Michael P Manns

Michael P Manns

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Michael P Manns

Michael P Manns

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Clinical features and MRI progression of small duct primary sclerosing cholangitis (PSC).

Eur J Radiol 2020 Aug 1;129:109101. Epub 2020 Jun 1.

Karolinska University Hospital, Division of Radiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejrad.2020.109101DOI Listing
August 2020

Secondary sclerosing cholangitis in critically ill patients has a poor outcome but lower tumour incidence than primary sclerosing cholangitis.

United European Gastroenterol J 2020 Jul 4;8(6):716-724. Epub 2020 May 4.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1177/2050640620924274DOI Listing
July 2020

Genetic variants of UDP-glucuronosyltransferase 1A genes are associated with disease presentation and outcome in primary sclerosing cholangitis.

Liver Int 2020 Jul 6;40(7):1645-1654. Epub 2020 May 6.

Department of Internal Medicine 1, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/liv.14487DOI Listing
July 2020

Sequential systemic treatment in patients with hepatocellular carcinoma.

Aliment Pharmacol Ther 2020 Jul 20;52(1):205-212. Epub 2020 May 20.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/apt.15789DOI Listing
July 2020

Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis.

Antimicrob Agents Chemother 2020 Jul 22;64(8). Epub 2020 Jul 22.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

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http://dx.doi.org/10.1128/AAC.00143-20DOI Listing
July 2020

Sofosbuvir monotherapy fails to achieve HEV RNA elimination in patients with chronic hepatitis E - The HepNet SofE pilot study.

J Hepatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany; German Center for Infection Research (DZIF); Partner Site Hannover-Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.05.020DOI Listing
July 2020

Second-line and Third-line therapy for Autoimmune Hepatitis A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group.

J Hepatol 2020 Jul 21. Epub 2020 Jul 21.

Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian PSC Research Centre, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; European Reference Network on Hepatological Diseases (ERN RARE-LIVER).

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http://dx.doi.org/10.1016/j.jhep.2020.07.023DOI Listing
July 2020

MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.

J Hepatol 2020 Jul 30. Epub 2020 Jul 30.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.07.039DOI Listing
July 2020

The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis.

Aliment Pharmacol Ther 2020 Jun 22;51(11):1160-1168. Epub 2020 Apr 22.

Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/apt.15722DOI Listing
June 2020

Chemosaturation with percutaneous hepatic perfusion is effective in patients with ocular melanoma and cholangiocarcinoma.

J Cancer Res Clin Oncol 2020 Jun 20. Epub 2020 Jun 20.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00432-020-03289-5DOI Listing
June 2020

Therapeutic plasma exchange in acute on chronic liver failure.

J Clin Apher 2020 Jun 24. Epub 2020 Jun 24.

Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/jca.21799DOI Listing
June 2020

Absence of Atg7 in the liver disturbed hepatic regeneration after liver injury.

Liver Int 2020 May 20;40(5):1225-1238. Epub 2020 Mar 20.

Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14425DOI Listing
May 2020

Endoscopic decompression of acute intestinal distension is associated with reduced mortality in critically ill patients.

BMC Gastroenterol 2020 Apr 6;20(1):87. Epub 2020 Apr 6.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1186/s12876-020-01233-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137233PMC
April 2020

Liver stiffness across different chronic liver disease under therapy with statin in a real life cohort.

Eur J Gastroenterol Hepatol 2020 Apr 8. Epub 2020 Apr 8.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover.

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http://dx.doi.org/10.1097/MEG.0000000000001719DOI Listing
April 2020

Nonocclusive Mesenteric Ischemia and Interventional Local Vasodilatory Therapy: A Meta-Analysis and Systematic Review of the Literature.

J Intensive Care Med 2020 Feb 23;35(2):128-139. Epub 2019 Oct 23.

Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1177/0885066619879884DOI Listing
February 2020

Autoimmune hepatitis induction can occur in the liver.

Liver Int 2020 02 1;40(2):377-381. Epub 2019 Dec 1.

Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14296DOI Listing
February 2020

MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis.

Hepatology 2020 Feb 3. Epub 2020 Feb 3.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/hep.31153DOI Listing
February 2020

The future of autoimmune liver diseases - Understanding pathogenesis and improving morbidity and mortality.

Liver Int 2020 02;40 Suppl 1:149-153

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14378DOI Listing
February 2020

Frequency of Potential Drug-Drug Interactions in the Changing Field of HCV Therapy.

Open Forum Infect Dis 2020 Feb 3;7(2):ofaa040. Epub 2020 Feb 3.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1093/ofid/ofaa040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033915PMC
February 2020

Effects of adenovirus-induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model.

Liver Int 2019 12 10;39(12):2330-2340. Epub 2019 Jul 10.

Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/liv.14183DOI Listing
December 2019

Quality of Life Is Associated With Wearable-Based Physical Activity in Patients With Inflammatory Bowel Disease: A Prospective, Observational Study.

Clin Transl Gastroenterol 2019 Nov 1. Epub 2019 Nov 1.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.14309/ctg.0000000000000094DOI Listing
November 2019

Therapeutic plasma exchange in acute liver failure.

J Clin Apher 2019 Oct 26;34(5):589-597. Epub 2019 Jul 26.

Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/jca.21737DOI Listing
October 2019

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes.

J Autoimmun 2019 09 5;103:102289. Epub 2019 Jun 5.

Dept. of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany; Dept. of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.05.017DOI Listing
September 2019

Systemic arterial blood pressure determines the therapeutic window of non-selective beta blockers in decompensated cirrhosis.

Aliment Pharmacol Ther 2019 09 2;50(6):696-706. Epub 2019 Aug 2.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/apt.15439DOI Listing
September 2019

Treatment of Chronic Hepatitis C: Efficacy, Side Effects and Complications.

Visc Med 2019 Jun 21;35(3):161-170. Epub 2019 May 21.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1159/000500963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616049PMC
June 2019

Second-line chemotherapy in biliary tract cancer: Outcome and prognostic factors.

Liver Int 2019 05 18;39(5):914-923. Epub 2019 Mar 18.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14063DOI Listing
May 2019

Utility of viral kinetics in HCV therapy - It is not over until it is over?

Liver Int 2019 05;39(5):815-817

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14047DOI Listing
May 2019

Endoscopic biliary drainage in patients with cholangiocarcinoma - self-expanding metal polyethylene stents.

Scand J Gastroenterol 2019 May 24;54(5):640-645. Epub 2019 May 24.

a Department of Gastroenterology, Hepatology and Endocrinology , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/00365521.2019.1614661DOI Listing
May 2019

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

J Hepatol 2019 04 13;70(4):593-602. Epub 2018 Nov 13.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183252
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http://dx.doi.org/10.1016/j.jhep.2018.11.003DOI Listing
April 2019

SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.

J Hepatol 2019 04 23;70(4):603-614. Epub 2018 Nov 23.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Center for Infection Research, DZIF, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.012DOI Listing
April 2019

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.

J Hepatol 2019 04 22;70(4):722-734. Epub 2018 Dec 22.

Research Group MicroRNA in Liver Regeneration, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183263
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http://dx.doi.org/10.1016/j.jhep.2018.12.016DOI Listing
April 2019

Outcomes of renal dysfunction in patients with acute liver failure.

United European Gastroenterol J 2019 04 3;7(3):388-396. Epub 2018 Dec 3.

Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1177/2050640618817061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466757PMC
April 2019

Recommendations on the Use of Magnetic Resonance Imaging for Collaborative Multicenter Studies in Primary Sclerosing Cholangitis.

Hepatology 2019 03 23;69(3):1358-1359. Epub 2019 Feb 23.

Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/hep.30276DOI Listing
March 2019

Shear wave elastography prior to transjugular intrahepatic portosystemic shunt may predict the decrease in hepatic vein pressure gradient.

Abdom Radiol (NY) 2019 03;44(3):1127-1134

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00261-018-1795-6DOI Listing
March 2019

An Imaging Biomarker for Assessing Hepatic Function in Patients With Primary Sclerosing Cholangitis.

Clin Gastroenterol Hepatol 2019 01 11;17(1):192-199.e3. Epub 2018 Jul 11.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.05.011DOI Listing
January 2019

Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn's disease.

Eur J Gastroenterol Hepatol 2019 01;31(1):99-108

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover.

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http://dx.doi.org/10.1097/MEG.0000000000001262DOI Listing
January 2019

Different kinetics of liver stiffness using shear wave elastography in patients with chronic hepatitis C infection treated with interferon-free regimens.

Eur J Gastroenterol Hepatol 2019 01;31(1):67-74

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MEG.0000000000001259DOI Listing
January 2019

Novel therapeutic targets in autoimmune hepatitis.

J Autoimmun 2018 12 4;95:34-46. Epub 2018 Nov 4.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
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http://dx.doi.org/10.1016/j.jaut.2018.10.022DOI Listing
December 2018

Editorial: "real world data" of AIH-time to connect!

Aliment Pharmacol Ther 2018 12;48(11-12):1315-1316

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.

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http://doi.wiley.com/10.1111/apt.15028
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http://dx.doi.org/10.1111/apt.15028DOI Listing
December 2018

Impact of direct-acting antiviral therapy on the need for liver transplantation related to hepatitis C in Germany.

J Hepatol 2018 10 6;69(4):982-984. Epub 2018 Aug 6.

Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg Essen, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Leberstiftungs-GmbH Deutschland, Hannover, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig Site, Germany; Helmholtz Center for Infection Research (HZI), Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.jhep.2018.07.001DOI Listing
October 2018

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B.

J Hepatol 2018 09 29;69(3):584-593. Epub 2018 Jun 29.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), c/o CRC Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183205
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http://dx.doi.org/10.1016/j.jhep.2018.05.004DOI Listing
September 2018

Association Between Type 2 Diabetes Mellitus, HbA1c and the Risk for Spontaneous Bacterial Peritonitis in Patients with Decompensated Liver Cirrhosis and Ascites.

Clin Transl Gastroenterol 2018 09 24;9(9):189. Epub 2018 Sep 24.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1038/s41424-018-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155293PMC
September 2018

Clinical characteristics of patients with liver cirrhosis and spontaneous portosystemic shunts detected by ultrasound in a tertiary care and transplantation centre.

Scand J Gastroenterol 2018 Sep 29;53(9):1107-1113. Epub 2018 Sep 29.

a Department of Gastroenterology, Hepatology and Endocrinology , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/00365521.2018.1498913DOI Listing
September 2018

Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis.

J Mol Med (Berl) 2018 08 20;96(8):831-843. Epub 2018 Jun 20.

Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00109-018-1658-1DOI Listing
August 2018

The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities.

Lancet 2018 08 27;392(10148):621-622. Epub 2018 Jul 27.

European Association for the Study of the Liver, Geneva, Switzerland.

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http://dx.doi.org/10.1016/S0140-6736(18)31734-3DOI Listing
August 2018

Ethanol sclerotherapy or polidocanol sclerotherapy for symptomatic hepatic cysts.

United European Gastroenterol J 2018 Jul 8;6(6):919-925. Epub 2018 Mar 8.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1177/2050640618764940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047294PMC
July 2018

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity.

Nat Commun 2018 06 11;9(1):2275. Epub 2018 Jun 11.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41467-018-04685-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995831PMC
June 2018