Publications by authors named "Michael R Savona"

68Publications

Learning from dispersed manual annotations with an optimized data weighting policy.

J Med Imaging (Bellingham) 2020 Jul 30;7(4):044002. Epub 2020 Jul 30.

Vanderbilt University, Department of Electrical Engineering and Computer Science, Nashville, Tennessee, United States.

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http://dx.doi.org/10.1117/1.JMI.7.4.044002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394463PMC
July 2020

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Nat Med 2020 Aug 3. Epub 2020 Aug 3.

Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-020-1008-zDOI Listing
August 2020

Establishing specific response criteria for MDS/MPN - Getting closer to reality?

Best Pract Res Clin Haematol 2020 06 7;33(2):101170. Epub 2020 May 7.

Department of Medicine and Program in Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2020.101170DOI Listing
June 2020

Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia.

Gene 2020 Aug 15;752:144758. Epub 2020 May 15.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2020.144758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401316PMC
August 2020

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes.

N Engl J Med 2020 01;382(2):140-151

From Service d'Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris and Université Paris 7, Paris (P.F., L.A.), Service des Maladies du Sang, Hôpital Huriez, Centre Hospitalier Universitaire (CHU) de Lille, Lille (B.Q.), the Department of Internal Medicine, CHU Toulouse, Institut Universitaire du Cancer de Toulouse, Toulouse (O.B.-R.), and Université Cote d'Azur, Département d'Hématologie Clinique, CHU Nice, Nice (T.C.) - all in France; Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig University Hospital, Leipzig (U.P.), Klinik für Hämatologie, Onkologie, and Klinische Immunologie, Universitätsklinik Düsseldorf, Düsseldorf (U.G.), and Klinik und Poliklinik für Innere Medizin III, Technische Universität München, Munich (K.S.G.) - all in Germany; the Department of Haemato-Oncology, King's College London, London (G.J.M.), Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford (P.V.), and the Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds (D.B.) - all in the United Kingdom; the Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston (G.G.-M.); Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto (R.B.); MDS Unit, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence (V.S.), the Department of Oncology and Hematology, S. Orsola-Malpighi University Hospital, Bologna (C.F.), the University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia (M.C.), the Hematology Unit, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria (F.S., V.G.), and Dipartimento Biomedicina e Prevenzione, University of Rome Tor Vergata, Rome (M.-T.V.) - all in Italy; the Hematology Department, University Hospital of Salamanca, Institute of Biomedical Research of Salamanca, Salamanca (M.D.-C.), Unidad de Hematología, Hospital Universitario Virgen del Rocío, Seville (J.F.F.), and the Department of Hematology, Hospital Universitario Cruces, Vizcaya (B.A.) - all in Spain; the Department of Hematology Science, School of Medicine, Ankara University, Ankara, Turkey (O.I.); the Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland (M.A.S.); the Department of Hematology, Algemeen Ziekenhuis Sint-Jan, Bruges (D.S.), and Universitair Ziekenhuis Gent, Ghent (D.M.) - both in Belgium; the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (A.E.D.); the Division of Hematology-Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center (J.G.J.), and Albert Einstein College of Medicine (A.V.) - both in New York; the Department of Hematology, University Medical Center of Groningen, University of Groningen, Groningen, the Netherlands (E.V.); Stanford University Cancer Center, Stanford, CA (P.L.G.); the Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm (E.H.-L.); the Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT (A.M.Z.); Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville (M.R.S.); Celgene, Summit, NJ (A.L., J.Z., A.R., D.R.D.); Celgene International, Boudry, Switzerland (A.B.); Acceleron Pharma, Cambridge, MA (P.G.L., M.L.S.); and Moffitt Cancer Center, Tampa, FL (R.S.K., A.F.L.).

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http://dx.doi.org/10.1056/NEJMoa1908892DOI Listing
January 2020

Evidence of vaccinia dissemination despite lack of major reaction following smallpox vaccination.

Vaccine 2020 02 31;38(7):1589-1592. Epub 2019 Dec 31.

Department of Medicine, David Grant United States Air Force Medical Center, 101 Bodin Circle, Travis AFB, CA 94535, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.12.046DOI Listing
February 2020

Improving Splenomegaly Segmentation by Learning from Heterogeneous Multi-Source Labels.

Proc SPIE Int Soc Opt Eng 2019 Feb 15;10949. Epub 2019 Mar 15.

Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235.

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http://dx.doi.org/10.1117/12.2512842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874226PMC
February 2019

The evolving role of next generation sequencing in myelodysplastic syndromes.

Br J Haematol 2020 01 1;188(2):224-239. Epub 2019 Oct 1.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1111/bjh.16212DOI Listing
January 2020

Symptom Burden and Blood Counts in Patients With Polycythemia Vera in the United States: An Analysis From the REVEAL Study.

Clin Lymphoma Myeloma Leuk 2019 09 13;19(9):579-584.e1. Epub 2019 Jun 13.

Department of Hematology and Oncology, The University of Texas Health Science Center, San Antonio, TX.

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http://dx.doi.org/10.1016/j.clml.2019.06.001DOI Listing
September 2019

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.

Cancer Discov 2019 Jul;9(7):831-833

Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0510DOI Listing
July 2019

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia.

Clin Cancer Res 2019 08 29;25(16):4907-4916. Epub 2019 May 29.

Myeloma Research, Sarah Cannon Research Institute, Nashville, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3728DOI Listing
August 2019

Incorporating Precision BH3 Warheads Into the Offensive Against Acute Myeloid Leukemia.

J Clin Oncol 2019 07 21;37(21):1785-1789. Epub 2019 May 21.

2 Alfred Hospital, Melbourne, VIC, Australia.

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https://ascopubs.org/doi/10.1200/JCO.19.00400
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http://dx.doi.org/10.1200/JCO.19.00400DOI Listing
July 2019

The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.

Nucleic Acids Res 2019 05;47(8):3921-3936

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1093/nar/gkz127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486546PMC
May 2019

Acceleration of spleen segmentation with end-to-end deep learning method and automated pipeline.

Comput Biol Med 2019 04 5;107:109-117. Epub 2019 Feb 5.

Department of Electrical Engineering, Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN, 37235, USA; Vanderbilt University Institute of Imaging Science, 161 21st Avenue South, Nashville, TN, 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.compbiomed.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086455PMC
April 2019

Low clinical trial accrual of patients with myelodysplastic syndromes: Causes and potential solutions.

Cancer 2018 12 5;124(24):4601-4609. Epub 2018 Oct 5.

Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/cncr.31769
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http://dx.doi.org/10.1002/cncr.31769DOI Listing
December 2018

Leveraging JAK-STAT regulation in myelofibrosis to improve outcomes with allogeneic hematopoietic stem-cell transplant.

Ther Adv Hematol 2018 Sep 16;9(9):251-259. Epub 2018 Jul 16.

Vanderbilt-Ingram Cancer, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2040620718786437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130097PMC
September 2018

Genotypic and clinical heterogeneity within NCCN favorable-risk acute myeloid leukemia.

Leuk Res 2018 02 2;65:67-73. Epub 2018 Jan 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856485PMC
February 2018

Therapy for Chronic Myelomonocytic Leukemia in a New Era.

Curr Hematol Malig Rep 2017 10;12(5):468-477

Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s11899-017-0408-8DOI Listing
October 2017

The Challenge of Treating Myelodysplastic Syndromes/Myeloproliferative Neoplasms.

Clin Lymphoma Myeloma Leuk 2017 07;17S:S37-S42

Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S21522650173021
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http://dx.doi.org/10.1016/j.clml.2017.02.012DOI Listing
July 2017

A phase 2 study of simtuzumab in patients with primary, post-polycythaemia vera or post-essential thrombocythaemia myelofibrosis.

Br J Haematol 2017 Mar 21;176(6):939-949. Epub 2017 Feb 21.

Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA, USA.

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http://dx.doi.org/10.1111/bjh.14501DOI Listing
March 2017

Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.

Curr Hematol Malig Rep 2016 12;11(6):441-448

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s11899-016-0356-8DOI Listing
December 2016

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.

Cell Rep 2016 08 4;16(7):2003-16. Epub 2016 Aug 4.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996374PMC
August 2016

Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes.

Onco Targets Ther 2016 15;9:2273-86. Epub 2016 Apr 15.

Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

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http://dx.doi.org/10.2147/OTT.S83868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844455PMC
May 2016

Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy.

Cancer Immunol Res 2016 06 10;4(6):474-480. Epub 2016 Mar 10.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891280PMC
June 2016

Unfavorable-risk acute myeloid leukemia dissected.

Curr Opin Hematol 2016 Mar;23(2):144-9

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000225DOI Listing
March 2016

Molecular monitoring and minimal residual disease in the management of chronic myelogenous leukemia.

Authors:
Michael R Savona

J Community Support Oncol 2014 May;12(5):171-8

Vanderbilt University Medical Center, Nashville, TN USA

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http://dx.doi.org/10.12788/jcso.0042DOI Listing
May 2014

Are we altering the natural history of primary myelofibrosis?

Authors:
Michael R Savona

Leuk Res 2014 Sep 9;38(9):1004-12. Epub 2014 May 9.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.04.012DOI Listing
September 2014

Identifying the time to change BCR-ABL inhibitor therapy in patients with chronic myeloid leukemia.

Acta Haematol 2013 15;130(4):268-78. Epub 2013 Aug 15.

Sarah Cannon Research Institute, Nashville, Tenn., USA.

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https://www.karger.com/Article/FullText/353163
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http://dx.doi.org/10.1159/000353163DOI Listing
January 2014

HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.

Cell Host Microbe 2011 Mar;9(3):223-234

Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2011.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102232PMC
March 2011

CD9 phones home with a TEM of its own.

Blood 2011 Feb;117(6):1775-6

San Antonio Military Medical Center, USA.

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http://www.bloodjournal.org/content/117/6/1775.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-11-32
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http://dx.doi.org/10.1182/blood-2010-11-320077DOI Listing
February 2011

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.

Nat Med 2010 Apr 7;16(4):446-51. Epub 2010 Mar 7.

Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.

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http://www.nature.com/articles/nm.2109
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http://dx.doi.org/10.1038/nm.2109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892382PMC
April 2010

Overcoming resistance in chronic myelogenous leukemia.

Leuk Lymphoma 2009 Nov;50(11):1785-93

Division of Hematology-Oncology, Department of Medicine, San Antonio Military Medical Center, San Antonio, TX 78236, USA.

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http://dx.doi.org/10.3109/10428190903267559DOI Listing
November 2009

The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia.

Am J Hematol 2009 Apr;84(4):228-30

Department of Medicine, Hematology-Oncology, San Antonio Military Medical Center, San Antonio, Texas, USA.

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http://dx.doi.org/10.1002/ajh.21365DOI Listing
April 2009

Erythropoietin-stimulating agents in oncology.

Cancer J 2008 Mar-Apr;14(2):75-84

University of Michigan, Ann Arbor, MI 48109-5843, USA.

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https://insights.ovid.com/crossref?an=00130404-200803000-000
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http://dx.doi.org/10.1097/PPO.0b013e31816a5f51DOI Listing
September 2008

Comparison of a semipermeable dressing bonded to an absorbent pad and a semipermeable dressing over a separate gauze pad for containment of vaccinia virus at the vaccination site.

Infect Control Hosp Epidemiol 2007 Dec 19;28(12):1339-43. Epub 2007 Oct 19.

Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

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https://www.cambridge.org/core/product/identifier/S019594170
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http://dx.doi.org/10.1086/523277DOI Listing
December 2007