Publications by authors named "Michael R Stratton"

100Publications

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.

Cell Stem Cell 2020 Aug 15;27(2):326-335.e4. Epub 2020 Jul 15.

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.06.018DOI Listing
August 2020

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

BMC Genomics 2019 Aug 30;20(1):685. Epub 2019 Aug 30.

Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1186/s12864-019-6041-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717374PMC
August 2019

Somatic evolution and global expansion of an ancient transmissible cancer lineage.

Science 2019 08;365(6452)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1126/science.aau9923DOI Listing
August 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

Br J Haematol 2019 02 30;184(4):676-679. Epub 2018 Mar 30.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.15155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766952PMC
February 2019

Universal Patterns of Selection in Cancer and Somatic Tissues.

Cell 2017 Nov 19;171(5):1029-1041.e21. Epub 2017 Oct 19.

Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395PMC
November 2017

Short inverted repeats contribute to localized mutability in human somatic cells.

Nucleic Acids Res 2017 Nov;45(19):11213-11221

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkx731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737083PMC
November 2017

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783858PMC
December 2015

A mutational signature in gastric cancer suggests therapeutic strategies.

Nat Commun 2015 Oct 29;6:8683. Epub 2015 Oct 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/ncomms9683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918743PMC
October 2015

The genome as a record of environmental exposure.

Mutagenesis 2015 Nov 6;30(6):763-70. Epub 2015 Oct 6.

Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK,

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http://dx.doi.org/10.1093/mutage/gev073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637815PMC
November 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

COSMIC: exploring the world's knowledge of somatic mutations in human cancer.

Nucleic Acids Res 2015 Jan 29;43(Database issue):D805-11. Epub 2014 Oct 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA.

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http://dx.doi.org/10.1093/nar/gku1075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383913PMC
January 2015

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

Genome Res 2014 Oct 16;24(10):1624-36. Epub 2014 Jul 16.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1101/gr.175547.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199376PMC
October 2014

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes.

Curr Opin Genet Dev 2014 Feb 29;24:52-60. Epub 2013 Dec 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1016/j.gde.2013.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990474PMC
February 2014

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells.

Elife 2014 Jan 1;3:e01630. Epub 2014 Jan 1.

Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936288PMC
http://dx.doi.org/10.7554/eLife.01630DOI Listing
January 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.

Elife 2013 Apr 16;2:e00534. Epub 2013 Apr 16.

Protein and Nucleic Acid Chemistry Division , Medical Research Council Laboratory of Molecular Biology , Cambridge , United Kingdom.

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http://dx.doi.org/10.7554/eLife.00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628087PMC
April 2013

Journeys into the genome of cancer cells.

EMBO Mol Med 2013 Feb 22;5(2):169-72. Epub 2013 Jan 22.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1002/emmm.201202388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569633PMC
February 2013

Deciphering signatures of mutational processes operative in human cancer.

Cell Rep 2013 Jan 10;3(1):246-59. Epub 2013 Jan 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1016/j.celrep.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588146PMC
January 2013

Predisposition gene identification in common cancers by exome sequencing: insights from familial breast cancer.

Breast Cancer Res Treat 2012 Jul 18;134(1):429-33. Epub 2012 Apr 18.

Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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http://link.springer.com/10.1007/s10549-012-2057-x
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http://dx.doi.org/10.1007/s10549-012-2057-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781770PMC
July 2012