Publications by authors named "Michael Platten"

100Publications

Decreased admissions and change in arrival mode in patients with cerebrovascular events during the first surge of the COVID-19 pandemic.

Neurol Res Pract 2020 16;2:47. Epub 2020 Nov 16.

Department of Neurology and Mannheim Center for Translational Neuroscience, Heidelberg University, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany.

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http://dx.doi.org/10.1186/s42466-020-00094-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668014PMC
November 2020

Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study.

Neuropsychiatr Dis Treat 2020 30;16:2221-2227. Epub 2020 Sep 30.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.2147/NDT.S273913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535112PMC
September 2020

Susceptibility-Weighted 3T MRI of the Swallow Tail Sign in Multiple Sclerosis: A Case Control Study.

J Neuroimaging 2020 Aug 28. Epub 2020 Aug 28.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/jon.12775DOI Listing
August 2020

Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial.

Radiology 2020 Oct 28;297(1):164-175. Epub 2020 Jul 28.

From the Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany (P.K., G.B., I.P., M.S., M.F., U.N., S.H., M.B.); Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University Hospital, Aarhus, Denmark (M.B.H., L.Ø.); Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany (M.N., T.K., A.W., W.W.); Department of Neurology, Medical University Innsbruck, Innsbruck, Austria (M.N.); Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany (F.I., K.H.M.H.); Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (T.K., W.W.); Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany (F.S., A.v.D.); Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany (F.S., A.v.D.); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (M.W.); Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany (M.P.); Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.H.M.H.); Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark (L.Ø.); Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.v.d.B.); and European Organization for Research and Treatment of Cancer (EORTC), Brussels, Belgium (T.G.).

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http://dx.doi.org/10.1148/radiol.2020200978DOI Listing
October 2020

Investigation of the "central vein sign" in infratentorial multiple sclerosis lesions.

Mult Scler Relat Disord 2020 Oct 17;45:102409. Epub 2020 Jul 17.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Theodor-Kutzer-Ufer 1 - 3, 68167 Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.102409DOI Listing
October 2020

Nivolumab for Treatment of Progressive Multifocal Leukoencephalopathy in Sézary Syndrome.

Eur J Neurol 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurology, Ruprecht-Karls-Universität Heidelberg Medizinische Fakultät Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1111/ene.14433DOI Listing
July 2020

Diffusion-weighted MRI in transient global amnesia and its diagnostic implications.

Neurology 2020 07 12;95(2):e206-e212. Epub 2020 Jun 12.

From the Department of Neurology (K.S., C.H., R.G., M.G., A.E., M.P., A.G.), Mannheim Center of Translational Neuroscience, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany; and Department of Neurology (L.R.C.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000009783DOI Listing
July 2020

Decreased utilization of mental health emergency service during the COVID-19 pandemic.

Eur Arch Psychiatry Clin Neurosci 2020 Jun 9. Epub 2020 Jun 9.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00406-020-01151-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282463PMC
June 2020

Acute Stroke in Times of the COVID-19 Pandemic: A Multicenter Study.

Stroke 2020 07 9;51(7):2224-2227. Epub 2020 Jun 9.

Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Germany (C. Hoyer, A.E., M.P., K.S.).

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http://dx.doi.org/10.1161/STROKEAHA.120.030395DOI Listing
July 2020

Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma.

Cancer Med 2020 02 10;9(3):1263-1275. Epub 2019 Dec 10.

Wilhelm Sander-NeuroOncology Unit and Department of Neurology, Regensburg University Hospital, Regensburg, Germany.

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http://dx.doi.org/10.1002/cam4.2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997055PMC
February 2020

The therapeutic potential of targeting tryptophan catabolism in cancer.

Br J Cancer 2020 01 10;122(1):30-44. Epub 2019 Dec 10.

Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Unit for Molecular Epidemiology, Berlin, Germany.

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http://dx.doi.org/10.1038/s41416-019-0664-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964670PMC
January 2020

cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma.

J Neurooncol 2020 Jan 28;146(1):9-23. Epub 2019 Nov 28.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03348-zDOI Listing
January 2020

MRI-Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis.

J Neuroimaging 2020 03 20;30(2):198-204. Epub 2019 Nov 20.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/jon.12676DOI Listing
March 2020

TCR validation toward gene therapy for cancer.

Methods Enzymol 2019 6;629:419-441. Epub 2019 Nov 6.

German Cancer Research Center, DKFZ, Heidelberg, Germany; University Hospital Mannheim, Mannheim, Germany; University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.10.010DOI Listing
June 2020

High-throughput discovery of cancer-targeting TCRs.

Methods Enzymol 2019 6;629:401-417. Epub 2019 Nov 6.

German Cancer Research Center, DKFZ, Heidelberg, Germany; University Hospital Mannheim, Mannheim, Germany; University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.10.009DOI Listing
June 2020

Characterization of Contrast-Enhancing and Non-contrast-enhancing Multiple Sclerosis Lesions Using Susceptibility-Weighted Imaging.

Front Neurol 2019 18;10:1082. Epub 2019 Oct 18.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.3389/fneur.2019.01082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813212PMC
October 2019

Driving mesenchymal transition in glioblastoma.

Authors:
Michael Platten

Neuro Oncol 2020 01;22(1):1-2

Department of Neurology, Medical Faculty Mannheim, Heidelberg University and German Cancer Consortium Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noz195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080218PMC
January 2020

Uncompleted emergency department care and discharge against medical advice in patients with neurological complaints: a chart review.

BMC Emerg Med 2019 10 11;19(1):52. Epub 2019 Oct 11.

Department of Neurology, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68135, Mannheim, Germany.

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http://dx.doi.org/10.1186/s12873-019-0273-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788079PMC
October 2019

Fulminant Cytotoxic Edema in a Patient with Pneumococcal Meningoencephalitis.

J Clin Neurol 2019 Oct;15(4):575-577

Department of Neuroradiology, Universitätsklinikum Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.3988/jcn.2019.15.4.575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785469PMC
October 2019

Interaction between the heart and the brain in transient global amnesia.

J Neurol 2019 Dec 10;266(12):3048-3057. Epub 2019 Sep 10.

Department of Neurology, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68135, Mannheim, Germany.

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http://link.springer.com/10.1007/s00415-019-09529-0
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http://dx.doi.org/10.1007/s00415-019-09529-0DOI Listing
December 2019

Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics.

Front Immunol 2019 11;10:1302. Epub 2019 Jun 11.

Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579921PMC
July 2020

[Treatment-associated neurological symptoms of cancer patients and their treatment].

Nervenarzt 2019 Jun;90(6):587-593

Neurologische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

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http://dx.doi.org/10.1007/s00115-019-0712-8DOI Listing
June 2019

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study.

Neurology 2019 06 10;92(24):e2754-e2763. Epub 2019 May 10.

From the University Medical Center & German Cancer Research Center (M.N., F.S., I.H., P.K., M.P., M.B., W.W.), Heidelberg, Germany; EORTC Headquarters (T.G., V.G.), Brussels, Belgium; Brain Tumor Center at Erasmus MC Cancer Institute (J.E.C.B., W.T., M.J.v.d.B.), Rotterdam, the Netherlands; Medical Oncology Department (A.A.B.), AUSL-Bologna-IRCCS Scienze Neurologiche, Bologna, Italy; Haaglanden Medical Center (M.J.B.T.), the Hague; Leiden University Medical Center (M.J.B.T.), the Netherlands; Institut Gustave Roussy (J.D.), Villejuif; Sorbonne Université (A.I.), Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris; Institut de Cancerologie de l'Ouest (ICO)-Centre Rene Gauducheau (M.C.), Saint-Herblain, France; Leuven Cancer Institute-KU Leuven (P.M.C.), Belgium; Department of Neurology and Brain Tumor Center (M.W.), University Hospital and University of Zurich, Switzerland; Institut Régional du Cancer Montpellier (M.F.); University of Lille (E.L.R.), U-1192, Inserm; CHU Lille (E.L.R.), General and Stereotaxic Neurosurgery Service; Oscar Lambret Center (E.L.R.), Neurology, Lille, France; Department of Neurology (M.P.), Medical Faculty Mannheim, Heidelberg University, Germany; and Department of Neurology (M.N.), Medical University Innsbruck, Austria.

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http://dx.doi.org/10.1212/WNL.0000000000007643DOI Listing
June 2019

How to integrate immunotherapy into standard of care in glioblastoma.

Authors:
Michael Platten

Neuro Oncol 2019 06;21(6):699-700

Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, and German Cancer Consortium, Clinical Cooperation Unit, Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noz043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556846PMC
June 2019

Susceptibility-weighted imaging in malignant melanoma brain metastasis.

J Magn Reson Imaging 2019 10 21;50(4):1251-1259. Epub 2019 Feb 21.

Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jmri.26692DOI Listing
October 2019

Practice-changing developments in neuro-oncology: embracing heterogeneity.

Authors:
Michael Platten

Ther Adv Neurol Disord 2019 8;12:1756286419827688. Epub 2019 Feb 8.

Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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http://journals.sagepub.com/doi/10.1177/1756286419827688
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http://dx.doi.org/10.1177/1756286419827688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376551PMC
February 2019

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.

Nat Rev Drug Discov 2019 05;18(5):379-401

DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), INF 280, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41573-019-0016-5DOI Listing
May 2019

Temporal evolution of acute multiple sclerosis lesions on serial sodium (Na) MRI.

Mult Scler Relat Disord 2019 Apr 17;29:48-54. Epub 2019 Jan 17.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193002
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http://dx.doi.org/10.1016/j.msard.2019.01.027DOI Listing
April 2019

Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis.

Magn Reson Imaging 2019 05 7;58:1-5. Epub 2019 Jan 7.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1 - 3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.mri.2019.01.007DOI Listing
May 2019

MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria.

Radiology 2019 02 4;290(2):359-367. Epub 2018 Dec 4.

From the Department of Neuroradiology (A.H., J.J., X.H., S.H., M.B., M.O.B.), Centre for Infectious Diseases, Parasitology Unit (J.P., A.K.M.), and Center for Childhood and Adolescent Medicine, General Pediatrics (J.P.), University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; German Centre for Infection Research (DZIF), Heidelberg, Germany (J.P., A.K.M.); DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.D., M.P., M.O.B.); NeuroImaging Centre Research, Department of Neuroscience, Ruhr-University Bochum, Bochum, Germany (X.H.); Center for Systems Biology and Institute for Innovation in Imaging (C.W., J.W.C.) and Division of Neuroradiology, Department of Radiology (J.W.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; and Neurology Clinic, University Hospital Mannheim, Mannheim, Germany (M.P.).

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http://dx.doi.org/10.1148/radiol.2018181051DOI Listing
February 2019

Brain Atrophy in Natalizumab-treated Patients with Multiple Sclerosis: A 5-year Retrospective Study.

J Neuroimaging 2019 Mar 28;29(2):190-192. Epub 2018 Nov 28.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Baden-Württemberg, Germany.

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http://dx.doi.org/10.1111/jon.12586DOI Listing
March 2019

Acute Corticonuclear Tract Ischemic Stroke with Isolated Central Facial Palsy.

J Stroke Cerebrovasc Dis 2019 Feb 13;28(2):495-498. Epub 2018 Nov 13.

Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183061
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.030DOI Listing
February 2019

T cells engineered to home in on brain cancer.

Authors:
Michael Platten

Nature 2018 09;561(7723):319-320

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http://dx.doi.org/10.1038/d41586-018-05883-7DOI Listing
September 2018

Perspectives of immunotherapy in isocitrate dehydrogenase-mutant gliomas.

Curr Opin Oncol 2018 11;30(6):368-374

German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ).

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http://dx.doi.org/10.1097/CCO.0000000000000478DOI Listing
November 2018

Understanding and Treating Glioblastoma.

Neurol Clin 2018 08;36(3):485-499

Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ncl.2018.04.006DOI Listing
August 2018

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.

Int J Radiat Oncol Biol Phys 2018 12 31;102(5):1472-1480. Epub 2018 Jul 31.

Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.2004DOI Listing
December 2018

Author Correction: Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Sci Rep 2018 Apr 18;8(1):6361. Epub 2018 Apr 18.

Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41598-018-24807-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906574PMC
April 2018

Vaccine Strategies in Gliomas.

Curr Treat Options Neurol 2018 Mar 28;20(5):11. Epub 2018 Mar 28.

Department of Neurology, Heidelberg Medical Center, University of Heidelberg, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11940-018-0498-1DOI Listing
March 2018

Concepts for Immunotherapies in Gliomas.

Semin Neurol 2018 02 16;38(1):62-72. Epub 2018 Mar 16.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0037-1620274DOI Listing
February 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma.

Ther Adv Neurol Disord 2018 5;11:1756285617753423. Epub 2018 Feb 5.

Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1177/1756285617753423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808960PMC
February 2018

Spatiotemporal evolution of venous narrowing in acute MS lesions.

Neurol Neuroimmunol Neuroinflamm 2018 Mar 17;5(2):e440. Epub 2018 Jan 17.

Department of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773855PMC
March 2018

Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Sci Rep 2018 01 10;8(1):313. Epub 2018 Jan 10.

Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41598-017-18477-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762902PMC
January 2018

Lomustine and Bevacizumab in Progressive Glioblastoma.

N Engl J Med 2017 11;377(20):1954-1963

From the University Medical Center and German Cancer Research Center, Heidelberg, Germany (W.W., M.B., F.S., I.H., A.D., M.P.); the European Organization for Research and Treatment of Cancer, Brussels (T.G., V.G.), and Leuven Cancer Institute-KU Leuven, Leuven (P.M.C.) - both in Belgium; Haaglanden Medical Center, The Hague (M.T.), Erasmus MC Cancer Institute, Rotterdam (W.T., J.C.B., M.J.B.), and VU University Medical Center, Amsterdam (M.K.) - all in the Netherlands; the Medical Oncology Department, Azienda Unità Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy (A.A.B.); Institut Gustave Roussy, Villejuif (J.D.), Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, INSERM Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Sorbonne Universités, University Pierre and Marie Curie 06 UMR S1127, and Institut du Cerveau et de la Moelle Épinière, Paris (A.I.), Institut de Cancerologie de l'Ouest-Centre Rene Gauducheau, Saint-Herblain (M.C.), Institut Régional du Cancer Montpellier, Montpellier (M.F.), and Centre Hospitalier Régional Universitaire de Lille, Lille (E.L.R., F.D.) - all in France; and the Departments of Oncology and Neurology, University Hospital and University of Zurich, Zurich, Switzerland (R.S., M.W.).

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http://dx.doi.org/10.1056/NEJMoa1707358DOI Listing
November 2017

Synergy of vaccination and agonist OX40 treatment-toward a mechanism-driven combination of glioma immunotherapy.

Neuro Oncol 2018 01;20(1):4-5

Department of Neurology and National Center for Tumor Diseases, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761563PMC
January 2018

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Neuro Oncol 2018 01;20(2):174-183

Neurology Clinic & German Consortium for Translational Cancer Research (DKTK), Heidelberg University Medical Center & DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777484PMC
January 2018

The promises of immunotherapy in gliomas.

Curr Opin Neurol 2017 Dec;30(6):650-658

aDepartment of Neurology, University Hospital Mannheim, Heidelberg University bCCU Neuroimmunology and Brain Tumor Immunology, First Division, German Cancer Research Center (DKFZ) cDepartment of Neurology and National Center for Tumor Diseases, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1097/WCO.0000000000000491DOI Listing
December 2017

Fully automated joint space width measurement and digital X-ray radiogrammetry in early RA.

RMD Open 2017 29;3(1):e000369. Epub 2017 Jun 29.

Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1136/rmdopen-2016-000369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574453PMC
June 2017

Lack of T1 hyperintensity in the dentate nucleus after 15 administrations of a macrocyclic contrast agent in multiple sclerosis.

J Neurol Neurosurg Psychiatry 2018 Mar 14;89(3):324-326. Epub 2017 Jul 14.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1136/jnnp-2017-316102DOI Listing
March 2018

HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report.

Case Rep Neurol 2017 May-Aug;9(2):121-126. Epub 2017 May 16.

Department of Neurology, University Medical Centre Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1159/000475544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471757PMC
May 2017

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

Structure 2017 07 9;25(7):1025-1033.e3. Epub 2017 Jun 9.

Crystallography Department, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.05.008DOI Listing
July 2017

Vaccine-based immunotherapeutic approaches to gliomas and beyond.

Nat Rev Neurol 2017 Jun 12;13(6):363-374. Epub 2017 May 12.

Department of Neurosurgery, Duke University Medical Center, 200 Trent Drive, Duke South, Blue Zone, 1st Floor, Room 1554, Durham 27710, North Carolina, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.64DOI Listing
June 2017

Suppression of Th1 differentiation by tryptophan supplementation in vivo.

Amino Acids 2017 07 18;49(7):1169-1175. Epub 2017 Apr 18.

DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00726-017-2415-4DOI Listing
July 2017

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

Oncoimmunology 2016 15;5(12):e1240858. Epub 2016 Nov 15.

DKTK CCU Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg, Germany; Department of Neurology and National Center of Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Department of Neurology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1240858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214097PMC
November 2016