Michael S Kobor

Michael S Kobor

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Michael S Kobor

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CoMeBack: DNA methylation array data analysis for co-methylated regions.

Bioinformatics 2020 May;36(9):2675-2683

BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btaa049DOI Listing
May 2020

Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict.

Dev Psychobiol 2020 03 13;62(2):138-153. Epub 2019 Nov 13.

Department of Human Behavior, Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://dx.doi.org/10.1002/dev.21935DOI Listing
March 2020

Genetic susceptibility to asthma increases the vulnerability to indoor air pollution.

Eur Respir J 2020 Mar 26;55(3). Epub 2020 Mar 26.

Dept of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1183/13993003.01831-2019DOI Listing
March 2020

Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex.

Front Genet 2020 11;11:35. Epub 2020 Feb 11.

Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fgene.2020.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026456PMC
February 2020

Social Environment and Epigenetics.

Curr Top Behav Neurosci 2019 ;42:83-126

Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/7854_2019_114DOI Listing
January 2020

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.

J Am Acad Child Adolesc Psychiatry 2019 12 9;58(12):1207-1216. Epub 2019 Mar 9.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733663PMC
December 2019

Inflammation-related genes are associated with epigenetic aging in HIV.

J Neurovirol 2019 12 8;25(6):853-865. Epub 2019 Jul 8.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://link.springer.com/10.1007/s13365-019-00777-4
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http://dx.doi.org/10.1007/s13365-019-00777-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923602PMC
December 2019

Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization.

J Allergy Clin Immunol 2019 12 27;144(6):1729-1731.e5. Epub 2019 Aug 27.

University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.047DOI Listing
December 2019

Reversal of epigenetic aging and immunosenescent trends in humans.

Aging Cell 2019 12 8;18(6):e13028. Epub 2019 Sep 8.

Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/acel.13028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138PMC
December 2019

5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns.

Mutagenesis 2019 12;34(4):315-322

School of Public Health, Center for Environmental Research and Children's Health (CERCH), University of California, Berkeley, Berkeley, CA, USA.

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http://dx.doi.org/10.1093/mutage/gez023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922517PMC
December 2019

Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring.

J Physiol 2019 11 22;597(22):5349-5364. Epub 2019 Aug 22.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1113/JP277936DOI Listing
November 2019

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.

J Biol Chem 2019 11 10;294(44):16080-16094. Epub 2019 Sep 10.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada

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http://dx.doi.org/10.1074/jbc.RA119.008515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827322PMC
November 2019

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Sci Rep 2019 10 8;9(1):14409. Epub 2019 Oct 8.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/s41598-019-50873-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783553PMC
October 2019

Biological embedding of experience: A primer on epigenetics.

Proc Natl Acad Sci U S A 2019 Oct 17. Epub 2019 Oct 17.

Program in Child and Brain Development, CIFAR, MaRS Centre, Toronto, ON, M5G 1M1, Canada;

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http://dx.doi.org/10.1073/pnas.1820838116DOI Listing
October 2019

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.

Psychoneuroendocrinology 2019 05 14;103:156-162. Epub 2019 Jan 14.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany; University of California, Irvine, Development, Health, and Disease Research Program, Orange, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183055
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http://dx.doi.org/10.1016/j.psyneuen.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554513PMC
May 2019

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

Am J Phys Anthropol 2019 05 16;169(1):3-11. Epub 2019 Feb 16.

Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ajpa.23800DOI Listing
May 2019

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.

EBioMedicine 2019 Apr 26;42:188-202. Epub 2019 Mar 26.

Department of Psychiatry, Faculty of Medicine, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada; Sackler Institute for Epigenetics & Psychobiology, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491717PMC
April 2019

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

N Engl J Med 2019 04;380(15):1433-1441

From Amsterdam University Medical Centers, University of Amsterdam, Departments of Clinical Chemistry, Pediatrics, and Clinical Genetics, Emma Children's Hospital, Amsterdam Gastroenterology and Metabolism (A.B.P.K., R.L., J.K., J. Meijer, L.A.T., M.T., M.W., R.J.A.W., H.R.W., C.D.M.K.), and United for Metabolic Diseases (A.B.P.K., R.J.A.W., H.R.W., C.D.M.K.), Amsterdam, and the Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht (J.J.F.A.V., J.H.V.), and the Project MinE ALS Sequencing Consortium (J.J.F.A.V., J.H.V.), Utrecht - all in the Netherlands; the Departments of Biochemistry and Molecular Biology and Medical Genetics, Cumming School of Medicine, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary (M.T.-G.), Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute (P.A.R., M.J.J., M.S.K., J. MacIsaac, W.W.W., C.D.M.K.), the Faculty of Pharmaceutical Sciences (B.I.D., G.E.B.W., C.J.R.), and the Departments of Medical Genetics (C.M., I.-S.R.-B., W.W.W.) and Pediatrics (C.D.M.K.), University of British Columbia, Vancouver, the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital and University of Toronto (K.B.-A., F.K., M.L., Y.W., X.-Y.W.), the Centre for Applied Genomics, Genetics and Genome Biology, the Hospital for Sick Children (C.N., S.W.S., B.T., R.K.C.Y.), and the Department of Molecular Genetics (C.N., S.W.S., R.K.C.Y.), the McLaughlin Centre (S.W.S.), and the Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, Institute of Medical Science (X.-Y.W.), University of Toronto, Toronto, and the Division of Medical Genetics, Department of Pediatrics, Children's Hospital Eastern Ontario, University of Ottawa, Ottawa (J.S.W., M.T.G.) - all in Canada; the Departments of Medicine and Physiology, National University of Singapore (M.A.P.), and the Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research (M.A.P., B.S., X.X., J.Z.) - both in Singapore; Uppsala University, Department of Chemistry-Biomedical Center, Uppsala, Sweden (D.D.); Illumina, San Diego, CA (E.D., M.A.E.); Gene Structure and Disease Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (B.H., D.K., K.U.); and the Department of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom (S.S.).

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http://dx.doi.org/10.1056/NEJMoa1806627DOI Listing
April 2019

DNA methylation as a predictor of fetal alcohol spectrum disorder.

Clin Epigenetics 2018 12;10. Epub 2018 Jan 12.

1Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia Canada.

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http://dx.doi.org/10.1186/s13148-018-0439-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767049PMC
February 2019

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clin Epigenetics 2018 5;10:32. Epub 2018 Mar 5.

Nottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, Division of Respiratory Medicine, University of Nottingham, Nottingham University Hospitals NHS Trust, City Hospital, Nottingham, UK.

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http://dx.doi.org/10.1186/s13148-018-0464-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838860PMC
February 2019

Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children.

Epigenetics 2018 15;13(6):655-664. Epub 2018 Aug 15.

a School of Public Health, Center for Environmental Research and Children's Health (CERCH) , University of California, Berkeley , Berkeley , CA , USA.

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http://dx.doi.org/10.1080/15592294.2018.1497386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140901PMC
February 2019

Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage.

DNA Repair (Amst) 2019 02 6;74:1-16. Epub 2019 Jan 6.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.01.001DOI Listing
February 2019

Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.

Front Genet 2018 4;9:610. Epub 2018 Dec 4.

Department of Cellular & Physiological Sciences, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fgene.2018.00610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290329PMC
December 2018

Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes.

Psychoneuroendocrinology 2018 11 5;97:131-134. Epub 2018 Jul 5.

Psychology Department, Northwestern University, United States; Institute for Policy Research, Northwestern University, United States. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2018.07.007DOI Listing
November 2018

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Epigenomics 2018 11 23;10(11):1445-1461. Epub 2018 Oct 23.

Department of Psychiatry, Center for Health & Community, Weill Neuroscience Institute, University of California, San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA.

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http://dx.doi.org/10.2217/epi-2018-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462839PMC
November 2018

Exposure to childhood abuse is associated with human sperm DNA methylation.

Transl Psychiatry 2018 10 2;8(1):194. Epub 2018 Oct 2.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, and BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://www.nature.com/articles/s41398-018-0252-1
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http://dx.doi.org/10.1038/s41398-018-0252-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168447PMC
October 2018

Epigenetic analysis of human postmortem brain tissue.

Handb Clin Neurol 2018 ;150:237-261

Department of Medical Genetics, University of British Columbia, and Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, Vancouver, BC, Canada; Human Early Learning Partnership, University of British Columbia, Vancouver, and Child and Brain Development, Canadian Institute for Advanced Research, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-63639-3.00017-7DOI Listing
August 2018

Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?

Mol Psychiatry 2018 Aug 6. Epub 2018 Aug 6.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41380-018-0121-6DOI Listing
August 2018

Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.

AIDS 2018 07;32(11):1465-1474

MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, J-Block, Groote Schuur Hospital, Observatory, Cape Town, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026068PMC
July 2018

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.

Exp Gerontol 2018 05 12;105:47-52. Epub 2017 Oct 12.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2017.10.010DOI Listing
May 2018

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.

Clin Epigenetics 2017 25;9:75. Epub 2017 Jul 25.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, Department of Medical Genetics, University of British Columbia, 950 W 28th Ave, Vancouver, BC V5Z 4H4 Canada.

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http://dx.doi.org/10.1186/s13148-017-0370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526324PMC
April 2018

DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.

Appl Physiol Nutr Metab 2018 Mar 19;43(3):233-239. Epub 2017 Oct 19.

c Centre for Hip Health and Mobility, Robert H. N. Ho Research Centre, the University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

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http://dx.doi.org/10.1139/apnm-2017-0436DOI Listing
March 2018

Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.

Epigenetics Chromatin 2017 27;10:21. Epub 2017 Apr 27.

Division of General Medical Disciplines, Department of Medicine, School of Medicine, Stanford University, 1070 Arastradero Road, Suite 300, Palo Alto, CA 94304 USA.

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http://dx.doi.org/10.1186/s13072-017-0128-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408416PMC
January 2018

Principles and Challenges of Applying Epigenetic Epidemiology to Psychology.

Annu Rev Psychol 2018 01 16;69:459-485. Epub 2017 Oct 16.

Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital, Vancouver, British Columbia V6H 3N1, Canada; email: , ,

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http://dx.doi.org/10.1146/annurev-psych-122414-033653DOI Listing
January 2018

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

Transl Psychiatry 2018 01 10;8(1):15. Epub 2018 Jan 10.

The Ludmer Centre for Neuroinformatics and Mental Health, Douglas Hospital Research Centre and Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, QC, H4H1R3, Canada.

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http://dx.doi.org/10.1038/s41398-017-0063-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802588PMC
January 2018

An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs.

Clin Epigenetics 2017 2;9:11. Epub 2017 Feb 2.

Department of Medical Genetics, BC Children's Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1186/s13148-017-0320-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290610PMC
December 2017

Epigenetic correlates of neonatal contact in humans.

Dev Psychopathol 2017 12;29(5):1517-1538

British Columbia Children's Hospital.

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http://dx.doi.org/10.1017/S0954579417001213DOI Listing
December 2017

Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach.

Methods Mol Biol 2017 ;1589:99-106

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, Canada, V5Z 4H4.

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http://dx.doi.org/10.1007/7651_2015_262DOI Listing
October 2017

Worldwide patterns of human epigenetic variation.

Nat Ecol Evol 2017 Oct 28;1(10):1577-1583. Epub 2017 Aug 28.

Department of Biology, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41559-017-0299-zDOI Listing
October 2017

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.

Sci Rep 2017 09 21;7(1):12123. Epub 2017 Sep 21.

Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1038/s41598-017-12422-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608967PMC
September 2017

The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.

BMC Genet 2017 06 21;18(1):57. Epub 2017 Jun 21.

Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W, MIP309A, Hamilton, ON, Canada.

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http://dx.doi.org/10.1186/s12863-017-0525-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480116PMC
June 2017

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?

Epigenomics 2017 03 17;9(3):291-311. Epub 2017 Feb 17.

Department of Medical Genetics, Centre for Molecular Medicine & Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2217/epi-2016-0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549650PMC
March 2017

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.

J Allergy Clin Immunol 2017 01 10;139(1):112-121. Epub 2016 May 10.

Air Pollution Exposure Laboratory, Chan-Yeung Centre for Occupational and Environmental Lung Disease, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.046DOI Listing
January 2017

Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.

Mol Cell Biol 2016 11 28;36(22):2768-2781. Epub 2016 Oct 28.

St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Centre de Recherche du CHU de Québec-Axe Oncologie, Hôtel-Dieu de Québec, Québec City, Quebec, Canada

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http://dx.doi.org/10.1128/MCB.00112-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086519PMC
November 2016

Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.

Trends Parasitol 2016 07 30;32(7):515-521. Epub 2016 Apr 30.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Human Early Learning Partnership, School of Population and Public Health, Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S14714922163000
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http://dx.doi.org/10.1016/j.pt.2016.04.002DOI Listing
July 2016

DNA methylation signature of human fetal alcohol spectrum disorder.

Epigenetics Chromatin 2016 29;9:25. Epub 2016 Jun 29.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC Canada.

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http://dx.doi.org/10.1186/s13072-016-0074-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926300PMC
June 2016

DNA methylation profiling in human Huntington's disease brain.

Hum Mol Genet 2016 05 6;25(10):2013-2030. Epub 2016 Mar 6.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1093/hmg/ddw076DOI Listing
May 2016

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).

BMC Bioinformatics 2016 Mar 8;17:120. Epub 2016 Mar 8.

Department of Pathology and Laboratory Medicine, Brown University, 70 Ship St., Providence, 02912, RI, USA.

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http://dx.doi.org/10.1186/s12859-016-0943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782368PMC
March 2016

A single flexible RNAPII-CTD integrates many different transcriptional programs.

Transcription 2016 03 17;7(2):50-6. Epub 2016 Mar 17.

a Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia , Vancouver , British Columbia , Canada.

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http://dx.doi.org/10.1080/21541264.2016.1163451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853039PMC
March 2016

funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.

Bioinformatics 2016 Feb 24;32(4):593-5. Epub 2015 Oct 24.

Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada, Department of Biochemistry, Université de Sherbrooke, QC J1K 2R1, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada, Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada and.

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http://dx.doi.org/10.1093/bioinformatics/btv615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743629PMC
February 2016

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.

Epigenetics 2015 18;10(5):361-72. Epub 2015 Apr 18.

a Center for Brain Science; Department of Molecular Cellular Biology; Harvard University ; Cambridge , MA , USA.

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http://dx.doi.org/10.1080/15592294.2015.1026031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622680PMC
January 2016

Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.

Horm Behav 2016 Jan 27;77:42-52. Epub 2015 Jun 27.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.yhbeh.2015.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691570PMC
January 2016

Rtt107 BRCT domains act as a targeting module in the DNA damage response.

DNA Repair (Amst) 2016 Jan 10;37:22-32. Epub 2015 Nov 10.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.10.007DOI Listing
January 2016

DNA methylation and healthy human aging.

Aging Cell 2015 Dec 25;14(6):924-32. Epub 2015 Apr 25.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/acel.12349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693469PMC
December 2015

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.

PLoS Genet 2015 Oct 23;11(10):e1005608. Epub 2015 Oct 23.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1005608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619828PMC
October 2015

Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data.

Data Brief 2015 Sep 9;4:239-52. Epub 2015 Jun 9.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Human Early Learning Partnership, University of British Columbia, Room 2024, 950 West 28th Avenue, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.dib.2015.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510447PMC
September 2015

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells.

Clin Epigenetics 2015 11;7:95. Epub 2015 Sep 11.

Child & Family Research Institute, 950 W 28th Avenue, Vancouver, BC V5Z 4H4 Canada ; Department of Pediatrics, University of British Columbia, Vancouver, BC V6T 1Z3 Canada.

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http://dx.doi.org/10.1186/s13148-015-0129-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567832PMC
September 2015

A pooling-based approach to mapping genetic variants associated with DNA methylation.

Genome Res 2015 Jun 24;25(6):907-17. Epub 2015 Apr 24.

Department of Biology, Stanford University, Stanford, California 94305, USA;

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http://dx.doi.org/10.1101/gr.183749.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448686PMC
June 2015

Concordant and discordant DNA methylation signatures of aging in human blood and brain.

Epigenetics Chromatin 2015 9;8:19. Epub 2015 May 9.

Centre for Molecular Medicine and Therapeutics, Child & Family Research Institute, 950 W 28th ave, Vancouver, BC V5Z4H4 Canada ; Department of Medical Genetics, University of British Columbia, 950 W 28th ave, Vancouver, BC V5Z4H4 Canada ; Canadian Institute for Advanced Research, Toronto, ON Canada.

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http://www.epigeneticsandchromatin.com/content/8/1/19
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http://dx.doi.org/10.1186/s13072-015-0011-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430927PMC
May 2015

Discordance of DNA methylation variance between two accessible human tissues.

Sci Rep 2015 Feb 9;5:8257. Epub 2015 Feb 9.

1] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada [2] Human Early Learning Partnership, School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z8, Canada.

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http://dx.doi.org/10.1038/srep08257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321176PMC
February 2015

Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain.

Alcohol Clin Exp Res 2015 Feb;39(2):251-61

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/acer.12622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833439PMC
February 2015

Development and the epigenome: the 'synapse' of gene-environment interplay.

Dev Sci 2015 Jan;18(1):1-23

Departments of Pediatrics and Psychiatry, University of California, San Francisco, USA; Child and Brain Development Program, Canadian Institute for Advanced Research, Canada.

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http://dx.doi.org/10.1111/desc.12282DOI Listing
January 2015

Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.

Part Fibre Toxicol 2014 Dec 9;11:71. Epub 2014 Dec 9.

Air Pollution Exposure Laboratory, Chan-Yeung Centre for Occupational and Environmental Lung Disease, Department of Medicine, Division of Respiratory Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, British Columbia, V5Z1L9, Canada.

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http://dx.doi.org/10.1186/s12989-014-0071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268899PMC
December 2014