Michael P Murphy

Michael P Murphy

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Michael P Murphy

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Rerouting metabolism to activate macrophages.

Authors:
Michael P Murphy

Nat Immunol 2019 Sep;20(9):1097-1099

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/s41590-019-0455-5DOI Listing
September 2019

A precise method for determining acetabular component anteversion after total hip arthroplasty.

Bone Joint J 2019 Sep;101-B(9):1042-1049

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois, USA.

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http://dx.doi.org/10.1302/0301-620X.101B9.BJJ-2019-0085.R1DOI Listing
September 2019

Procedural Complexity of TransCarotid Artery Revascularization Is Not Increased in Irradiated and Reoperative Necks.

Ann Vasc Surg 2019 Aug 5. Epub 2019 Aug 5.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.avsg.2019.05.063DOI Listing
August 2019

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.

Pediatr Nephrol 2019 Jul 2;34(7):1167-1174. Epub 2018 Jun 2.

Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1007/s00467-018-3984-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366561PMC
July 2019

Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction.

J Vasc Surg 2019 Jun 24;69(6):1679-1684. Epub 2018 Dec 24.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2018.09.044DOI Listing
June 2019

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.

Biochim Biophys Acta Mol Basis Dis 2019 Jun 15;1865(6):1192-1200. Epub 2019 Jan 15.

Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193001
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http://dx.doi.org/10.1016/j.bbadis.2019.01.014DOI Listing
June 2019

Aggressive Surveillance Is Needed to Detect Endoleaks and Junctional Separation between Device Components after Zenith Fenestrated Aortic Reconstruction.

Ann Vasc Surg 2019 May 24;57:129-136. Epub 2019 Jan 24.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.avsg.2018.09.038DOI Listing
May 2019

Detection of changes in mitochondrial hydrogen sulfide in the fish model (Poeciliidae).

Biol Open 2019 May 9;8(5). Epub 2019 May 9.

MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK

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http://dx.doi.org/10.1242/bio.041467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550084PMC
May 2019

Outcomes associated with a transcarotid artery revascularization-centered protocol in high-risk carotid revascularizations using the ENROUTE neuroprotection system.

J Vasc Surg 2019 Mar 6;69(3):807-813. Epub 2018 Oct 6.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07415214183198
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http://dx.doi.org/10.1016/j.jvs.2018.06.222DOI Listing
March 2019

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Cell Chem Biol 2019 Mar 31;26(3):449-461.e8. Epub 2019 Jan 31.

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436940PMC
March 2019

Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells.

J Immunol 2019 Mar 4;202(6):1715-1723. Epub 2019 Feb 4.

Cellular and Molecular Biology Department, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain; and

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http://dx.doi.org/10.4049/jimmunol.1800575DOI Listing
March 2019

The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.

Cell Physiol Biochem 2019 28;52(2):186-197. Epub 2019 Feb 28.

Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.

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https://www.cellphysiolbiochem.com/Articles/000013/
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http://dx.doi.org/10.33594/000000013DOI Listing
March 2019

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.

Free Radic Biol Med 2019 01 31;130:318-327. Epub 2018 Oct 31.

REQUIMTE/LAQV, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E 6BT London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183131
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340810PMC
January 2019

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Redox Biol 2019 01 20;20:544-555. Epub 2018 Nov 20.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183072
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http://dx.doi.org/10.1016/j.redox.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279977PMC
January 2019

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Nat Metab 2019 Jan;1:16-33

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/s42255-018-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485344PMC
January 2019

Osteopontin may be a driver of abdominal aortic aneurysm formation.

J Vasc Surg 2018 12 3;68(6S):22S-29S. Epub 2018 Feb 3.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Richard Roudebush VA Medical Center, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.10.068DOI Listing
December 2018

Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation.

Vascular 2018 Dec 5;26(6):608-614. Epub 2018 Jun 5.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, USA.

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http://dx.doi.org/10.1177/1708538118777657DOI Listing
December 2018

Adjunctive visceral artery chimney in patients undergoing Zenith Fenestrated aortic repair.

J Vasc Surg 2018 12;68(6):1688-1695

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2018.03.421DOI Listing
December 2018

Mitochondria as a therapeutic target for common pathologies.

Nat Rev Drug Discov 2018 12 5;17(12):865-886. Epub 2018 Nov 5.

WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK.

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http://www.nature.com/doifinder/10.1038/nrd.2018.174
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http://dx.doi.org/10.1038/nrd.2018.174DOI Listing
December 2018

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.

Elife 2018 12 27;7. Epub 2018 Dec 27.

School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.

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https://elifesciences.org/articles/41044
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http://dx.doi.org/10.7554/eLife.41044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307857PMC
December 2018

Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells.

Free Radic Biol Med 2018 11 19;128:97-110. Epub 2018 Mar 19.

ARC Centre of Excellence for Free Radical Chemistry, Faculty of Science and Engineering, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.008DOI Listing
November 2018

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy.

Cell Death Differ 2018 11 24;25(11):1921-1937. Epub 2018 Jul 24.

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

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http://www.nature.com/articles/s41418-018-0165-9
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http://dx.doi.org/10.1038/s41418-018-0165-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219511PMC
November 2018

The Causes and Consequences of Nonenzymatic Protein Acylation.

Trends Biochem Sci 2018 11 18;43(11):921-932. Epub 2018 Aug 18.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.07.002DOI Listing
November 2018

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

J Biol Chem 2018 11 19;293(44):17208-17217. Epub 2018 Sep 19.

From the MRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY,

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http://dx.doi.org/10.1074/jbc.RA118.002579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222118PMC
November 2018

Use of the Zenith Fenestrated platform to rescue failing endovascular and open aortic reconstructions is safe and technically feasible.

J Vasc Surg 2018 10 18;68(4):1017-1022. Epub 2018 May 18.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2018.01.038DOI Listing
October 2018

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.

Free Radic Biol Med 2018 10 22;126:322-333. Epub 2018 Aug 22.

University of Exeter Medical School, Exeter, Devon EX1 2LU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.025DOI Listing
October 2018

Metabolic control of ferroptosis in cancer.

Authors:
Michael P Murphy

Nat Cell Biol 2018 10;20(10):1104-1105

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/s41556-018-0209-xDOI Listing
October 2018

A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain.

J Neurotrauma 2018 Sep 18;35(17):2025-2035. Epub 2018 May 18.

1 Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Cambridge, United Kingdom .

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http://dx.doi.org/10.1089/neu.2017.5459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098406PMC
September 2018

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α.

Biochim Biophys Acta Mol Basis Dis 2018 09 26;1864(9 Pt B):2859-2870. Epub 2018 May 26.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183018
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http://dx.doi.org/10.1016/j.bbadis.2018.05.018DOI Listing
September 2018

Institutional experience with the Zenith Fenestrated aortic stent graft.

J Vasc Surg 2018 08 1;68(2):331-336. Epub 2018 Feb 1.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.11.063DOI Listing
August 2018

Ethnic minorities with critical limb ischemia derive equal amputation risk reduction from autologous cell therapy compared with whites.

J Vasc Surg 2018 08 1;68(2):560-566. Epub 2018 Mar 1.

Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.11.088DOI Listing
August 2018

Description of human AAA by cytokine and immune cell aberrations compared to risk-factor matched controls.

Surgery 2018 08 30;164(2):354-358. Epub 2018 Apr 30.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056326PMC
August 2018

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury.

Free Radic Biol Med 2018 08 3;124:517-524. Epub 2018 Jul 3.

Department of Pediatrics, Division of Neonatology, Columbia University, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389362PMC
August 2018

Newly made mitochondrial DNA drives inflammation.

Authors:
Michael P Murphy

Nature 2018 08;560(7717):176-177

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http://dx.doi.org/10.1038/d41586-018-05764-zDOI Listing
August 2018

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species.

Cell Rep 2018 Aug;24(6):1445-1455

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092265PMC
August 2018

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Cell 2018 08;174(4):780-784

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.030DOI Listing
August 2018

Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia.

J Vasc Surg 2018 07 1;68(1):176-181.e1. Epub 2018 Feb 1.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Richard L. Roudebush VA Medical Center, and VA Center for Molecular and Cellular Therapeutics in Cardiovascular Disease, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.09.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019117PMC
July 2018

Perioperative Outcomes are Adversely Affected by Poor Pretransfer Adherence to Acute Limb Ischemia Practice Guidelines.

Ann Vasc Surg 2018 Jul 23;50:46-51. Epub 2018 Feb 23.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1016/j.avsg.2017.11.050DOI Listing
July 2018

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.

Redox Biol 2018 06 20;16:344-351. Epub 2018 Mar 20.

Institute of Health Science, University of Highlands and Islands, Inverness IV2 3JH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953219PMC
June 2018

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.

Hypertension 2018 06 16;71(6):1056-1063. Epub 2018 Apr 16.

From the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945293PMC
June 2018

Control of mitochondrial superoxide production by reverse electron transport at complex I.

J Biol Chem 2018 06 9;293(25):9869-9879. Epub 2018 May 9.

From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom,

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http://dx.doi.org/10.1074/jbc.RA118.003647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016480PMC
June 2018

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.

J Appl Physiol (1985) 2018 May 26;124(5):1194-1202. Epub 2017 Oct 26.

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, Colorado.

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http://dx.doi.org/10.1152/japplphysiol.00670.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008077PMC
May 2018

Results of nonoperative management of acute limb ischemia in infants.

J Vasc Surg 2018 05 8;67(5):1480-1483. Epub 2017 Dec 8.

Division of Vascular Surgery, Department of Surgery, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.09.036DOI Listing
May 2018

Cryopreserved Homografts in Infected Infrainguinal Fields Are Associated with Frequent Reinterventions and Poor Amputation-Free Survival.

Ann Vasc Surg 2018 May 5;49:24-29. Epub 2018 Feb 5.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1016/j.avsg.2017.10.032DOI Listing
May 2018

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload.

Free Radic Biol Med 2018 03 2;117:18-29. Epub 2018 Feb 2.

Medical Research Council Mitochondrial Biology Unit, Cambridge BioMedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866124PMC
March 2018

Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle.

Free Radic Biol Med 2018 03 9;117:180-190. Epub 2018 Feb 9.

Departments of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Departments of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Departments of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896769PMC
March 2018

Immune Modulation as a Treatment for Abdominal Aortic Aneurysms.

Circ Res 2018 03;122(7):925-927

From the Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880296PMC
March 2018

Rationale and Design of the ARREST Trial Investigating Mesenchymal Stem Cells in the Treatment of Small Abdominal Aortic Aneurysm.

Ann Vasc Surg 2018 Feb 13;47:230-237. Epub 2017 Sep 13.

Division of Vascular Surgery, Department of Surgery, IU Health Center for Aortic Disease, Indiana University School of Medicine, Indianapolis, IN; VA Center for Molecular and Cellular Therapeutics in Cardiovascular Disease, Richard L. Roudebush VA Medical Center, Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.avsg.2017.08.044DOI Listing
February 2018

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Eur Respir J 2018 Feb 1. Epub 2018 Feb 1.

Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig-University, 35392 Giessen, Germany.

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http://dx.doi.org/10.1183/13993003.01024-2017DOI Listing
February 2018

Glycolysis promotes caspase-3 activation in lipid rafts in T cells.

Cell Death Dis 2018 01 19;9(2):62. Epub 2018 Jan 19.

Vermont Center for Immunology and Infectious Diseases, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

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http://www.nature.com/articles/s41419-017-0099-z
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http://dx.doi.org/10.1038/s41419-017-0099-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833351PMC
January 2018

Adult venous endothelium is a niche for highly proliferative and vasculogenic endothelial colony-forming cells.

J Vasc Surg 2017 12 24;66(6):1854-1863. Epub 2017 Jun 24.

Health Center for Aortic Disease, Indiana University Health Center for Aortic Disease, Indianapolis, Ind; Department of Cellular and Integrative Physiology, Indiana University Health Center for Aortic Disease, Indianapolis, Ind; Department of Surgery, Indiana University Health Center for Aortic Disease, Indianapolis, Ind; Indiana Center for Vascular Biology and Medicine, Indiana University Health Center for Aortic Disease, Indianapolis, Ind.

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http://dx.doi.org/10.1016/j.jvs.2016.11.059DOI Listing
December 2017

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness.

Arterioscler Thromb Vasc Biol 2017 12 28;37(12):2322-2332. Epub 2017 Sep 28.

From the Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, University of Cambridge, United Kingdom (E.P.K.Y., J.R., H.Y., L.S., A.K.U., K.F., A.F., N.F., M.B.); Department of Biomedical Sciences, University of Nottingham, Malaysia Campus, Selangor, Malaysia (Y.-F.P.); and MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (A.L., M.P.M.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701734PMC
December 2017

cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.

Circulation 2017 Dec 19;136(24):2337-2355. Epub 2017 Oct 19.

Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Germany (S.F., A.K., J.S., E.M., P.R., R.L.)

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028723DOI Listing
December 2017

TSG-6 is highly expressed in human abdominal aortic aneurysms.

J Surg Res 2017 12 12;220:311-319. Epub 2017 Aug 12.

Indiana University School of Medicine, Richard Roudebush Veteran Affairs Medical Center, Department of Surgery, Division of Vascular Surgery and Center for Aortic Disease, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2017.06.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864112PMC
December 2017

Staged endovascular repair of an abdominal aortic aneurysm adjacent to a chronic high-flow iliocaval traumatic arteriovenous fistula.

J Vasc Surg Cases Innov Tech 2017 Dec 18;3(4):247-250. Epub 2017 Dec 18.

Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Ind.

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https://linkinghub.elsevier.com/retrieve/pii/S24684287173007
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http://dx.doi.org/10.1016/j.jvscit.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765185PMC
December 2017

Identification and quantification of protein -nitrosation by nitrite in the mouse heart during ischemia.

J Biol Chem 2017 09 14;292(35):14486-14495. Epub 2017 Jul 14.

the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and

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http://dx.doi.org/10.1074/jbc.M117.798744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582841PMC
September 2017

Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.

Mol Genet Metab 2017 09 25;122(1-2):43-50. Epub 2017 Jul 25.

Centro de Biología Molecular Severo Ochoa, UAM-CSIC, Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), CIBERER, IdiPaz, Universidad Autónoma, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.07.009DOI Listing
September 2017

Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins.

Free Radic Biol Med 2017 07 31;108:374-382. Epub 2017 Mar 31.

MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488967PMC
July 2017

Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.

Liver Int 2017 07 27;37(7):1002-1012. Epub 2017 Apr 27.

Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, University of Barcelona Medical School, Barcelona, Spain.

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http://dx.doi.org/10.1111/liv.13436DOI Listing
July 2017

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.

Cell Rep 2017 05;19(6):1202-1213

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28049 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Universidad Autónoma de Madrid, 28049 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.036DOI Listing
May 2017

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells).

Circulation 2017 Apr 16;135(15):1417-1428. Epub 2017 Feb 16.

From Texas Heart Institute (E.C.P., J.T.W., A.G., D.A.T., M.R., B.C., N.P.), CHI St. Luke's Health (R.M.), Houston; Indiana University School of Medicine, Indianapolis (M.P.M., K.L.M., P.G.); University of Louisville, KY (R.B., J.L., S.W.); Stanford University School of Medicine, CA (P.C.Y., N.J.L., R.L.D., F.K., E.G.R., M.R.S.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (J.A., J.H.T., J.G.); Cedars-Sinai Heart Institute, Los Angeles, CA (T.D.H.); University of Florida School of Medicine, Gainesville (C.J.P., R.D.A., S.B., D.L., E.H.); University of Minnesota Medical School, Minneapolis (G.R., B.B.-D., E.C., A.T.H.); University of Miami Miller School of Medicine, FL (O.V., J.M.H., I.H.S., D.D.); Orlando Health, FL (V.S.K.); University of Colorado School of Medicine and CPC Clinical Research, Aurora (W.R.H.); Johns Hopkins University, Baltimore, MD (B.A.- V., J.A.L.); Baylor College of Medicine, Houston, TX (A.P.G., A.G.D., J. Bloom, S.R.); University of Texas School of Public Health, Houston (J. Bettencourt, D.L., L.P., L.S., M.C., S.L.S., R.W.V., L.M.); National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (R.F.E.); and University of Kansas School of Medicine, Kansas City (R.D.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388585PMC
April 2017

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives.

Interface Focus 2017 Apr;7(2):20160117

The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences , The Medical School, Newcastle University , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.1098/rsfs.2016.0117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311907PMC
April 2017

Using chemical biology to assess and modulate mitochondria: progress and challenges.

Interface Focus 2017 Apr;7(2):20160151

MRC Mitochondrial Biology Unit , Hills Road, Cambridge CB2 0XY , UK.

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http://dx.doi.org/10.1098/rsfs.2016.0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311910PMC
April 2017

Getting A Leg Up on Cell Therapy for Critical Limb Ischemia.

Circ Res 2017 04;120(8):1227-1228

From the Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856450PMC
April 2017

Murine ultrasound-guided transabdominal para-aortic injections of self-assembling type I collagen oligomers.

J Control Release 2017 03 24;249:53-62. Epub 2017 Jan 24.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States; Center for Cancer Research, Purdue University, West Lafayette, IN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323294PMC
March 2017

Understanding and preventing mitochondrial oxidative damage.

Authors:
Michael P Murphy

Biochem Soc Trans 2016 10;44(5):1219-1226

MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, U.K.

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http://dx.doi.org/10.1042/BST20160108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095902PMC
October 2016