Michael Milosevic

Michael Milosevic

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Michael Milosevic

Michael Milosevic

Publications by authors named "Michael Milosevic"

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Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?

Authors:
Jelena Lukovic Kathy Han Melania Pintilie Naz Chaudary Richard P Hill Anthony Fyles Michael Milosevic

Clin Transl Radiat Oncol 2019 Nov 3;19:110-115. Epub 2019 Oct 3.

Princess Margaret Cancer Centre, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.ctro.2019.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682PMC
November 2019

Correction: Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy.

Authors:
Magali Lecavalier-Barsoum Naz Chaudary Kathy Han Melania Pintilie Richard P Hill Michael Milosevic

Br J Cancer 2019 Oct;121(7):626

University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1038/s41416-019-0545-zDOI Listing
October 2019

Clinical Outcomes of Surgically Unresectable Endometrial Cancers.

Authors:
Jessica L Conway Jelena Lukovic Sarah E Ferguson Jiahui Zhang Wei Xu Neesha Dhani Jennifer Croke Anthony Fyles Michael Milosevic Alexandra Rink Marjan Rouzbahman Kathy Han

Am J Clin Oncol 2019 Oct;42(10):777-782

Departments of Radiation Oncology.

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http://dx.doi.org/10.1097/COC.0000000000000600DOI Listing
October 2019

National Trends and Dynamic Responses in the Canadian Radiation Oncology Workforce From 1990 to 2018.

Authors:
Shaun K Loewen Corinne M Doll Ross Halperin Matthew Parliament Robert G Pearcey Michael F Milosevic Andrea Bezjak Eric Vigneault Michael Brundage

Int J Radiat Oncol Biol Phys 2019 Sep 27;105(1):31-41. Epub 2019 Apr 27.

Department of Radiation Oncology, Cancer Centre of Southeastern Ontario, Kingston, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.019DOI Listing
September 2019

Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

Authors:
Jessica L Conway Rachel Gerber Kathy Han Haiyan Jiang Jason Xie Akbar Beiki-Ardakani Anthony Fyles Michael Milosevic Deborah Williamson Jennifer Croke

Brachytherapy 2019 Mar - Apr;18(2):133-140. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2018.09.005DOI Listing
July 2019

Scale-up of radiotherapy for cervical cancer in the era of human papillomavirus vaccination in low-income and middle-income countries: a model-based analysis of need and economic impact.

Authors:
Danielle Rodin Emily A Burger Rifat Atun Michael Barton Mary Gospodarowicz Surbhi Grover Timothy P Hanna David A Jaffray Felicia M Knaul Yolande Lievens Eduardo Zubizarreta Michael Milosevic

Lancet Oncol 2019 Jul 28;20(7):915-923. Epub 2019 May 28.

Radiation Medicine Program, Princess Margaret Cancer Centre Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(19)30308-0DOI Listing
July 2019

Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy.

Authors:
Magali Lecavalier-Barsoum Naz Chaudary Kathy Han Melania Pintilie Richard P Hill Michael Milosevic

Br J Cancer 2019 Jul 26;121(3):249-256. Epub 2019 Jun 26.

University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1038/s41416-019-0497-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738100PMC
July 2019

HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors.

Authors:
Ghassan Allo Mei Ling Yap Julie Cuartero Michael Milosevic Sarah Ferguson Helen Mackay Suzanne Kamel-Reid Ilan Weinreb Danny Ghazarian Melania Pintilie Blaise A Clarke

Int J Gynecol Pathol 2019 Jul 3. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan (G.A.) Departments of Radiation Oncology (M.L.Y., J.C., M.M.) Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Medical Oncology (H.M.) Laboratory Medicine and Pathobiology (S.K.R., I.W., D.G., B.A.C.) Biostatistics (M.P.), Princess Margaret Cancer Centre/University Health Network, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0000000000000620DOI Listing
July 2019

Repeatability and reproducibility of MRI-based radiomic features in cervical cancer.

Authors:
Sandra Fiset Mattea L Welch Jessica Weiss Melania Pintilie Jessica L Conway Michael Milosevic Anthony Fyles Alberto Traverso David Jaffray Ur Metser Jason Xie Kathy Han

Radiother Oncol 2019 Jun 19;135:107-114. Epub 2019 Mar 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193010
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http://dx.doi.org/10.1016/j.radonc.2019.03.001DOI Listing
June 2019

Moving toward uniform and evidence-based practice of radiotherapy for management of cervical cancer in Ontario, Canada.

Authors:
Negin Shahid Timothy Craig Mary Westerland Allison Ashworth Michelle Ang David D'Souza Raxa Sankreacha Anthony Fyles Michael Milosevic Iwa Kong

Brachytherapy 2018 Jul - Aug;17(4):660-666. Epub 2018 Apr 19.

Juravinski Cancer Center, Hamilton, ON, Canada; Radiation Oncology, Department of Oncology, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2018.03.003DOI Listing
March 2019

Vulnerabilities of radiomic signature development: The need for safeguards.

Authors:
Mattea L Welch Chris McIntosh Benjamin Haibe-Kains Michael F Milosevic Leonard Wee Andre Dekker Shao Hui Huang Thomas G Purdie Brian O'Sullivan Hugo J W L Aerts David A Jaffray

Radiother Oncol 2019 01 8;130:2-9. Epub 2018 Nov 8.

Department of Medical Biophysics, University of Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; IBBME, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; The Techna Institute for the Advancement of Technology for Health, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.10.027DOI Listing
January 2019

Measurement of Tumor Hypoxia in Patients With Locally Advanced Cervical Cancer Using Positron Emission Tomography with F-Fluoroazomyin Arabinoside.

Authors:
Kathy Han Tina Shek Douglass Vines Brandon Driscoll Anthony Fyles David Jaffray Harald Keller Ur Metser Melania Pintilie Jason Xie Ivan Yeung Michael Milosevic

Int J Radiat Oncol Biol Phys 2018 11 2;102(4):1202-1209. Epub 2018 Mar 2.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183032
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http://dx.doi.org/10.1016/j.ijrobp.2018.02.030DOI Listing
November 2018

Improving patient outcomes and radiotherapy systems: A pan-Canadian approach to patient-reported outcome use.

Authors:
Amanda Caissie Erika Brown Rob Olson Lisa Barbera Carol-Anne Davis Michael Brundage Michael Milosevic

Med Phys 2018 Oct 24;45(10):e841-e844. Epub 2018 Aug 24.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, M5G-2M9, Canada.

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http://dx.doi.org/10.1002/mp.12878DOI Listing
October 2018

Targeting the CXCL12/CXCR4 pathway and myeloid cells to improve radiation treatment of locally advanced cervical cancer.

Authors:
Magali Lecavalier-Barsoum Naz Chaudary Kathy Han Marianne Koritzinsky Richard Hill Michael Milosevic

Int J Cancer 2018 09 5;143(5):1017-1028. Epub 2018 Mar 5.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.31297DOI Listing
September 2018

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

Authors:
Shawn Stapleton Michael Dunne Michael Milosevic Charles W Tran Matthew J Gold Ali Vedadi Trevor D Mckee Pamela S Ohashi Christine Allen David A Jaffray

ACS Nano 2018 08 20;12(8):7583-7600. Epub 2018 Jul 20.

Department of Medical Biophysics , University of Toronto , Toronto , ON M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acsnano.7b06301DOI Listing
August 2018

Brachytherapy patient safety events in an academic radiation medicine program.

Authors:
Shira Felder Lyndon Morley Elizabeth Ng Kitty Chan Heather Ballantyne Anne Di Tomasso Jette Borg Jean-Pierre Bissonnette Stephen Breen John Waldron Alexandra Rink Michael Milosevic

Brachytherapy 2018 Jan - Feb;17(1):16-23. Epub 2017 Jul 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2017.06.010DOI Listing
July 2018

Technique adaptation, strategic replanning, and team learning during implementation of MR-guided brachytherapy for cervical cancer.

Authors:
Julia Skliarenko Marco Carlone Kari Tanderup Kathy Han Akbar Beiki-Ardakani Jette Borg Kitty Chan Jennifer Croke Alexandra Rink Anna Simeonov Reem Ujaimi Jason Xie Anthony Fyles Michael Milosevic

Brachytherapy 2018 Jan - Feb;17(1):86-93

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2017.11.010DOI Listing
July 2018

Comparison of dosimetric parameters derived from whole organ and wall contours for bladder and rectum in cervical cancer patients treated with intracavitary and interstitial brachytherapy.

Authors:
Rachel Gerber Alexandra Rink Jennifer Croke Jette Borg Akbar Beiki-Ardakani Anthony Fyles Michael Milosevic Jason Xie Harald Keller Kathy Han

Radiother Oncol 2018 Jun 6;127(3):456-459. Epub 2018 Feb 6.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.01.015DOI Listing
June 2018

Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology.

Authors:
Robert G Bristow Brian Alexander Michael Baumann Scott V Bratman J Martin Brown Kevin Camphausen Peter Choyke Deborah Citrin Joseph N Contessa Adam Dicker David G Kirsch Mechthild Krause Quynh-Thu Le Michael Milosevic Zachary S Morris Jann N Sarkaria Paul M Sondel Phuoc T Tran George D Wilson Henning Willers Rebecca K S Wong Paul M Harari

Lancet Oncol 2018 05;19(5):e240-e251

Department of Human Oncology, University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1016/S1470-2045(18)30096-2DOI Listing
May 2018

Intermediate dose-volume parameters and the development of late rectal toxicity after MRI-guided brachytherapy for locally advanced cervix cancer.

Authors:
Reem Ujaimi Michael Milosevic Anthony Fyles Akbar Beiki-Ardakani Marco Carlone Haiyan Jiang Patricia Lindsay Jason Xie Rachel Gerber Jennifer Croke Julia Skliarenko Wilfred Levin Kathy Han

Brachytherapy 2017 Sep - Oct;16(5):968-975.e2. Epub 2017 Jul 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15384721173039
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http://dx.doi.org/10.1016/j.brachy.2017.06.007DOI Listing
April 2018

Quality in cancer care: Lessons from the Canadian partnership for quality radiotherapy.

Authors:
Erika Brown Michael Milosevic

Healthc Manage Forum 2018 Jan;31(1):18-21

2 Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/0840470417716684DOI Listing
January 2018

Impact of tissue transport on PET hypoxia quantification in pancreatic tumours.

Authors:
Edward Taylor Jennifer Gottwald Ivan Yeung Harald Keller Michael Milosevic Neesha C Dhani Iram Siddiqui David W Hedley David A Jaffray

EJNMMI Res 2017 Dec 22;7(1):101. Epub 2017 Dec 22.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1186/s13550-017-0347-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741574PMC
December 2017

The predictive value of nadir neutrophil count during treatment of cervical cancer: Interactions with tumor hypoxia and interstitial fluid pressure (IFP).

Authors:
Rachel Glicksman Naz Chaudary Melania Pintilie Eric Leung Blaise Clarke Kieyan Sy Richard P Hill Kathy Han Anthony Fyles Michael Milosevic

Clin Transl Radiat Oncol 2017 Oct 15;6:15-20. Epub 2017 Sep 15.

Radiation Medicine Program, Princess Margaret Cancer Centre and University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ctro.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862663PMC
October 2017

Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma.

Authors:
Yannan N Dou Naz Chaudary Martin C Chang Michael Dunne Huang Huang David A Jaffray Michael Milosevic Christine Allen

J Control Release 2017 Sep 29;262:182-191. Epub 2017 Jul 29.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.039DOI Listing
September 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

Authors:
Girish S Kulkarni Thomas Hermanns Yanliang Wei Bimal Bhindi Raj Satkunasivam Paul Athanasopoulos Peter J Bostrom Cynthia Kuk Kathy Li Arnoud J Templeton Srikala S Sridhar Theodorus H van der Kwast Peter Chung Robert G Bristow Michael Milosevic Padraig Warde Neil E Fleshner Michael A S Jewett Shaheena Bashir Alexandre R Zlotta

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2016.69.2327DOI Listing
July 2017

Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study.

Authors:
Louise Murray Joseph Longo Jonathan Wan Caroline Chung Lisa Wang Laura Dawson Michael Milosevic Amit Oza Anthony Brade

Radiother Oncol 2017 07 28;124(1):74-79. Epub 2017 Jun 28.

Department of Radiation Oncology, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.06.007DOI Listing
July 2017

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Authors:
Eric Leung Rob A Cairns Naz Chaudary Ravi N Vellanki Tuula Kalliomaki Eduardo H Moriyama Hilda Mujcic Brian C Wilson Bradly G Wouters Richard Hill Michael Milosevic

BMC Cancer 2017 Jun 15;17(1):418. Epub 2017 Jun 15.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1186/s12885-017-3402-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473006PMC
June 2017

Neutrophil-lymphocyte ratio dynamics during concurrent chemo-radiotherapy for glioblastoma is an independent predictor for overall survival.

Authors:
Matthew Mason Catherine Maurice Mairead G McNamara Minh Thi Tieu Zarnie Lwin Barbara-Ann Millar Cynthia Menard Normand Laperriere Michael Milosevic Eshetu G Atenafu Warren Mason Caroline Chung

J Neurooncol 2017 05 22;132(3):463-471. Epub 2017 Mar 22.

Department of Radiation Oncology, University Health Network-Princess Margaret Cancer Centre/University of Toronto, 610 University Ave., Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-017-2395-yDOI Listing
May 2017

Genomic biomarkers for precision radiation medicine.

Authors:
Scott V Bratman Michael F Milosevic Fei-Fei Liu Benjamin Haibe-Kains

Lancet Oncol 2017 05;18(5):e238

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Computer Science, University of Toronto, Toronto, ON, Canada; Ontario Institute of Cancer Research, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(17)30263-2DOI Listing
May 2017

The Practice of Radiation Oncology in Canada.

Authors:
Nafisha Lalani Bernard Cummings Ross Halperin Eileen Rakovitch Michael Brundage Eric Vigneault Michael Milosevic

Int J Radiat Oncol Biol Phys 2017 04 14;97(5):876-880. Epub 2016 Dec 14.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2016.11.055DOI Listing
April 2017

MR-guided brachytherapy for cervical cancer: Quantifying process waste and identifying opportunities for system performance improvement.

Authors:
Kitty Chan Tara Rosewall Brenda Kenefick Michael Milosevic

Pract Radiat Oncol 2016 Jul-Aug;6(4):233-40. Epub 2015 Nov 11.

Radiation Medicine Program, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://ac.els-cdn.com/S1879850015004026/1-s2.0-S187985001500
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http://dx.doi.org/10.1016/j.prro.2015.11.003DOI Listing
March 2017

The Canadian National System for Incident Reporting in Radiation Treatment (NSIR-RT) Taxonomy.

Authors:
Michael Milosevic Crystal Angers Brian Liszewski C Suzanne Drodge Eve-Lyne Marchand Jean Pierre Bissonnette Erika Brown Peter Dunscombe Jordan Hunt Haiyan Jiang Krista Louie Gunita Mitera Kathryn Moran Tony Panzarella Matthew Parliament Spencer Ross Michael Brundage

Pract Radiat Oncol 2016 Sep-Oct;6(5):334-341. Epub 2016 Jan 30.

Cancer Center of Southeastern Ontario and Queen's University, Kingston, Canada.

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http://dx.doi.org/10.1016/j.prro.2016.01.013DOI Listing
March 2017

Radiation therapy quality-of-care indicators for locally advanced cervical cancer: A consensus guideline.

Authors:
Jennifer Croke Anthony Fyles Lisa Barbera David D'Souza Robert Pearcey Teri Stuckless Brenda Bass Michael Brundage Michael Milosevic

Pract Radiat Oncol 2016 Sep-Oct;6(5):315-323. Epub 2016 Jan 28.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.prro.2016.01.012DOI Listing
March 2017

Plerixafor Improves Primary Tumor Response and Reduces Metastases in Cervical Cancer Treated with Radio-Chemotherapy.

Authors:
Naz Chaudary Melania Pintilie Salomeh Jelveh Patricia Lindsay Richard P Hill Michael Milosevic

Clin Cancer Res 2017 Mar 3;23(5):1242-1249. Epub 2016 Oct 3.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1730DOI Listing
March 2017

A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovarian and fallopian tube cancers.

Authors:
Kim A Reiss Joseph M Herman Deborah Armstrong Marianna Zahurak Anthony Fyles Anthony Brade Michael Milosevic Laura A Dawson Angela Scardina Patricia Fischer Amy Hacker-Prietz Robert J Kinders Lihua Wang Alice Chen Sarah Temkin Naomi Horiba Lee-Anne Stayner Lillian L Siu Nilofer S Azad

Gynecol Oncol 2017 03 18;144(3):486-490. Epub 2017 Jan 18.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital, Department of Medical Oncology, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330287PMC
March 2017

Radiation effects on the tumor microenvironment: Implications for nanomedicine delivery.

Authors:
Shawn Stapleton David Jaffray Michael Milosevic

Adv Drug Deliv Rev 2017 01 1;109:119-130. Epub 2016 Jun 1.

Radiation Medicine Program, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2016.05.021DOI Listing
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Authors:
Naz Chaudary Melania Pintilie David Hedley Richard P Hill Michael Milosevic Helen Mackay

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

Quantifying hypoxia in human cancers using static PET imaging.

Authors:
Edward Taylor Ivan Yeung Harald Keller Bradley G Wouters Michael Milosevic David W Hedley David A Jaffray

Phys Med Biol 2016 11 25;61(22):7957-7974. Epub 2016 Oct 25.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Techna Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1088/0031-9155/61/22/7957DOI Listing
November 2016

A prospective study of DWI, DCE-MRI and FDG PET imaging for target delineation in brachytherapy for cervical cancer.

Authors:
Kathy Han Jennifer Croke Warren Foltz Ur Metser Jason Xie Tina Shek Brandon Driscoll Cynthia Ménard Doug Vines Catherine Coolens Anna Simeonov Akbar Beiki-Ardakani Eric Leung Wilfred Levin Anthony Fyles Michael F Milosevic

Radiother Oncol 2016 09 12;120(3):519-525. Epub 2016 Aug 12.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2016.08.002DOI Listing
September 2016

The Utility of Serum CA9 for Prognostication in Prostate Cancer.

Authors:
Alan D Smith Mathew Truong Rob Bristow Paul Yip Michael F Milosevic Anthony M Joshua

Anticancer Res 2016 09;36(9):4489-92

Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.21873/anticanres.10994DOI Listing
September 2016

Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicists (COMP) - Driving safety and quality assurance practice in Canada through the development of technical quality control guidelines.

Authors:
Jean-Pierre Bissonnette Michael Milosevic Marco Carlone Kyle E Malkoske

J Appl Clin Med Phys 2016 09 8;17(5):548-549. Epub 2016 Sep 8.

University of Toronto; Techna Institute; Princess Margaret Cancer Centre.

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http://dx.doi.org/10.1120/jacmp.v17i6.6507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874091PMC
September 2016

PMH 9907: Long-term outcomes of a randomized phase 3 study of short-term bicalutamide hormone therapy and dose-escalated external-beam radiation therapy for localized prostate cancer.

Authors:
Andrew J McPartlin Rachel Glicksman Melania Pintilie Debbie Tsuji Gary Mok Andrew Bayley Peter Chung Robert G Bristow Mary K Gospodarowicz Charles N Catton Michael Milosevic Padraig R Warde

Cancer 2016 Aug 24;122(16):2595-603. Epub 2016 May 24.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.30093DOI Listing
August 2016

Planned versus 'delivered' bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT.

Authors:
Tara Rosewall Janelle Wheat Geoffrey Currie Vickie Kong Andrew J Bayley Joanne Moseley Peter Chung Charles Catton Tim Craig Michael Milosevic

Radiother Oncol 2016 06 9;119(3):417-22. Epub 2016 Apr 9.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2016.03.022DOI Listing
June 2016

Developing a prognostic micro-RNA signature for human cervical carcinoma.

Authors:
Christine How Melania Pintilie Jeff P Bruce Angela B Y Hui Blaise A Clarke Philip Wong Shaoming Yin Rui Yan Daryl Waggott Paul C Boutros Anthony Fyles David W Hedley Richard P Hill Michael Milosevic Fei-Fei Liu

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Association of Apparent Diffusion Coefficient with Disease Recurrence in Patients with Locally Advanced Cervical Cancer Treated with Radical Chemotherapy and Radiation Therapy.

Authors:
Adam Gladwish Michael Milosevic Anthony Fyles Jason Xie Jaydeep Halankar Ur Metser Haiyan Jiang Nathan Becker Wilfred Levin Lee Manchul Warren Foltz Kathy Han

Radiology 2016 Apr 27;279(1):158-66. Epub 2015 Oct 27.

From the Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada (A.G., M.M., A.F., J.X., N.B., W.L., L.M., W.F., K.H.); Departments of Radiation Oncology (A.G., M.M., A.F., J.X., N.B., W.L., L.M., W.F., K.H.) and Biostatistics (H.J.), University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9; and Department of Medical Imaging, University Health Network, Toronto, ON, Canada (J.H., U.R.).

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http://dx.doi.org/10.1148/radiol.2015150400DOI Listing
April 2016

Association between Metformin Use and Mortality after Cervical Cancer in Older Women with Diabetes.

Authors:
Kathy Han Melania Pintilie Lorraine L Lipscombe Iliana C Lega Michael F Milosevic Anthony W Fyles

Cancer Epidemiol Biomarkers Prev 2016 Mar 31;25(3):507-12. Epub 2015 Dec 31.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1008DOI Listing
March 2016

Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake.

Authors:
Cristiane Metran-Nascente Ivan Yeung Douglass C Vines Ur Metser Neesha C Dhani David Green Michael Milosevic David Jaffray David W Hedley

J Nucl Med 2016 Mar 14;57(3):361-6. Epub 2016 Jan 14.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

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http://dx.doi.org/10.2967/jnumed.115.167650DOI Listing
March 2016

Automated Delineation of the Normal Urinary Bladder on Planning CT and Cone Beam CT.

Authors:
Tara Rosewall Jason Xie Vickie Kong Andrew J Bayley Peter Chung Geoffrey Currie Janelle Wheat Michael Milosevic

J Med Imaging Radiat Sci 2016 Mar 18;47(1):21-29. Epub 2015 Nov 18.

Department of Radiation Oncology, Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jmir.2015.09.011DOI Listing
March 2016

The initiation of a multidisciplinary bladder cancer clinic and the uptake of neoadjuvant chemotherapy: A time-series analysis.

Authors:
Madhur Nayan Bimal Bhindi Julie L Yu Muhammad Mamdani Neil E Fleshner Thomas Hermanns Peter Chung Michael Milosevic Robert Bristow Padraig Warde Robert J Hamilton Antonio Finelli Michael A S Jewett Alexandre R Zlotta Srikala S Sridhar Girish S Kulkarni

Can Urol Assoc J 2016 Jan-Feb;10(1-2):25-30

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada;

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http://dx.doi.org/10.5489/cuaj.3315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771554PMC
March 2016

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

Authors:
Michael F Milosevic Carol A Townsley Naz Chaudary Blaise Clarke Melania Pintilie Stacy Fan Rachel Glicksman Masoom Haider Sunmo Kim Helen MacKay Ivan Yeung Richard P Hill Anthony Fyles Amit M Oza

Int J Radiat Oncol Biol Phys 2016 Jan 18;94(1):111-117. Epub 2015 Sep 18.

Department of Medical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.009DOI Listing
January 2016

Hypoxia and Predicting Radiation Response.

Authors:
Richard P Hill Robert G Bristow Anthony Fyles Marianne Koritzinsky Michael Milosevic Bradly G Wouters

Semin Radiat Oncol 2015 Oct 15;25(4):260-72. Epub 2015 May 15.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.004DOI Listing
October 2015

Quantitative Imaging in Radiation Oncology: An Emerging Science and Clinical Service.

Authors:
David Anthony Jaffray Caroline Chung Catherine Coolens Warren Foltz Harald Keller Cynthia Menard Michael Milosevic Julia Publicover Ivan Yeung

Semin Radiat Oncol 2015 Oct 15;25(4):292-304. Epub 2015 May 15.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; TECHNA Institute/University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.002DOI Listing
October 2015

Delineating the inner bladder surface using uniform contractions from the outer surface under variable bladder filling conditions.

Authors:
Tara Rosewall Andrew Bayley Charles Catton Peter Chung Geoffrey Currie Robert Heaton Janelle Wheat Michael Milosevic

Br J Radiol 2015 Sep 24;88(1053):20140818. Epub 2015 Jul 24.

1 Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1259/bjr.20140818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743562PMC
September 2015

Expanding global access to radiotherapy.

Authors:
Rifat Atun David A Jaffray Michael B Barton Freddie Bray Michael Baumann Bhadrasain Vikram Timothy P Hanna Felicia M Knaul Yolande Lievens Tracey Y M Lui Michael Milosevic Brian O'Sullivan Danielle L Rodin Eduardo Rosenblatt Jacob Van Dyk Mei Ling Yap Eduardo Zubizarreta Mary Gospodarowicz

Lancet Oncol 2015 Sep;16(10):1153-86

Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S147020451500222
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http://dx.doi.org/10.1016/S1470-2045(15)00222-3DOI Listing
September 2015

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.

Authors:
Shawn Stapleton Michael Milosevic Ian F Tannock Christine Allen David A Jaffray

J Control Release 2015 Aug 10;211:163-70. Epub 2015 Jun 10.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2015.06.008DOI Listing
August 2015

Deriving patient-specific planning target volume for partial bladder image guided radiation therapy.

Authors:
Vickie Kong Tara Rosewall Susan Chen Tim Craig Robert Bristow Michael Milosevic Maisie Kwan Peter Chung

Pract Radiat Oncol 2014 Sep-Oct;4(5):323-329. Epub 2013 Nov 21.

Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.prro.2013.10.005DOI Listing
May 2015

Chromosomal instability as a prognostic marker in cervical cancer.

Authors:
Christine How Jeff Bruce Jonathan So Melania Pintilie Benjamin Haibe-Kains Angela Hui Blaise A Clarke David W Hedley Richard P Hill Michael Milosevic Anthony Fyles Fei-Fei Liu

BMC Cancer 2015 May 6;15:361. Epub 2015 May 6.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s12885-015-1372-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433070PMC
May 2015

Quality standards in radiation medicine.

Authors:
Holly Donaldson Jeffrey Cao John French Caitlin Gillan Michael Milosevic Catarina Lam Peter Dunscombe

Pract Radiat Oncol 2014 Jul-Aug;4(4):208-14. Epub 2013 Nov 5.

Department of Oncology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2013.09.004DOI Listing
March 2015

The clinical significance of hypoxia in human cancers.

Authors:
Neesha Dhani Anthony Fyles David Hedley Michael Milosevic

Semin Nucl Med 2015 Mar;45(2):110-21

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2014.11.002DOI Listing
March 2015

Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status.

Authors:
Shao Hui Huang John N Waldron Michael Milosevic Xiaowei Shen Jolie Ringash Jie Su Li Tong Bayardo Perez-Ordonez Ilan Weinreb Andrew J Bayley John Kim Andrew Hope B C John Cho Meredith Giuliani Albiruni Razak David Goldstein Willa Shi Fei-Fei Liu Wei Xu Brian O'Sullivan

Cancer 2015 Feb 21;121(4):545-55. Epub 2014 Oct 21.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/cncr.29100DOI Listing
February 2015

MR-guided prostate biopsy for planning of focal salvage after radiation therapy.

Authors:
Cynthia Ménard Douglas Iupati Julia Publicover Jenny Lee Jessamine Abed Gerald O'Leary Anna Simeonov Warren D Foltz Michael Milosevic Charles Catton Gerard Morton Robert Bristow Andrew Bayley Eshetu G Atenafu Andrew J Evans David A Jaffray Peter Chung Kristy K Brock Masoom A Haider

Radiology 2015 Jan 8;274(1):181-91. Epub 2014 Sep 8.

From the Radiation Medicine Program (C.M., D.I., J.P., J.L., J.A., A.S., W.D.F., M.M., C.C., R.B., A.B., D.A.J., P.C., K.K.B.) and Department of Biostatistics (E.G.A.), Princess Margaret Cancer Centre, 610 University Ave, Room 5-809, Toronto, ON, Canada M4X 1C3; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada (C.M., D.I., A.S., M.M., C.C., G.M., R.B., A.B., D.A.J., P.C., K.K.B.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.), Departments of Anesthesia (G.O.) and Pathology (A.J.E.), University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Center, Toronto, Ontario, Canada (G.M.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.); and Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (M.A.H.).

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http://dx.doi.org/10.1148/radiol.14122681DOI Listing
January 2015

Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study.

Authors:
Emilie Lalonde Adrian S Ishkanian Jenna Sykes Michael Fraser Helen Ross-Adams Nicholas Erho Mark J Dunning Silvia Halim Alastair D Lamb Nathalie C Moon Gaetano Zafarana Anne Y Warren Xianyue Meng John Thoms Michal R Grzadkowski Alejandro Berlin Cherry L Have Varune R Ramnarine Cindy Q Yao Chad A Malloff Lucia L Lam Honglei Xie Nicholas J Harding Denise Y F Mak Kenneth C Chu Lauren C Chong Dorota H Sendorek Christine P'ng Colin C Collins Jeremy A Squire Igor Jurisica Colin Cooper Rosalind Eeles Melania Pintilie Alan Dal Pra Elai Davicioni Wan L Lam Michael Milosevic David E Neal Theodorus van der Kwast Paul C Boutros Robert G Bristow

Lancet Oncol 2014 Dec 13;15(13):1521-1532. Epub 2014 Nov 13.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(14)71021-6DOI Listing
December 2014

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.

Authors:
Alejandro Berlin Emilie Lalonde Jenna Sykes Gaetano Zafarana Kenneth C Chu Varune R Ramnarine Adrian Ishkanian Dorota H S Sendorek Ivan Pasic Wan L Lam Igor Jurisica Theo van der Kwast Michael Milosevic Paul C Boutros Robert G Bristow

Oncotarget 2014 Nov;5(22):11081-90

Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology, Pharmacology & Toxicology and Biostatistics, Computer Science, University of Toronto, Toronto, ON, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://www.oncotarget.com/fulltext/2404
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294365PMC
http://dx.doi.org/10.18632/oncotarget.2404DOI Listing
November 2014

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Authors:
Michael F Milosevic Melania Pintilie David W Hedley Robert G Bristow Bradly G Wouters Amit M Oza Stephane Laframboise Richard P Hill Anthony W Fyles

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Dosimetrically triggered adaptive intensity modulated radiation therapy for cervical cancer.

Authors:
Karen Lim James Stewart Valerie Kelly Jason Xie Kristy K Brock Joanne Moseley Young-Bin Cho Anthony Fyles Anna Lundin Henrik Rehbinder Johan Löf David A Jaffray Michael Milosevic

Int J Radiat Oncol Biol Phys 2014 Sep 8;90(1):147-54. Epub 2014 Jul 8.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.039DOI Listing
September 2014

The Effect of Dose Grid Resolution on Dose Volume Histograms for Slender Organs at Risk during Pelvic Intensity-modulated Radiotherapy.

Authors:
Tara Rosewall Vickie Kong Robert Heaton Geoffrey Currie Michael Milosevic Janelle Wheat

J Med Imaging Radiat Sci 2014 Sep 7;45(3):204-209. Epub 2014 Jun 7.

Charles Sturt University, New South Wales, Australia; Australian School of Advanced Medicine, Macquarie University, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.jmir.2014.01.006DOI Listing
September 2014

A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.

Authors:
Shawn Stapleton Michael Milosevic Christine Allen Jinzi Zheng Michael Dunne Ivan Yeung David A Jaffray

PLoS One 2013 2;8(12):e81157. Epub 2013 Dec 2.

Department of Medical Biophysics, University of Toronto, Ontario, Canada ; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846845PMC
August 2014

Oncology scan--the role of personalized medicine in gynecologic cancers.

Authors:
Catheryn Yashar Michael Milosevic

Int J Radiat Oncol Biol Phys 2014 Aug 8;89(5):947-9. Epub 2014 Jul 8.

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http://dx.doi.org/10.1016/j.ijrobp.2014.02.033DOI Listing
August 2014

A facility for magnetic resonance-guided radiation therapy.

Authors:
David A Jaffray Marco C Carlone Michael F Milosevic Stephen L Breen Teodor Stanescu Alexandra Rink Hamideh Alasti Anna Simeonov Michael C Sweitzer Jeffrey D Winter

Semin Radiat Oncol 2014 Jul;24(3):193-5

IMRIS, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.semradonc.2014.02.012DOI Listing
July 2014

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Authors:
Antoaneta Belcheva Thergiory Irrazabal Susan J Robertson Catherine Streutker Heather Maughan Stephen Rubino Eduardo H Moriyama Julia K Copeland Anu Surendra Sachin Kumar Blerta Green Kaoru Geddes Rossanna C Pezo William W Navarre Michael Milosevic Brian C Wilson Stephen E Girardin Thomas M S Wolever Winfried Edelmann David S Guttman Dana J Philpott Alberto Martin

Cell 2014 Jul;158(2):288-299

Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.051DOI Listing
July 2014

MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.

Authors:
Christine How Angela B Y Hui Nehad M Alajez Wei Shi Paul C Boutros Blaise A Clarke Rui Yan Melania Pintilie Anthony Fyles David W Hedley Richard P Hill Michael Milosevic Fei-Fei Liu

PLoS One 2013 4;8(7):e67846. Epub 2013 Jul 4.

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701631PMC
February 2014

Hybrid adaptive radiotherapy with on-line MRI in cervix cancer IMRT.

Authors:
Seungjong Oh James Stewart Joanne Moseley Valerie Kelly Karen Lim Jason Xie Anthony Fyles Kristy K Brock Anna Lundin Henrik Rehbinder Michael Milosevic David Jaffray Young-Bin Cho

Radiother Oncol 2014 Feb 10;110(2):323-8. Epub 2013 Dec 10.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2013.11.006DOI Listing
February 2014

In reply to Smith and Eifel.

Authors:
Kathy Han Michael Milosevic Anthony Fyles Akila N Viswanathan

Int J Radiat Oncol Biol Phys 2014 Feb;88(2):460-1

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2013.10.026DOI Listing
February 2014

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Authors:
Vanessa E Zannella Alan Dal Pra Hala Muaddi Trevor D McKee Shawn Stapleton Jenna Sykes Rachel Glicksman Selim Chaib Paul Zamiara Michael Milosevic Bradly G Wouters Robert G Bristow Marianne Koritzinsky

Clin Cancer Res 2013 Dec 18;19(24):6741-50. Epub 2013 Oct 18.

Authors' Affiliations: Princess Margaret Cancer Centre and Radiation Medicine Program, University Health Network; Institute of Medical Science, Department of Radiation Oncology, Faculty of Medicine, Department of Medical Biophysics, University of Toronto; Selective Therapies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; and Department of Radiation Oncology (Maastro Lab), GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1787DOI Listing
December 2013

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Authors:
Hilda Mujcic Anika Nagelkerke Kasper M A Rouschop Stephen Chung Naz Chaudary Paul N Span Blaise Clarke Michael Milosevic Jenna Sykes Richard P Hill Marianne Koritzinsky Bradly G Wouters

Clin Cancer Res 2013 Nov 17;19(22):6126-37. Epub 2013 Sep 17.

Authors' Affiliations: Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network; Departments of Laboratory Medicine and Pathobiology, Radiation Oncology, and Medical Biophysics; Radiation Medicine Program, Department of Biostatistics, Princess Margaret Cancer Centre, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht; and Departments of Radiation Oncology and Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0526DOI Listing
November 2013

Trends in the utilization of brachytherapy in cervical cancer in the United States.

Authors:
Kathy Han Michael Milosevic Anthony Fyles Melania Pintilie Akila N Viswanathan

Int J Radiat Oncol Biol Phys 2013 Sep 9;87(1):111-9. Epub 2013 Jul 9.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2013.05.033DOI Listing
September 2013

TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair.

Authors:
Alan Dal Pra Emilie Lalonde Jenna Sykes Fiona Warde Adrian Ishkanian Alice Meng Chad Maloff John Srigley Anthony M Joshua Gyorgy Petrovics Theodorus van der Kwast Andrew Evans Michael Milosevic Fred Saad Colin Collins Jeremy Squire Wan Lam Tarek A Bismar Paul C Boutros Robert G Bristow

Clin Cancer Res 2013 Sep 5;19(18):5202-9. Epub 2013 Aug 5.

Authors' Affiliations: Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology and Biostatistics, University of Toronto; Radiation Medicine Program, Princess Margaret Hospital, University Health Network; Informatics and Bio-Computing Platform, Ontario Institute for Cancer Research, Toronto, Ontario; Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre; Laboratory for Advanced Genome Analysis - Vancouver Prostate Centre, Vancouver, British Columbia; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Rockville, Maryland; Division of Urology, University of Montreal Health Center, Montreal, Quebec; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario; and Department of Pathology and Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1049DOI Listing
September 2013

Oncology scan - gynecological cancers: new treatments, old treatments, imaging, and meta-analyses.

Authors:
Arno J Mundt Catheryn Yashar Loren Mell Nina Mayr Michael Milosevic

Int J Radiat Oncol Biol Phys 2013 Jun;86(2):207-10

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http://dx.doi.org/10.1016/j.ijrobp.2013.01.026DOI Listing
June 2013

Postoperative radiotherapy improves local control and survival in patients with uterine leiomyosarcoma.

Authors:
Philip Wong Kathy Han Jenna Sykes Charles Catton Stephane Laframboise Anthony Fyles Lee Manchul Wilfred Levin Michael Milosevic

Radiat Oncol 2013 May 24;8:128. Epub 2013 May 24.

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http://dx.doi.org/10.1186/1748-717X-8-128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679953PMC
May 2013

Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer.

Authors:
Warren D Foltz Andy Wu Peter Chung Charles Catton Andrew Bayley Michael Milosevic Robert Bristow Padraig Warde Anna Simeonov David A Jaffray Masoom A Haider Cynthia Ménard

J Magn Reson Imaging 2013 Apr 23;37(4):909-16. Epub 2012 Oct 23.

Radiation Medicine Program, Princess Margaret Hospital, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jmri.23885DOI Listing
April 2013

Tumor and normal tissue dosimetry changes during MR-guided pulsed-dose-rate (PDR) brachytherapy for cervical cancer.

Authors:
Marita Morgia Julie Cuartero Lorraine Walsh John Jezioranski Kirsten Keeler Jason Xie Christine Massey Debbie Williamson Young-Bin Cho Seungjong Oh Anthony Fyles Michael Milosevic

Radiother Oncol 2013 Apr 27;107(1):46-51. Epub 2013 Mar 27.

Radiation Medicine Program, Princess Margaret Cancer Centre/University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2013.02.012DOI Listing
April 2013

The significance of tumoral ERCC1 status in patients with locally advanced cervical cancer treated with chemoradiation therapy: a multicenter clinicopathologic analysis.

Authors:
Corinne M Doll Christina Aquino-Parsons Melania Pintilie Alexander C Klimowicz Stephanie K Petrillo Michael Milosevic Peter S Craighead Blaise Clarke Susan P Lees-Miller Anthony W Fyles Anthony M Magliocco

Int J Radiat Oncol Biol Phys 2013 Mar 24;85(3):721-7. Epub 2012 Jul 24.

Department of Oncology, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2012.06.021DOI Listing
March 2013

Imaging biomarker dynamics in an intracranial murine glioma study of radiation and antiangiogenic therapy.

Authors:
Caroline Chung Shahrzad Jalali Warren Foltz Kelly Burrell Petra Wildgoose Patricia Lindsay Christian Graves Kevin Camphausen Michael Milosevic David Jaffray Gelareh Zadeh Cynthia Ménard

Int J Radiat Oncol Biol Phys 2013 Mar 26;85(3):805-12. Epub 2012 Aug 26.

Department of Radiation Oncology, University Health Network-Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2012.07.005DOI Listing
March 2013

A comparison of dynamic contrast-enhanced CT and MR imaging-derived measurements in patients with cervical cancer.

Authors:
Sun Mo Kim Masoom A Haider Michael Milosevic Ivan W T Yeung

Clin Physiol Funct Imaging 2013 Mar 27;33(2):150-61. Epub 2012 Nov 27.

Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1111/cpf.12010DOI Listing
March 2013

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma.

Authors:
Chad M McKee Danmei Xu Yunhong Cao Sheheryar Kabraji Danny Allen Veerle Kersemans John Beech Sean Smart Freddie Hamdy Adrian Ishkanian Jenna Sykes Melania Pintile Michael Milosevic Theodorus van der Kwast Gaetano Zafarana Varune Rohan Ramnarine Igor Jurisica Chad Mallof Wan Lam Robert G Bristow Ruth J Muschel

J Clin Invest 2012 Nov 8;122(11):4025-36. Epub 2012 Oct 8.

Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI59348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484431PMC
November 2012

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

Authors:
Jennifer A Locke Gaetano Zafarana Chad A Malloff Wan L Lam Jenna Sykes Melania Pintilie Varune Rohan Ramnarine Alice Meng Omer Ahmed Igor Jurisica Emma Tomlinson Guns Theo van der Kwast Michael Milosevic Robert G Bristow

Prostate 2012 Sep 27;72(12):1295-305. Epub 2011 Dec 27.

Department of Radiation Oncology, Medical Biophysics, Laboratory Medicine and Pathology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pros.22478
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http://dx.doi.org/10.1002/pros.22478DOI Listing
September 2012

Targeting tumoral hypoxia: finding opportunity in complexity.

Authors:
Neesha Dhani Michael Milosevic

Future Oncol 2012 Sep;8(9):1065-8

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http://dx.doi.org/10.2217/fon.12.100DOI Listing
September 2012

Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).

Authors:
Naz Chaudary Melania Pintilie Joerg Schwock Neesha Dhani Blaise Clarke Michael Milosevic Anthony Fyles Richard P Hill

Cancers (Basel) 2012 Aug 29;4(3):821-45. Epub 2012 Aug 29.

Ontario Cancer Institute/Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.3390/cancers4030821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712708PMC
August 2012

Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy.

Authors:
Gaetano Zafarana Adrian S Ishkanian Chad A Malloff Jennifer A Locke Jenna Sykes John Thoms Wan L Lam Jeremy A Squire Maisa Yoshimoto Varune Rohan Ramnarine Alice Meng Omar Ahmed Igor Jurisica Igor Jurisca Michael Milosevic Melania Pintilie Theo van der Kwast Robert G Bristow

Cancer 2012 Aug 26;118(16):4053-62. Epub 2012 Jan 26.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26729DOI Listing
August 2012

Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies.

Authors:
Gibin Powathil Mohammad Kohandel Michael Milosevic Siv Sivaloganathan

Comput Math Methods Med 2012 29;2012:410602. Epub 2012 Jan 29.

Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1155/2012/410602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287099PMC
July 2012

Inverse relationship between biochemical outcome and acute toxicity after image-guided radiotherapy for prostate cancer.

Authors:
Danny Vesprini Charles Catton Lindsay Jacks Gina Lockwood Tara Rosewall Andrew Bayley Peter Chung Mary Gospodarowicz Cynthia Ménard Michael Milosevic Alan Nichol Marketa Skala Padraig Warde Robert G Bristow

Int J Radiat Oncol Biol Phys 2012 Jun 16;83(2):608-16. Epub 2011 Nov 16.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2011.07.019DOI Listing
June 2012

Simultaneous nonrigid registration, segmentation, and tumor detection in MRI guided cervical cancer radiation therapy.

Authors:
Chao Lu Sudhakar Chelikani David A Jaffray Michael F Milosevic Lawrence H Staib James S Duncan

IEEE Trans Med Imaging 2012 Jun 6;31(6):1213-27. Epub 2012 Feb 6.

Department of Electrical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1109/TMI.2012.2186976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889159PMC
June 2012

Deriving mechanisms responsible for the lack of correlation between hypoxia and acidity in solid tumors.

Authors:
Hamid R Molavian Mohammad Kohandel Michael Milosevic Sivabal Sivaloganathan

PLoS One 2011 9;6(12):e28101. Epub 2011 Dec 9.

Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028101PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235095PMC
April 2012

Managing a national radiation oncologist workforce: a workforce planning model.

Authors:
Teri Stuckless Michael Milosevic Catherine de Metz Matthew Parliament Brent Tompkins Michael Brundage

Radiother Oncol 2012 Apr 31;103(1):123-9. Epub 2012 Jan 31.

Division of Radiation Oncology, Cancer Care Program, NL, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016781401100765
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http://dx.doi.org/10.1016/j.radonc.2011.12.025DOI Listing
April 2012

Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer.

Authors:
Michael Milosevic Padraig Warde Cynthia Ménard Peter Chung Ants Toi Adrian Ishkanian Michael McLean Melania Pintilie Jenna Sykes Mary Gospodarowicz Charles Catton Richard P Hill Robert Bristow

Clin Cancer Res 2012 Apr 31;18(7):2108-14. Epub 2012 Mar 31.

Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2711DOI Listing
April 2012

Pathological predictors for site of local recurrence after radiotherapy for prostate cancer.

Authors:
Supriya Chopra Ants Toi Nathan Taback Andrew Evans Masoom A Haider Michael Milosevic Robert G Bristow Peter Chung Andrew Bayley Gerard Morton Danny Vesprini Padraig Warde Charles Catton Cynthia Ménard

Int J Radiat Oncol Biol Phys 2012 Mar;82(3):e441-8

Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2011.05.035DOI Listing
March 2012

Hypoxia, androgen deprivation and systemic metastases in prostate cancer (in response to "Antivascular effects of neoadjuvant androgen deprivation for prostate cancer: an in vivo human study using susceptibility and relaxitivity dynamic MRI": in regard to Alonzi R et al. (Int J Radiat Oncol Biol Phys 2011;80(3):721-727).

Authors:
Alan Dal Pra Michael Milosevic Richard Hill Bradley Wouters Padraig Warde Robert G Bristow

Int J Radiat Oncol Biol Phys 2012 Mar;82(4):1319

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http://dx.doi.org/10.1016/j.ijrobp.2011.11.017DOI Listing
March 2012

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.

Authors:
Yi Wang Olga Roche Chaoying Xu Eduardo H Moriyama Pardeep Heir Jacky Chung Frederik C Roos Yonghong Chen Greg Finak Michael Milosevic Brian C Wilson Bin Tean Teh Morag Park Meredith S Irwin Michael Ohh

Proc Natl Acad Sci U S A 2012 Mar 12;109(13):4892-7. Epub 2012 Mar 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1112129109
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http://dx.doi.org/10.1073/pnas.1112129109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323978PMC
March 2012

NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy.

Authors:
Jennifer A Locke Gaetano Zafarana Adrian S Ishkanian Michael Milosevic John Thoms Cherry L Have Chad A Malloff Wan L Lam Jeremy A Squire Melania Pintilie Jenna Sykes Varune Rohan Ramnarine Alice Meng Omer Ahmed Igor Jurisica Theo van der Kwast Robert G Bristow

Clin Cancer Res 2012 Jan 2;18(1):308-16. Epub 2011 Nov 2.

Department of Radiation Oncology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-2147DOI Listing
January 2012

The Effects of External Beam Radiotherapy on the Normal Urinary Bladder-A Histopathological Review.

Authors:
Tara Rosewall Marc Potvin Andrew Bayley Charles Catton Geoffrey Currie Janelle Wheat Michael Milosevic

J Med Imaging Radiat Sci 2011 Dec 12;42(4):189-197. Epub 2011 Jun 12.

Radiation Medicine Program, Princess Margaret Hospital and Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jmir.2011.03.002DOI Listing
December 2011