Michael P Epstein

Michael P Epstein

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Michael P Epstein

Michael P Epstein

Publications by authors named "Michael P Epstein"

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TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.

Am J Hum Genet 2019 Aug 20;105(2):258-266. Epub 2019 Jun 20.

Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698804PMC
August 2019

Epilepsy in families: Age at onset is a familial trait, independent of syndrome.

Ann Neurol 2019 Jul 20;86(1):91-98. Epub 2019 May 20.

Epilepsy Research Centre, Department of Medicine, University of Melbourne (Austin Health), Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1002/ana.25499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565452PMC
July 2019

Robust Rare-Variant Association Tests For Quantitative Traits in General Pedigrees.

Stat Biosci 2018 Dec 5;10(3):491-505. Epub 2017 Jun 5.

Department of Human Genetics, Emory University, Atlanta, GA.

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http://dx.doi.org/10.1007/s12561-017-9197-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329454PMC
December 2018

Powerful and robust cross-phenotype association test for case-parent trios.

Genet Epidemiol 2018 07 20;42(5):447-458. Epub 2018 Feb 20.

Department of Human Genetics and Center for Computational and Quantitative Genetics, Emory University, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1002/gepi.22116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013339PMC
July 2018

Testing cross-phenotype effects of rare variants in longitudinal studies of complex traits.

Genet Epidemiol 2018 06 30;42(4):320-332. Epub 2018 Mar 30.

Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado, United States of America.

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http://dx.doi.org/10.1002/gepi.22121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980726PMC
June 2018

Kernel machine methods for integrative analysis of genome-wide methylation and genotyping studies.

Genet Epidemiol 2018 03 29;42(2):156-167. Epub 2017 Dec 29.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America.

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http://dx.doi.org/10.1002/gepi.22100DOI Listing
March 2018

Reply to Plüss et al.: The strength of PEMapper/PECaller lies in unbiased calling using large sample sizes.

Proc Natl Acad Sci U S A 2017 10 15;114(40):E8323. Epub 2017 Sep 15.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1714535114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635938PMC
October 2017

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits.

Genetics 2017 08 22;206(4):1779-1790. Epub 2017 Jun 22.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109

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http://dx.doi.org/10.1534/genetics.116.199646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560787PMC
August 2017

PEMapper and PECaller provide a simplified approach to whole-genome sequencing.

Proc Natl Acad Sci U S A 2017 03 21;114(10):E1923-E1932. Epub 2017 Feb 21.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1618065114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347547PMC
March 2017

Gastrointestinal Health in Classic Galactosemia.

JIMD Rep 2017 1;33:27-32. Epub 2016 Jul 1.

Department of Human Genetics, Emory University School of Medicine, Room 325.2 Whitehead Building, 615 Michael Street, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/8904_2016_575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413454PMC
July 2016

Genetic effects on sleep/wake variation of seizures.

Epilepsia 2016 Apr 6;57(4):557-65. Epub 2016 Mar 6.

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083250PMC
http://dx.doi.org/10.1111/epi.13330DOI Listing
April 2016

An Adaptive Genetic Association Test Using Double Kernel Machines.

Stat Biosci 2015 Oct 24;7(2):262-281. Epub 2014 Jun 24.

Department of Statistics, Department of Public Health Sciences, Pennsylvania State University, University Park, PA 16802, U.S.A.

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http://dx.doi.org/10.1007/s12561-014-9116-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666603PMC
October 2015

Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits.

Genet Epidemiol 2015 Jul 17;39(5):366-75. Epub 2015 Apr 17.

Department of Human Genetics, Emory University, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1002/gepi.21901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469530PMC
July 2015

Testing in Microbiome-Profiling Studies with MiRKAT, the Microbiome Regression-Based Kernel Association Test.

Am J Hum Genet 2015 May;96(5):797-807

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570290PMC
May 2015

Analysis of gene-gene interactions using gene-trait similarity regression.

Hum Hered 2014 21;78(1):17-26. Epub 2014 Jun 21.

Bioinformatics Research Center, North Carolina State University, Raleigh, N.C., USA.

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http://dx.doi.org/10.1159/000360161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115296PMC
April 2015

Flexible and robust methods for rare-variant testing of quantitative traits in trios and nuclear families.

Genet Epidemiol 2014 Sep 14;38(6):542-51. Epub 2014 Jul 14.

Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1002/gepi.21839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138536PMC
September 2014

Utilizing population controls in rare-variant case-parent association tests.

Am J Hum Genet 2014 Jun 15;94(6):845-53. Epub 2014 May 15.

Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA; Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121482PMC
June 2014

Accounting for population stratification in DNA methylation studies.

Genet Epidemiol 2014 Apr 29;38(3):231-41. Epub 2014 Jan 29.

Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090102PMC
April 2014

Assessing the impact of population stratification on association studies of rare variation.

Hum Hered 2013 31;76(1):28-35. Epub 2013 Jul 31.

Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Ga., USA.

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http://genepath.med.harvard.edu/~reich/Freedman.2004.pdf
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http://www.karger.com?doi=10.1159/000353270
Publisher Site
http://dx.doi.org/10.1159/000353270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406348PMC
February 2014

Cryptic residual GALT activity is a potential modifier of scholastic outcome in school age children with classic galactosemia.

J Inherit Metab Dis 2013 Nov 15;36(6):1049-61. Epub 2013 Jan 15.

Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/s10545-012-9575-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657299PMC
November 2013

De novo mutations in epileptic encephalopathies.

Nature 2013 Sep 11;501(7466):217-21. Epub 2013 Aug 11.

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http://dx.doi.org/10.1038/nature12439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773011PMC
September 2013

Modifiers of ovarian function in girls and women with classic galactosemia.

J Clin Endocrinol Metab 2013 Jul 20;98(7):E1257-65. Epub 2013 May 20.

Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1210/jc.2013-1374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701263PMC
July 2013

SNP set association analysis for familial data.

Genet Epidemiol 2012 Dec 11;36(8):797-810. Epub 2012 Sep 11.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.21676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683469PMC
December 2012

A permutation procedure to correct for confounders in case-control studies, including tests of rare variation.

Am J Hum Genet 2012 Aug 19;91(2):215-23. Epub 2012 Jul 19.

Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415546PMC
August 2012

Families or Unrelated: The Evolving Debate in Genetic Association Studies.

J Biom Biostat 2012 Jun;3(4):e108

Department of Human Genetics, Emory University, 615 Michael St, Atlanta GA 30322.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112473PMC
June 2012

The FMR1 premutation and attention-deficit hyperactivity disorder (ADHD): evidence for a complex inheritance.

Behav Genet 2012 May 19;42(3):415-22. Epub 2011 Nov 19.

Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1007/s10519-011-9520-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696489PMC
May 2012

Sparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies.

Genet Epidemiol 2012 May 16;36(4):293-302. Epub 2012 Apr 16.

Department of Statistics, Hankuk University of Foreign Studies, Yongin, Korea.

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http://doi.wiley.com/10.1002/gepi.21621
Publisher Site
http://dx.doi.org/10.1002/gepi.21621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596262PMC
May 2012

Ovarian function in Duarte galactosemia.

Fertil Steril 2011 Aug 29;96(2):469-473.e1. Epub 2011 Jun 29.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1016/j.fertnstert.2011.05.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773175PMC
August 2011

Fast and robust association tests for untyped SNPs in case-control studies.

Hum Hered 2010 30;70(3):167-76. Epub 2010 Jul 30.

Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA. andrew.s.allen @ duke.edu

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http://dx.doi.org/10.1159/000308456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952185PMC
January 2011

Powerful SNP-set analysis for case-control genome-wide association studies.

Am J Hum Genet 2010 Jun;86(6):929-42

Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032061PMC
June 2010

Biomarkers of ovarian function in girls and women with classic galactosemia.

Fertil Steril 2009 Jul 5;92(1):344-51. Epub 2008 Aug 5.

Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.fertnstert.2008.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746959PMC
July 2009

Fragile X-associated primary ovarian insufficiency: evidence for additional genetic contributions to severity.

Genet Epidemiol 2008 Sep;32(6):553-9

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1002/gepi.20329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881575PMC
September 2008

A powerful and flexible multilocus association test for quantitative traits.

Am J Hum Genet 2008 Feb;82(2):386-97

Department of Biostatistics, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ajhg.2007.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664991PMC
February 2008

Gender differences in 542 Chinese inpatients with schizophrenia.

Schizophr Res 2007 Dec 12;97(1-3):88-96. Epub 2007 Jul 12.

Beijing Anding Hospital, Capital Medical University, Beijing, PR China.

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http://dx.doi.org/10.1016/j.schres.2007.05.025DOI Listing
December 2007

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.

Proc Natl Acad Sci U S A 2007 Sep 19;104(39):15537-42. Epub 2007 Sep 19.

Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0707484104
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http://dx.doi.org/10.1073/pnas.0707484104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000537PMC
September 2007

Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans.

Eur J Hum Genet 2007 Aug 25;15(8):878-83. Epub 2007 Apr 25.

Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, CT, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5201838DOI Listing
August 2007

A simple and improved correction for population stratification in case-control studies.

Am J Hum Genet 2007 May 29;80(5):921-30. Epub 2007 Mar 29.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1086/516842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852732PMC
May 2007

Improved association analyses of disease subtypes in case-parent triads.

Genet Epidemiol 2006 Apr;30(3):209-19

Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1002/gepi.20138DOI Listing
April 2006

Genetic association analysis using data from triads and unrelated subjects.

Am J Hum Genet 2005 Apr 14;76(4):592-608. Epub 2005 Feb 14.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1086/429225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199297PMC
April 2005

Comparison of prospective and retrospective methods for haplotype inference in case-control studies.

Genet Epidemiol 2004 Nov;27(3):192-201

Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

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http://dx.doi.org/10.1002/gepi.20020DOI Listing
November 2004

A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.

Am J Med Genet A 2004 Nov;130A(4):372-7

Department of Ophthalmology & Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1002/ajmg.a.30267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1249494PMC
November 2004

Inference on haplotype effects in case-control studies using unphased genotype data.

Am J Hum Genet 2003 Dec 20;73(6):1316-29. Epub 2003 Nov 20.

Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180397PMC
http://dx.doi.org/10.1086/380204DOI Listing
December 2003

Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophy.

Am J Ophthalmol 2003 Apr;135(4):461-70

Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA.

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http://dx.doi.org/10.1016/s0002-9394(02)02032-9DOI Listing
April 2003

A tobit variance-component method for linkage analysis of censored trait data.

Am J Hum Genet 2003 Mar 13;72(3):611-20. Epub 2003 Feb 13.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1086/367924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180237PMC
March 2003

Comment on "Ascertainment adjustment in complex diseases".

Genet Epidemiol 2002 Oct;23(3):209-13

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109-2029, USA.

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http://dx.doi.org/10.1002/gepi.10197DOI Listing
October 2002

Ascertainment-adjusted parameter estimates revisited.

Am J Hum Genet 2002 Apr 5;70(4):886-95. Epub 2002 Mar 5.

Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029, USA.

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http://dx.doi.org/10.1086/339517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379117PMC
April 2002