Publications by authors named "Michael Oellerich"

100Publications

Special Collection on the Value of Laboratory Medicine.

J Appl Lab Med 2020 09;5(5):841-843

Department of Clinical Pharmacology, George-August-University University Medical Center Goettingen, Göttingen, Germany.

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September 2020

Donor-Derived Cell-Free DNA Testing in Solid Organ Transplantation: A Value Proposition.

J Appl Lab Med 2020 09;5(5):993-1004

Department of Clinical Pharmacology, University Medical Center Goettingen, Goettingen, Germany.

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September 2020

In Memoriam: Professor Folke Sjöqvist.

Ther Drug Monit 2020 Jun;42(3):353

*Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado; †Department of Clinical Pharmacology, Georg-August Universität, Göttingen, Germany; and ‡Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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June 2020

Plasma EGFR mutation testing in non-small cell lung cancer: A value proposition.

Clin Chim Acta 2019 Aug 21;495:481-486. Epub 2019 May 21.

Department of Clinical Pharmacology, University Medical Center Goettingen, Goettingen, Germany.

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August 2019

Circulating Cell-Free DNA-Diagnostic and Prognostic Applications in Personalized Cancer Therapy.

Ther Drug Monit 2019 04;41(2):115-120

Department of Clinical Pharmacology, University Medical Center Goettingen, Goettingen, Germany.

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April 2019

Cell-Free Plasma DNA for Disease Stratification and Prognosis in Head and Neck Cancer.

Clin Chem 2018 06 16;64(6):959-970. Epub 2018 Apr 16.

Clinic of Otorhinolaryngology, Ludwig-Maximilian University of Munich, Germany.

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June 2018

Diagnostic value of alpha-1-fetoprotein (AFP) as a biomarker for hepatocellular carcinoma recurrence after liver transplantation.

Clin Biochem 2018 Feb 17;52:20-25. Epub 2017 Oct 17.

Department of Clinical Pharmacology, University Medical Center Göttingen, Kreuzbergring 36, 37075 Göttingen, Germany. Electronic address:

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February 2018

Using circulating cell-free DNA to monitor personalized cancer therapy.

Crit Rev Clin Lab Sci 2017 05 10;54(3):205-218. Epub 2017 Apr 10.

a Department of Clinical Pharmacology , University Medical Center Göttingen , Göttingen , Germany.

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May 2017

Therapeutic drug monitoring - Key to personalized pharmacotherapy.

Clin Biochem 2017 May 14;50(7-8):375-379. Epub 2017 Jan 14.

Department of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany. Electronic address:

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May 2017

Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial.

Ther Drug Monit 2017 02;39(1):21-28

*Department of Pediatrics I, University Children's Hospital, Heidelberg; †University Children's Hospital, Tübingen, Germany; ‡Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium; §Department of Pediatrics, the Queen Silvia Children's Hospital, Göteborg, Sweden; ¶Semmelweis University, Transplantation and Surgical Clinic, Budapest, Hungary; ‖Department of Pediatrics, University Hospital Prague-Motol, Praha, Czech Republic **Nephrology and Renal Transplant Unit, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy; and ††Department of Clinical Pharmacology, Georg-August University, Göttingen, Germany.

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February 2017

Leveraging the real value of laboratory medicine with the value proposition.

Clin Chim Acta 2016 Nov 17;462:183-186. Epub 2016 Sep 17.

School of Pharmacy and Medical Sciences, University of South Australia and Chemical Pathology Directorate, SA Pathology, Adelaide, South Australia 5000, Australia. Electronic address:

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November 2016

Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.

Ther Drug Monit 2016 Apr;38(2):170-89

*Risch Laboratories Group, Schaan, Principality of Liechtenstein; †Klinikum Stuttgart, Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; ‡iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus, Denver; §Pharmacology, APHP, Hôpital Européen G Pompidou, Paris Descartes University, France; ¶Department of Pathology and Genomic Medicine, Houston Methodist Hospital, TX; ‖ASI Ltd, St George's-University of London, United Kingdom; **Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; ††Clinical Pharmacology Unit, Institute of Cardiology, Medical University of Warsaw, Poland; ‡‡Department of Drug Chemistry, Medical University of Warsaw, Poland; §§Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, NY; ¶¶UMR 850 INSERM, University Limoges, CHU Limoges, France; ‖‖Department of Clinical Pharmacology, Georg-August University, University Medical Center Göttingen, Germany; and ***Clinical Chemistry Department, Université Catholique de Louvain, LTAP, Cliniques Universitaires St Luc, Brussels, Belgium.

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April 2016

Therapeutic Drug Monitoring of Everolimus: A Consensus Report.

Ther Drug Monit 2016 Apr;38(2):143-69

*Klinikum Stuttgart, Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; †Department of Internal Medicine, Division of Nephrology and Renal Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; ‡Analytical Services International, London, United Kingdom; §Pharmacology, APHP, Hôpital Européen G Pompidou, Paris Descartes University, Paris, France; Departments of ¶Internal Medicine and ‖Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; **Clinical Pharmacology Unit, Institute of Cardiology, Warsaw, Poland; ††Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center, Hospital Clinic of Barcelona, University of Barcelona, Spain; ‡‡Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin Berlin, Berlin, Germany; §§Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; ¶¶Hepatobiliary Surgery and Liver Transplantation Unit, University of Pisa Medical Hospital, Pisa, Italy; ‖‖Pharmacology and Toxicology Laboratory (CDB), CIBERehd, IDIBAPS, Hospital Clinic of Barcelona, University of Barcelona, Spain; ***Department of Pharmacy, Kyushu University Hospital, Kyushu University, Fukuoka, Japan; †††Department of Clinical Pharmacology & Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; ‡‡‡Risch Laboratories Group, Schaan, Principality of Liechtenstein; §§§UMR 850 INSERM, University of Limoges, CHU Limoges, Limoges, France; ¶¶¶Department of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany; ‖‖‖Toxicology and Drug Monitoring Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, MN; ****Clinical Chemistry Department, Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium;

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April 2016

Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.

Ther Drug Monit 2016 Apr;38 Suppl 1:S1-20

*Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Spain; †Klinikum Stuttgart, ZentralInstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; ‡Departments of Internal Medicine and Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, the Netherlands; §Department of Nephrology, University of Heidelberg, University Hospital Heidelberg and Mannheim, Heidelberg; ¶Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin Berlin, Germany; ‖Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique and Clinical Chemistry Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium; **C42 Clinical Research & Development, Department of Anesthesiology, University of Colorado, Aurora; ††Immunology Laboratory, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain; ‡‡Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany; §§Department of Pharmacology, Oslo University Hospital, Norway; ¶¶U850 INSERM, Université de Limoges, CHU Limoges, France; ‖‖Division of Nephrology and Renal Transplantation, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands; ***Liver Diseases Department, National Center for Liver Transplantation, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay; †††Department of Drug Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland; and ‡‡‡Department of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.

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April 2016

Pharmacokinetic Analysis of Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium in Calcineurin Inhibitor-Free Renal Transplant Recipients.

Ther Drug Monit 2016 06;38(3):388-92

*Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology; †Department of Nephrology, Medical Clinic III, Johann Wolfgang Goethe University, Frankfurt/Main; ‡MVZ Medizinisches Labor Oldenburg; §Department of Clinical Pharmacology, University Hospital Göttingen; ¶Praxis und Dialyse Langen; ‖Clinical Trial Centre Rhine-Main (KSRM) at the Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University; and **Kuratorium für Dialyse und Nierentransplantation, e.V., Frankfurt/Main, Germany.

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June 2016

Graft-Derived Cell-Free DNA as a Marker of Transplant Graft Injury.

Ther Drug Monit 2016 Apr;38 Suppl 1:S75-9

*Institute of Clinical Pharmacology, University Medicine Göttingen, Göttingen, Germany; †Chronix Biomedical GmbH, Göttingen, Germany; and ‡Department of General, Visceral and Pediatric Surgery, University Medicine Go[Combining Diaeresis]ttingen, Göttingen, Germany.

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April 2016

Thiopurines induce oxidative stress in T-lymphocytes: a proteomic approach.

Mediators Inflamm 2015 22;2015:434825. Epub 2015 Mar 22.

Institute of Clinical Chemistry/UMG Laboratories, University Medical Centre Goettingen, 37075 Goettingen, Germany.

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April 2016

Lack of correlation between Treg quantification assays in inflammatory bowel disease patients.

World J Gastroenterol 2015 Mar;21(11):3325-9

Gunnar Brandhorst, Darinka Todorova Petrova, Sebastian Weigand, Christoph Eberle, Nicolas von Ahsen, Department of Clinical Chemistry, University Medical Center, 37075 Goettingen, Germany.

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March 2015

Offie Soldin, PhD, MBA.

Ther Drug Monit 2015 Feb;37(1)

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February 2015

Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping.

Int J Mol Sci 2014 Dec 12;15(12):23179-95. Epub 2014 Dec 12.

Institute for Clinical Chemistry/UMG-Laboratories, University Medical Center, Robert-Koch-Str. 40, Goettingen 37075, Germany.

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December 2014

Graft-derived cell-free DNA as an early organ integrity biomarker after transplantation of a marginal HELLP syndrome donor liver.

Transplantation 2014 Sep;98(5):e43-5

1 Department of Clinical Chemistry University Medical Center Goettingen Goettingen, Germany 2 Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany 3 Chronix Biomedical, Goetheallee Goettingen, Germany.

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September 2014

The changing face of laboratory medicine: a more service and less academically oriented profession?

Clin Chem 2015 Feb 26;61(2):322-9. Epub 2014 Aug 26.

Professor of Medicine, Queen's University Belfast; Associate Medical Director (Research and Development), Belfast Health and Social Care Trust, Northern Ireland, UK.

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February 2015

Allergic aspergillosis and the antigens of Aspergillus fumigatus.

Curr Protein Pept Sci 2014 ;15(5):403-23

CSIR-Institute of Genomics and Integrative Biology, University Campus, Mall Road, Delhi-110007, India.

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June 2015

Identification of the novel interacting partners of the mammalian target of rapamycin complex 1 in human CCRF-CEM and HEK293 cells.

Int J Mol Sci 2014 Mar 18;15(3):4823-36. Epub 2014 Mar 18.

Institute for Clinical Chemistry/UMG-Laboratories, University Medical Centre, Robert-Koch-Str. 40, Goettingen 37075, Germany.

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March 2014

Comparability and imprecision of 8 frequently used commercially available immunoassays for therapeutic drug monitoring.

Ther Drug Monit 2014 Aug;36(4):433-41

*Central Institute of Clinical Chemistry and Laboratory Medicine, Klinikum Stuttgart, Stuttgart; †Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen; and ‡Institute of Laboratory Medicine, Marienhospital Stuttgart, Stuttgart, Germany.

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August 2014

Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions.

Exp Cell Res 2014 Apr 7;322(2):277-89. Epub 2014 Feb 7.

Institute of Clinical Chemistry/UMG-Laboratories, University Medical Centre, Robert Koch Strasse 40, 37075 Goettingen, Germany. Electronic address:

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April 2014

Use of graft-derived cell-free DNA as an organ integrity biomarker to reexamine effective tacrolimus trough concentrations after liver transplantation.

Ther Drug Monit 2014 Apr;36(2):136-40

*Department of Clinical Chemistry, University Medical Center Göttingen; †Chronix Biomedical, Göttingen; and ‡Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Germany.

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April 2014

Differential expression of proteins in brain regions of Alzheimer's disease patients.

Neurochem Res 2014 Jan 4;39(1):208-15. Epub 2013 Dec 4.

Neurochemistry Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.

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January 2014

Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach.

PLoS One 2013 13;8(2):e56246. Epub 2013 Feb 13.

Department of Genomics & Molecular Medicine, Institute of Genomics and Integrative Biology, New Delhi, India.

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August 2013

Pharmacokinetics of meropenem in critically ill patients with severe infections.

Ther Drug Monit 2013 Feb;35(1):63-70

Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany.

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February 2013

Establishment of thiopurine S-methyltransferase gene knockdown in jurkat T-lymphocytes: an in vitro model of TPMT polymorphism.

Ther Drug Monit 2012 Oct;34(5):584-92

Department of Clinical Chemistry, University Medical Centre Goettingen, Goettingen, Germany.

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October 2012

Formation of monoethylglycinexylidide (MEGX) in clinically healthy dogs.

Can J Vet Res 2011 Oct;75(4):317-20

Institute of Veterinary Medicine, University of Goettingen, Goettingen, Germany.

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October 2011

Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer's disease patients.

J Neurochem 2012 Jun 24;121(6):954-63. Epub 2012 Apr 24.

Neurochemistry Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

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June 2012

Confronting the challenge: individualized immune monitoring after organ transplantation using the cellular immune function assay.

Clin Chim Acta 2012 Sep 3;413(17-18):1374-8. Epub 2012 Feb 3.

Tissue Typing Laboratory, Beilinson Campus, Rabin Medical Center, Petach-Tikva 49100, Israel.

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September 2012

Liquid chromatography-tandem mass spectrometry or automated immunoassays: what are the future trends in therapeutic drug monitoring?

Clin Chem 2012 May 17;58(5):821-5. Epub 2012 Jan 17.

Department of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany.

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May 2012

Potential biomarkers in the sera of breast cancer patients from bahawalpur, pakistan.

Biomark Cancer 2012 10;4:19-34. Epub 2012 Dec 10.

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. ; Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

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November 2013

Fetal calf serum heat inactivation and lipopolysaccharide contamination influence the human T lymphoblast proteome and phosphoproteome.

Proteome Sci 2011 Nov 15;9(1):71. Epub 2011 Nov 15.

Department of Clinical Chemistry, University Medical Centre, Goettingen, Germany.

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November 2011

Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment.

Proteome Sci 2011 Sep 20;9:57. Epub 2011 Sep 20.

Department of Clinical Chemistry, University Medical Centre Goettingen, 37075, Goettingen, Germany.

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September 2011

Differential kidney proteome profiling in a murine model of renal fibrosis under treatment with mycophenolate mofetil.

Pathobiology 2011 26;78(3):162-70. Epub 2011 May 26.

Department of Clinical Chemistry, University Hospital Göttingen, Germany. darinka.petrova @ med.uni-goettingen.de

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November 2011

Pre-analytical effects of different lithium heparin plasma separation tubes in the routine clinical chemistry laboratory.

Clin Chem Lab Med 2011 Sep 24;49(9):1473-7. Epub 2011 May 24.

Department of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany.

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September 2011

Proteomics approach to identify the interacting partners of cellular prion protein and characterization of Rab7a interaction in neuronal cells.

J Proteome Res 2011 Jul 7;10(7):3123-35. Epub 2011 Jun 7.

Department of Clinical Chemistry, University Medical Center Goettingen, Robert-Koch-Strasse 40, 37075, Goettingen, Germany.

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July 2011

Individually tailored immunosuppression: is there a role for biomarkers?

Clin Chem 2011 Mar 12;57(3):376-81. Epub 2011 Jan 12.

Department of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany.

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March 2011

Novel cytosolic allergens of Aspergillus fumigatus identified from germinating conidia.

J Proteome Res 2010 Nov 7;9(11):5530-41. Epub 2010 Oct 7.

Division of Diagnostics and Biochemistry, Institute of Genomics and Integrative Biology, Delhi-110007, India.

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November 2010

T-786C polymorphism of the NOS-3 gene and the endothelial cell response to fluid shear stress-a proteome analysis.

J Proteome Res 2009 Jun;8(6):3161-8

Department of Clinical Chemistry, University Hospital Gottingen, Robert-Koch-Strausse 40, 37075 Gottingen, Germany.

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June 2009

Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference.

Ther Drug Monit 2009 Apr;31(2):139-52

Department of Clinical Chemistry, Laboratory of Toxicology and Therapeutic Drug Monitoring, Université Catholique de Louvain, University Hospital St Luc, 10 Hippocrate Avenue, Brussels, Belgium.

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April 2009

Long-term pharmacokinetics of mycophenolic acid in pediatric renal transplant recipients over 3 years posttransplant.

Ther Drug Monit 2008 Oct;30(5):570-5

University Children's Hospital, Division of Pediatric Nephrology, Im Neuenheimer Feld 153, Heidelberg, Germany.

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October 2008

Genotyping of CYP3A5 polymorphisms among Bulgarian patients with sporadic colorectal cancer and controls.

Onkologie 2007 Nov 8;30(11):559-63. Epub 2007 Nov 8.

Department of Medical Genetics, Medical University, Aleksandrovska University Hospital, Sofia, Bulgaria.

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November 2007

Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma.

Clin Biochem 2007 Nov 18;40(16-17):1194-200. Epub 2007 Jul 18.

Department of Trauma Surgery, Plastic and Reconstructive Surgery, University Medicine Goettingen, Georg-August University, Robert-Koch-Strasse 40, D 37075 Göttingen, Germany.

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November 2007

The role of therapeutic drug monitoring in individualizing immunosuppressive drug therapy: recent developments.

Ther Drug Monit 2006 Dec;28(6):720-5

Abteilung Klinische Chemie, Georg-August-University Göttingen, Germany.

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December 2006

Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats.

Biochimie 2007 Mar 16;89(3):393-402. Epub 2006 Oct 16.

Abteilung Klinische Chemie, Georg-August-Universität, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.

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March 2007

AmpliChip CYP450 GeneChip: a new gene chip that allows rapid and accurate CYP2D6 genotyping.

Ther Drug Monit 2006 Oct;28(5):673-7

Department of Clinical Chemistry, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany.

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October 2006

Quantification by liquid chromatography tandem mass spectrometry of mycophenolic acid and its phenol and acyl glucuronide metabolites.

Clin Chem 2006 Oct 24;52(10):1962-4. Epub 2006 Aug 24.

Universitätsklinikum Göttingen, Abteilung Klinische Chemie/Zentrallabor, 37075 Göttingen, Germany.

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October 2006