Michael Milosevic

Michael Milosevic

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Michael Milosevic

Michael Milosevic

Publications by authors named "Michael Milosevic"

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Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?

Clin Transl Radiat Oncol 2019 Nov 3;19:110-115. Epub 2019 Oct 3.

Princess Margaret Cancer Centre, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.ctro.2019.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682PMC
November 2019

National Trends and Dynamic Responses in the Canadian Radiation Oncology Workforce From 1990 to 2018.

Int J Radiat Oncol Biol Phys 2019 Sep 27;105(1):31-41. Epub 2019 Apr 27.

Department of Radiation Oncology, Cancer Centre of Southeastern Ontario, Kingston, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.019DOI Listing
September 2019

Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

Brachytherapy 2019 Mar - Apr;18(2):133-140. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2018.09.005DOI Listing
July 2019

Scale-up of radiotherapy for cervical cancer in the era of human papillomavirus vaccination in low-income and middle-income countries: a model-based analysis of need and economic impact.

Lancet Oncol 2019 Jul 28;20(7):915-923. Epub 2019 May 28.

Radiation Medicine Program, Princess Margaret Cancer Centre Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(19)30308-0DOI Listing
July 2019

HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors.

Int J Gynecol Pathol 2019 Jul 3. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan (G.A.) Departments of Radiation Oncology (M.L.Y., J.C., M.M.) Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Medical Oncology (H.M.) Laboratory Medicine and Pathobiology (S.K.R., I.W., D.G., B.A.C.) Biostatistics (M.P.), Princess Margaret Cancer Centre/University Health Network, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0000000000000620DOI Listing
July 2019

Repeatability and reproducibility of MRI-based radiomic features in cervical cancer.

Radiother Oncol 2019 Jun 19;135:107-114. Epub 2019 Mar 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193010
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http://dx.doi.org/10.1016/j.radonc.2019.03.001DOI Listing
June 2019

Moving toward uniform and evidence-based practice of radiotherapy for management of cervical cancer in Ontario, Canada.

Brachytherapy 2018 Jul - Aug;17(4):660-666. Epub 2018 Apr 19.

Juravinski Cancer Center, Hamilton, ON, Canada; Radiation Oncology, Department of Oncology, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2018.03.003DOI Listing
March 2019

Vulnerabilities of radiomic signature development: The need for safeguards.

Radiother Oncol 2019 01 8;130:2-9. Epub 2018 Nov 8.

Department of Medical Biophysics, University of Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; IBBME, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; The Techna Institute for the Advancement of Technology for Health, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.10.027DOI Listing
January 2019

Measurement of Tumor Hypoxia in Patients With Locally Advanced Cervical Cancer Using Positron Emission Tomography with F-Fluoroazomyin Arabinoside.

Int J Radiat Oncol Biol Phys 2018 11 2;102(4):1202-1209. Epub 2018 Mar 2.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183032
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http://dx.doi.org/10.1016/j.ijrobp.2018.02.030DOI Listing
November 2018

Improving patient outcomes and radiotherapy systems: A pan-Canadian approach to patient-reported outcome use.

Med Phys 2018 Oct 24;45(10):e841-e844. Epub 2018 Aug 24.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, M5G-2M9, Canada.

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http://dx.doi.org/10.1002/mp.12878DOI Listing
October 2018

Targeting the CXCL12/CXCR4 pathway and myeloid cells to improve radiation treatment of locally advanced cervical cancer.

Int J Cancer 2018 09 5;143(5):1017-1028. Epub 2018 Mar 5.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.31297DOI Listing
September 2018

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

ACS Nano 2018 08 20;12(8):7583-7600. Epub 2018 Jul 20.

Department of Medical Biophysics , University of Toronto , Toronto , ON M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acsnano.7b06301DOI Listing
August 2018

Brachytherapy patient safety events in an academic radiation medicine program.

Brachytherapy 2018 Jan - Feb;17(1):16-23. Epub 2017 Jul 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2017.06.010DOI Listing
July 2018

Technique adaptation, strategic replanning, and team learning during implementation of MR-guided brachytherapy for cervical cancer.

Brachytherapy 2018 Jan - Feb;17(1):86-93

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2017.11.010DOI Listing
July 2018

Comparison of dosimetric parameters derived from whole organ and wall contours for bladder and rectum in cervical cancer patients treated with intracavitary and interstitial brachytherapy.

Radiother Oncol 2018 Jun 6;127(3):456-459. Epub 2018 Feb 6.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.01.015DOI Listing
June 2018

Intermediate dose-volume parameters and the development of late rectal toxicity after MRI-guided brachytherapy for locally advanced cervix cancer.

Brachytherapy 2017 Sep - Oct;16(5):968-975.e2. Epub 2017 Jul 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15384721173039
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http://dx.doi.org/10.1016/j.brachy.2017.06.007DOI Listing
April 2018

Quality in cancer care: Lessons from the Canadian partnership for quality radiotherapy.

Healthc Manage Forum 2018 Jan;31(1):18-21

2 Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/0840470417716684DOI Listing
January 2018

Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma.

J Control Release 2017 Sep 29;262:182-191. Epub 2017 Jul 29.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.039DOI Listing
September 2017

Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.

J Clin Oncol 2017 Jul 14;35(20):2299-2305. Epub 2017 Apr 14.

Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J. Bostrom, Kathy Li, Arnoud J. Templeton, Srikala S. Sridhar, Peter Chung, Robert G. Bristow, Michael Milosevic, Padraig Warde, Neil E. Fleshner, Michael A.S. Jewett, Shaheena Bashir, and Alexandre R. Zlotta, Princess Margaret Cancer Center, University Health Network, University of Toronto; Cynthia Kuk and Alexandre R. Zlotta, Mount Sinai Hospital, University of Toronto; Theodorus H. Van Der Kwast, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2016.69.2327DOI Listing
July 2017

Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study.

Radiother Oncol 2017 07 28;124(1):74-79. Epub 2017 Jun 28.

Department of Radiation Oncology, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.06.007DOI Listing
July 2017

Neutrophil-lymphocyte ratio dynamics during concurrent chemo-radiotherapy for glioblastoma is an independent predictor for overall survival.

J Neurooncol 2017 05 22;132(3):463-471. Epub 2017 Mar 22.

Department of Radiation Oncology, University Health Network-Princess Margaret Cancer Centre/University of Toronto, 610 University Ave., Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-017-2395-yDOI Listing
May 2017

Genomic biomarkers for precision radiation medicine.

Lancet Oncol 2017 05;18(5):e238

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Computer Science, University of Toronto, Toronto, ON, Canada; Ontario Institute of Cancer Research, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(17)30263-2DOI Listing
May 2017

The Practice of Radiation Oncology in Canada.

Int J Radiat Oncol Biol Phys 2017 04 14;97(5):876-880. Epub 2016 Dec 14.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2016.11.055DOI Listing
April 2017

MR-guided brachytherapy for cervical cancer: Quantifying process waste and identifying opportunities for system performance improvement.

Pract Radiat Oncol 2016 Jul-Aug;6(4):233-40. Epub 2015 Nov 11.

Radiation Medicine Program, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://ac.els-cdn.com/S1879850015004026/1-s2.0-S187985001500
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http://dx.doi.org/10.1016/j.prro.2015.11.003DOI Listing
March 2017

Radiation therapy quality-of-care indicators for locally advanced cervical cancer: A consensus guideline.

Pract Radiat Oncol 2016 Sep-Oct;6(5):315-323. Epub 2016 Jan 28.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.prro.2016.01.012DOI Listing
March 2017

Plerixafor Improves Primary Tumor Response and Reduces Metastases in Cervical Cancer Treated with Radio-Chemotherapy.

Clin Cancer Res 2017 Mar 3;23(5):1242-1249. Epub 2016 Oct 3.

Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1730DOI Listing
March 2017

Radiation effects on the tumor microenvironment: Implications for nanomedicine delivery.

Adv Drug Deliv Rev 2017 01 1;109:119-130. Epub 2016 Jun 1.

Radiation Medicine Program, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2016.05.021DOI Listing
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

Quantifying hypoxia in human cancers using static PET imaging.

Phys Med Biol 2016 11 25;61(22):7957-7974. Epub 2016 Oct 25.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Techna Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1088/0031-9155/61/22/7957DOI Listing
November 2016

A prospective study of DWI, DCE-MRI and FDG PET imaging for target delineation in brachytherapy for cervical cancer.

Radiother Oncol 2016 09 12;120(3):519-525. Epub 2016 Aug 12.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2016.08.002DOI Listing
September 2016

The Utility of Serum CA9 for Prognostication in Prostate Cancer.

Anticancer Res 2016 09;36(9):4489-92

Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.21873/anticanres.10994DOI Listing
September 2016

Planned versus 'delivered' bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT.

Radiother Oncol 2016 06 9;119(3):417-22. Epub 2016 Apr 9.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2016.03.022DOI Listing
June 2016

Developing a prognostic micro-RNA signature for human cervical carcinoma.

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Association of Apparent Diffusion Coefficient with Disease Recurrence in Patients with Locally Advanced Cervical Cancer Treated with Radical Chemotherapy and Radiation Therapy.

Radiology 2016 Apr 27;279(1):158-66. Epub 2015 Oct 27.

From the Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada (A.G., M.M., A.F., J.X., N.B., W.L., L.M., W.F., K.H.); Departments of Radiation Oncology (A.G., M.M., A.F., J.X., N.B., W.L., L.M., W.F., K.H.) and Biostatistics (H.J.), University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9; and Department of Medical Imaging, University Health Network, Toronto, ON, Canada (J.H., U.R.).

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http://dx.doi.org/10.1148/radiol.2015150400DOI Listing
April 2016

Association between Metformin Use and Mortality after Cervical Cancer in Older Women with Diabetes.

Cancer Epidemiol Biomarkers Prev 2016 Mar 31;25(3):507-12. Epub 2015 Dec 31.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1008DOI Listing
March 2016

Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake.

J Nucl Med 2016 Mar 14;57(3):361-6. Epub 2016 Jan 14.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

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http://dx.doi.org/10.2967/jnumed.115.167650DOI Listing
March 2016

Automated Delineation of the Normal Urinary Bladder on Planning CT and Cone Beam CT.

J Med Imaging Radiat Sci 2016 Mar 18;47(1):21-29. Epub 2015 Nov 18.

Department of Radiation Oncology, Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jmir.2015.09.011DOI Listing
March 2016

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

Int J Radiat Oncol Biol Phys 2016 Jan 18;94(1):111-117. Epub 2015 Sep 18.

Department of Medical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.009DOI Listing
January 2016

Hypoxia and Predicting Radiation Response.

Semin Radiat Oncol 2015 Oct 15;25(4):260-72. Epub 2015 May 15.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.004DOI Listing
October 2015

Quantitative Imaging in Radiation Oncology: An Emerging Science and Clinical Service.

Semin Radiat Oncol 2015 Oct 15;25(4):292-304. Epub 2015 May 15.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; TECHNA Institute/University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2015.05.002DOI Listing
October 2015

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.

J Control Release 2015 Aug 10;211:163-70. Epub 2015 Jun 10.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659150061
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http://dx.doi.org/10.1016/j.jconrel.2015.06.008DOI Listing
August 2015

Deriving patient-specific planning target volume for partial bladder image guided radiation therapy.

Pract Radiat Oncol 2014 Sep-Oct;4(5):323-329. Epub 2013 Nov 21.

Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.prro.2013.10.005DOI Listing
May 2015

Quality standards in radiation medicine.

Pract Radiat Oncol 2014 Jul-Aug;4(4):208-14. Epub 2013 Nov 5.

Department of Oncology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2013.09.004DOI Listing
March 2015

The clinical significance of hypoxia in human cancers.

Semin Nucl Med 2015 Mar;45(2):110-21

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2014.11.002DOI Listing
March 2015

MR-guided prostate biopsy for planning of focal salvage after radiation therapy.

Radiology 2015 Jan 8;274(1):181-91. Epub 2014 Sep 8.

From the Radiation Medicine Program (C.M., D.I., J.P., J.L., J.A., A.S., W.D.F., M.M., C.C., R.B., A.B., D.A.J., P.C., K.K.B.) and Department of Biostatistics (E.G.A.), Princess Margaret Cancer Centre, 610 University Ave, Room 5-809, Toronto, ON, Canada M4X 1C3; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada (C.M., D.I., A.S., M.M., C.C., G.M., R.B., A.B., D.A.J., P.C., K.K.B.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.), Departments of Anesthesia (G.O.) and Pathology (A.J.E.), University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Center, Toronto, Ontario, Canada (G.M.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.); and Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (M.A.H.).

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http://dx.doi.org/10.1148/radiol.14122681DOI Listing
January 2015

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.

Oncotarget 2014 Nov;5(22):11081-90

Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology, Pharmacology & Toxicology and Biostatistics, Computer Science, University of Toronto, Toronto, ON, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://www.oncotarget.com/fulltext/2404
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294365PMC
http://dx.doi.org/10.18632/oncotarget.2404DOI Listing
November 2014

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Dosimetrically triggered adaptive intensity modulated radiation therapy for cervical cancer.

Int J Radiat Oncol Biol Phys 2014 Sep 8;90(1):147-54. Epub 2014 Jul 8.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.039DOI Listing
September 2014

The Effect of Dose Grid Resolution on Dose Volume Histograms for Slender Organs at Risk during Pelvic Intensity-modulated Radiotherapy.

J Med Imaging Radiat Sci 2014 Sep 7;45(3):204-209. Epub 2014 Jun 7.

Charles Sturt University, New South Wales, Australia; Australian School of Advanced Medicine, Macquarie University, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.jmir.2014.01.006DOI Listing
September 2014

A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.

PLoS One 2013 2;8(12):e81157. Epub 2013 Dec 2.

Department of Medical Biophysics, University of Toronto, Ontario, Canada ; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846845PMC
August 2014

Oncology scan--the role of personalized medicine in gynecologic cancers.

Int J Radiat Oncol Biol Phys 2014 Aug 8;89(5):947-9. Epub 2014 Jul 8.

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http://dx.doi.org/10.1016/j.ijrobp.2014.02.033DOI Listing
August 2014

Hybrid adaptive radiotherapy with on-line MRI in cervix cancer IMRT.

Radiother Oncol 2014 Feb 10;110(2):323-8. Epub 2013 Dec 10.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2013.11.006DOI Listing
February 2014

In reply to Smith and Eifel.

Int J Radiat Oncol Biol Phys 2014 Feb;88(2):460-1

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2013.10.026DOI Listing
February 2014

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Clin Cancer Res 2013 Dec 18;19(24):6741-50. Epub 2013 Oct 18.

Authors' Affiliations: Princess Margaret Cancer Centre and Radiation Medicine Program, University Health Network; Institute of Medical Science, Department of Radiation Oncology, Faculty of Medicine, Department of Medical Biophysics, University of Toronto; Selective Therapies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; and Department of Radiation Oncology (Maastro Lab), GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1787DOI Listing
December 2013

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Clin Cancer Res 2013 Nov 17;19(22):6126-37. Epub 2013 Sep 17.

Authors' Affiliations: Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network; Departments of Laboratory Medicine and Pathobiology, Radiation Oncology, and Medical Biophysics; Radiation Medicine Program, Department of Biostatistics, Princess Margaret Cancer Centre, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht; and Departments of Radiation Oncology and Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0526DOI Listing
November 2013

Trends in the utilization of brachytherapy in cervical cancer in the United States.

Int J Radiat Oncol Biol Phys 2013 Sep 9;87(1):111-9. Epub 2013 Jul 9.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2013.05.033DOI Listing
September 2013

TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair.

Clin Cancer Res 2013 Sep 5;19(18):5202-9. Epub 2013 Aug 5.

Authors' Affiliations: Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology and Biostatistics, University of Toronto; Radiation Medicine Program, Princess Margaret Hospital, University Health Network; Informatics and Bio-Computing Platform, Ontario Institute for Cancer Research, Toronto, Ontario; Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre; Laboratory for Advanced Genome Analysis - Vancouver Prostate Centre, Vancouver, British Columbia; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Rockville, Maryland; Division of Urology, University of Montreal Health Center, Montreal, Quebec; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario; and Department of Pathology and Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1049DOI Listing
September 2013

Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer.

J Magn Reson Imaging 2013 Apr 23;37(4):909-16. Epub 2012 Oct 23.

Radiation Medicine Program, Princess Margaret Hospital, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jmri.23885DOI Listing
April 2013

Imaging biomarker dynamics in an intracranial murine glioma study of radiation and antiangiogenic therapy.

Int J Radiat Oncol Biol Phys 2013 Mar 26;85(3):805-12. Epub 2012 Aug 26.

Department of Radiation Oncology, University Health Network-Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2012.07.005DOI Listing
March 2013

A comparison of dynamic contrast-enhanced CT and MR imaging-derived measurements in patients with cervical cancer.

Clin Physiol Funct Imaging 2013 Mar 27;33(2):150-61. Epub 2012 Nov 27.

Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1111/cpf.12010DOI Listing
March 2013

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

Prostate 2012 Sep 27;72(12):1295-305. Epub 2011 Dec 27.

Department of Radiation Oncology, Medical Biophysics, Laboratory Medicine and Pathology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pros.22478
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http://dx.doi.org/10.1002/pros.22478DOI Listing
September 2012

Targeting tumoral hypoxia: finding opportunity in complexity.

Future Oncol 2012 Sep;8(9):1065-8

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http://dx.doi.org/10.2217/fon.12.100DOI Listing
September 2012

Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).

Cancers (Basel) 2012 Aug 29;4(3):821-45. Epub 2012 Aug 29.

Ontario Cancer Institute/Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.3390/cancers4030821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712708PMC
August 2012

Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies.

Comput Math Methods Med 2012 29;2012:410602. Epub 2012 Jan 29.

Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1155/2012/410602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287099PMC
July 2012

Inverse relationship between biochemical outcome and acute toxicity after image-guided radiotherapy for prostate cancer.

Int J Radiat Oncol Biol Phys 2012 Jun 16;83(2):608-16. Epub 2011 Nov 16.

Radiation Medicine Program, Princess Margaret Hospital, University Health Network, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2011.07.019DOI Listing
June 2012

Simultaneous nonrigid registration, segmentation, and tumor detection in MRI guided cervical cancer radiation therapy.

IEEE Trans Med Imaging 2012 Jun 6;31(6):1213-27. Epub 2012 Feb 6.

Department of Electrical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1109/TMI.2012.2186976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889159PMC
June 2012

Managing a national radiation oncologist workforce: a workforce planning model.

Radiother Oncol 2012 Apr 31;103(1):123-9. Epub 2012 Jan 31.

Division of Radiation Oncology, Cancer Care Program, NL, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016781401100765
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http://dx.doi.org/10.1016/j.radonc.2011.12.025DOI Listing
April 2012

Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer.

Clin Cancer Res 2012 Apr 31;18(7):2108-14. Epub 2012 Mar 31.

Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2711DOI Listing
April 2012

The Effects of External Beam Radiotherapy on the Normal Urinary Bladder-A Histopathological Review.

J Med Imaging Radiat Sci 2011 Dec 12;42(4):189-197. Epub 2011 Jun 12.

Radiation Medicine Program, Princess Margaret Hospital and Department of Radiation Oncology, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jmir.2011.03.002DOI Listing
December 2011