Michael R Zile

Michael R Zile

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Michael R Zile

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Angiotensin Receptor-Neprilysin Inhibitor Therapy Reverses Pulmonary Hypertension in End-Stage Heart Failure Patients Awaiting Transplantation.

Circ Heart Fail 2020 Feb 14;13(2):e006696. Epub 2020 Feb 14.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.K.Z., S.C., M.A.H., M.M.K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006696DOI Listing
February 2020

Comparison of BNP and NT-proBNP in Patients With Heart Failure and Reduced Ejection Fraction.

Circ Heart Fail 2020 Feb 17;13(2):e006541. Epub 2020 Feb 17.

BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (R.R., P.S.J., S.L.K., P.W., J.J.V.M.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006541DOI Listing
February 2020

Should We Test for Diastolic Dysfunction? How and How Often?

JACC Cardiovasc Imaging 2020 Jan 12;13(1 Pt 2):297-309. Epub 2019 Jun 12.

Department of Internal Medicine, Division of Cardiology, Medical University of South Carolina and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.

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http://dx.doi.org/10.1016/j.jcmg.2019.02.029DOI Listing
January 2020

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction.

JACC Basic Transl Sci 2019 Dec 20;4(8):924-937. Epub 2019 Nov 20.

State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.jacbts.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939002PMC
December 2019

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

N Engl J Med 2019 10 1;381(17):1609-1620. Epub 2019 Sep 1.

From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charité Universitätsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montréal, Université de Montréal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Université de Lorraine, Centre Hospitalier Régional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontifícia Universidade Católica de Campinas, São Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.).

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http://dx.doi.org/10.1056/NEJMoa1908655DOI Listing
October 2019

Relation of Lymphangiogenic Factor Vascular Endothelial Growth Factor-D to Elevated Pulmonary Artery Wedge Pressure.

Am J Cardiol 2019 09 6;124(5):756-762. Epub 2019 Jun 6.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina; Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.

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http://dx.doi.org/10.1016/j.amjcard.2019.05.056DOI Listing
September 2019

Repetitive Acute Hemodynamic Load: Progression From Systolic Decompensation to Cellular/Extracellular Compensation to Diastolic Decompensation.

JACC Basic Transl Sci 2019 Aug 26;4(4):542-545. Epub 2019 Aug 26.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

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http://dx.doi.org/10.1016/j.jacbts.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712276PMC
August 2019

Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF.

JACC Heart Fail 2019 Jun 8;7(6):457-465. Epub 2019 May 8.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2019.02.015DOI Listing
June 2019

Income Inequality and Outcomes in Heart Failure: A Global Between-Country Analysis.

JACC Heart Fail 2019 04 6;7(4):336-346. Epub 2019 Feb 6.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2018.11.005DOI Listing
April 2019

Safety and Feasibility of a Nocturnal Heart Rate Elevation-Exploration of a Novel Treatment Concept.

J Card Fail 2019 01 17;25(1):67-71. Epub 2018 Jul 17.

Department of Medicine, Cardiology Division, Larner College of Medicine at the University of Vermont, Burlington, Vermont. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2018.06.009DOI Listing
January 2019

Elevated Wall Tension Leads to Reduced miR-133a in the Thoracic Aorta by Exosome Release.

J Am Heart Assoc 2019 01;8(1):e010332

1 Division of Cardiothoracic Surgery Department of Surgery Medical University of South Carolina Charleston SC.

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http://dx.doi.org/10.1161/JAHA.118.010332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405702PMC
January 2019

Role of High-Dose Beta-Blockers in Patients with Heart Failure with Preserved Ejection Fraction and Elevated Heart Rate.

Am J Med 2018 12 1;131(12):1473-1481. Epub 2018 Aug 1.

Veterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.07.008DOI Listing
December 2018

Bioactive Signaling in Next-Generation Pharmacotherapies for Heart Failure: A Review.

JAMA Cardiol 2018 12;3(12):1232-1243

Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia.

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http://dx.doi.org/10.1001/jamacardio.2018.3789DOI Listing
December 2018

Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction.

Am J Physiol Heart Circ Physiol 2018 10 13;315(4):H958-H967. Epub 2018 Jul 13.

College of Engineering and Computing, University of South Carolina , Columbia, South Carolina.

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https://www.physiology.org/doi/10.1152/ajpheart.00279.2018
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00279.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230914PMC
October 2018

Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure.

JACC Heart Fail 2018 07 4;6(7):564-569. Epub 2018 Mar 4.

Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2018.02.007DOI Listing
July 2018

Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis.

Am J Physiol Heart Circ Physiol 2018 07 9;315(1):H92-H100. Epub 2018 Mar 9.

Division of Cardiology, Department of Medicine, Medical University of South Carolina , Charleston, South Carolina.

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http://dx.doi.org/10.1152/ajpheart.00719.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087775PMC
July 2018

Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure.

JACC Heart Fail 2018 06 11;6(6):489-498. Epub 2018 Apr 11.

British Heart Foundation (BHF) Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2018.02.004DOI Listing
June 2018

Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure).

Circ Heart Fail 2018 04;11(4):e004745

Minneapolis VA Health Care System and University of Minnesota (O.V.). University of Colorado, Aurora (S.M.P.). Brigham and Women's Hospital, Harvard University, Boston, MA (B.C., A.S.D., S.D.S.). Novartis Pharmaceuticals Corporation, East Hanover, NJ (J.K., M.L., V.S.). University of Glasgow, United Kingdom (J.J.V.M.). Baylor University Medical Center, Dallas, TX (M.P.). Université de Montréal, Canada (J.R.). Medical University of South Carolina, Charleston (M.R.Z.). University of Gothenburg, Sweden (K.S.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004745DOI Listing
April 2018

Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade.

Am J Physiol Renal Physiol 2018 02 11;314(2):F210-F218. Epub 2017 Oct 11.

Divison of Nephrology, Medical University of South Carolina , Charleston, South Carolina.

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http://dx.doi.org/10.1152/ajprenal.00389.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866454PMC
February 2018

Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy.

Circ Heart Fail 2017 Nov;10(11)

From the BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (L.S., P.S.J., J.J.V.M.); Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil (F.R.); Instituto DAMIC/Fundacion Rusculleda, Cordoba, Argentina (F.M.); Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil (L.C.B.); Grupo de Ciencias Cardiovasculares, Fundación Cardiovascular de Colombia, Santander (L.E.E.); Clinica Shaio, Bogota, Colombia (E.A.G.); Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus (W.T.A.); Stavanger University Hospital, University of Bergen, Norway (K.D.); Rigshospitalet Copenhagen University Hospital, Denmark (L.K.); Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.); Institut de Cardiologie de Montréal, Université de Montréal, Canada (J.L.R.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA (S.D.S.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden (K.S.); National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.); Medical University of South Carolina and Ralph H. Johnson Veterans Administration Medical Center, Charleston (M.R.Z.); and Novartis Pharma, Basel, Switzerland (C.R.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004361DOI Listing
November 2017

Palliative Care for Advanced Heart Failure in a Department of Veterans Affairs Regional Hospice Program: Patient Selection, a Treatment Protocol, and Clinical Course.

J Palliat Med 2017 10 22;20(10):1068-1073. Epub 2017 May 22.

1 Department of Medicine, Medical University of South Carolina , Charleston, South Carolina.

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http://dx.doi.org/10.1089/jpm.2017.0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915223PMC
October 2017

Evaluation of systolic and diastolic properties of hypertensive heart failure using speckle-tracking echocardiography with high volume rates.

Heart Vessels 2017 Oct 21;32(10):1202-1213. Epub 2017 Jun 21.

Department of Cardiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

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http://dx.doi.org/10.1007/s00380-017-0995-2DOI Listing
October 2017

Heart Rate and Outcomes in Hospitalized Patients With Heart Failure With Preserved Ejection Fraction.

J Am Coll Cardiol 2017 Oct;70(15):1861-1871

Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC; Department of Medicine, George Washington University, Washington, DC; Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.08.022DOI Listing
October 2017

Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation.

Circ Heart Fail 2017 Oct;10(10)

From the BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (S.L.K., P.S.J., U.M.M., R.R., J.J.V.M.); Department of Cardiology, Rigshospitalet University Hospital, Copenhagen, Denmark (S.L.K., U.M.M., R.R., L.K.); The Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus (W.TA.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.D., S.D.S.); Stavanger University Hospital, Stavanger, and Department of Clinical Science, the Institute of Internal Medicine, University of Bergen, Norway (K.D.); Institut de Cardiologie de Montréal, Université de Montréal, Canada (J.L.R.); Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston (M.R.Z.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden (K.S.); Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.); and Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004409DOI Listing
October 2017

Health-Related Quality of Life Outcomes in PARADIGM-HF.

Circ Heart Fail 2017 Aug;10(8)

From the Brigham and Women's Hospital, Boston, MA (E.F.L., B.L.C., J.L., A.S.D., S.D.S.); BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (J.J.V.M.); Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.); Novartis, East Hanover, NJ (M.P.L., V.C.S.); Institut de Cardiologie de Montreal, Université de Montreal, Canada (J.L.R.); Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston, SC (M.R.Z.); and Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden and National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003430DOI Listing
August 2017

Declining Risk of Sudden Death in Heart Failure.

N Engl J Med 2017 07;377(1):41-51

From the British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (L.S., P.S.J., M.C.P., J.J.V.M.), and Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing (J.G.F.C.), University of Glasgow, the Department of Cardiology, Golden Jubilee National Hospital (M.C.P.), and the Cardiology Department, Glasgow Royal Infirmary (H.J.D.), Glasgow, and the National Heart and Lung Institute, Imperial College London, London (J.G.F.C.) - all in the United Kingdom; the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (B.L.C., S.D.S.); the Department of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche Mario Negri, Milan (S.B., R.L.), Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence (A.P.M.), and Maria Cecilia Hospital, Gruppo Villa Maria Care and Research, Ettore Sansavini Health Science Foundation, Cotignola (L.T.) - all in Italy; Duke Clinical Research Institute, Duke University, Durham, NC (C.B.G.); Rikshospitalet University Hospital, Oslo (J.K.); the Department of Cardiology, Rigshospitalet Copenhagen University Hospital, Copenhagen (L.K.); Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas (M.P.); the Department of Medicine, University of Michigan, Ann Arbor (B.P.); the Center for Person-Centered Care (K.S.) and Sahlgrenska Academy (J.W.), University of Gothenburg, Gothenburg, Sweden; INSERM Centre d'Investigation Clinique 1433, Université de Lorraine and Centre Hospitalier Universitaire, Nancy, France (F.Z.); and the Medical University of South Carolina and Ralph H. Johnson Veterans Affairs Medical Center, Charleston (M.R.Z.).

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http://www.nejm.org/doi/10.1056/NEJMoa1609758
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http://dx.doi.org/10.1056/NEJMoa1609758DOI Listing
July 2017

Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction.

Semin Thorac Cardiovasc Surg 2016 Summer;28(2):320-328. Epub 2016 Jun 2.

Medical University of South Carolina, Charleston, South Carolina; Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina.

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http://dx.doi.org/10.1053/j.semtcvs.2016.04.017DOI Listing
June 2017

Clinical and Echocardiographic Characteristics and Cardiovascular Outcomes According to Diabetes Status in Patients With Heart Failure and Preserved Ejection Fraction: A Report From the I-Preserve Trial (Irbesartan in Heart Failure With Preserved Ejection Fraction).

Circulation 2017 Feb 4;135(8):724-735. Epub 2017 Jan 4.

From BHF Cardiovascular Research Centre, University of Glasgow, Scotland, UK (S.L.K., U.M.M., P.S.J., M.C.P., J.J.V.M.); Department of Cardiology, Rigshospitalet University Hospital, Copenhagen, Denmark (S.L.K., U.M.M., L.K.); Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK (D.P.); Mayo Clinic, Rochester, MN (S.W.); Western University, London, ON, Canada (R.S.M.); Ralph H. Johnsons Veterans Affairs Medical Center and Medical University of South Carolina, Charleston (M.R.Z.); Division of Cardiology, University of Minnesota, Minneapolis (I.S.A.); Université Paris 6 and Hospital Pitié-Salpétrière, Paris, France (M.K.); University of Maryland Medical Center, Baltimore (J.S.G.); and Georgetown University and Washington DC Veterans Affairs Medical Center (P.E.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024593DOI Listing
February 2017

Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction.

J Card Fail 2017 Jan 16;23(1):20-28. Epub 2016 Jun 16.

Veterans Affairs Medical Center, Minneapolis, Minnesota; University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.cardfail.2016.06.006DOI Listing
January 2017

Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor: Relationship to Mortality in Patients With Chronic Heart Failure.

Circ Heart Fail 2017 Jan;10(1)

From the RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston (M.R.Z., S.E.H., C.F.B.); Medtronic, Inc, Minneapolis, MN (T.D.B., F.J.K.); The Ohio State University, Columbus (W.T.A.), University of Alabama at Birmingham (R.C.B.); and Brigham and Women's Hospital, Boston, MA (L.S.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003594DOI Listing
January 2017

Natriuretic Peptides, 6-Min Walk Test, and Quality-of-Life Questionnaires as Clinically Meaningful Endpoints in HF Trials.

J Am Coll Cardiol 2016 Dec;68(24):2690-2707

INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.09.936DOI Listing
December 2016

Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction.

Circ Heart Fail 2016 Nov;9(11)

From the Department of Medicine, Stony Brook University, NY (J.B., C.E.H.); Division of Cardiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (J.E.U.); Division of Cardiology, University of Michigan School of Medicine, Ann Arbor (B.P.); Division of Cardiology (C.Y., S.J.S.) and Center for Cardiovascular Innovation (M.G.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.D.-N); Merck & Co, Kenilworth, NJ (H.S.B.); Medtronic, Mounds View, MN (R.L.C., J.J.S.); Amgen Inc, Thousand Oaks, CA (C.D., A.H., J.M.); Bayer Pharma AG, Wuppertal, Germany (W.D., F.K., K.L., L.R., S.R.); Department of Cardiology, HELIOS Clinic Wuppertal, University Hospital Witten/Herdecke, Germany (W.D.); Novartis Pharmaceuticals Inc, East Hanover, NJ (P.K.-M., M.L., S.M.); Clinical Research in Cardiovascular Disease Division, Merck Research Laboratories, Rahway, NJ (M.J.P.); AstraZeneca Global Medicines Development, Gaithersburg, MD (P.S.P.); Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT (A.S.); Dipartimento Cardiovascolare, Azienda Ospedaliera Papa Giovannni XXIII, Bergamo, Italy (M.S.); Department of Medical Sciences, IRCCS San Raffaele Pisana, Roma, Italy (G.R.); Cardiovascular and Cell Science Institute, St George's University of London, United Kingdom (G.R.); Division of Cardiovascular and Renal Products, the United States Food and Drug Administration, Silver Spring, MD (P.D., N.S.); Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Germany (S.D.A.); and Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston (M.R.Z.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003358DOI Listing
November 2016

Impact of Body Mass Index on the Accuracy of N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic Peptide for Predicting Outcomes in Patients With Chronic Heart Failure and Reduced Ejection Fraction: Insights From the PARADIGM-HF Study (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial).

Circulation 2016 11;134(22):1785-1787

From Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (W.N., B.L.C., A.S.D., S.D.S.); Department of Internal Medicine, University of Campinas, Campinas, Brazil (W.N.); British Heart Foundation Cardiovascular Research Centre, University of Glasgow, United Kingdom (J.J.M.); Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.); Division of Cardiology, Medical University of South Carolina, Ralph H. Johnston Veterans Administration Medical Center, Charleston (M.R.Z.); Institut de Cardiologie de Montréal, Université de Montréal, Canada (J.L.R.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden (K.S.); and Novartis Pharmaceuticals Corporation, East Hanover, NJ (M.L., V.C.S., M.F.P.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024976DOI Listing
November 2016

Relevance of Changes in Serum Creatinine During a Heart Failure Trial of Decongestive Strategies: Insights From the DOSE Trial.

J Card Fail 2016 Oct 30;22(10):753-60. Epub 2016 Jun 30.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; Program of Applied Translational Research, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2016.06.423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435117PMC
October 2016

Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?

Circulation 2016 10 14;134(15):1100-1104. Epub 2016 Sep 14.

From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069174PMC
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023648DOI Listing
October 2016

Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy.

Circ Heart Fail 2016 09;9(9)

From the BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (N.O., P.S.J., J.J.V.M.); Novartis Pharmaceutical Corporation, East Hanover, NJ (J.G., M.P.L., A.R.R., V.C.S.); Institut de Cardiologie de Montréal, Université de Montréal, Quebec, Canada (J.L.R.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden (K.S.); National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.); Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston (M.R.Z.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (S.D.S.); and Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003212DOI Listing
September 2016

Clinical outcomes according to QRS duration and morphology in the irbesartan in patients with heart failure and preserved systolic function (I-PRESERVE) trial.

Eur J Heart Fail 2016 08 15;18(8):1021-31. Epub 2016 May 15.

Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, Scotland, UK.

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http://dx.doi.org/10.1002/ejhf.547DOI Listing
August 2016

The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio.

Int J Cardiol 2016 Jul 14;215:521-6. Epub 2016 Apr 14.

Program of Applied Translational Research, Yale University, New Haven, Connecticut, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.04.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986924PMC
July 2016

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.

Circulation 2016 Jul;134(1):73-90

From Division of Cardiology, Department of Medicine, and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.); Sections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, (B.A.B.); Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands (L.v.H., W.J.P.); Department of Cardiology, Onze Lieve Vrouw Gasthuis, Amsterdam, The Netherlands (L.v.H.); Department of Medicine, Medical University of South Carolina (MUSC) and the RHJ Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); and Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD (D.A.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930115PMC
July 2016

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium.

Am J Physiol Endocrinol Metab 2016 06 3;310(11):E1027-35. Epub 2016 May 3.

Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina; Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina; and.

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http://dx.doi.org/10.1152/ajpendo.00040.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935141PMC
June 2016

Importance of Clinical Worsening of Heart Failure Treated in the Outpatient Setting: Evidence From the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF).

Circulation 2016 Jun 20;133(23):2254-62. Epub 2016 Apr 20.

From BHF Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (N.O., P.S.J., J.J.V.M.); Novartis Pharmaceutical Corporation, East Hanover, NJ (J.G., M.P.L., A.R.R., V.C.S.); Institut de Cardiologie, Université de Montréal, Canada (J.L.R.); Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden and National Heart and Lung Institute, Imperial College, London, United Kingdom (K.S.); Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston, SC (M.R.Z.); Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (S.D.S.); and Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (M.P.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020729DOI Listing
June 2016

Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

J Lipid Res 2016 Apr 21;57(4):546-62. Epub 2016 Feb 21.

Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425 Ralph H. Johnson Veteran Affairs Medical Center, Charleston, SC 29401.

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http://dx.doi.org/10.1194/jlr.M060061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808764PMC
April 2016

Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

Circ Heart Fail 2016 Apr;9(4):e002763

From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.B.S.S., G.Q.R., B.C., S.D.S., A.M.S.); Cardiology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal of Rio Grande do Sul, Porto Alegre, Brazil (A.B.S.S.); Division of Cardiovascular Medicine, Sarver Heart Center, University of Arizona College of Medicine, Tucson (N.K.S.); Cardiology Division, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.); Cardiovascular Division, VA Medical Center, Minneapolis, MN (I.S.A.); Cardiology Division, University of Utah School of Medicine, Salt Lake City (J.F.); RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston (M.R.Z.); and Cardiology Division, University of Michigan School of Medicine, Ann Arbor (B.P.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826720PMC
April 2016

Prediction of All-Cause Mortality Based on the Direct Measurement of Intrathoracic Impedance.

Circ Heart Fail 2016 Jan 23;9(1):e002543. Epub 2015 Dec 23.

From the Division of Cardiology, Department of Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston (M.R.Z., C.F.B.); and Medtronic, Plc., Minneapolis, MN (V.S., J.W.J., E.N.W., T.D.B.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692195PMC
January 2016

Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study.

Circ Heart Fail 2016 Jan;9(1)

From the Department of Medicine, Medical University of South Carolina, Charleston (M.R.Z., C.F.B.); RHJ Department of Veterans Affairs Medical Center, Charleston, SC (M.R.Z., C.F.B.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (P.S.J., B.L.C., S.D.S.); BHF Glasgow Cardiovascular Research Center, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J., J.J.V.M.M.); Department of Cardiology, Medical University of Graz, Graz, Austria (B.P.); Department of Internal Medicine and Cardiology, Charité, Campus Virchow Klinikum, Berlin, Germany (B.P.); Department of Internal Medicine and Cardiology, German Heart Center, Berlin, Germany (B.P.); Department of Cardiology, University of Groningen, Groningen, The Netherlands (A.A.V.); and Novartis Pharmaceuticals, East Hanover, NJ (M.F.P., V.S., M.L.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485256PMC
January 2016

Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial.

Circ Heart Fail 2016 Jan;9(1)

From the British Heart Foundation, Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (S.L.K., D.P., P.J., J.J.V.M.); Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark (S.L.K.); Department of Cardiovascular Sciences, University of Leicester, Leicester, UK (I.S.); NIHR Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK (I.S.); Department of Cardiology, Porto Medical School, Porto, Portugal (J.S.C.); Heart and Vascular Center Semmelweiss University, Budapest, Hungary (B.M.); Instituo DAMIC, Cordoba National University, Cordoba, Argentina (F.M.); Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, OH (R.C.S.); Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.S.D); Novartis Pharmaceutical Corporation, East Hanover, NJ (M.P.L., A.R.R., V.C.S.); Institut de Cardiologie, Université de Montréal, Montréal, Québec, Canada (J.L.R.); Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden (K.S.); RHJ Department of Veterans Administration Medical Center, Medical University of South Carolina, Charleston (M.R.Z.); and Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (M.P.).

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718182PMC
January 2016