Michael R Schlabach

Michael R Schlabach

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Michael R Schlabach

Michael R Schlabach

Publications by authors named "Michael R Schlabach"

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20Publications

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Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Genes Dev 2017 10;31(19):1933-1938

Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.304857.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710139PMC
October 2017

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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http://dx.doi.org/10.1016/j.cell.2017.07.005DOI Listing
July 2017

A chemical genetics approach for the functional assessment of novel cancer genes.

Cancer Res 2015 May 18;75(10):1949-58. Epub 2015 Mar 18.

Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2930DOI Listing
May 2015

Recurrent hemizygous deletions in cancers may optimize proliferative potential.

Science 2012 Jul 24;337(6090):104-9. Epub 2012 May 24.

Department of Genetics, Harvard University Medical School, and Division of Genetics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1219580
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http://dx.doi.org/10.1126/science.1219580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027969PMC
July 2012

Synthetic design of strong promoters.

Proc Natl Acad Sci U S A 2010 Feb 21;107(6):2538-43. Epub 2010 Jan 21.

Department of Genetics, Division of Genetics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard University Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0914803107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823900PMC
February 2010

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Cell 2009 May;137(5):835-48

Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2009.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768667PMC
May 2009

Design of 240,000 orthogonal 25mer DNA barcode probes.

Proc Natl Acad Sci U S A 2009 Feb 26;106(7):2289-94. Epub 2009 Jan 26.

Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0812506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631075PMC
February 2009

Profiling essential genes in human mammary cells by multiplex RNAi screening.

Science 2008 Feb;319(5863):617-20

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1126/science.1149185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981861PMC
February 2008

Cancer proliferation gene discovery through functional genomics.

Science 2008 Feb;319(5863):620-4

Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1149200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981870PMC
February 2008

Second-generation shRNA libraries covering the mouse and human genomes.

Nat Genet 2005 Nov 2;37(11):1281-8. Epub 2005 Oct 2.

Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/ng1650DOI Listing
November 2005

A genetic screen for candidate tumor suppressors identifies REST.

Cell 2005 Jun;121(6):837-48

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.03.033DOI Listing
June 2005