Publications by authors named "Michael Parker"

100Publications

Management of large bore access complications in the era of trans-catheter aortic valve replacement.

Vascular 2020 Nov 4:1708538120969468. Epub 2020 Nov 4.

Department of Surgery, Cardiothoracic Surgery, Inova Fairfax, Fairfax, VA, USA.

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http://dx.doi.org/10.1177/1708538120969468DOI Listing
November 2020

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.

mBio 2020 09 29;11(5). Epub 2020 Sep 29.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

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http://dx.doi.org/10.1128/mBio.02351-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527733PMC
September 2020

SARS-CoV-2 challenge studies: ethics and risk minimisation.

J Med Ethics 2020 Sep 25. Epub 2020 Sep 25.

The Ethox Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/medethics-2020-106504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520819PMC
September 2020

Structural coercion in the context of community engagement in global health research conducted in a low resource setting in Africa.

BMC Med Ethics 2020 Sep 21;21(1):90. Epub 2020 Sep 21.

Malawi Liverpool Wellcome Trust Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi.

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http://dx.doi.org/10.1186/s12910-020-00530-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504839PMC
September 2020

A structural view of PA2G4 isoforms with opposing functions in cancer.

J Biol Chem 2020 Nov 20;295(47):16100-16112. Epub 2020 Sep 20.

St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia

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http://dx.doi.org/10.1074/jbc.REV120.014293DOI Listing
November 2020

Ethical challenges in pathogen sequencing: a systematic scoping review.

Wellcome Open Res 2020 3;5:119. Epub 2020 Jun 3.

Wellcome Centre for Ethics and Humanities and Ethox Centre, University of Oxford, Oxford, OX3 7LF, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.15806.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445679PMC
June 2020

Deployment of Engineered Microbes: Contributions to the Bioeconomy and Considerations for Biosecurity.

Health Secur 2020 Jul/Aug;18(4):278-296

Michael T. Parker, PhD, is an Assistant Dean, Office of the Dean, Georgetown University, Washington, DC. Aditya M. Kunjapur, PhD, is an Assistant Professor, Chemical and Biomolecular Engineering, University of Delaware, Newark, DE.

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http://dx.doi.org/10.1089/hs.2020.0010DOI Listing
August 2020

A qualitative study on aspects of consent for genomic research in communities with low literacy.

BMC Med Ethics 2020 06 12;21(1):48. Epub 2020 Jun 12.

Sickle Cell Programme, Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, UN Road, Upanga, Block 9, Dar es Salaam, Tanzania.

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http://dx.doi.org/10.1186/s12910-020-00488-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291634PMC
June 2020

Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing.

Science 2020 05 31;368(6491). Epub 2020 Mar 31.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1126/science.abb6936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164555PMC
May 2020

Investigating the Palatability of Lamb and Beef Components Used in the Production of Pet Food for Cats.

Animals (Basel) 2020 Mar 27;10(4). Epub 2020 Mar 27.

School of Agriculture and Environment, Massey University, Palmerston North 4442, New Zealand.

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http://dx.doi.org/10.3390/ani10040558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222388PMC
March 2020

Fair Allocation of Scarce Medical Resources in the Time of Covid-19.

N Engl J Med 2020 05 23;382(21):2049-2055. Epub 2020 Mar 23.

From the Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia (E.J.E., A.G., C.Z., C.B.); the University of Denver Sturm College of Law, Denver (G.P.); the Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto (R.U.), and the School of Health Studies, Western University, London, ON (M.S.) - both in Canada; the Preventive Medicine Department, Federal University of São Paulo, São Paulo (B.T.); the Wellcome Centre of Ethics and Humanities, the Ethox Centre, University of Oxford, Oxford, United Kingdom (M.P.); and the Department of Emergency Medicine, George Washington University Hospital, Washington, DC (J.P.P.).

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http://dx.doi.org/10.1056/NEJMsb2005114DOI Listing
May 2020

Publisher Correction: In emergencies, health research must go beyond public engagement toward a true partnership with those affected.

Nat Med 2020 03;26(3):441

Wellcome Centre for Ethics and Humanities and the Ethox Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41591-020-0794-7DOI Listing
March 2020

Effects of Maillard-reacted beef bone hydrolysate on the physicochemical properties of extruded meat alternatives.

J Food Sci 2020 Mar 9;85(3):567-575. Epub 2020 Feb 9.

School of Food and Advanced Technology, Massey Univ., Private Bag 11222, Palmerston North, 4442, New Zealand.

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http://dx.doi.org/10.1111/1750-3841.14960DOI Listing
March 2020

Stakeholder views on the acceptability of human infection studies in Malawi.

BMC Med Ethics 2020 02 5;21(1):14. Epub 2020 Feb 5.

Malawi-Liverpool Wellcome Trust Clinical Research Programme, P.O. Box 30096, Chichiri, Blantyre, 3, Malawi.

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http://dx.doi.org/10.1186/s12910-020-0454-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003337PMC
February 2020

In emergencies, health research must go beyond public engagement toward a true partnership with those affected.

Nat Med 2020 03;26(3):308-309

Wellcome Centre for Ethics and Humanities and the Ethox Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41591-020-0758-yDOI Listing
March 2020

MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis.

Brain 2020 01;143(1):55-68

Laboratory of Embryology and Genetics of Human Malformation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1163, Institut Imagine, Paris, France.

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http://dx.doi.org/10.1093/brain/awz379DOI Listing
January 2020

Repurposing of drugs as STAT3 inhibitors for cancer therapy.

Semin Cancer Biol 2019 Nov 8. Epub 2019 Nov 8.

Cancer and Inflammation Program, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, Vic., Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.09.022DOI Listing
November 2019

Call to action for equitable access to human milk for vulnerable infants.

Lancet Glob Health 2019 11;7(11):e1484-e1486

Ethox Centre/Wellcome Centre for Ethics and Humanities, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2214-109X(19)30402-4DOI Listing
November 2019

Passive data collection and use in healthcare: A systematic review of ethical issues.

Int J Med Inform 2019 09 22;129:242-247. Epub 2019 Jun 22.

Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Neurosurgery, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijmedinf.2019.06.015DOI Listing
September 2019

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals.

Angew Chem Int Ed Engl 2019 11 19;58(47):16780-16784. Epub 2019 Aug 19.

School of Molecular Sciences, University of Western Australia, Perth, WA, 6009, Australia.

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http://dx.doi.org/10.1002/anie.201906602DOI Listing
November 2019

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Nat Microbiol 2019 11 5;4(11):1990-2000. Epub 2019 Aug 5.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/s41564-019-0524-4DOI Listing
November 2019

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

iScience 2019 Sep 19;19:110-118. Epub 2019 Jul 19.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669322PMC
September 2019

Chest Tube Management Practices by Trauma Surgeons.

J Surg Res 2019 12 10;244:225-230. Epub 2019 Jul 10.

Department of Surgery, Inova Fairfax Medical Campus, Falls Church, Virginia. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.06.032DOI Listing
December 2019

Changes in the physicochemical properties and flavour compounds of beef bone hydrolysates after Maillard reaction.

Food Res Int 2019 09 15;123:642-649. Epub 2019 May 15.

School of Food and Advanced Technology, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.foodres.2019.05.024DOI Listing
September 2019

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin.

mBio 2019 07 2;10(4). Epub 2019 Jul 2.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

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http://dx.doi.org/10.1128/mBio.01017-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606804PMC
July 2019

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation.

Chem Rev 2019 07 17;119(13):7721-7736. Epub 2019 Jun 17.

School of Chemistry, Bio21 Institute , University of Melbourne , Melbourne , Victoria 3010 , Australia.

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http://dx.doi.org/10.1021/acs.chemrev.9b00090DOI Listing
July 2019

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.

Proc Natl Acad Sci U S A 2019 07 20;116(28):13943-13951. Epub 2019 Jun 20.

Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

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http://dx.doi.org/10.1073/pnas.1903297116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628828PMC
July 2019

How should assent to research be sought in low income settings? Perspectives from parents and children in Southern Malawi.

BMC Med Ethics 2019 05 14;20(1):32. Epub 2019 May 14.

Ethox Centre and Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, OX37LF, UK.

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http://dx.doi.org/10.1186/s12910-019-0369-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515587PMC
May 2019

Looking back on wartime service: Reminiscence by James G. Van Straten.

Aging Ment Health 2019 09 6;23(9):1067-1073. Epub 2019 May 6.

b University of Alabama , Tuscaloosa , Alabama , USA.

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http://dx.doi.org/10.1080/13607863.2019.1609904DOI Listing
September 2019

Dual diagnosis causing severe phenotype in a patient with Angelman syndrome.

Clin Dysmorphol 2019 Jul;28(3):160-163

Sheffield Clinical Genetics Service.

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http://dx.doi.org/10.1097/MCD.0000000000000280DOI Listing
July 2019

Patient and public involvement: Two sides of the same coin or different coins altogether?

Bioethics 2019 07 8;33(6):708-715. Epub 2019 Apr 8.

The Ethox Centre, Medical Sciences Division, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bioe.12584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116097PMC
July 2019

The ethics of sequencing infectious disease pathogens for clinical and public health.

Nat Rev Genet 2019 06;20(6):313-315

Wellcome Centre for Ethics and Humanities and Ethox Centre, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41576-019-0109-3
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http://dx.doi.org/10.1038/s41576-019-0109-3DOI Listing
June 2019

Health-emergency disaster risk management and research ethics.

Lancet 2019 01;393(10167):112-113

Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183312
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http://dx.doi.org/10.1016/S0140-6736(18)33126-XDOI Listing
January 2019

Refining the Primrose syndrome phenotype: A study of five patients with ZBTB20 de novo variants and a review of the literature.

Am J Med Genet A 2019 03 13;179(3):344-349. Epub 2019 Jan 13.

South West Thames Regional Genetics Service, St. George's University Hospitals NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1002/ajmg.a.61024DOI Listing
March 2019

A systematic review of dyadic approaches to reminiscence and life review among older adults.

Aging Ment Health 2019 09 31;23(9):1074-1085. Epub 2018 Dec 31.

d The University of Alabama , Tuscaloosa , AL , USA.

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https://www.tandfonline.com/doi/full/10.1080/13607863.2018.1
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http://dx.doi.org/10.1080/13607863.2018.1555696DOI Listing
September 2019

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.

Antiviral Res 2019 02 20;162:178-185. Epub 2018 Dec 20.

Department of Microbiology, School of Dental Medicine and the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.12.011DOI Listing
February 2019

Clinical report follow up: Type 1 Collagenopathy presenting with a Russell-Silver phenotype.

Am J Med Genet A 2019 01 17;179(1):139-140. Epub 2018 Dec 17.

Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom.

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http://dx.doi.org/10.1002/ajmg.a.60680DOI Listing
January 2019

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations.

J Biol Chem 2019 01 12;294(1):20-27. Epub 2018 Nov 12.

the Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia, and

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006053
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http://dx.doi.org/10.1074/jbc.RA118.006053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322872PMC
January 2019

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.

Hum Immunol 2019 May 9;80(5):281-289. Epub 2018 Nov 9.

Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

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https://www.sciencedirect.com/journal/human-immunology/artic
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https://linkinghub.elsevier.com/retrieve/pii/S01988859183057
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http://dx.doi.org/10.1016/j.humimm.2018.11.002DOI Listing
May 2019

A Prospective Study of Immediate Breast Reconstruction with Laser-Assisted Indocyanine Green Angiography.

Plast Reconstr Surg Glob Open 2018 Sep 6;6(9):e1774. Epub 2018 Sep 6.

Plastic & Reconstructive Surgery, Summa Health System, Akron, Ohio.

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http://dx.doi.org/10.1097/GOX.0000000000001774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191238PMC
September 2018

Survival following rectal cancer surgery: does the age matter?

Acta Chir Belg 2019 Oct 9;119(5):282-288. Epub 2018 Oct 9.

Department of Colorectal Surgery, Colchester Hospital University , Colchester , UK.

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https://www.tandfonline.com/doi/full/10.1080/00015458.2018.1
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http://dx.doi.org/10.1080/00015458.2018.1515395DOI Listing
October 2019

Protein structure and computational drug discovery.

Biochem Soc Trans 2018 10 20;46(5):1367-1379. Epub 2018 Sep 20.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1042/BST20180202DOI Listing
October 2018

Health professionals' and researchers' perspectives on prenatal whole genome and exome sequencing: 'We can't shut the door now, the genie's out, we need to refine it'.

PLoS One 2018 21;13(9):e0204158. Epub 2018 Sep 21.

Department of Population Health, The Ethox Centre and Wellcome Trust Centre for Ethics and Humanities, University of Oxford, Headington, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150486PMC
March 2019

Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities.

Int Health 2019 01;11(1):7-14

The Ethox Centre and Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, University of Oxford, UK.

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http://dx.doi.org/10.1093/inthealth/ihy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314154PMC
January 2019

Six dimensions of research trial acceptability: how much, what, when, in what circumstances, to whom and why?

Soc Sci Med 2018 09 25;213:190-198. Epub 2018 Jul 25.

Malawi Liverpool Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, P.O. Box 30096, Chichiri, Blantyre 3, Malawi; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02779536183040
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http://dx.doi.org/10.1016/j.socscimed.2018.07.040DOI Listing
September 2018

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Biophys Rev 2018 Oct 16;10(5):1337-1348. Epub 2018 Aug 16.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s12551-018-0448-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233344PMC
October 2018

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

MAbs 2018 10 12;10(7):1018-1029. Epub 2018 Sep 12.

a St. Vincent's Institute of Medical Research , Australian Cancer Research Foundation Rational Drug Discovery Centre , Fitzroy , Victoria , Australia.

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http://dx.doi.org/10.1080/19420862.2018.1494107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204844PMC
October 2018

"I think maybe 10 years seems a bit long." Beliefs and attitudes of women who had never used intrauterine contraception.

BMJ Sex Reprod Health 2018 Apr 22;44(2):90-96. Epub 2018 Jan 22.

Anglia Ruskin University, Postgraduate Medical Institute, Chelmsford, UK.

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http://dx.doi.org/10.1136/bmjsrh-2017-101798DOI Listing
April 2018

Big data phenotyping in rare diseases: some ethical issues.

Genet Med 2019 02;21(2):272-274

Big Data Institute, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41436-018-0067-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752288PMC
February 2019

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase.

ChemMedChem 2018 08 6;13(15):1555-1565. Epub 2018 Jul 6.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1002/cmdc.201800129DOI Listing
August 2018

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Structure 2018 07 24;26(7):948-959.e5. Epub 2018 May 24.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, VIC 3010, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.04.014DOI Listing
July 2018