Michael Ohh

Michael Ohh

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Michael Ohh

Michael Ohh

Publications by authors named "Michael Ohh"

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A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.

Mol Cancer Res 2019 Aug 19. Epub 2019 Aug 19.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0461DOI Listing
August 2019

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α.

Nat Commun 2019 Jul 23;10(1):3293. Epub 2019 Jul 23.

Department of Laboratory Medicine & Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

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http://dx.doi.org/10.1038/s41467-019-11149-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650433PMC
July 2019

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Cell Metab 2018 12 20;28(6):817-832.e8. Epub 2018 Sep 20.

Lady Davis Institute, SMBD JGH, McGill University, Montreal, QC H3A 1A3, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.09.001DOI Listing
December 2018

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease.

Nat Commun 2018 08 22;9(1):3359. Epub 2018 Aug 22.

Department of Laboratory Medicine & Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

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http://www.nature.com/articles/s41467-018-05554-1
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http://dx.doi.org/10.1038/s41467-018-05554-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105673PMC
August 2018

Consequences of VHL Loss on Global DNA Methylome.

Sci Rep 2018 02 20;8(1):3313. Epub 2018 Feb 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Room 1510, M5G1M1, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-018-21524-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820357PMC
February 2018

Hydroxylation-Dependent Interaction of Substrates to the Von Hippel-Lindau Tumor Suppressor Protein (VHL).

Methods Mol Biol 2016 ;1458:87-94

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8.

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http://dx.doi.org/10.1007/978-1-4939-3801-8_7DOI Listing
January 2018

A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells.

J Biol Chem 2017 01 12;292(3):936-944. Epub 2016 Dec 12.

From the Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10065,

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http://dx.doi.org/10.1074/jbc.M116.757864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247665PMC
January 2017

New structural and functional insight into the regulation of Ras.

Semin Cell Dev Biol 2016 10 11;58:70-8. Epub 2016 Jun 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S1A8, Canada; Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.06.006DOI Listing
October 2016

Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.

J Biol Chem 2016 Apr 4;291(14):7357-72. Epub 2016 Feb 4.

From the Departments of Laboratory Medicine and Pathobiology and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8 and

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http://dx.doi.org/10.1074/jbc.M115.694562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817168PMC
April 2016

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.

Nat Commun 2015 Nov 30;6:8859. Epub 2015 Nov 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, M5S1A8 Ontario, Canada.

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http://dx.doi.org/10.1038/ncomms9859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674766PMC
November 2015

Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.

Proc Natl Acad Sci U S A 2014 Sep 25;111(36):E3785-94. Epub 2014 Aug 25.

Departments of Laboratory Medicine and Pathobiology and Biochemistry, University of Toronto, Toronto, ON, Canada M5S1A8;

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http://dx.doi.org/10.1073/pnas.1406559111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246987PMC
September 2014

The multifaceted von Hippel-Lindau tumour suppressor protein.

FEBS Lett 2014 Aug 25;588(16):2704-11. Epub 2014 Feb 25.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.02.026DOI Listing
August 2014

SOCS-1 mediates ubiquitylation and degradation of GM-CSF receptor.

PLoS One 2013 26;8(9):e76370. Epub 2013 Sep 26.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784415PMC
July 2014

Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia.

Cancer Res 2013 Apr 11;73(8):2540-50. Epub 2013 Feb 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3425DOI Listing
April 2013

DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.

Mol Cell Biol 2013 Apr 11;33(8):1621-31. Epub 2013 Feb 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1128/MCB.01342-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624248PMC
April 2013

The updated biology of hypoxia-inducible factor.

EMBO J 2012 May 4;31(11):2448-60. Epub 2012 May 4.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/emboj.2012.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365421PMC
May 2012

Transcriptional regulation of genes via hypoxia-inducible factor.

Methods Mol Biol 2012 ;809:189-99

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-376-9_13DOI Listing
March 2012

Tumor strengths and frailties: Cancer SUMmOns Otto's metabolism.

Authors:
Michael Ohh

Nat Med 2012 Jan 6;18(1):30-1. Epub 2012 Jan 6.

University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.2631DOI Listing
January 2012

NEDD8 pathways in cancer, Sine Quibus Non.

Cancer Cell 2011 Feb;19(2):168-76

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ccr.2011.01.002DOI Listing
February 2011

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.

EMBO Rep 2010 Oct 10;11(10):777-83. Epub 2010 Sep 10.

Department of Molecular Genetics, University of Toronto, Cell Biology Program, Hospital for Sick Children Research Institute, Department of Paediatrics, 555 University Avenue, Toronto, Ontario, M5G 1L7, Canada.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2010.125
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http://dx.doi.org/10.1038/embor.2010.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948183PMC
October 2010

Oxygen-mediated endocytosis in cancer.

Authors:
Yi Wang Michael Ohh

J Cell Mol Med 2010 Mar 15;14(3):496-503. Epub 2010 Jan 15.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1582-4934.2010.01016.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823452PMC
March 2010

Regulation of endocytosis via the oxygen-sensing pathway.

Nat Med 2009 Mar 1;15(3):319-24. Epub 2009 Mar 1.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nm.1922DOI Listing
March 2009

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

J Biol Chem 2008 Dec 22;283(50):34495-9. Epub 2008 Oct 22.

Department of Biological Sciences, Hunter College, The City University of New York, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.C800170200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596400PMC
December 2008

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL.

EMBO Rep 2008 May 7;9(5):486-91. Epub 2008 Mar 7.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1038/embor.2008.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373363PMC
May 2008

Beyond the hypoxia-inducible factor-centric tumour suppressor model of von Hippel-Lindau.

Curr Opin Oncol 2008 Jan;20(1):83-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/CCO.0b013e3282f310deDOI Listing
January 2008

Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma.

Lab Invest 2007 Dec 1;87(12):1252-64. Epub 2007 Oct 1.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.3700684DOI Listing
December 2007

Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression.

Cell Cycle 2007 Nov 29;6(22):2810-6. Epub 2007 Aug 29.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.6.22.4947DOI Listing
November 2007

Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase.

J Biol Chem 2007 May 2;282(21):15652-66. Epub 2007 Apr 2.

Department of Medical Biophysics, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M608318200DOI Listing
May 2007

The role of VHL in the regulation of E-cadherin: a new connection in an old pathway.

Cell Cycle 2007 Jan 5;6(1):56-9. Epub 2007 Jan 5.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.6.1.3668DOI Listing
January 2007

Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response.

J Virol 2006 Nov 23;80(21):10712-23. Epub 2006 Aug 23.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01014-06
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http://dx.doi.org/10.1128/JVI.01014-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1641802PMC
November 2006

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.

J Biol Chem 2006 Nov 14;281(45):34096-103. Epub 2006 Sep 14.

Cancer Research Program and Division of Haematology-Oncology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M603654200DOI Listing
November 2006

Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.

Neoplasia 2006 Nov;8(11):956-63

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://linkinghub.elsevier.com/retrieve/pii/S147655860680080
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http://dx.doi.org/10.1593/neo.06520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716018PMC
November 2006

pVHL's kryptonite: E2-EPF UCP.

Authors:
Michael Ohh

Cancer Cell 2006 Aug;10(2):95-7

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.ccr.2006.07.016DOI Listing
August 2006

Ubiquitin pathway in VHL cancer syndrome.

Authors:
Michael Ohh

Neoplasia 2006 Aug;8(8):623-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1593/neo.06442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1601944PMC
August 2006

Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis.

Cancer Res 2006 Feb;66(3):1313-9

McGill Cancer Center and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2560DOI Listing
February 2006

Expression of p53 in renal carcinoma cells is independent of pVHL.

Mutat Res 2005 Oct 5;578(1-2):23-32. Epub 2005 Jul 5.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ont., Canada M5S 1A8.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.02.016DOI Listing
October 2005

Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.

FASEB J 2005 Sep;19(11):1396-406

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.05-3788comDOI Listing
September 2005

Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.

J Biol Chem 2005 Jun 11;280(23):22205-11. Epub 2005 Apr 11.

Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M503220200DOI Listing
June 2005

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma.

Am J Physiol Renal Physiol 2004 Jul;287(1):F1-6

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://ajprenal.physiology.org/content/ajprenal/287/1/F1.ful
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http://ajprenal.physiology.org/cgi/doi/10.1152/ajprenal.0042
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http://dx.doi.org/10.1152/ajprenal.00424.2003DOI Listing
July 2004

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer.

Am J Nephrol 2004 Jan-Feb;24(1):1-13. Epub 2003 Dec 3.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada.

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https://www.karger.com/Article/FullText/75346
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http://dx.doi.org/10.1159/000075346DOI Listing
June 2004

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development.

Mol Cell Biol 2004 Apr;24(8):3251-61

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381603PMC
http://dx.doi.org/10.1128/mcb.24.8.3251-3261.2004DOI Listing
April 2004

Molecular cloning and characterization of the von Hippel-Lindau-like protein.

Mol Cancer Res 2004 Jan;2(1):43-52

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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January 2004

The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-kappaB-dependent antiapoptotic pathway.

Authors:
Heng Qi Michael Ohh

Cancer Res 2003 Nov;63(21):7076-80

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada.

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November 2003

VHL and kidney cancer.

Methods Mol Biol 2003 ;222:167-83

Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1385/1-59259-328-3:167DOI Listing
June 2003

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.

J Biol Chem 2003 Mar 21;278(13):11032-40. Epub 2003 Jan 21.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M208681200
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http://dx.doi.org/10.1074/jbc.M208681200DOI Listing
March 2003

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.

EMBO Rep 2002 Feb 29;3(2):177-82. Epub 2002 Jan 29.

Department of Adult Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/embo-reports/kvf028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083969PMC
February 2002