Michael R Speicher

Michael R Speicher

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Michael R Speicher

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Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

J Natl Cancer Inst 2018 Dec;110(12):1328-1341

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1093/jnci/djy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292796PMC
December 2018

One size does not fit all: Size-based plasma DNA diagnostics.

Sci Transl Med 2018 11;10(466)

Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, A-8010 Graz, Austria.

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http://dx.doi.org/10.1126/scitranslmed.aav3873DOI Listing
November 2018

Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide.

Int J Cancer 2018 09 10;143(5):1236-1248. Epub 2018 Apr 10.

Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Neue Stiftingtalstraße 6, A-8010, Graz, Austria.

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http://dx.doi.org/10.1002/ijc.31397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099279PMC
September 2018

Digital Circulating Tumor Cell Analyses for Prostate Cancer Precision Oncology.

Cancer Discov 2018 03;8(3):269-271

Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0075DOI Listing
March 2018

Single-Stranded DNA Library Preparation Does Not Preferentially Enrich Circulating Tumor DNA.

Clin Chem 2017 10 14;63(10):1656-1659. Epub 2017 Aug 14.

Institute of Human Genetics Medical University of Graz Graz, Austria

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http://dx.doi.org/10.1373/clinchem.2017.277988DOI Listing
October 2017

The potential of liquid biopsies for the early detection of cancer.

NPJ Precis Oncol 2017 17;1(1):36. Epub 2017 Oct 17.

1Institute of Human Genetics, Medical University of Graz, Neue Stiftingtalstraße 6, A-8010 Graz, Austria.

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http://dx.doi.org/10.1038/s41698-017-0039-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871864PMC
October 2017

Patient monitoring through liquid biopsies using circulating tumor DNA.

Int J Cancer 2017 09 25;141(5):887-896. Epub 2017 May 25.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, Graz, A-8010, Austria.

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http://dx.doi.org/10.1002/ijc.30759DOI Listing
September 2017

Searching for cancer vulnerabilities amid genetic chaos.

Genome Biol 2017 08 3;18(1):147. Epub 2017 Aug 3.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010, Graz, Austria.

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http://dx.doi.org/10.1186/s13059-017-1283-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541741PMC
August 2017

Emerging concepts in liquid biopsies.

BMC Med 2017 04 6;15(1):75. Epub 2017 Apr 6.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010, Graz, Austria.

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http://dx.doi.org/10.1186/s12916-017-0840-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382440PMC
April 2017

Inferring expressed genes by whole-genome sequencing of plasma DNA.

Nat Genet 2016 10 29;48(10):1273-8. Epub 2016 Aug 29.

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1038/ng.3648DOI Listing
October 2016

Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.

Mol Oncol 2016 Mar 17;10(3):494-502. Epub 2015 Dec 17.

Medical University of Graz, Institute of Human Genetics, Harrachgasse 21/8, A-8010 Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528970PMC
March 2016

Co-occurrence of MYC amplification and TP53 mutations in human cancer.

Nat Genet 2016 Feb;48(2):104-6

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1038/ng.3468DOI Listing
February 2016

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Sci Transl Med 2016 Feb;8(327):327ra26

INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France. Université Paris Descartes, Sorbonne Paris Cité, UMRS1138, F-75006 Paris, France. Sorbonne Universités, UPMC Univ Paris 06, UMRS1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.

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http://dx.doi.org/10.1126/scitranslmed.aad6352DOI Listing
February 2016

Preexisting TP53 mutation in therapy-related acute myeloid leukemia.

Ann Hematol 2015 Mar 20;94(3):527-9. Epub 2014 Aug 20.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 38D, A-8036, Graz, Austria.

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http://dx.doi.org/10.1007/s00277-014-2191-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317506PMC
March 2015

Circulating tumor cells and DNA as liquid biopsies.

Genome Med 2013 23;5(8):73. Epub 2013 Aug 23.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.

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http://dx.doi.org/10.1186/gm477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979149PMC
June 2014

PTEN action in leukaemia dictated by the tissue microenvironment.

Nature 2014 Jun 4;510(7505):402-6. Epub 2014 May 4.

1] Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [2] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA [3] Howard Hughes Medical Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165899PMC
June 2014

Single-cell analysis: toward the clinic.

Genome Med 2013 27;5(8):74. Epub 2013 Aug 27.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.

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http://dx.doi.org/10.1186/gm478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978650PMC
May 2014

Tumor signatures in the blood.

Nat Biotechnol 2014 May;32(5):441-3

Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1038/nbt.2897DOI Listing
May 2014

Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course.

J Am Acad Dermatol 2014 Apr 14;70(4):716-723. Epub 2014 Jan 14.

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2013.11.028DOI Listing
April 2014

A survey of tools for variant analysis of next-generation genome sequencing data.

Brief Bioinform 2014 Mar 21;15(2):256-78. Epub 2013 Jan 21.

Division for Bioinformatics, Innsbruck Medical University, Innrain 80, 6020 Innsbruck, Austria. Tel.: +43-512-9003-71401; Fax: +43-512-9003-73100;

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http://dx.doi.org/10.1093/bib/bbs086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956068PMC
March 2014

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Immunity 2013 Oct;39(4):782-95

INSERM U872, Laboratory of Integrative Cancer Immunology, Paris 75006, France; Université Paris Descartes, Paris 75006, France; Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris 75006, France.

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http://dx.doi.org/10.1016/j.immuni.2013.10.003DOI Listing
October 2013

Complete and pure trisomy 18p due to a complex chromosomal rearrangement in a male adult with mild intellectual disability.

Am J Med Genet A 2013 Jul 21;161A(7):1806-12. Epub 2013 May 21.

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/ajmg.a.35986DOI Listing
July 2013

Toward an improved definition of the tumor spectrum associated with BAP1 germline mutations.

J Clin Oncol 2012 Nov 1;30(32):e337-40. Epub 2012 Oct 1.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 20, New York, NY 10065, USA.

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http://dx.doi.org/10.1200/JCO.2011.41.2965DOI Listing
November 2012

High-resolution analysis of alterations in medullary thyroid carcinoma genomes.

Int J Cancer 2012 Jul 28;131(2):E66-73. Epub 2011 Nov 28.

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/ijc.26494DOI Listing
July 2012

Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.

Gastroenterology 2012 May 15;142(5):1229-1239.e3. Epub 2012 Feb 15.

Institute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1053/j.gastro.2012.02.009DOI Listing
May 2012

Further evidence for the pathogenicity of 15q24 microduplications distal to the minimal critical regions.

Am J Med Genet A 2010 Dec;152A(12):3173-8

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://doi.wiley.com/10.1002/ajmg.a.33750
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http://dx.doi.org/10.1002/ajmg.a.33750DOI Listing
December 2010

Effect of genome-wide association studies, direct-to-consumer genetic testing, and high-speed sequencing technologies on predictive genetic counselling for cancer risk.

Lancet Oncol 2010 Sep 25;11(9):890-8. Epub 2010 May 25.

Medical University of Graz, Institute of Human Genetics, Graz, Austria.

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http://dx.doi.org/10.1016/S1470-2045(09)70359-6DOI Listing
September 2010

Pheochromocytoma in a 2.75-year-old-girl with a germline von Hippel-Lindau mutation Q164R.

Am J Med Genet A 2010 Jul;152A(7):1752-5

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/ajmg.a.33407DOI Listing
July 2010

Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms.

J Invest Dermatol 2010 Apr 19;130(4):1152-7. Epub 2009 Nov 19.

Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1534783
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http://dx.doi.org/10.1038/jid.2009.369DOI Listing
April 2010

Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS).

Genome Res 2009 Nov 1;19(11):2081-9. Epub 2009 Oct 1.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.093856.109
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http://dx.doi.org/10.1101/gr.093856.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775603PMC
November 2009

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Nat Genet 2009 Oct 30;41(10):1138-43. Epub 2009 Aug 30.

Institute of Molecular Medicine and Max-Planck-Research Department on Stem Cell Aging, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/ng.426DOI Listing
October 2009

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.

Blood 2009 Jun 25;113(26):6716-25. Epub 2009 Mar 25.

Stem Cell Research Unit, and Department of Hematology and Stem Cell Transplantation, University Clinic of Internal Medicine, Medical University of Graz, Auenbrugger Pl 38, Graz, Austria.

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http://www.bloodjournal.org/content/113/26/6716.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-09-18
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http://dx.doi.org/10.1182/blood-2008-09-181362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710924PMC
June 2009

Monitoring chromosome rearrangements.

Adv Exp Med Biol 2005 ;570:19-41

Institute for Human Genetics, Technical University, Munich, Germany.

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http://link.springer.com/10.1007/1-4020-3764-3_2
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http://dx.doi.org/10.1007/1-4020-3764-3_2DOI Listing
September 2008

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation.

Chromosoma 2008 Apr 8;117(2):123-35. Epub 2007 Nov 8.

Department of Cell Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1007/s00412-007-0131-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755729PMC
April 2008

Single-cell isolation from cell suspensions and whole genome amplification from single cells to provide templates for CGH analysis.

Nat Protoc 2007 ;2(12):3173-84

Institute of Human Genetics, Center for Applied Biomedicine, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.

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http://dx.doi.org/10.1038/nprot.2007.476DOI Listing
February 2008

Defining 'chromosomal instability'.

Trends Genet 2008 Feb 14;24(2):64-9. Epub 2008 Jan 14.

Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.tig.2007.11.006DOI Listing
February 2008

Radial chromatin positioning is shaped by local gene density, not by gene expression.

Chromosoma 2007 Jun 27;116(3):285-306. Epub 2007 Feb 27.

Department of Biology II, Anthropology and Human Genetics, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1007/s00412-007-0098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688818PMC
June 2007

Multiplex-fluorescence in situ hybridization for chromosome karyotyping.

Nat Protoc 2006 ;1(3):1172-84

Institute of Medical Biology and Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.

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http://dx.doi.org/10.1038/nprot.2006.160DOI Listing
June 2007

[Genetic counseling in multiple pregnancies].

Gynakol Geburtshilfliche Rundsch 2007 ;47(1):9-13

Institut fur Medizinische Biologie und Humangenetik, Medizinische Universitat Graz, Graz, Osterreich.

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http://dx.doi.org/10.1159/000098120DOI Listing
April 2007

High resolution array-CGH analysis of single cells.

Nucleic Acids Res 2007 18;35(3):e15. Epub 2006 Dec 18.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkl1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1807964PMC
March 2007

Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment.

Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4594-9. Epub 2007 Mar 5.

Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Ismaningerstrasse 22, D-81675 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.0604716104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810334PMC
March 2007

Digital karyotyping reveals frequent inactivation of the dystrophin/DMD gene in malignant melanoma.

Cell Cycle 2007 Jan 19;6(2):189-98. Epub 2007 Jan 19.

Molecular Oncology, Independent Max-Planck-Research Group, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.4161/cc.6.2.3733DOI Listing
January 2007

Delineation of a 2q deletion in a girl with dysmorphic features and epilepsy.

Am J Med Genet A 2006 Apr;140(7):764-8

Institut für Humangenetik, Technische Universität München, München, Germany.

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http://dx.doi.org/10.1002/ajmg.a.31141DOI Listing
April 2006

Micro-array analyses decipher exceptional complex familial chromosomal rearrangement.

Hum Genet 2006 Mar 3;119(1-2):145-53. Epub 2006 Jan 3.

Institut für Humangenetik, Technische Universität München, Trogerstr. 32, 81675 München, Germany.

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http://link.springer.com/10.1007/s00439-005-0103-z
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http://dx.doi.org/10.1007/s00439-005-0103-zDOI Listing
March 2006

Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.

Blood 2006 Jan 22;107(2):742-51. Epub 2005 Sep 22.

Gesellschaft für Strahlenforschung (GSF)-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-05-2093DOI Listing
January 2006

Securin is not required for chromosomal stability in human cells.

PLoS Biol 2005 Dec 29;3(12):e416. Epub 2005 Nov 29.

Institute of Human Genetics, Technical University Munich, Munich, Germany.

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https://dx.plos.org/10.1371/journal.pbio.0030416
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http://dx.doi.org/10.1371/journal.pbio.0030416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287505PMC
December 2005

The new cytogenetics: blurring the boundaries with molecular biology.

Nat Rev Genet 2005 Oct;6(10):782-92

Institut für Humangenetik, Technische Universität München, Germany.

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https://www.umanitoba.ca/institutes/manitoba_institute_cell_
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http://dx.doi.org/10.1038/nrg1692DOI Listing
October 2005

Live cell catapulting and recultivation does not change the karyotype of HCT116 tumor cells.

Cancer Genet Cytogenet 2005 Sep;161(2):174-7

Institut für Humangenetik, Technische Universität München, Trogerstr. 32, D-81675 München, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2005.01.013DOI Listing
September 2005

Sequential application of interphase-FISH and CGH to single cells.

Lab Invest 2005 Apr;85(4):582-92

Institut für Humangenetik, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1038/labinvest.3700249DOI Listing
April 2005

A cell-based screening strategy that predicts mutations in oncogenic tyrosine kinases: implications for clinical resistance in targeted cancer treatment.

Cell Cycle 2005 Mar 25;4(3):400-6. Epub 2005 Mar 25.

Department of Internal Medicine III, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.4161/cc.4.3.1560DOI Listing
March 2005

Generation of chromosome painting probes from single chromosomes by laser microdissection and linker-adaptor PCR.

Chromosome Res 2004 ;12(4):337-43

Department für Geowissenschaften, University of Munich, Theresienstr. 41, D-80333 Munich, Germany.

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http://dx.doi.org/10.1023/B:CHRO.0000034132.77192.5fDOI Listing
February 2005

Multicolor chromosome painting in diagnostic and research applications.

Chromosome Res 2004 ;12(1):15-23

Institut für Humangenetik, Technische Universität München, Trogerstr. 32, D-81675 München, Germany.

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September 2004

Order of genetic events is critical determinant of aberrations in chromosome count and structure.

Genes Chromosomes Cancer 2004 Aug;40(4):298-306

Institute of Human Genetics, Technical University, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20051DOI Listing
August 2004

Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients.

Clin Cancer Res 2004 May;10(10):3457-64

Institut für Humangenetik, Technische Universität München, München, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-03-0818DOI Listing
May 2004

Hyper-recombination and genetic instability in BLM-deficient epithelial cells.

Cancer Res 2003 Dec;63(24):8578-81

Howard Hughes Medical Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA.

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December 2003

Multicolor deconvolution microscopy of thick biological specimens.

Am J Pathol 2003 Feb;162(2):373-9

Institut für Humangenetik, Technische Universität München, München, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851164PMC
http://dx.doi.org/10.1016/S0002-9440(10)63832-1DOI Listing
February 2003