Publications by authors named "Michael Peyton"

52Publications

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis.

Neoplasia 2020 08 13;22(8):294-310. Epub 2020 May 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281309PMC
August 2020

Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine.

Cancer Res 2020 03 16;80(5):929-936. Epub 2020 Jan 16.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056593PMC
March 2020

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 12 26;76(5):838-851.e5. Epub 2019 Sep 26.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898782PMC
December 2019

Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer.

Bioinformatics 2016 05 10;32(9):1373-9. Epub 2016 Jan 10.

Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA, Center for Systems and Synthetic Biology and Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848405PMC
May 2016

Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial.

Clin Cancer Res 2013 Dec 28;19(24):6967-75. Epub 2013 Oct 28.

Authors' Affiliations: Departments of Thoracic/Head and Neck Medical Oncology, Biostatistics and Applied Mathematics, Translational Molecular Pathology, Diagnostic Imaging, Diagnostic Radiology, and Bioinformatics and Computational Biology; Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston; The Hamon Center for Therapeutic Oncology Research and Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas; Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Charlotte, North Carolina; Medical Oncology, Yale Cancer Center, New Haven, Connecticut; Division of Medical Oncology, University of Ottawa, Ottawa, Ontario; Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, Baltimore, Maryland; UC San Diego Moores Cancer Center, La Jolla, California; and Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052-CNRS 5286, Centre Léon Bérard, Lyon, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905243PMC
December 2013

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.

Cell 2013 Sep;154(6):1269-84

Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cell.2013.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917713PMC
September 2013

Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy.

BMC Genomics 2013 Jun 1;14:372. Epub 2013 Jun 1.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1186/1471-2164-14-372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680091PMC
June 2013

Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.

Mol Cancer Ther 2012 Nov 28;11(11):2473-82. Epub 2012 Aug 28.

Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Mail Code 8852, Dallas, TX 75390-8852, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495993PMC
November 2012

SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner.

Cancer Res 2011 Dec 2;71(24):7640-8. Epub 2011 Nov 2.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382117PMC
December 2011

STAT3 mediates resistance to MEK inhibitor through microRNA miR-17.

Cancer Res 2011 May 28;71(10):3658-68. Epub 2011 Mar 28.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392199PMC
May 2011

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.

Mol Cancer Ther 2011 Feb;10(2):336-46

Hamon Center for Therapeutic Oncology Research, Simmons Cancer Center, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061393PMC
February 2011

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression.

Proc Natl Acad Sci U S A 2010 Jun 14;107(26):11936-41. Epub 2010 Jun 14.

Howard Hughes Medical Institute and Department of Biochemistry and Hamon Center for Therapeutic Oncology Research and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1005667107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900705PMC
June 2010

MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells.

Mol Pharm 2010 Feb;7(1):32-40

Department of Pharmacology, Simmons Comprehensive Cancer Center, Department of Internal Medicine, Division of Translational Research, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1021/mp9001393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891983PMC
February 2010

SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.

EMBO J 2009 Apr 5;28(8):1001-15. Epub 2009 Mar 5.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1038/emboj.2009.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683698PMC
April 2009

Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines.

J Thorac Oncol 2009 Feb;4(2):161-6

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

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http://dx.doi.org/10.1097/JTO.0b013e318194fae7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758160PMC
February 2009

Implications of EGFR inhibition in ovarian cancer cell proliferation.

Gynecol Oncol 2008 Jun;109(3):411-7

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.

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http://dx.doi.org/10.1016/j.ygyno.2008.02.030DOI Listing
June 2008

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

Cancer Cell 2007 Nov;12(5):445-56

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431210PMC
November 2007

Synthetic lethal screen identification of chemosensitizer loci in cancer cells.

Nature 2007 Apr;446(7137):815-9

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nature05697DOI Listing
April 2007

Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation.

Cancer Res 2006 Oct;66(19):9601-8

Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC 7.208, Mail Code 9187, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2627DOI Listing
October 2006

Gefitinib versus cetuximab in lung cancer: round one.

J Natl Cancer Inst 2005 Aug;97(16):1168-9

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http://dx.doi.org/10.1093/jnci/dji247DOI Listing
August 2005

Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.

Gastroenterology 2005 Mar;128(3):717-27

Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1053/j.gastro.2004.11.052DOI Listing
March 2005

The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer.

Oncogene 2005 Apr;24(16):2735-8

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390-8593, USA.

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http://www.nature.com/articles/1207694
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1207694DOI Listing
April 2005

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.

Cancer Res 2004 Dec;64(24):9027-34

Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3703DOI Listing
December 2004