Publications by authors named "Michael Sattler"

100Publications

Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.

Chem Commun (Camb) 2020 Nov 25. Epub 2020 Nov 25.

Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Lichtenbergstraße 4, 85747, Garching, Germany and Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1039/d0cc04383dDOI Listing
November 2020

The charged linker modulates conformations and molecular interactions of Hsp90.

Chembiochem 2020 Nov 4. Epub 2020 Nov 4.

Technische Universitat Munchen, Department of Chemistry, Lichtenbergstr. 4, 85747, Garching, GERMANY.

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http://dx.doi.org/10.1002/cbic.202000699DOI Listing
November 2020

Active coacervate droplets as a model for membraneless organelles and protocells.

Nat Commun 2020 10 14;11(1):5167. Epub 2020 Oct 14.

Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-020-18815-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560875PMC
October 2020

The dynamics of linear polyubiquitin.

Sci Adv 2020 Oct 14;6(42). Epub 2020 Oct 14.

Department of Chemistry and Institute for Advanced Study, Technical University of Munich, Garching 85747, Germany.

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http://dx.doi.org/10.1126/sciadv.abc3786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556843PMC
October 2020

Albumin-binding domain extends half-life of glucagon-like peptide-1.

Eur J Pharmacol 2020 Oct 10:173650. Epub 2020 Oct 10.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2020.173650DOI Listing
October 2020

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.

Mol Cell 2020 10 26;80(1):102-113.e6. Epub 2020 Aug 26.

Department of Biochemistry, Ludwig Maximilians University, 81377 Munich, Germany; Gene Center, Ludwig Maximilians University, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534798PMC
October 2020

When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.

Structure 2020 07;28(7):730-732

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany; Bavarian NMR Center and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2020.06.005DOI Listing
July 2020

Correction for Softley et al., "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase".

Antimicrob Agents Chemother 2020 06 23;64(7). Epub 2020 Jun 23.

Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Garching, Germany

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http://dx.doi.org/10.1128/AAC.01077-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318002PMC
June 2020

Paramagnetic NMR in drug discovery.

J Biomol NMR 2020 Jul 10;74(6-7):287-309. Epub 2020 Jun 10.

Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Lichtenbergstraße 4, 85747, Garching, Germany.

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http://dx.doi.org/10.1007/s10858-020-00322-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311382PMC
July 2020

Detection of atrial fibrillation with implantable loop recorders in horses.

Equine Vet J 2020 Jun 7. Epub 2020 Jun 7.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/evj.13301DOI Listing
June 2020

Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.

J Mol Biol 2020 Jun 22;432(14):4127-4138. Epub 2020 May 22.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Center for Integrated Protein Science Munich at Bavarian NMR Center and Biomolecular NMR, Department Chemie, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2020.05.012DOI Listing
June 2020

Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.

Mol Pharm 2020 May 13;17(5):1663-1673. Epub 2020 Apr 13.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 300308 Tianjin, China.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00098DOI Listing
May 2020

Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase.

Antimicrob Agents Chemother 2020 05 21;64(6). Epub 2020 May 21.

Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Garching, Germany

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http://dx.doi.org/10.1128/AAC.00123-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269475PMC
May 2020

Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes.

J Mol Biol 2020 04 19;432(9):2890-2912. Epub 2020 Mar 19.

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany; Bavarian NMR Center and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2020.03.014DOI Listing
April 2020

Water envelope has a critical impact on the design of protein-protein interaction inhibitors.

Chem Commun (Camb) 2020 Apr 20;56(31):4360-4363. Epub 2020 Mar 20.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. and BIGCHEM GmbH, Valerystr. 49, 85716 Unterschleißheim, Germany.

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http://dx.doi.org/10.1039/c9cc07714fDOI Listing
April 2020

Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.

Nat Commun 2020 03 16;11(1):1410. Epub 2020 Mar 16.

Center for Integrated Protein Science Munich at the Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, D85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-020-15050-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075974PMC
March 2020

Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.

Neurochem Int 2020 06 6;136:104713. Epub 2020 Mar 6.

Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Research Unit Neurobiology of Diabetes, 85764, Neuherberg, Germany; Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Institute for Diabetes and Obesity, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany; Technical University of Munich, Neurobiology of Diabetes, TUM School of Medicine, 81675, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2020.104713DOI Listing
June 2020

Conformational control of small GTPases by AMPylation.

Proc Natl Acad Sci U S A 2020 03 2;117(11):5772-5781. Epub 2020 Mar 2.

Center for Integrated Protein Science Munich, Department Chemistry, Technical University of Munich, 85747 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1917549117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084064PMC
March 2020

New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC).

ChemMedChem 2020 03 21;15(5):468-470. Epub 2020 Feb 21.

Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany.

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http://dx.doi.org/10.1002/cmdc.202000019DOI Listing
March 2020

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.

J Med Chem 2020 02 23;63(3):1156-1177. Epub 2020 Jan 23.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences , University of Copenhagen , Universitetsparken 2 , 2100 Copenhagen , Denmark.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01492DOI Listing
February 2020

Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.

Angew Chem Int Ed Engl 2020 03 28;59(14):5771-5781. Epub 2020 Jan 28.

Helmholtz-Zentrum München (HMGU), Deutsches Forschungszentrum für Gesundheit und Umwelt, Institute of Structural Biology, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1002/anie.201914559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154662PMC
March 2020

The molecular basis of chaperone-mediated interleukin 23 assembly control.

Nat Commun 2019 09 11;10(1):4121. Epub 2019 Sep 11.

Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-019-12006-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739322PMC
September 2019

The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.

Nat Commun 2019 08 9;10(1):3626. Epub 2019 Aug 9.

Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-019-11518-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689086PMC
August 2019

Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.

Biochim Biophys Acta Mol Cell Res 2019 12 29;1866(12):118520. Epub 2019 Jul 29.

Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, 44780 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2019.07.015DOI Listing
December 2019

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.

Nat Commun 2019 07 29;10(1):3393. Epub 2019 Jul 29.

Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152, Martinsried, Germany.

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http://www.nature.com/articles/s41467-019-11339-x
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http://dx.doi.org/10.1038/s41467-019-11339-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662825PMC
July 2019

Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats.

J Mol Cell Biol 2019 10;11(10):845-859

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, 85764, Germany.

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http://dx.doi.org/10.1093/jmcb/mjz086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917512PMC
October 2019

Potentiation of ABCA3 lipid transport function by ivacaftor and genistein.

J Cell Mol Med 2019 08 18;23(8):5225-5234. Epub 2019 Jun 18.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1111/jcmm.14397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652914PMC
August 2019

Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.

Angew Chem Int Ed Engl 2019 07 5;58(28):9429-9433. Epub 2019 Jun 5.

Lehrstuhl für Biomolekulare NMR-Spektroskopie, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.

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http://dx.doi.org/10.1002/anie.201902994DOI Listing
July 2019

Selective isotope labeling for NMR structure determination of proteins in complex with unlabeled ligands.

J Biomol NMR 2019 Apr 30;73(3-4):183-189. Epub 2019 Apr 30.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://link.springer.com/10.1007/s10858-019-00241-9
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http://dx.doi.org/10.1007/s10858-019-00241-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525670PMC
April 2019

Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.

J Mol Biol 2019 05 23;431(11):2213-2221. Epub 2019 Apr 23.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.04.017DOI Listing
May 2019

The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.

Mol Cell 2019 04 12;74(1):73-87.e8. Epub 2019 Mar 12.

Center for Integrated Protein Science at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.011DOI Listing
April 2019

Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.

Curr Pharm Des 2018 ;24(41):4932-4946

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

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http://dx.doi.org/10.2174/1381612825666190206105232DOI Listing
November 2019

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.

Curr Opin Microbiol 2018 12 24;46:116-122. Epub 2018 Nov 24.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2018.11.003DOI Listing
December 2018

The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.

Structure 2019 02 15;27(2):327-334.e3. Epub 2018 Nov 15.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany; Center for Integrated Protein Science Munich at Chair of Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, Garching 85747, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183036
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http://dx.doi.org/10.1016/j.str.2018.10.005DOI Listing
February 2019

Luciferase Advisor: High-Accuracy Model To Flag False Positive Hits in Luciferase HTS Assays.

J Chem Inf Model 2018 05 18;58(5):933-942. Epub 2018 Apr 18.

Institute of Structural Biology , Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) , Ingolstaedter Landstrasse 1 , 85764 Neuherberg , Germany.

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http://dx.doi.org/10.1021/acs.jcim.7b00574DOI Listing
May 2018

A switch point in the molecular chaperone Hsp90 responding to client interaction.

Nat Commun 2018 04 16;9(1):1472. Epub 2018 Apr 16.

Center for integrated protein science at the Department Chemie of the Technische Universität München, 84748, Garching, Germany.

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http://dx.doi.org/10.1038/s41467-018-03946-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902578PMC
April 2018

Identification of small-molecule inhibitors of USP2a.

Eur J Med Chem 2018 Apr 5;150:261-267. Epub 2018 Mar 5.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.03.009DOI Listing
April 2018

Ultrashort Broadband Cooperative Pulses for Multidimensional Biomolecular NMR Experiments.

Angew Chem Int Ed Engl 2018 10 25;57(44):14498-14502. Epub 2018 Apr 25.

Center for Integrated Protein Science Munich (CIPSM) at Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstr. 4, 85747, Garching, Germany.

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http://doi.wiley.com/10.1002/anie.201800220
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http://dx.doi.org/10.1002/anie.201800220DOI Listing
October 2018

Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain.

Angew Chem Int Ed Engl 2018 01 8;57(2):486-490. Epub 2017 Dec 8.

Department Chemie, Technische Universität München, TUM, Lichtenbergstraße 4, 85747, Garching, Germany.

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http://dx.doi.org/10.1002/anie.201708233DOI Listing
January 2018

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53.

RNA 2017 12 7;23(12):1780-1787. Epub 2017 Sep 7.

Max-Planck-Institute of Biochemistry, Department of Structural Cell Biology, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1261/rna.062901.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688999PMC
December 2017

A chemical compound inhibiting the Aha1-Hsp90 chaperone complex.

J Biol Chem 2017 10 28;292(41):17073-17083. Epub 2017 Aug 28.

From the Center for Integrated Protein Science Munich, Department of Chemistry, Technische Universität München, D-85747 Garching, Germany,

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http://dx.doi.org/10.1074/jbc.M117.797829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641884PMC
October 2017

Expression and purification of a difficult sarcomeric protein: Telethonin.

Protein Expr Purif 2017 Dec 12;140:74-80. Epub 2017 Aug 12.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Institute of Structural Biology, Helmholtz Center Munich, National Research Center for Environmental Health, Neuherberg, Germany; Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2017.08.007DOI Listing
December 2017

Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy.

Chemistry 2017 Oct 12;23(57):14267-14277. Epub 2017 Sep 12.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://doi.wiley.com/10.1002/chem.201702423
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http://dx.doi.org/10.1002/chem.201702423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862035PMC
October 2017

RNA structure refinement using NMR solvent accessibility data.

Sci Rep 2017 07 14;7(1):5393. Epub 2017 Jul 14.

Center for Integrated Protein Science Munich, Department Chemie, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41598-017-05821-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511288PMC
July 2017

Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.

Microb Cell 2017 Jul 3;4(7):229-232. Epub 2017 Jul 3.

Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, 44780 Bochum, Germany.

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http://dx.doi.org/10.15698/mic2017.07.581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507685PMC
July 2017

Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.

Angew Chem Int Ed Engl 2017 08 5;56(32):9322-9325. Epub 2017 Jul 5.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1002/anie.201702904DOI Listing
August 2017

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.

Sci Rep 2017 04 21;7(1):1051. Epub 2017 Apr 21.

Munich Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41598-017-01031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430869PMC
April 2017

Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition.

Methods 2017 04 16;118-119:119-136. Epub 2017 Mar 16.

Center for Integrated Protein Science Munich (CiPSM) at the Department of Chemistry, Technische Universität München, 85748 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.03.015DOI Listing
April 2017

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.

Nat Struct Mol Biol 2017 02 16;24(2):152-161. Epub 2017 Jan 16.

Institute of Structural Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

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http://www.nature.com/articles/nsmb.3351
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http://dx.doi.org/10.1038/nsmb.3351DOI Listing
February 2017

Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.

Proc Natl Acad Sci U S A 2016 11 31;113(46):E7169-E7175. Epub 2016 Oct 31.

Department of Chemistry, Ludwig-Maximilians University, Munich, D-81377 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1605873113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135374PMC
November 2016

Importance of cycle timing for the function of the molecular chaperone Hsp90.

Nat Struct Mol Biol 2016 Nov 10;23(11):1020-1028. Epub 2016 Oct 10.

Center for Integrated Protein Science Munich, Department of Chemistry, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1038/nsmb.3305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248305PMC
November 2016

Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.

J Med Chem 2016 11 4;59(22):10190-10197. Epub 2016 Nov 4.

Institute of Structural Biology, Helmholtz Zentrum München , Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01118DOI Listing
November 2016

Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions.

Front Mol Biosci 2016 13;3:54. Epub 2016 Sep 13.

Institut de Biologie Structurale, CEA, Centre National de la Recherche Scientifique, University Grenoble Alpes Grenoble, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020063PMC
http://dx.doi.org/10.3389/fmolb.2016.00054DOI Listing
September 2016

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex.

Chemistry 2016 Oct 8;22(43):15350-15359. Epub 2016 Sep 8.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1002/chem.201602784DOI Listing
October 2016

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.

Nat Commun 2016 Mar 24;7:11032. Epub 2016 Mar 24.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg DE-85764, Germany.

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http://dx.doi.org/10.1038/ncomms11032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603727PMC
March 2016

RNA recognition by Roquin in posttranscriptional gene regulation.

Wiley Interdiscip Rev RNA 2016 07 4;7(4):455-69. Epub 2016 Feb 4.

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1002/wrna.1333DOI Listing
July 2016

Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure.

J Am Chem Soc 2016 Feb 29;138(5):1601-10. Epub 2016 Jan 29.

Magnetic Resonance Center "CERM" and Department of Chemistry "Ugo Schiff", University of Florence and Magnetic Resonance Consortium (CIRMMP) , Via L. Sacconi 6, 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1021/jacs.5b11598DOI Listing
February 2016

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.

Nat Commun 2015 Nov 16;6:8875. Epub 2015 Nov 16.

Heidelberg University Biochemistry Center (BZH), INF 328, Heidelberg D-69120, Germany.

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http://dx.doi.org/10.1038/ncomms9875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660199PMC
November 2015

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.

J Biol Chem 2015 Dec 28;290(52):30843-54. Epub 2015 Oct 28.

From the Center for Integrated Protein Science München at Department of Chemistry, Technische Universität München, 85748 Garching, Germany and

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http://dx.doi.org/10.1074/jbc.M115.693150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692213PMC
December 2015

Structural biology of the import pathways of peroxisomal matrix proteins.

Biochim Biophys Acta 2016 May 9;1863(5):804-13. Epub 2015 Oct 9.

Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Center for Integrated Protein Science Munich (CIPSM) at Department of Chemistry, Technische Universität München, Lichtenbergstr.4, 85747 Garching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.09.034DOI Listing
May 2016

Towards the molecular mechanism of the integration of peroxisomal membrane proteins.

Biochim Biophys Acta 2016 May 3;1863(5):863-9. Epub 2015 Oct 3.

EMBL Hamburg, c/o DESY, Building 25A, Notkestraße 85, 22603 Hamburg, Germany; University of Hamburg Clinical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819957PMC
May 2016

Efficient segmental isotope labeling of multi-domain proteins using Sortase A.

J Biomol NMR 2015 Sep 30;63(1):1-8. Epub 2015 Aug 30.

Institute of Structural Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1007/s10858-015-9981-0DOI Listing
September 2015

Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements.

Methods Enzymol 2015 26;558:333-362. Epub 2015 Mar 26.

Institute of Structural Biology, Helmholtz Zentrum München, Oberschleißheim, Germany; Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879150008
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http://dx.doi.org/10.1016/bs.mie.2015.02.006DOI Listing
March 2016

Deciphering the protein-RNA recognition code: combining large-scale quantitative methods with structural biology.

Bioessays 2015 Aug 8;37(8):899-908. Epub 2015 Jun 8.

Institute of Structural Biology, Helmholtz Zentrum M, ü, nchen, München, Germany.

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http://doi.wiley.com/10.1002/bies.201500033
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http://dx.doi.org/10.1002/bies.201500033DOI Listing
August 2015

The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation.

PLoS Pathog 2015 May 29;11(5):e1004910. Epub 2015 May 29.

Department of Gene Vectors, Hematologikum, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1004910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449002PMC
May 2015