital Winterthur, Winterthur **Division of Gastroenterology and Hepatology, Kinderspital St Gallen, St Gallen ††Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Hospital Lausanne-CHUV, Lausanne ‡‡Department of Pediatrics, University Hospital Geneva-HCUG, Geneva §§Division of Gastroenterology and Hepatology, University Children's Hospital Bern, Bern ||||Division of Gastroenterology and Nutrition, University Children's Hospital Basel-UKBB, Basel ¶¶Department of Pediatrics, Kantonsspital Luzern-LUKS, Luzern ##Private Practice, Pediatric Unit, Clinique des Grangettes, Geneva ***Private Practice, Onex †††Division of Gastroenterology and Hepatology, University Hospital Basel, Basel ‡‡‡Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne §§§Department of Pediatrics, Hopital Cantonal de Fribourg, Fribourg, Switzerland.

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http://dx.doi.org/10.1097/MPG.0000000000001455DOI Listing
August 2017

Prediction of low bone mineral density in patients with inflammatory bowel diseases.

United European Gastroenterol J 2016 Oct 30;4(5):669-676. Epub 2016 Jun 30.

Division of Gastroenterology and Hepatology, University Hospital Zurich and Zurich University, Switzerland.

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http://dx.doi.org/10.1177/2050640616658224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042312PMC
October 2016

Anti-MMP-9 Antibody: A Promising Therapeutic Strategy for Treatment of Inflammatory Bowel Disease Complications with Fibrosis.

Inflamm Bowel Dis 2016 09;22(9):2041-57

*Calypso Biotech SA, Plan-les-Ouates, Geneva, Switzerland; and †Clinic of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1097/MIB.0000000000000863DOI Listing
September 2016

The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease.

United European Gastroenterol J 2016 Aug 19;4(4):506-14. Epub 2016 Feb 19.

Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://journals.sagepub.com/doi/10.1177/2050640616635957
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http://dx.doi.org/10.1177/2050640616635957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971795PMC
August 2016

Cytomegalovirus disease in inflammatory bowel disease: epidemiology and disease characteristics in a large single-centre experience.

Eur J Gastroenterol Hepatol 2016 Nov;28(11):1329-34

aDivision of Gastroenterology and Hepatology, University Hospital Zurich bZurich Center for Integrative Human Physiology, University of Zurich cDivision of Gastroenterology and Hepatology, Triemli Hospital dDivision of Gastroenterology and Hepatology, Clinic Bethanien, Zurich eDivision of Gastroenterology and Hepatology, Kantonsspital St Gallen, Switzerland.

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http://dx.doi.org/10.1097/MEG.0000000000000716DOI Listing
November 2016

The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis.

United European Gastroenterol J 2016 Jun 6;4(3):325-32. Epub 2015 Aug 6.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

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http://journals.sagepub.com/doi/10.1177/2050640615600115
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http://dx.doi.org/10.1177/2050640615600115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924425PMC
June 2016

Orbital Pseudotumor as a Rare Extrahepatic Manifestation of Hepatitis C Infection.

Case Rep Gastroenterol 2016 Jan-Apr;10(1):108-14. Epub 2016 May 19.

Division of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000444011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929361PMC
July 2016

Malignancies in Patients with Inflammatory Bowel Disease: A Single-Centre Experience.

Digestion 2016 18;94(1):1-8. Epub 2016 Jun 18.

Division of Gastroenterology and Hepatology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

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http://dx.doi.org/10.1159/000447259DOI Listing
March 2017

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.

World J Gastroenterol 2016 Jan;22(3):1034-44

Marianne R Spalinger, Gerhard Rogler, Michael Scharl, Division of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://www.wjgnet.com/1007-9327/full/v22/i3/1034.htm
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http://dx.doi.org/10.3748/wjg.v22.i3.1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716018PMC
January 2016