Michael S Neuberger

Michael S Neuberger

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Michael S Neuberger

Michael S Neuberger

Publications by authors named "Michael S Neuberger"

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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.

Elife 2013 Apr 16;2:e00534. Epub 2013 Apr 16.

Protein and Nucleic Acid Chemistry Division , Medical Research Council Laboratory of Molecular Biology , Cambridge , United Kingdom.

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http://dx.doi.org/10.7554/eLife.00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628087PMC
April 2013

The cytoplasmic AID complex.

Semin Immunol 2012 Aug 13;24(4):273-80. Epub 2012 Jun 13.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.smim.2012.05.004DOI Listing
August 2012

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).

Proc Natl Acad Sci U S A 2011 Nov 31;108(45):18366-71. Epub 2011 Oct 31.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1106729108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215039PMC
November 2011

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase.

J Exp Med 2011 Nov 31;208(12):2385-91. Epub 2011 Oct 31.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1084/jem.20110856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256965PMC
November 2011

A high-throughput assay for DNA deaminases.

Methods Mol Biol 2011 ;718:171-84

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-018-8_11DOI Listing
June 2011

The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification.

FASEB J 2011 Apr;25(4):1123-32

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://www.fasebj.org/doi/10.1096/fj.11-0402ufm
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http://dx.doi.org/10.1096/fj.11-0402ufmDOI Listing
April 2011

The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin.

Eur J Immunol 2011 Feb 23;41(2):485-90. Epub 2010 Dec 23.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.201041011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437479PMC
February 2011

Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.

J Biol Chem 2010 Mar 17;285(10):7111-8. Epub 2009 Dec 17.

Department of Bioscience and Biotechnology, Graduate School of Agriculture, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.052977
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http://dx.doi.org/10.1074/jbc.M109.052977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844160PMC
March 2010

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.

J Exp Med 2010 Jan 4;207(1):141-53. Epub 2010 Jan 4.

Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, England, UK.

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http://dx.doi.org/10.1084/jem.20092238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812546PMC
January 2010

The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3.

J Virol 2009 Nov 2;83(22):11550-9. Epub 2009 Sep 2.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH.

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http://dx.doi.org/10.1128/JVI.01430-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772689PMC
November 2009

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity.

Nat Struct Mol Biol 2009 Jul 21;16(7):769-76. Epub 2009 Jun 21.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1038/nsmb.1623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851237PMC
July 2009

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.

Proc Natl Acad Sci U S A 2009 Apr 7;106(16):6736-41. Epub 2009 Apr 7.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0810808106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672500PMC
April 2009

Preface.

Philos Trans R Soc Lond B Biol Sci 2009 Mar;364(1517):561-2

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://www.royalsocietypublishing.org/doi/10.1098/rstb.2008.
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http://dx.doi.org/10.1098/rstb.2008.0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660926PMC
March 2009

Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.

J Virol 2008 Nov 10;82(22):10998-1008. Epub 2008 Sep 10.

Department of Immunology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.1128/JVI.01311-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573259PMC
November 2008

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Mol Cell 2008 Aug;31(4):474-84

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.07.009DOI Listing
August 2008

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

Cancer Res 2008 Jun;68(12):4571-9

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet Medical Center and University of Oslo, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0168DOI Listing
June 2008

Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.

J Virol 2008 May 13;82(9):4660-4. Epub 2008 Feb 13.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02469-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293047PMC
May 2008

Antibody diversification by somatic mutation: from Burnet onwards.

Immunol Cell Biol 2008 Feb 8;86(2):124-32. Epub 2008 Jan 8.

1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.icb.7100160DOI Listing
February 2008

Dependence of antibody gene diversification on uracil excision.

J Exp Med 2007 Dec 10;204(13):3209-19. Epub 2007 Dec 10.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 QH, UK.

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http://dx.doi.org/10.1084/jem.20071768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150978PMC
December 2007

Molecular mechanisms of antibody somatic hypermutation.

Annu Rev Biochem 2007 ;76:1-22

Institut de Recherches Cliniques de Montréal, H2W 1R7 Montréal, Québec, Canada.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.76.
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http://dx.doi.org/10.1146/annurev.biochem.76.061705.090740DOI Listing
September 2007

DNA deamination in immunity: AID in the context of its APOBEC relatives.

Adv Immunol 2007 ;94:37-73

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/S0065-2776(06)94002-4DOI Listing
September 2007

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.

J Exp Med 2007 Jan 26;204(1):7-10. Epub 2006 Dec 26.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1084/jem.20062409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118430PMC
January 2007

Insights into DNA deaminases.

Nat Struct Mol Biol 2007 Jan;14(1):7-9

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http://dx.doi.org/10.1038/nsmb0107-7DOI Listing
January 2007

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

J Exp Med 2006 Sep 7;203(9):2085-94. Epub 2006 Aug 7.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

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http://www.jem.org/lookup/doi/10.1084/jem.20061067
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http://dx.doi.org/10.1084/jem.20061067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118391PMC
September 2006

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells.

Mol Immunol 2006 Mar 24;43(8):1099-108. Epub 2005 Aug 24.

University of Minnesota, Department of Biochemistry, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.molimm.2005.07.024DOI Listing
March 2006

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.

EMBO J 2006 Feb 12;25(3):585-95. Epub 2006 Jan 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383525PMC
February 2006

Mice deficient in APOBEC2 and APOBEC3.

Mol Cell Biol 2005 Aug;25(16):7270-7

Medical Research Council Laboratory of Molecular Biology, Division of PNAC, Cambridge, UK.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.16.7270-7277.2005
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http://dx.doi.org/10.1128/MCB.25.16.7270-7277.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190257PMC
August 2005

Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities.

Nucleic Acids Res 2005 4;33(6):1913-23. Epub 2005 Apr 4.

Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1093/nar/gki343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074398PMC
April 2005

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

Mol Biol Evol 2005 Feb 20;22(2):367-77. Epub 2004 Oct 20.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1093/molbev/msi026DOI Listing
February 2005

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

Nat Rev Immunol 2005 02;5(2):171-8

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/nri1553DOI Listing
February 2005

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.

Mol Cell 2004 Oct;16(2):163-71

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650400613
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http://dx.doi.org/10.1016/j.molcel.2004.10.011DOI Listing
October 2004

The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

Curr Biol 2003 Nov;13(22):2009-13

Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/j.cub.2003.10.034DOI Listing
November 2003

By-products of immunoglobulin somatic hypermutation.

Genes Chromosomes Cancer 2003 Sep;38(1):32-9

Department of Clinical Immunology, University of Göteborg, Göteborg, Sweden.

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http://dx.doi.org/10.1002/gcc.10241DOI Listing
September 2003

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.

Nat Immunol 2003 Jul;4(7):641-3

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/ni0703-641DOI Listing
July 2003

DNA deamination mediates innate immunity to retroviral infection.

Cell 2003 Jun;113(6):803-9

Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0092-8674(03)00423-9DOI Listing
June 2003

Immunity through DNA deamination.

Trends Biochem Sci 2003 Jun;28(6):305-12

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK CB2 2QH.

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http://linkinghub.elsevier.com/retrieve/pii/S096800040300111
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http://dx.doi.org/10.1016/S0968-0004(03)00111-7DOI Listing
June 2003

In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).

J Biol Chem 2003 May 14;278(22):19583-6. Epub 2003 Apr 14.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.C300114200DOI Listing
May 2003

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.

Nat Biotechnol 2002 Nov 15;20(11):1129-34. Epub 2002 Oct 15.

Medical Research Laboratory of Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://www.nature.com/articles/nbt752
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http://dx.doi.org/10.1038/nbt752DOI Listing
November 2002

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

Mol Cell 2002 Nov;10(5):1247-53

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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November 2002

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Curr Biol 2002 Oct;12(20):1748-55

Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(02)01215-0DOI Listing
October 2002

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

Nature 2002 Sep 31;419(6902):43-8. Epub 2002 Jul 31.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/nature00981DOI Listing
September 2002

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.

Nature 2002 Jul;418(6893):99-103

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://www.nature.com/articles/nature00862
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http://dx.doi.org/10.1038/nature00862DOI Listing
July 2002

AID is essential for immunoglobulin V gene conversion in a cultured B cell line.

Curr Biol 2002 Mar;12(5):435-8

Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(02)00717-0DOI Listing
March 2002

Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?

Eur J Immunol 2002 02;32(2):348-55

Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, GB.

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http://dx.doi.org/10.1002/1521-4141(200202)32:2<348::AID-IMMU348>3.0.CO;2-5DOI Listing
February 2002