Publications by authors named "Michael P Murphy"

100Publications

Mitochondria as Therapeutic Targets in Transplantation.

Trends Mol Med 2020 Sep 17. Epub 2020 Sep 17.

Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK; Medical Research Council (MRC) Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2020.08.001DOI Listing
September 2020

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury.

Redox Biol 2020 Sep 12;36:101640. Epub 2020 Jul 12.

Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2020.101640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372157PMC
September 2020

Active RNA interference in mitochondria.

Cell Res 2020 Aug 17. Epub 2020 Aug 17.

Key Laboratory for RNA Biology, Institute of Biophysics, Chinese Academy of Science, Beijing, 100101, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41422-020-00394-5DOI Listing
August 2020

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker.

Mol Pharm 2020 Sep 5;17(9):3526-3540. Epub 2020 Aug 5.

Molecular Research Center, Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.0c00533DOI Listing
September 2020

Reply to: In vivo quantification of mitochondrial membrane potential.

Nature 2020 Jul;583(7815):E19-E20

Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-020-2367-9DOI Listing
July 2020

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon.

Redox Biol 2020 Sep 21;36:101606. Epub 2020 Jun 21.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2020.101606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327929PMC
September 2020

Targeting mitochondrial fitness as a strategy for healthy vascular aging.

Clin Sci (Lond) 2020 Jun;134(12):1491-1519

Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS20190559DOI Listing
June 2020

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.

Proc Natl Acad Sci U S A 2020 06 15;117(26):15160-15171. Epub 2020 Jun 15.

Molecular Immunity Unit, Department of Medicine, Medical Research Council Laboratory of Molecular Biology, University of Cambridge, Cambridge CB2 0QH, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2000943117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334513PMC
June 2020

Perioperative and Long-term Results of Zenith Fenestrated Aortic Repair in Women.

Ann Vasc Surg 2020 May 29. Epub 2020 May 29.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2020.05.036DOI Listing
May 2020

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss.

Redox Biol 2020 07 5;34:101558. Epub 2020 May 5.

Laboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Chile. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2020.101558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248293PMC
July 2020

How should we talk about metabolism?

Nat Immunol 2020 Jul;21(7):713-715

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-020-0691-8DOI Listing
July 2020

Stable mitochondrial CICIII supercomplex interactions in reptiles versus homeothermic vertebrates.

J Exp Biol 2020 Jun 17;223(Pt 12). Epub 2020 Jun 17.

Department of Biology, Aarhus University, 8000 Aarhus, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jeb.223776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328143PMC
June 2020

Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae.

Free Radic Biol Med 2020 Jul 6;154:105-118. Epub 2020 May 6.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2020.04.029DOI Listing
July 2020

Characterising acetabular component orientation with pelvic motion during total hip arthroplasty.

Hip Int 2020 May 6:1120700020925013. Epub 2020 May 6.

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120700020925013DOI Listing
May 2020

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- mice.

Lupus Sci Med 2020 04 16;7(1). Epub 2020 Apr 16.

Vermont Center for Immunology and Infectious Diseases, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/lupus-2020-000387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199895PMC
April 2020

Deletion of Expression in Aortic Smooth Muscle Cells Ameliorates Aortic Dissection.

JACC Basic Transl Sci 2020 Feb 24;5(2):145-147. Epub 2020 Feb 24.

Department of Surgery, Division of Vascular Surgery, the Indiana University School of Medicine, Indianapolis, Indiana.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacbts.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046534PMC
February 2020

The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance: A worm model for adrenoleukodystrophy.

Free Radic Biol Med 2020 May 1;152:797-809. Epub 2020 Feb 1.

Neurometabolic Diseases Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, Spain; CIBERER U759, Center for Biomedical Research on Rare Diseases, Spain; ICREA (Institució Catalana de Recerca i Estudis Avançats), Barcelona, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2020.01.177DOI Listing
May 2020

Minimum twelve-year follow-up of fixed- vs mobile-bearing total knee arthroplasty: Double blinded randomized trial.

J Clin Orthop Trauma 2020 Jan-Feb;11(1):154-159. Epub 2019 Mar 29.

Loyola University Medical Center, Department of Orthopaedic Surgery and Rehabilitation, 2160 S. First Avenue, Maguire Suite 1700, Maywood, IL, 60153, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcot.2019.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985168PMC
March 2019

Prospective Comparison of Available Primary Total Knee Arthroplasty Sizing Equations.

J Arthroplasty 2020 May 5;35(5):1239-1246.e1. Epub 2019 Dec 5.

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arth.2019.11.041DOI Listing
May 2020

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo.

Free Radic Biol Med 2020 02 5;147:37-47. Epub 2019 Dec 5.

MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975167PMC
February 2020

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice.

Free Radic Biol Med 2020 01 18;146:372-382. Epub 2019 Nov 18.

REQUIMTE/LAQV, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, Porto, Portugal; Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E 6BT, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970224PMC
January 2020

Species- and tissue-specific differences in ROS metabolism during exposure to hypoxia and hyperoxia plus recovery in marine sculpins.

J Exp Biol 2019 11 21;222(Pt 22). Epub 2019 Nov 21.

Department of Zoology, University of British Columbia, 6270 University Blvd, Vancouver, BC V6T 1Z4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jeb.206896DOI Listing
November 2019

A precise method for determining acetabular component anteversion after total hip arthroplasty.

Bone Joint J 2019 Sep;101-B(9):1042-1049

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1302/0301-620X.101B9.BJJ-2019-0085.R1DOI Listing
September 2019

Procedural Complexity of TransCarotid Artery Revascularization Is Not Increased in Irradiated and Reoperative Necks.

Ann Vasc Surg 2019 Nov 5;61:212-217. Epub 2019 Aug 5.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2019.05.063DOI Listing
November 2019

Rerouting metabolism to activate macrophages.

Authors:
Michael P Murphy

Nat Immunol 2019 09;20(9):1097-1099

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0455-5DOI Listing
September 2019

Detection of changes in mitochondrial hydrogen sulfide in the fish model (Poeciliidae).

Biol Open 2019 May 9;8(5). Epub 2019 May 9.

MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.041467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550084PMC
May 2019

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Nat Metab 2019 Jan;1:16-33

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42255-018-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485344PMC
January 2019

The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.

Cell Physiol Biochem 2019 28;52(2):186-197. Epub 2019 Feb 28.

Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.

View Article

Download full-text PDF

Source
https://www.cellphysiolbiochem.com/Articles/000013/
Publisher Site
http://dx.doi.org/10.33594/000000013DOI Listing
March 2019

Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells.

J Immunol 2019 03 4;202(6):1715-1723. Epub 2019 Feb 4.

Cellular and Molecular Biology Department, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1800575DOI Listing
March 2019

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Cell Chem Biol 2019 03 31;26(3):449-461.e8. Epub 2019 Jan 31.

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436940PMC
March 2019

Aggressive Surveillance Is Needed to Detect Endoleaks and Junctional Separation between Device Components after Zenith Fenestrated Aortic Reconstruction.

Ann Vasc Surg 2019 May 24;57:129-136. Epub 2019 Jan 24.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.09.038DOI Listing
May 2019

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.

Biochim Biophys Acta Mol Basis Dis 2019 06 15;1865(6):1192-1200. Epub 2019 Jan 15.

Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, PR China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09254439193001
Publisher Site
http://dx.doi.org/10.1016/j.bbadis.2019.01.014DOI Listing
June 2019

Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction.

J Vasc Surg 2019 06 24;69(6):1679-1684. Epub 2018 Dec 24.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.09.044DOI Listing
June 2019

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.

Elife 2018 12 27;7. Epub 2018 Dec 27.

School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.

View Article

Download full-text PDF

Source
https://elifesciences.org/articles/41044
Publisher Site
http://dx.doi.org/10.7554/eLife.41044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307857PMC
December 2018

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Redox Biol 2019 01 20;20:544-555. Epub 2018 Nov 20.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22132317183072
Publisher Site
http://dx.doi.org/10.1016/j.redox.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279977PMC
January 2019

Mitochondria as a therapeutic target for common pathologies.

Nat Rev Drug Discov 2018 12 5;17(12):865-886. Epub 2018 Nov 5.

WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nrd.2018.174
Publisher Site
http://dx.doi.org/10.1038/nrd.2018.174DOI Listing
December 2018

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.

Free Radic Biol Med 2019 01 31;130:318-327. Epub 2018 Oct 31.

REQUIMTE/LAQV, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E 6BT London, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08915849183131
Publisher Site
http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340810PMC
January 2019

Outcomes associated with a transcarotid artery revascularization-centered protocol in high-risk carotid revascularizations using the ENROUTE neuroprotection system.

J Vasc Surg 2019 03 6;69(3):807-813. Epub 2018 Oct 6.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07415214183198
Publisher Site
http://dx.doi.org/10.1016/j.jvs.2018.06.222DOI Listing
March 2019

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

J Biol Chem 2018 11 19;293(44):17208-17217. Epub 2018 Sep 19.

From the MRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.002579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222118PMC
November 2018

Metabolic control of ferroptosis in cancer.

Authors:
Michael P Murphy

Nat Cell Biol 2018 10;20(10):1104-1105

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41556-018-0209-xDOI Listing
October 2018

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.

Free Radic Biol Med 2018 10 22;126:322-333. Epub 2018 Aug 22.

University of Exeter Medical School, Exeter, Devon EX1 2LU, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.08.025DOI Listing
October 2018

The Causes and Consequences of Nonenzymatic Protein Acylation.

Trends Biochem Sci 2018 11 18;43(11):921-932. Epub 2018 Aug 18.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2018.07.002DOI Listing
November 2018

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Cell 2018 08;174(4):780-784

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.07.030DOI Listing
August 2018

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species.

Cell Rep 2018 08;24(6):1445-1455

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092265PMC
August 2018

Newly made mitochondrial DNA drives inflammation.

Authors:
Michael P Murphy

Nature 2018 08;560(7717):176-177

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/d41586-018-05764-zDOI Listing
August 2018

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy.

Cell Death Differ 2018 11 24;25(11):1921-1937. Epub 2018 Jul 24.

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41418-018-0165-9
Publisher Site
http://dx.doi.org/10.1038/s41418-018-0165-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219511PMC
November 2018

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury.

Free Radic Biol Med 2018 08 3;124:517-524. Epub 2018 Jul 3.

Department of Pediatrics, Division of Neonatology, Columbia University, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389362PMC
August 2018

Adjunctive visceral artery chimney in patients undergoing Zenith Fenestrated aortic repair.

J Vasc Surg 2018 12;68(6):1688-1695

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.03.421DOI Listing
December 2018

Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation.

Vascular 2018 Dec 5;26(6):608-614. Epub 2018 Jun 5.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1708538118777657DOI Listing
December 2018

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.

Pediatr Nephrol 2019 07 2;34(7):1167-1174. Epub 2018 Jun 2.

Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-018-3984-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366561PMC
July 2019

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α.

Biochim Biophys Acta Mol Basis Dis 2018 09 26;1864(9 Pt B):2859-2870. Epub 2018 May 26.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09254439183018
Publisher Site
http://dx.doi.org/10.1016/j.bbadis.2018.05.018DOI Listing
September 2018

Use of the Zenith Fenestrated platform to rescue failing endovascular and open aortic reconstructions is safe and technically feasible.

J Vasc Surg 2018 10 18;68(4):1017-1022. Epub 2018 May 18.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.01.038DOI Listing
October 2018

Control of mitochondrial superoxide production by reverse electron transport at complex I.

J Biol Chem 2018 06 9;293(25):9869-9879. Epub 2018 May 9.

From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.003647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016480PMC
June 2018

Description of human AAA by cytokine and immune cell aberrations compared to risk-factor matched controls.

Surgery 2018 08 30;164(2):354-358. Epub 2018 Apr 30.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surg.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056326PMC
August 2018

A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain.

J Neurotrauma 2018 09 18;35(17):2025-2035. Epub 2018 May 18.

1 Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Cambridge, United Kingdom .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/neu.2017.5459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098406PMC
September 2018

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.

Hypertension 2018 06 16;71(6):1056-1063. Epub 2018 Apr 16.

From the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945293PMC
June 2018

Immune Modulation as a Treatment for Abdominal Aortic Aneurysms.

Circ Res 2018 03;122(7):925-927

From the Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.312870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880296PMC
March 2018

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.

Redox Biol 2018 06 20;16:344-351. Epub 2018 Mar 20.

Institute of Health Science, University of Highlands and Islands, Inverness IV2 3JH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953219PMC
June 2018

Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells.

Free Radic Biol Med 2018 11 19;128:97-110. Epub 2018 Mar 19.

ARC Centre of Excellence for Free Radical Chemistry, Faculty of Science and Engineering, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.008DOI Listing
November 2018

Ethnic minorities with critical limb ischemia derive equal amputation risk reduction from autologous cell therapy compared with whites.

J Vasc Surg 2018 08 1;68(2):560-566. Epub 2018 Mar 1.

Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2017.11.088DOI Listing
August 2018

Perioperative Outcomes are Adversely Affected by Poor Pretransfer Adherence to Acute Limb Ischemia Practice Guidelines.

Ann Vasc Surg 2018 Jul 23;50:46-51. Epub 2018 Feb 23.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2017.11.050DOI Listing
July 2018

Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle.

Free Radic Biol Med 2018 03 9;117:180-190. Epub 2018 Feb 9.

Departments of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Departments of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Departments of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896769PMC
March 2018

Cryopreserved Homografts in Infected Infrainguinal Fields Are Associated with Frequent Reinterventions and Poor Amputation-Free Survival.

Ann Vasc Surg 2018 May 5;49:24-29. Epub 2018 Feb 5.

Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2017.10.032DOI Listing
May 2018

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload.

Free Radic Biol Med 2018 03 2;117:18-29. Epub 2018 Feb 2.

Medical Research Council Mitochondrial Biology Unit, Cambridge BioMedical Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866124PMC
March 2018

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Eur Respir J 2018 Feb 1. Epub 2018 Feb 1.

Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig-University, 35392 Giessen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01024-2017DOI Listing
February 2018

Osteopontin may be a driver of abdominal aortic aneurysm formation.

J Vasc Surg 2018 12 3;68(6S):22S-29S. Epub 2018 Feb 3.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Richard Roudebush VA Medical Center, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2017.10.068DOI Listing
December 2018

Institutional experience with the Zenith Fenestrated aortic stent graft.

J Vasc Surg 2018 08 1;68(2):331-336. Epub 2018 Feb 1.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2017.11.063DOI Listing
August 2018

Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia.

J Vasc Surg 2018 07 1;68(1):176-181.e1. Epub 2018 Feb 1.

Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Richard L. Roudebush VA Medical Center, and VA Center for Molecular and Cellular Therapeutics in Cardiovascular Disease, Indianapolis, Ind. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2017.09.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019117PMC
July 2018