Publications by authors named "Michael Ostrowski"

100Publications

PTEN in the Stroma.

Cold Spring Harb Perspect Med 2019 10 1;9(10). Epub 2019 Oct 1.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina 29425, USA.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a036111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771362PMC
October 2019

Modeling Human Cancer-induced Cachexia.

Cell Rep 2019 08;28(6):1612-1622.e4

Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program, The Ohio State University, Columbus, OH 43210, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733019PMC
August 2019

Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.

Cancer Res 2019 08 18;79(16):4124-4134. Epub 2019 Jun 18.

Departments of Medicine and of Pathology and Cell Biology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-4110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753942PMC
August 2019

Nanofiber-expanded human CD34 cells heal cutaneous wounds in streptozotocin-induced diabetic mice.

Sci Rep 2019 06 10;9(1):8415. Epub 2019 Jun 10.

Department of Internal Medicine, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/s41598-019-44932-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557810PMC
June 2019

Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.

BMB Rep 2019 Oct;52(10):595-600

State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827575PMC
October 2019

Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation.

iScience 2019 Jan 27;11:238-245. Epub 2018 Dec 27.

Department of Cancer Biology and Genetics and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Hollings Cancer Center, 86 Jonathan Lucas St, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327072PMC
January 2019

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.

Neoplasia 2019 01 12;21(1):132-145. Epub 2018 Dec 12.

Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH 43210; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183040
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http://dx.doi.org/10.1016/j.neo.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293034PMC
January 2019

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.

Mol Cancer Res 2018 07 28;16(7):1092-1102. Epub 2018 Mar 28.

Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713455PMC
July 2018

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Dev Cell 2017 05;41(4):392-407.e6

Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, McGill University, Montreal, QC H3A 1A1, Canada; Hollings Cancer Center, Medical University of South Carolina, Hollings Cancer Center 124J, 86 Jonathan Lucas Street, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508591PMC
May 2017

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.

Neoplasia 2017 Jun 11;19(6):496-508. Epub 2017 May 11.

The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440288PMC
June 2017

The ETS family of oncogenic transcription factors in solid tumours.

Nat Rev Cancer 2017 06 28;17(6):337-351. Epub 2017 Apr 28.

The Comprehensive Cancer Center, The Ohio State University.

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http://dx.doi.org/10.1038/nrc.2017.20DOI Listing
June 2017

FGFR and PTEN signaling interact during lens development to regulate cell survival.

Dev Biol 2016 Feb 5;410(2):150-163. Epub 2016 Jan 5.

Department of Biology, Cell Molecular and Structural Biology Graduate Program, Miami University, Oxford, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767529PMC
February 2016

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.

Oncotarget 2015 Dec;6(42):44509-22

Division of Medical Oncology, Department of Internal Medicine, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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http://www.oncotarget.com/fulltext/6332
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http://dx.doi.org/10.18632/oncotarget.6332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792572PMC
December 2015

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

Genes Dev 2015 Aug;29(16):1707-20

Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Genetics, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA;

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http://dx.doi.org/10.1101/gad.262568.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561480PMC
August 2015

Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.

J Cell Physiol 2016 Mar;231(3):630-40

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio.

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http://doi.wiley.com/10.1002/jcp.25108
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http://dx.doi.org/10.1002/jcp.25108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664053PMC
March 2016

Cry protein crystals: a novel platform for protein delivery.

PLoS One 2015 1;10(6):e0127669. Epub 2015 Jun 1.

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127669PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451076PMC
March 2016

Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies.

Mol Cancer Ther 2015 Jan 5;14(1):307-14. Epub 2014 Nov 5.

Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio. Department of Radiation Oncology, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297221PMC
January 2015

MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.

PLoS One 2014 26;9(6):e100693. Epub 2014 Jun 26.

Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100693PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072627PMC
February 2015

Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.

Front Oncol 2014 23;4:87. Epub 2014 Apr 23.

Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University , Columbus, OH , USA ; Comprehensive Cancer Center, The Ohio State University , Columbus, OH , USA.

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http://dx.doi.org/10.3389/fonc.2014.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006052PMC
May 2014

Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle.

Circ Res 2013 Aug 1;113(5):562-70. Epub 2013 Jul 1.

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.301510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970202PMC
August 2013

Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma.

Mol Ther 2013 Aug 4;21(8):1517-25. Epub 2013 Jun 4.

Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1038/mt.2013.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734660PMC
August 2013

Setting Snail2's pace during EMT.

Nat Cell Biol 2012 Nov;14(11):1122-3

Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/ncb2616DOI Listing
November 2012

Loss of fibroblast HIF-1α accelerates tumorigenesis.

Cancer Res 2012 Jul 3;72(13):3187-95. Epub 2012 May 3.

Molecular Biology Section, Division of Biological Sciences, Department of Medicine, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089958PMC
July 2012

NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.

Breast Cancer Res 2011 Aug 31;13(4):R83. Epub 2011 Aug 31.

Department of Cancer Biology, Vanderbilt University, 771 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr2935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236346PMC
August 2011

NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.

J Immunol 2011 Sep 20;187(5):2740-7. Epub 2011 Jul 20.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1101495
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http://dx.doi.org/10.4049/jimmunol.1101495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159744PMC
September 2011

Transcription factor ets-2 plays an important role in the pathogenesis of pulmonary fibrosis.

Am J Respir Cell Mol Biol 2011 Nov 11;45(5):999-1006. Epub 2011 May 11.

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, 43210, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0490OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262682PMC
November 2011

Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.

Cancer Res 2011 Feb 8;71(4):1203-7. Epub 2011 Feb 8.

Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075554PMC
February 2011

E2f1-3 are critical for myeloid development.

J Biol Chem 2011 Feb 28;286(6):4783-95. Epub 2010 Nov 28.

College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M110.182733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039366PMC
February 2011

TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

PLoS One 2010 Aug 30;5(8):e12479. Epub 2010 Aug 30.

Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012479PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930001PMC
August 2010

A new role for OPG: putting RANKL in its place.

J Bone Miner Res 2010 Sep;25(9):1905-6

Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1002/jbmr.206DOI Listing
September 2010

MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.

Mol Cell 2010 Mar;37(5):620-32

Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125113PMC
March 2010

Allele-specific tumor spectrum in pten knockin mice.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5142-7. Epub 2010 Mar 1.

Department of Molecular Genetics, College of Biological Sciences, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0912524107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841921PMC
March 2010

An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis.

Cancer Res 2010 Feb 9;70(4):1323-33. Epub 2010 Feb 9.

Department of Molecular and Cellular Biochemistry, Center for Biostatistics, College of Public Health, and Tumor Microenvironment Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://cancerres.aacrjournals.org/content/70/4/1323.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822898PMC
February 2010

Transformed epithelial cells and fibroblasts/myofibroblasts interaction in breast tumor: a mathematical model and experiments.

J Math Biol 2010 Sep 10;61(3):401-21. Epub 2009 Nov 10.

Mathematical Biosciences Institute, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1007/s00285-009-0307-2DOI Listing
September 2010

Genomic alterations in tumor stroma.

Cancer Res 2009 Sep 25;69(17):6759-64. Epub 2009 Aug 25.

Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0985DOI Listing
September 2009

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

Science 2009 Aug 20;325(5944):1142-6. Epub 2009 Aug 20.

Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1176077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859703PMC
August 2009

A mouse model of yellow fluorescent protein (YFP) expression in hematopoietic cells to assess leukocyte-endothelial interactions in the microcirculation.

Microvasc Res 2009 Dec 12;78(3):294-300. Epub 2009 Aug 12.

Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 473 W. 12th Avenue, Room 110, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.mvr.2009.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073496PMC
December 2009

Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.

J Cell Physiol 2009 Jul;220(1):230-7

Department of Molecular and Cellular Biochemistry, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/jcp.21755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852098PMC
July 2009

Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.

Dev Dyn 2008 Oct;237(10):2926-35

Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/dvdy.21723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998709PMC
October 2008

Tensor classification of N-point correlation function features for histology tissue segmentation.

Med Image Anal 2009 Feb 25;13(1):156-66. Epub 2008 Jul 25.

Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.media.2008.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664199PMC
February 2009

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.

J Immunol 2008 May;180(10):6733-42

Australian Research Council Special Research Centre for Functional and Applied Genomics and the Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.4049/jimmunol.180.10.6733DOI Listing
May 2008

PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.

J Cell Physiol 2008 Jun;215(3):636-44

The New England Baptist Bone and Joint Institute, Department of Rheumatology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/jcp.21344DOI Listing
June 2008

Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome.

Nature 2008 Jan;451(7174):73-5

Department of Physiology and The Institute for Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature06446DOI Listing
January 2008

Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.

Mol Cell Biol 2007 Jun 2;27(11):4018-27. Epub 2007 Apr 2.

Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center, 370A Tzagournis Medical Research Facility, Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1128/MCB.01839-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900027PMC
June 2007

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.

J Biol Chem 2007 May 2;282(21):15921-9. Epub 2007 Apr 2.

Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M609723200DOI Listing
May 2007

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.

J Biol Chem 2007 Jan 14;282(3):1891-904. Epub 2006 Nov 14.

Institute for Molecular Biosciences, the University of Queensland, St. Lucia, Queensland 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M608572200DOI Listing
January 2007

Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks.

Crit Rev Eukaryot Gene Expr 2006 ;16(3):253-77

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1615/critreveukargeneexpr.v16.i3.40DOI Listing
December 2006

The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.

Hum Mol Genet 2006 Sep 18;15(17):2553-9. Epub 2006 Jul 18.

Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular and Cellular Biochemistry, Division of Human Genetics, The Ohio State University, Columbus, USA.

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http://academic.oup.com/hmg/article/15/17/2553/851337/The-ER
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http://dx.doi.org/10.1093/hmg/ddl177DOI Listing
September 2006

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

Mol Biol Cell 2006 Sep 5;17(9):3897-906. Epub 2006 Jul 5.

Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1091/mbc.e06-05-0470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1593166PMC
September 2006

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

Mol Immunol 2006 Apr 2;43(10):1557-64. Epub 2005 Nov 2.

Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.molimm.2005.09.022DOI Listing
April 2006

ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis.

Oncogene 2005 Jun;24(27):4370-9

Division of Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1208626DOI Listing
June 2005

The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.

J Biol Chem 2004 Dec 12;279(52):54416-25. Epub 2004 Oct 12.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M408188200
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http://dx.doi.org/10.1074/jbc.M408188200DOI Listing
December 2004

Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.

J Immunol 2004 Jul;173(2):1374-9

Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.4049/jimmunol.173.2.1374DOI Listing
July 2004

RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.

J Bone Miner Res 2004 Aug 29;19(8):1339-48. Epub 2004 Mar 29.

Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1359/JBMR.040321DOI Listing
August 2004

CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells.

J Biol Chem 2003 Dec 24;278(49):49358-68. Epub 2003 Sep 24.

Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1074/jbc.M308071200DOI Listing
December 2003

Ets-2 interacts with co-repressor BS69 to repress target gene expression.

Anticancer Res 2003 May-Jun;23(3A):2173-8

Department of Molecular Genetics, Comprehensive Cancer Center, Ohio State University, 484 W. 12th Ave., Columbus, OH 43210, USA.

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August 2003

Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.

J Biol Chem 2003 Jun 13;278(26):24209-16. Epub 2003 Apr 13.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M302940200DOI Listing
June 2003

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.

J Biol Chem 2003 May 10;278(20):17876-84. Epub 2003 Mar 10.

Department of Molecular Genetics and The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M209480200
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http://dx.doi.org/10.1074/jbc.M209480200DOI Listing
May 2003

Extra-embryonic function of Rb is essential for embryonic development and viability.

Nature 2003 Feb;421(6926):942-7

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1038/nature01417DOI Listing
February 2003

A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene.

Mol Endocrinol 2003 Jan;17(1):11-26

Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211-5300, USA.

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http://dx.doi.org/10.1210/me.2002-0223DOI Listing
January 2003

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse.

Blood 2003 Feb 12;101(3):1155-63. Epub 2002 Sep 12.

Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-02-05
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http://dx.doi.org/10.1182/blood-2002-02-0569DOI Listing
February 2003

PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway.

Hum Mol Genet 2002 Jul;11(15):1687-96

Clinical Cancer Genetics Program and Human Cancer Genetics Program, Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/hmg/11.15.1687DOI Listing
July 2002