Michael Pollak

Michael Pollak

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Michael Pollak

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mTOR as a central regulator of lifespan and aging.

F1000Res 2019 2;8. Epub 2019 Jul 2.

Département de Biochimie et Médecine Moléculaire, Université de Montréal, CP 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.12688/f1000research.17196.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156PMC
July 2019

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.

J Mol Endocrinol 2019 Feb;62(2):R83-R103

Lady Davis Institute, SMBD JGH, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1530/JME-18-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347283PMC
February 2019

Cancer Prevention: A Message from the New Editors-in-Chief.

Cancer Prev Res (Phila) 2019 Jan 27;12(1):1-2. Epub 2018 Dec 27.

Department of Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0349DOI Listing
January 2019

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Cell Metab 2018 12 20;28(6):817-832.e8. Epub 2018 Sep 20.

Lady Davis Institute, SMBD JGH, McGill University, Montreal, QC H3A 1A3, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.09.001DOI Listing
December 2018

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Cell Metab 2018 11 20;28(5):679-688.e4. Epub 2018 Sep 20.

Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.

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http://dx.doi.org/10.1016/j.cmet.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224605PMC
November 2018

Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling.

J Proteome Res 2018 09 23;17(9):3039-3049. Epub 2018 Aug 23.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology , Stuttgart , Germany and University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.8b00199DOI Listing
September 2018

Diet boosts the effectiveness of a cancer drug.

Authors:
Michael Pollak

Nature 2018 08;560(7719):439-440

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http://dx.doi.org/10.1038/d41586-018-05871-xDOI Listing
August 2018

Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study.

J Gerontol A Biol Sci Med Sci 2018 06;73(7):953-959

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1093/gerona/glx143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001890PMC
June 2018

Menstrual cycle characteristics and steroid hormone, prolactin, and growth factor levels in premenopausal women.

Cancer Causes Control 2017 Dec 31;28(12):1441-1452. Epub 2017 Oct 31.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10552-017-0971-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718047PMC
December 2017

Long-Term Use of Long-Acting Insulin Analogs and Breast Cancer Incidence in Women With Type 2 Diabetes.

J Clin Oncol 2017 Nov 27;35(32):3647-3653. Epub 2017 Sep 27.

Jennifer W. Wu, Laurent Azoulay, Jean-François Boivin, and Samy Suissa, McGill University; Jewish General Hospital; Michael Pollak, McGill University; and Agnieszka Majdan, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1200/JCO.2017.73.4491DOI Listing
November 2017

Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival.

Ann Surg Oncol 2017 Oct 5;24(11):3212-3219. Epub 2017 Jul 5.

Branch of Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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http://dx.doi.org/10.1245/s10434-017-5988-yDOI Listing
October 2017

The effects of metformin on gut microbiota and the immune system as research frontiers.

Authors:
Michael Pollak

Diabetologia 2017 09 2;60(9):1662-1667. Epub 2017 Aug 2.

Division of Cancer Prevention, Department of Oncology, McGill University, Montreal, QC, H3T 1E2, Canada.

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http://dx.doi.org/10.1007/s00125-017-4352-xDOI Listing
September 2017

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.

Oncotarget 2017 Aug 18;8(31):50542-50556. Epub 2016 Jul 18.

Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.10671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584165PMC
August 2017

Circulating levels of obesity-related markers and risk of renal cell carcinoma in the PLCO cancer screening trial.

Cancer Causes Control 2017 Jul 8;28(7):801-807. Epub 2017 May 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10552-017-0901-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535804PMC
July 2017

Serum C-peptide, Total and High Molecular Weight Adiponectin, and Pancreatic Cancer: Do Associations Differ by Smoking?

Cancer Epidemiol Biomarkers Prev 2017 06 17;26(6):914-922. Epub 2017 Jan 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Rockville, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457333PMC
June 2017

Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis.

Authors:
Michael N Pollak

Nat Rev Clin Oncol 2017 05 19;14(5):268. Epub 2017 Apr 19.

Departments of Oncology and Medicine, McGill University, and the Segal Cancer Centre, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2017.57DOI Listing
May 2017

Interactions of the Insulin-Like Growth Factor Axis and Vitamin D in Prostate Cancer Risk in the Prostate Cancer Prevention Trial.

Nutrients 2017 Apr 12;9(4). Epub 2017 Apr 12.

Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/nu9040378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409717PMC
April 2017

Physical Activity Increases after an Affectively Arousing Daily Life Event.

Front Psychol 2017 18;8:518. Epub 2017 Apr 18.

Department of Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, TulsaOK, USA.

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http://dx.doi.org/10.3389/fpsyg.2017.00518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394590PMC
April 2017

Metabolic heterogeneity signature of primary treatment-naïve prostate cancer.

Oncotarget 2017 Apr;8(16):25928-25941

The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.18632/oncotarget.15237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432227PMC
April 2017

Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?

Nat Rev Clin Oncol 2017 02 9;14(2):85-99. Epub 2016 Aug 9.

Departments of Oncology and Medicine, McGill University, McIntyre Medical Building, 3655 Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2016.120DOI Listing
February 2017

A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis.

J Gastroenterol Hepatol 2017 Jan;32(1):146-153

Segal Cancer Center, Lady Davis Institute of Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/jgh.13461DOI Listing
January 2017

Phosphodiesterase Type 5 Inhibitors and the Risk of Melanoma Skin Cancer.

Eur Urol 2016 11 10;70(5):808-815. Epub 2016 May 10.

Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.04.035DOI Listing
November 2016

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.

Aging Cell 2016 Oct 21;15(5):811-24. Epub 2016 Jun 21.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

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http://dx.doi.org/10.1111/acel.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013013PMC
October 2016

Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK Clinical Practice Research Datalink.

BMJ 2016 Oct 20;355:i5340. Epub 2016 Oct 20.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte-Catherine, H-425.1, Montréal H3T 1E2, Canada

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http://dx.doi.org/10.1136/bmj.i5340DOI Listing
October 2016

Exercise and Prostate Cancer: Evidence and Proposed Mechanisms for Disease Modification.

Cancer Epidemiol Biomarkers Prev 2016 09 7;25(9):1281-8. Epub 2016 Jul 7.

Department of Histopathology & Morbid Anatomy, Trinity College, Dublin, Ireland. Department of Histopathology, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0223DOI Listing
September 2016

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Genome Res 2016 05 16;26(5):636-48. Epub 2016 Mar 16.

Lady Davis Institute, SMBD Jewish General Hospital, Montreal, Canada H3T 1E2; Department of Oncology, McGill University, Montreal, Canada H3G 1Y6; Department of Experimental Medicine, McGill University, Montreal, Canada H3G 1Y6; Department of Biochemistry, McGill University, Montreal, Canada H3G 1Y6;

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http://dx.doi.org/10.1101/gr.197566.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864462PMC
May 2016

Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status.

J Natl Cancer Inst 2016 Apr 23;108(4). Epub 2015 Nov 23.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (KI, RN, MY, PL, ZRQ, SAK, KM, YS, YI, CSF, SO); Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD (KI, CCH); Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan (KI); Department of Nutrition (MS, RN, EG, KW), Department of Epidemiology (MS, EG, SO), and Department of Biostatistics (RN), Harvard T. H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine (SJ, XZ, EG, CSF, EC, ATC) and Department of Pathology (SO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA (PL, ATC); Department of Oncology, McGill University, Montreal, Quebec, Canada (MNP); Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (CSM); Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA (CSM); Department of Dermatology, Warren Alpert Medical School of Brown University, Province, RI (EC).

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http://jnci.oxfordjournals.org/content/108/4/djv363.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv36
Publisher Site
http://dx.doi.org/10.1093/jnci/djv363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668768PMC
April 2016

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

Cell Metab 2016 Apr;23(4):569-70

Goodman and Segal Cancer Centers, McGill University, 3755 Cote-Sainte-Catherine Road, Montreal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.010DOI Listing
April 2016

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum.

Mol Cancer Ther 2016 Mar 26;15(3):430-8. Epub 2016 Feb 26.

Department of Urology, University of California, Irvine, Orange, California. Department of Pharmacology, University of California, Irvine, Orange, California. Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0714-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783238PMC
March 2016

mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

Cell Cycle 2015 ;14(4):473-80

a Department of Biochemistry and Goodman Cancer Research Centre ; McGill University ; Montreal , QC Canada.

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http://dx.doi.org/10.4161/15384101.2014.991572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615141PMC
December 2015

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial.

Lancet Oncol 2015 Jul 8;16(7):839-47. Epub 2015 Jun 8.

Department of Medical Oncology, Academic Medical Centre, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00027-3DOI Listing
July 2015

Similarity of Serum and Plasma Insulin-like Growth Factor Concentrations.

Biomark Cancer 2015 8;7:13-7. Epub 2015 Jun 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.4137/BIC.S23088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467203PMC
June 2015

5α-Reductase Inhibitors and the Risk of Cancer-Related Mortality in Men With Prostate Cancer.

JAMA Oncol 2015 Jun;1(3):314-20

Department of Oncology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2015.0387DOI Listing
June 2015

Prediagnostic plasma IGFBP-1, IGF-1 and risk of prostate cancer.

Int J Cancer 2015 May 10;136(10):2418-26. Epub 2014 Nov 10.

Department of Nutrition, Harvard School of Public Health, Boston, MA.

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http://dx.doi.org/10.1002/ijc.29295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360136PMC
May 2015

Recovery of olfactory function induces neuroplasticity effects in patients with smell loss.

Neural Plast 2014 3;2014:140419. Epub 2014 Dec 3.

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1155/2014/140419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269319PMC
May 2015

Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms.

Diabetes 2015 May 9;64(5):1632-42. Epub 2015 Jan 9.

Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX Department of Nutrition, University of North Carolina, Chapel Hill, NC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC

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http://dx.doi.org/10.2337/db14-1132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407853PMC
May 2015

The use of aspirin and the risk of mortality in patients with prostate cancer.

J Urol 2015 Apr 14;193(4):1220-5. Epub 2014 Nov 14.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.11.018DOI Listing
April 2015

Germ line knockout of IGFBP-3 reveals influences of the gene on mammary gland neoplasia.

Breast Cancer Res Treat 2015 Feb 23;149(3):577-85. Epub 2015 Jan 23.

Lady Davis Institute for Medical Research of the Jewish General Hospital, Room E-423, 3755 Cote-Ste-Catherine Road, Montreal, QC, H3T 1E2, Canada,

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http://dx.doi.org/10.1007/s10549-015-3268-8DOI Listing
February 2015

Serine deprivation enhances antineoplastic activity of biguanides.

Cancer Res 2014 Dec 6;74(24):7521-33. Epub 2014 Nov 6.

Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. Department of Oncology, McGill University, Montreal, Quebec, Canada. Segal Cancer Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. Division of Cancer Prevention, McGill University, Montreal, Quebec, Canada.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-2643-TDOI Listing
December 2014

Metformin: from mechanisms of action to therapies.

Cell Metab 2014 Dec 30;20(6):953-66. Epub 2014 Oct 30.

INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.09.018DOI Listing
December 2014

Post-diagnostic use of beta-blockers and the risk of death in patients with prostate cancer.

Eur J Cancer 2014 Nov 6;50(16):2838-45. Epub 2014 Sep 6.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.08.006DOI Listing
November 2014

Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers.

Cancer Causes Control 2014 Nov 20;25(11):1427-37. Epub 2014 Sep 20.

Department of Behavioral and Community Health, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, USA.

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http://dx.doi.org/10.1007/s10552-014-0434-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316818PMC
November 2014

Metformin's potential in oncology.

Authors:
Michael Pollak

Clin Adv Hematol Oncol 2013 ;11(9):594-5

Alexander Goldfarb Research Chair and Professor Department of Oncology Department of Medicine McGill University Montreal, Canada.

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October 2014

The use of metformin in patients with prostate cancer and the risk of death.

Cancer Epidemiol Biomarkers Prev 2014 Oct 13;23(10):2111-8. Epub 2014 Jul 13.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada. Department of Oncology, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0056DOI Listing
October 2014

Serum transforming growth factor-β1 and risk of pancreatic cancer in three prospective cohort studies.

Cancer Causes Control 2014 Sep 10;25(9):1083-91. Epub 2014 Jun 10.

Epidemiology Research Program, American Cancer Society, National Home Office, 250 Williams Street, Atlanta, GA, 30303-1002, USA,

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http://dx.doi.org/10.1007/s10552-014-0409-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920694PMC
September 2014

Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer.

Gynecol Oncol 2014 Sep 24;134(3):607-14. Epub 2014 Jun 24.

Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Segal Cancer Center, Lady Davis Institute of Medical Research, McGill University, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada. Electronic address:

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https://www.mcgill.ca/pollak-lab/files/pollak-lab/anti-diabe
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http://linkinghub.elsevier.com/retrieve/pii/S009082581401054
Publisher Site
http://dx.doi.org/10.1016/j.ygyno.2014.06.014DOI Listing
September 2014

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.

Biochem J 2014 Sep;462(3):475-87

*Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, U.K.

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http://dx.doi.org/10.1042/BJ20140620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148174PMC
September 2014

Metformin directly acts on mitochondria to alter cellular bioenergetics.

Cancer Metab 2014 28;2:12. Epub 2014 Aug 28.

Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, QC H3A 1A3, Canada ; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montréal, QC H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/2049-3002-2-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147388PMC
September 2014

Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment.

Authors:
Michael Pollak

Nat Med 2014 Jun;20(6):591-3

Department of Oncology, McGill University and Segal Cancer Centre of the Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nm.3596DOI Listing
June 2014

Association of C-peptide and leptin with prostate cancer incidence in the Health Professionals Follow-up Study.

Cancer Causes Control 2014 May 25;25(5):625-32. Epub 2014 Mar 25.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Rm E6132, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s10552-014-0369-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028628PMC
May 2014

Phase II randomized study of figitumumab plus docetaxel and docetaxel alone with crossover for metastatic castration-resistant prostate cancer.

Clin Cancer Res 2014 04 17;20(7):1925-34. Epub 2014 Feb 17.

Authors' Affiliations: Royal Marsden NHS Foundation Trust and The Institute of Cancer Research UK, Sutton; Institut Català d'Oncologia, L'Hospitalet, Barcelona; University of Surrey, Surrey, United Kingdom; Yale University Cancer Center, New Haven; Centre Hospitalier de l'Universite de Montreal, Montreal; A Coruña University Hospital, A Coruña, Spain; Kantonsspital St. Gallen, St. Gallen, Switzerland; Fox Chase Cancer Center, Philadelphia, Pennsylvania; Pfizer Inc, Groton, Connecticut; and Lady Davis Institute for Medical Research, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1869DOI Listing
April 2014

Type 2 diabetes and the risk of mortality among patients with prostate cancer.

Cancer Causes Control 2014 Mar 3;25(3):329-38. Epub 2014 Jan 3.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte-Catherine, Montreal, QC, H3T 1E2, Canada.

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http://dx.doi.org/10.1007/s10552-013-0334-6DOI Listing
March 2014

Quantification of binding of IGF-1 to BI 836845, a candidate therapeutic antibody against IGF-1 and IGF-2, and effects of this antibody on IGF-1:IGFBP-3 complexes in vitro and in male C57BL/6 mice.

Endocrinology 2014 Mar 1;155(3):703-15. Epub 2014 Jan 1.

Departments of Medicine and Oncology, Lady Davis Institute for Medical Research and Segal Cancer Center, Jewish General Hospital and McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1210/en.2013-1791DOI Listing
March 2014

Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada).

Cancer Causes Control 2014 Mar 17;25(3):385-94. Epub 2014 Jan 17.

Cancer Control Research, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada,

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http://dx.doi.org/10.1007/s10552-014-0339-9DOI Listing
March 2014

Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate cancer growth.

Mol Cell Endocrinol 2014 Mar 1;384(1-2):117-25. Epub 2014 Feb 1.

The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.01.012DOI Listing
March 2014

Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with rapamycin.

Mol Cancer Ther 2014 Feb 2;13(2):399-409. Epub 2013 Dec 2.

Corresponding Author: Paul J. Adam, Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer Gasse 5-11, A-1121, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0598DOI Listing
February 2014

Variant NKX3.1 and Serum IGF-1: Investigation of Interaction in Prostate Cancer.

Genes Cancer 2013 Nov;4(11-12):535-45

Departments of Medicine and Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1177/1947601913506009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877662PMC
November 2013