Michael McGeachie

Michael McGeachie

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Michael McGeachie

Michael McGeachie

Publications by authors named "Michael McGeachie"

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37Publications

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Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.

Metabolites 2019 Sep 7;9(9). Epub 2019 Sep 7.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/metabo9090179DOI Listing
September 2019

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype.

Pediatr Pulmonol 2019 Feb 25;54(2):158-164. Epub 2018 Dec 25.

Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ppul.24219DOI Listing
February 2019

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness.

Crit Care 2018 12 29;22(1):360. Epub 2018 Dec 29.

Renal Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, MRB 418, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s13054-018-2275-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310975PMC
December 2018

Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator.

J Allergy Clin Immunol 2018 11 2;142(5):1479-1488.e12. Epub 2018 Mar 2.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111005PMC
November 2018

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.

Chest 2018 08 13;154(2):335-348. Epub 2018 Jun 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2018.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689076PMC
August 2018

Assessment of genetic factor and depression interactions for asthma symptom severity in cohorts of childhood and elderly asthmatics.

Exp Mol Med 2018 07 4;50(7):77. Epub 2018 Jul 4.

Department of Medicine, Channing Division of Network of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s12276-018-0110-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031659PMC
July 2018

Circulating microRNAs and prediction of asthma exacerbation in childhood asthma.

Respir Res 2018 06 26;19(1):128. Epub 2018 Jun 26.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0828-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020199PMC
June 2018

Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.

Am J Clin Nutr 2017 Oct 23;106(4):1092-1099. Epub 2017 Aug 23.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and

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http://dx.doi.org/10.3945/ajcn.117.158220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611786PMC
October 2017

Asthma remission: Predicting future airways responsiveness using an miRNA network.

J Allergy Clin Immunol 2017 08 24;140(2):598-600.e8. Epub 2017 Feb 24.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546990PMC
August 2017

Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease.

Curr Opin Allergy Clin Immunol 2017 Apr;17(2):104-109

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/ACI.0000000000000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577926PMC
April 2017

Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic.

Chest 2017 Feb 21;151(2):262-277. Epub 2016 Oct 21.

Channing Division of Network Medicine, Brigham Women's Hospital and Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310123PMC
February 2017

Whole genome prediction and heritability of childhood asthma phenotypes.

Immun Inflamm Dis 2016 12 28;4(4):487-496. Epub 2016 Nov 28.

Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1002/iid3.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134727PMC
December 2016

Decline in Lung Function in Childhood Asthma.

N Engl J Med 2016 08;375(7):e13

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http://dx.doi.org/10.1056/NEJMc1608228DOI Listing
August 2016

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

PLoS One 2015 16;10(10):e0140758. Epub 2015 Oct 16.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; BWH Pulmonary Genetics Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140758PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608673PMC
June 2016

Longitudinal Prediction of the Infant Gut Microbiome with Dynamic Bayesian Networks.

Sci Rep 2016 Feb 8;6:20359. Epub 2016 Feb 8.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1038/srep20359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745046PMC
February 2016

CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids.

Immun Inflamm Dis 2015 Dec 14;3(4):350-9. Epub 2015 Jul 14.

Channing Division of Network Medicine, Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMassachusetts02115; Center for Child Health Care Studies, Department of Population MedicineHarvard Pilgrim Health Care Institute and Harvard Medical SchoolBostonMassachusetts02115.

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http://dx.doi.org/10.1002/iid3.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693729PMC
December 2015

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.

J Allergy Clin Immunol 2015 Oct 24;136(4):885-92.e2. Epub 2015 Apr 24.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2015.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763940PMC
October 2015

The metabolomics of asthma control: a promising link between genetics and disease.

Immun Inflamm Dis 2015 Sep 7;3(3):224-38. Epub 2015 May 7.

Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/iid3.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578522PMC
September 2015

Measuring the corticosteroid responsiveness endophenotype in asthmatic patients.

J Allergy Clin Immunol 2015 Aug 5;136(2):274-81.e8. Epub 2015 May 5.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150043
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http://dx.doi.org/10.1016/j.jaci.2015.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530065PMC
August 2015

Genomic architecture of pharmacological efficacy and adverse events.

Pharmacogenomics 2014 Dec;15(16):2025-48

Department of Bioengineering & Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.2217/pgs.14.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308414PMC
December 2014

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases.

Genom Data 2014 Dec;2:202-211

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA ; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.gdata.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378545PMC
December 2014

Metabolomic derangements are associated with mortality in critically ill adult patients.

PLoS One 2014 30;9(1):e87538. Epub 2014 Jan 30.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America ; Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907548PMC
September 2014

CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data.

PLoS Comput Biol 2014 Jun 12;10(6):e1003676. Epub 2014 Jun 12.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Partners Health Care Center for Personalized Medicine, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055564PMC
June 2014

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Phenotype prediction by integrative network analysis of SNP and gene expression microarrays.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:6849-52

Children’s Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6091689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343740PMC
August 2012

The Local Geometry of Multiattribute Tradeoff Preferences.

Artif Intell 2011 May;175(7-8):1122-1152

Computer Science and ArtificialIntelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139 USA

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http://dx.doi.org/10.1016/j.artint.2010.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081600PMC
May 2011

Mapping transcription mechanisms from multimodal genomic data.

BMC Bioinformatics 2010 Oct 28;11 Suppl 9:S2. Epub 2010 Oct 28.

Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1186/1471-2105-11-S9-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967743PMC
October 2010