Publications by authors named "Michael Reth"

100Publications

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.

Life Sci Alliance 2020 06 27;3(6). Epub 2020 Apr 27.

BIOSS Centre for Biological Signalling Studies and Centre For Integrative Biological Signalling Studies, Albert Ludwigs University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.26508/lsa.202000700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190274PMC
June 2020

A new branched proximity hybridization assay for the quantification of nanoscale protein-protein proximity.

PLoS Biol 2019 12 11;17(12):e3000569. Epub 2019 Dec 11.

BIOSS Centre For Biological Signaling Studies and Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1371/journal.pbio.3000569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905527PMC
December 2019

TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections.

Elife 2019 08 21;8. Epub 2019 Aug 21.

Center for Comparative Medicine, University of California, Davis, Davis, United States.

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http://dx.doi.org/10.7554/eLife.46997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703853PMC
August 2019

A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex.

Proc Natl Acad Sci U S A 2019 07 17;116(27):13468-13473. Epub 2019 Jun 17.

BIOSS Centre For Biological Signaling Studies, Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany;

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http://dx.doi.org/10.1073/pnas.1907481116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613136PMC
July 2019

Antigen Receptor Function in the Context of the Nanoscale Organization of the B Cell Membrane.

Annu Rev Immunol 2019 04;37:97-123

BIOSS Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany; email:

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http://dx.doi.org/10.1146/annurev-immunol-042718-041704DOI Listing
April 2019

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.

Front Immunol 2019 18;10:497. Epub 2019 Mar 18.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431647PMC
September 2020

Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach.

Biol Chem 2019 03;400(4):555-563

BIOSS Centre for Biological Signalling Studies, Department of Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1515/hsz-2018-0308DOI Listing
March 2019

Conditional Selection of B Cells in Mice With an Inducible B Cell Development.

Front Immunol 2018 6;9:1806. Epub 2018 Aug 6.

Centre for Biological Signaling Studies (BIOSS), Biology III, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01806
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http://dx.doi.org/10.3389/fimmu.2018.01806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087743PMC
October 2019

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.

Pharm Res 2018 Jun 27;35(9):169. Epub 2018 Jun 27.

Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Bldg 93 Room 5.10, Grenzacherstrasse 124, 4070, Basel, CH, Switzerland.

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http://link.springer.com/10.1007/s11095-018-2448-8
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http://dx.doi.org/10.1007/s11095-018-2448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021477PMC
June 2018

Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.

EMBO J 2018 06 18;37(11). Epub 2018 Apr 18.

BIOSS Centre For Biological Signaling Studies, Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201797980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983214PMC
June 2018

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.

Proc Natl Acad Sci U S A 2018 03 5;115(12):3120-3125. Epub 2018 Mar 5.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1711335115
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http://dx.doi.org/10.1073/pnas.1711335115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866538PMC
March 2018

Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay.

Methods Mol Biol 2018 ;1707:171-181

Department of Molecular Immunology, BIOSS Centre for Biological Signaling Studies, Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany.

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http://link.springer.com/10.1007/978-1-4939-7474-0_12
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http://dx.doi.org/10.1007/978-1-4939-7474-0_12DOI Listing
October 2018

Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.

Nat Immunol 2017 Oct 14;18(10):1150-1159. Epub 2017 Aug 14.

Mechanoadaptation &Caveolae Biology Lab, Cell Biology &Physiology Program; Cell &Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

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http://dx.doi.org/10.1038/ni.3813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608079PMC
October 2017

The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.

Nat Immunol 2017 Aug 19;18(8):911-920. Epub 2017 Jun 19.

Department for Molecular Immunology, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/ni.3774DOI Listing
August 2017

CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.

Proc Natl Acad Sci U S A 2017 05 1;114(20):5231-5236. Epub 2017 May 1.

BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;

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http://dx.doi.org/10.1073/pnas.1621512114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441763PMC
May 2017

LED Thermo Flow - Combining Optogenetics with Flow Cytometry.

J Vis Exp 2016 12 30(118). Epub 2016 Dec 30.

Max-Planck Institute for Immunobiology und Epigenetics; Centre for Biological Signaling Studies, BIOSS, University of Freiburg; Institute for Biology III (Mol. Immunology), Albert-Ludwigs-Universität.

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http://dx.doi.org/10.3791/54707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226631PMC
December 2016

What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling.

Eur J Immunol 2016 11;46(11):2507-2511

Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/eji.201646705DOI Listing
November 2016

Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens.

EMBO J 2016 11 15;35(21):2371-2381. Epub 2016 Sep 15.

BIOSS Centre for Biological Signalling Studies, Department of Molecular Immunology, Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201694177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090217PMC
November 2016

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.

J Immunol 2016 Mar 3;196(5):2348-60. Epub 2016 Feb 3.

Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany; Institute of Immunology, University Hospital Ulm, 89081 Ulm, Germany

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http://dx.doi.org/10.4049/jimmunol.1501707DOI Listing
March 2016

Receptor Dissociation and B-Cell Activation.

Curr Top Microbiol Immunol 2016 ;393:27-43

BIOSS Centre for Biological Signalling Studies, Department of Molecular Immunology, Biology III, University of Freiburg, Freiburg im Breisgau, Germany.

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http://link.springer.com/content/pdf/10.1007%2F82_2015_482.p
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http://link.springer.com/10.1007/82_2015_482
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http://dx.doi.org/10.1007/82_2015_482DOI Listing
March 2016

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation.

Sci Signal 2015 Sep 15;8(394):ra93. Epub 2015 Sep 15.

BIOSS Centre for Biological Signalling Studies, University of Freiburg, D-79104 Freiburg, Germany. Department of Molecular Immunology, Institute of Biology III at the Faculty of Biology of the University of Freiburg, D-79104, and at the Max Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.

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http://dx.doi.org/10.1126/scisignal.2005887DOI Listing
September 2015

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

J Exp Med 2015 Sep 31;212(10):1693-708. Epub 2015 Aug 31.

Department of Molecular Immunology, BioIII, Faculty of Biology, University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany Centre for Biological Signaling Studies (BIOSS), Spemann Graduate School of Biology and Medicine (SGBM), Centre of Chronic Immunodeficiency (CCI), Department of Dermatology, Center for Biological Systems Analysis (ZBSA), Institute of Molecular Medicine and Cell Research, Comprehensive Cancer Centre Freiburg, and Institute of Pathology, University Medical Center Freiburg, University of Freiburg, 79104 Freiburg, Germany

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http://dx.doi.org/10.1084/jem.20141271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577850PMC
September 2015

Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.

J Immunol 2015 Aug 8;195(4):1548-63. Epub 2015 Jul 8.

Biochemical Institute, Christian Albrechts University of Kiel, D-24118 Kiel, Germany;

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http://dx.doi.org/10.4049/jimmunol.1403171DOI Listing
August 2015

Responsiveness of B cells is regulated by the hinge region of IgD.

Nat Immunol 2015 May 6;16(5):534-43. Epub 2015 Apr 6.

1] Institute of Immunology, University Hospital Ulm, Ulm, Germany. [2] BIOSS Center for Biological Signaling Studies, Albert-Ludwigs University of Freiburg, Freiburg, Germany. [3] Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.

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http://www.nature.com/articles/ni.3141
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http://dx.doi.org/10.1038/ni.3141DOI Listing
May 2015

TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.

Dev Cell 2015 Mar 26;32(5):617-30. Epub 2015 Feb 26.

Bioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany; Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands; BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany; Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807150006
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http://dx.doi.org/10.1016/j.devcel.2015.01.026DOI Listing
March 2015

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

Nature 2015 Feb 11;518(7540):542-6. Epub 2015 Feb 11.

Division of Cellular Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature14242DOI Listing
February 2015

Preface to special issue on nanoscale membrane organisations.

Biochim Biophys Acta 2015 Apr 10;1853(4):765-6. Epub 2015 Feb 10.

Department of Immunology, Institute of Biology III, Faculty of Biology, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Centre for Chronic Immunodeficiency CCI, University Clinics Freiburg, Schänzlestr. 18, 79104 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.02.003DOI Listing
April 2015

CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.

EMBO J 2015 Apr 28;34(7):925-39. Epub 2015 Jan 28.

Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany Department of Molecular Immunology, BioIII, Faculty of Biology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany BIOSS, Centre For Biological Signaling Studies, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201489732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388600PMC
April 2015

The nanoscale organization of the B lymphocyte membrane.

Biochim Biophys Acta 2015 Apr 15;1853(4):830-40. Epub 2014 Nov 15.

BIOSS Centre for Biological Signalling Studies, University of Freiburg, Germany; Department of Molecular Immunology, Biology III, University of Freiburg, Germany; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547082PMC
April 2015

Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.

Eur J Immunol 2015 Feb 2;45(2):603-11. Epub 2014 Dec 2.

Max Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany.

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http://dx.doi.org/10.1002/eji.201444538DOI Listing
February 2015

The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells.

J Exp Med 2014 Oct 6;211(11):2199-212. Epub 2014 Oct 6.

Division of Molecular Immunology, Nikolaus Fiebiger Center, Department of Internal Medicine III, Department of Radiation Oncology, Division of Ophthalmology, Department Kopfklinik, University of Erlangen-Nuremberg, D91054 Erlangen, Germany Institute for Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, D20246 Hamburg, Germany

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http://jem.rupress.org/content/211/11/2199.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20130795
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http://dx.doi.org/10.1084/jem.20130795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203943PMC
October 2014

Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.

Eur J Immunol 2014 Oct 19;44(10):3093-108. Epub 2014 Aug 19.

Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA; Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1002/eji.201344282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197127PMC
October 2014

PDK1 regulates B cell differentiation and homeostasis.

Proc Natl Acad Sci U S A 2014 Jul 16;111(26):9573-8. Epub 2014 Jun 16.

Program on Immunity and Pathogenesis, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; and

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http://dx.doi.org/10.1073/pnas.1314562111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084446PMC
July 2014

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.

Elife 2014 Jun 24;3:e02069. Epub 2014 Jun 24.

BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067077PMC
http://dx.doi.org/10.7554/eLife.02069DOI Listing
June 2014

The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.

J Immunol 2014 Jul 4;193(1):268-76. Epub 2014 Jun 4.

Department of Molecular Immunology, Max-Planck-Institut of Immunobiology and Epigenetics, Freiburg 79108, Germany; Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany; and BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg 79108, Germany

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http://dx.doi.org/10.4049/jimmunol.1203040DOI Listing
July 2014

The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.

J Immunol 2014 Jun 30;192(11):5406-14. Epub 2014 Apr 30.

Department of Biology, University of Erlangen, 91058 Erlangen, Germany;

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302875
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http://dx.doi.org/10.4049/jimmunol.1302875DOI Listing
June 2014

MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.

J Immunol 2014 Jun 23;192(11):5273-84. Epub 2014 Apr 23.

Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälisch Technical University (RWTH) Aachen, D-52074 Aachen, Germany;

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http://dx.doi.org/10.4049/jimmunol.1302209DOI Listing
June 2014

Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.

Authors:
Michael Reth

J Immunol 2014 May;192(9):4015-6

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May 2014

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.

J Exp Med 2014 Mar 3;211(3):427-40. Epub 2014 Mar 3.

BIOSS Centre for Biological Signalling Studies; and 2 Department of Molecular Immunology, Institute of Biology III, Faculty of Biology; University of Freiburg, D-79104 Freiburg, Germany.

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http://jem.rupress.org/content/211/3/427.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20131196
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http://dx.doi.org/10.1084/jem.20131196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949573PMC
March 2014

Signaling circuits in early B-cell development.

Adv Immunol 2014 ;122:129-75

BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany; Department of Molecular Immunology, BioIII, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology and Epigenetic Stübeweg 51, Freiburg, Germany.

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http://dx.doi.org/10.1016/B978-0-12-800267-4.00004-3DOI Listing
May 2014

Michael Neuberger (1953-2013).

Immunity 2013 Dec;39(6):987-8

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http://dx.doi.org/10.1016/j.immuni.2013.11.004DOI Listing
December 2013

Pre-clustering of the B cell antigen receptor demonstrated by mathematically extended electron microscopy.

Front Immunol 2013 6;4:427. Epub 2013 Dec 6.

Faculty of Biology, Department of Molecular Immunology, Albert Ludwigs University Freiburg , Freiburg , Germany ; Centre for Biological Signalling Studies BIOSS, Albert Ludwigs University Freiburg , Freiburg , Germany ; Medical Faculty, Centre for Chronic Immunodeficiency CCI, University Clinics Freiburg, Albert Ludwigs University Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.3389/fimmu.2013.00427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854567PMC
December 2013

Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip.

Mol Cell Proteomics 2013 Dec 26;12(12):3898-907. Epub 2013 Sep 26.

Microfluidic and Biological Engineering, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany;

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http://dx.doi.org/10.1074/mcp.M113.032821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861732PMC
December 2013

Matching cellular dimensions with molecular sizes.

Authors:
Michael Reth

Nat Immunol 2013 Aug;14(8):765-7

BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/ni.2621DOI Listing
August 2013

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12402-7. Epub 2013 Jul 8.

Department of Biology, University of Erlangen, 91058 Erlangen, Germany.

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http://dx.doi.org/10.1073/pnas.1304888110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725054PMC
July 2013

Immunoglobulins drive terminal maturation of splenic dendritic cells.

Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2282-7. Epub 2013 Jan 23.

Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1073/pnas.1210654110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568358PMC
February 2013

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.

Blood 2012 Jun 18;119(23):5438-48. Epub 2012 Apr 18.

Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1182/blood-2011-12-397976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369680PMC
June 2012

Synthetic immune signaling.

Curr Opin Biotechnol 2012 Oct 10;23(5):780-4. Epub 2012 Feb 10.

Center for Biological Signalling Studies BIOSS and Faculty of Biology, University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.copbio.2012.01.010DOI Listing
October 2012

The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: impact on SHIP1/Ig-α interaction.

Biochim Biophys Acta 2012 Feb 13;1823(2):206-14. Epub 2011 Dec 13.

RWTH Aachen University, Medical Faculty, Department of Biochemistry and Molecular Immunology, Institute of Biochemistry and Molecular Biology, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2011.11.019DOI Listing
February 2012

Drosophila S2 Schneider cells: a useful tool for rebuilding and redesigning approaches in synthetic biology.

Methods Mol Biol 2012 ;813:331-41

Faculty of Biology, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-412-4_20DOI Listing
March 2012

B cells that produce immunoglobulin E mediate colitis in BALB/c mice.

Gastroenterology 2012 Jan 6;142(1):96-108. Epub 2011 Oct 6.

International Centre for Genetic Engineering and Biotechnology and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1053/j.gastro.2011.09.044DOI Listing
January 2012

B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):710-5. Epub 2010 Dec 27.

Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1073/pnas.1012858108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021026PMC
January 2011

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.

Proc Natl Acad Sci U S A 2010 Oct 12;107(43):18563-8. Epub 2010 Oct 12.

Centre for Biological Signalling Studies, BIOSS, University of Freiburg, 79104 Freiburg, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1009048107
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972992PMC
October 2010

The dissociation activation model of B cell antigen receptor triggering.

FEBS Lett 2010 Dec 12;584(24):4872-7. Epub 2010 Oct 12.

Centre of Biological Signalling Studies BIOSS, University Freiburg, Freiburg, Germany.

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http://doi.wiley.com/10.1016/j.febslet.2010.09.045
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December 2010

Oligomeric organization of the B-cell antigen receptor on resting cells.

Nature 2010 Sep 5;467(7314):465-9. Epub 2010 Sep 5.

Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-Universität Freiburg, Department of Molecular Immunology, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1038/nature09357DOI Listing
September 2010

N-linked glycosylation selectively regulates autonomous precursor BCR function.

Nat Immunol 2010 Aug 11;11(8):759-65. Epub 2010 Jul 11.

Center for Biological Signalling Studies, Albert-Ludwigs Universität Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/ni.1903DOI Listing
August 2010

Arginine methylation of the B cell antigen receptor promotes differentiation.

J Exp Med 2010 Apr 15;207(4):711-9. Epub 2010 Mar 15.

Center for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1084/jem.20091303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856019PMC
April 2010

Voltage control for B cell activation.

Nat Immunol 2010 Mar;11(3):191-2

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March 2010

Autoinhibition and adapter function of Syk.

Immunol Rev 2009 Nov;232(1):286-99

Centre for Biological Signaling Studies (Bioss) and Department of Molecular Immunology, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max-Planck Institute for Immunobiology, Freiburg, Germany.

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http://doi.wiley.com/10.1111/j.1600-065X.2009.00837.x
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November 2009

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

Blood 2009 Dec 7;114(24):4960-7. Epub 2009 Oct 7.

Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D-38124 Braunschweig, Germany.

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http://dx.doi.org/10.1182/blood-2009-04-218156DOI Listing
December 2009

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.

Nat Rev Immunol 2009 Mar;9(3):195-205

Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nri2491DOI Listing
March 2009

Clustering models.

Adv Exp Med Biol 2008 ;640:64-73

Department of Molecular Immunology, Max Planck-Institute for Immunobiology and Faculty of Biology, University of Freiburg, Stuebeweg 51, 79108 Freiburg, Germany.

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http://link.springer.com/10.1007/978-0-387-09789-3_6
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December 2008

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk.

Eur J Immunol 2008 Sep;38(9):2475-87

Molecular Immunology, Institute of Biology III, University of Freiburg and Max Planck-Institute for Immunobiology, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.200738094DOI Listing
September 2008

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

Nat Immunol 2008 Jun;9(6):623-31

Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1038/ni.1616DOI Listing
June 2008

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

EMBO J 2008 May 27;27(9):1333-44. Epub 2008 Mar 27.

Faculty of Biology, Max-Planck Institute for Immunobiology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/emboj.2008.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374840PMC
May 2008

The TCR binding site does move.

Proc Natl Acad Sci U S A 2007 Oct 9;104(42):16398-9. Epub 2007 Oct 9.

Max-Planck-Institut for Immunbiology and Faculty of Biology III, University of Freiburg, Stübeweg 51, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.0708462104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034258PMC
October 2007

Mutations of the Igbeta gene cause agammaglobulinemia in man.

J Exp Med 2007 Sep 20;204(9):2047-51. Epub 2007 Aug 20.

Medical Genetics Unit, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.

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http://dx.doi.org/10.1084/jem.20070264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118692PMC
September 2007

Immunoreceptors and integrins.

Immunol Rev 2007 Aug;218:5-8

Institute for Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1111/j.1600-065X.2007.00549.xDOI Listing
August 2007

Association of protein kinase C-delta with the B cell antigen receptor complex.

Cell Signal 2007 Apr 13;19(4):715-22. Epub 2006 Nov 13.

Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2006.07.023DOI Listing
April 2007

Identification of disulfide bonds in the Ig-alpha/Ig-beta component of the B cell antigen receptor using the Drosophila S2 cell reconstitution system.

Int Immunol 2006 Sep 28;18(9):1385-96. Epub 2006 Jul 28.

Max Planck-Institut für Immunbiologie and University of Freiburg, Biologie III Stübeweg 51, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1093/intimm/dxl072DOI Listing
September 2006

Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.

Immunity 2006 Jun;24(6):729-39

The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.04.005DOI Listing
June 2006

Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes.

Immunol Lett 2006 Apr 1;104(1-2):131-7. Epub 2005 Dec 1.

Department of Molecular Immunology, Biologie III, University of Freiburg and Max Planck-Institut für Immunbiologie, Stübeweg 51, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.imlet.2005.11.004DOI Listing
April 2006

B cell signaling and tumorigenesis.

Annu Rev Immunol 2005 ;23:415-45

Institute for Biology III, Albert-Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115606DOI Listing
June 2005

A leucine zipper in the N terminus confers membrane association to SLP-65.

Nat Immunol 2005 Feb 16;6(2):204-10. Epub 2005 Jan 16.

Institute for Biology III, Albert-Ludwigs University of Freiburg and Max-Planck-Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1038/ni1163DOI Listing
February 2005

Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line.

Biochem Biophys Res Commun 2005 Feb;327(1):70-5

Department of Biotechnology, Okayama University, Tsushima-Naka 3-1-1, Okayama 700-8530, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2004.11.143DOI Listing
February 2005

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors.

Eur J Immunol 2005 Jan;35(1):31-41

Department of Molecular Immunology, Institute for Biology III, Albert Ludwigs University of Freiburg and Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.200425524DOI Listing
January 2005

Perspectives on the nature of BCR-mediated survival signals.

Mol Cell 2004 Jun;14(6):696-7

Department of Molecular Immunology, Max-Planck Institute for Immunobiology, Stübeweg 51, AG Reth, D-79108 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2004.06.015DOI Listing
June 2004

B-cell signal transduction: tyrosine phosphorylation, kinase activity, and calcium mobilization.

Methods Mol Biol 2004 ;271:189-212

Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Freiburg, Germany.

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http://dx.doi.org/10.1385/1-59259-796-3:189DOI Listing
July 2004

Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag.

Immunol Lett 2004 Mar;92(1-2):185-92

Department of Molecular Immunology, Biology III, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.imlet.2003.11.027DOI Listing
March 2004

B cell antigen receptor assembly and Syk activation in the S2 cell reconstitution system.

Immunol Lett 2004 Mar;92(1-2):67-73

Department of Molecular Immunology, Biology III, University of Freiburg, Stübeweg 51, 79108 Freiburg, Germany.

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March 2004