Michael O Hengartner

Michael O Hengartner

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Michael O Hengartner

Publications by authors named "Michael O Hengartner"

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.

Dis Model Mech 2014 Aug 15;7(8):963-76. Epub 2014 May 15.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum, University Hospital Eppendorf, 20246 Hamburg, Germany. Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1242/dmm.014449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107325PMC
August 2014

DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.

Nat Cell Biol 2014 Aug 27;16(8):812-20. Epub 2014 Jul 27.

Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190 CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1038/ncb3010DOI Listing
August 2014

Methylated glycans as conserved targets of animal and fungal innate defense.

Proc Natl Acad Sci U S A 2014 Jul 30;111(27):E2787-96. Epub 2014 May 30.

Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland;

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http://dx.doi.org/10.1073/pnas.1401176111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103367PMC
July 2014

A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.

PLoS One 2013 16;8(9):e74908. Epub 2013 Sep 16.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland ; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074908PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774775PMC
May 2014

Apoptotic cell death under hypoxia.

Physiology (Bethesda) 2014 May;29(3):168-76

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1152/physiol.00016.2013DOI Listing
May 2014

Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans.

PLoS Genet 2013 Nov 21;9(11):e1003943. Epub 2013 Nov 21.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland ; MLS Graduate School and MD/PhD program, Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1003943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836707PMC
November 2013

Model organisms proteomics--from holobionts to human nutrition.

Proteomics 2013 Sep;13(17):2537-41

Division of Systematic Proteome Research, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/pmic.201370144DOI Listing
September 2013

Mitochondria as a target of environmental toxicants.

Toxicol Sci 2013 Jul 29;134(1):1-17. Epub 2013 Apr 29.

Nicholas School of the Environment, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1093/toxsci/kft102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693132PMC
July 2013

A dynamic physical model of cell migration, differentiation and apoptosis in Caenorhabditis elegans.

Adv Exp Med Biol 2012 ;736:211-33

Department of Genetics, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-4419-7210-1_12DOI Listing
January 2013

Generic comparison of protein inference engines.

Mol Cell Proteomics 2012 Apr 4;11(4):O110.007088. Epub 2011 Nov 4.

Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1074/mcp.O110.007088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322578PMC
April 2012

The initiative on Model Organism Proteomes (iMOP) Session September 6, 2011, Geneva, Switzerland.

Proteomics 2012 Feb;12(3):346-50

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland; Quantitative Model Organism Proteomics, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/pmic.201290015DOI Listing
February 2012

Nuclear pore complex during neuronal degeneration: cracking the last barrier!

Nucleus 2010 Mar-Apr;1(2):136-8. Epub 2009 Nov 29.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.

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http://dx.doi.org/10.4161/nucl.1.2.10798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030687PMC
January 2012

The future of model organisms in human disease research.

Nat Rev Genet 2011 07 18;12(8):575-82. Epub 2011 Jul 18.

Medical Research Council Clinical Sciences Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nrg3047DOI Listing
July 2011

Biotoxicity assays for fruiting body lectins and other cytoplasmic proteins.

Methods Enzymol 2010 ;480:141-50

Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/S0076-6879(10)80007-2DOI Listing
December 2010

A worm rich in protein: Quantitative, differential, and global proteomics in Caenorhabditis elegans.

J Proteomics 2010 Oct 14;73(11):2186-97. Epub 2010 Apr 14.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jprot.2010.03.014DOI Listing
October 2010

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

Cell 2010 Jul;142(1):77-88

Institute of Molecular Cancer Research, University of Zurich, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2010.06.022DOI Listing
July 2010

ccz-1 mediates the digestion of apoptotic corpses in C. elegans.

J Cell Sci 2010 Jun;123(Pt 12):2001-7

Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1242/jcs.062331DOI Listing
June 2010

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.

Nature 2010 Jun;465(7298):577-83

Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nature09141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328299PMC
June 2010

Shotgun proteomics data from multiple organisms reveals remarkable quantitative conservation of the eukaryotic core proteome.

Proteomics 2010 Mar;10(6):1297-306

Institute of Molecular Life Sciences, University of Zurich, Switzerland.

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http://dx.doi.org/10.1002/pmic.200900414DOI Listing
March 2010

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.

PLoS Biol 2010 Feb 2;8(2):e1000297. Epub 2010 Feb 2.

Technische Universität Carolo Wilhelmina Braunschweig, Institut für Genetik, Braunschweig, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1000297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814829PMC
February 2010

A pathway for phagosome maturation during engulfment of apoptotic cells.

Nat Cell Biol 2008 May 20;10(5):556-66. Epub 2008 Apr 20.

Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1038/ncb1718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851549PMC
May 2008

Cell biology: dying to hold you.

Nature 2008 Jan;451(7178):530-1

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http://dx.doi.org/10.1038/451530aDOI Listing
January 2008

Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.

J Biol Chem 2007 May 19;282(20):15011-21. Epub 2007 Mar 19.

Molecular Cell Biology Laboratory, The Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1074/jbc.M611051200DOI Listing
May 2007

Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans.

Development 2006 Sep 16;133(18):3597-606. Epub 2006 Aug 16.

Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1242/dev.02534DOI Listing
September 2006

Sugar antennae for guidance signals: syndecans and glypicans integrate directional cues for navigating neurons.

ScientificWorldJournal 2006 Aug 25;6:1024-36. Epub 2006 Aug 25.

Neuroscience Center Zurich, University of Zurich, Winterthurerstrassse 190, CH-8057, Switzerland.

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http://dx.doi.org/10.1100/tsw.2006.202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917377PMC
August 2006

Finding function in novel targets: C. elegans as a model organism.

Nat Rev Drug Discov 2006 05;5(5):387-98

Devgen, Technologie-park 30, B-9052 Gent, Belgium.

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http://www.nature.com/articles/nrd2031
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http://dx.doi.org/10.1038/nrd2031DOI Listing
May 2006

URI-1 is required for DNA stability in C. elegans.

Development 2006 Feb;133(4):621-9

Eidgenoessische Technische Hochschule Zuerich, Institute of Cell Biology, CH-8093 Zuerich, Switzerland.

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http://dx.doi.org/10.1242/dev.02235DOI Listing
February 2006

Developmental apoptosis in C. elegans: a complex CEDnario.

Nat Rev Mol Cell Biol 2006 Feb;7(2):97-108

Division of Genetics, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nrm1836
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http://dx.doi.org/10.1038/nrm1836DOI Listing
February 2006

Syndecan regulates cell migration and axon guidance in C. elegans.

Development 2005 Oct 21;132(20):4621-33. Epub 2005 Sep 21.

Institute of Molecular Biology, University of Zurich, 8057, Switzerland.

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http://dx.doi.org/10.1242/dev.02042DOI Listing
October 2005

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

Curr Biol 2005 Feb;15(4):371-7

Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA.

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http://dx.doi.org/10.1016/j.cub.2005.01.050DOI Listing
February 2005

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.

Nature 2005 Mar;434(7029):93-9

Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA.

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http://dx.doi.org/10.1038/nature03263DOI Listing
March 2005

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

Curr Biol 2005 Feb;15(4):371-7

Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA.

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http://dx.doi.org/10.1016/j.cub.2005.01.050DOI Listing
February 2005

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

Nat Struct Mol Biol 2004 Aug 11;11(8):756-62. Epub 2004 Jul 11.

Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1038/nsmb800DOI Listing
August 2004

Cell biology. Tickling macrophages, a serious business.

Science 2004 May;304(5674):1123-4

Institute of Molecular Biology, University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1126/science.1099161DOI Listing
May 2004

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.

J Biol Chem 2004 Feb 24;279(7):6087-97. Epub 2003 Nov 24.

Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1074/jbc.M307087200DOI Listing
February 2004

The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans.

Biochem J 2002 Nov;368(Pt 1):263-71

Department of Pediatrics, Laval University Medical Research Centre and Faculty of Medicine, Laval University, Quebec, Canada.

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http://biochemj.org/lookup/doi/10.1042/bj20020669
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http://dx.doi.org/10.1042/BJ20020669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222961PMC
November 2002

The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis.

Development 2002 May;129(9):2141-53

Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA.

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May 2002

Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.

Proc Natl Acad Sci U S A 2002 Feb 5;99(4):2158-63. Epub 2002 Feb 5.

Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.032671599
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http://dx.doi.org/10.1073/pnas.032671599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122335PMC
February 2002