Michael Manns

Michael Manns

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Michael Manns

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Chronic Hepatitis E is associated with cholangitis.

Liver Int 2019 Oct 17;39(10):1876-1883. Epub 2019 Jun 17.

Department of Pathology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/liv.14137DOI Listing
October 2019

Defining virus-specific CD8+ TCR repertoires for therapeutic regeneration of T cells against chronic hepatitis E.

J Hepatol 2019 Oct 14;71(4):673-684. Epub 2019 Jun 14.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), Hannover, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.06.005DOI Listing
October 2019

Therapeutic plasma exchange in acute liver failure.

J Clin Apher 2019 Oct 26;34(5):589-597. Epub 2019 Jul 26.

Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/jca.21737DOI Listing
October 2019

Soluble immune markers in the different phases of chronic hepatitis B virus infection.

Sci Rep 2019 Oct 1;9(1):14118. Epub 2019 Oct 1.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41598-019-50729-5DOI Listing
October 2019

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes.

J Autoimmun 2019 Sep 5;103:102289. Epub 2019 Jun 5.

Dept. of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany; Dept. of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.05.017DOI Listing
September 2019

Systemic arterial blood pressure determines the therapeutic window of non-selective beta blockers in decompensated cirrhosis.

Aliment Pharmacol Ther 2019 Sep 2;50(6):696-706. Epub 2019 Aug 2.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/apt.15439DOI Listing
September 2019

The impact of proton pump inhibitors on the intestinal microbiota in chronic hepatitis C patients.

Scand J Gastroenterol 2019 Aug 30;54(8):1033-1041. Epub 2019 Jul 30.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/00365521.2019.1647280DOI Listing
August 2019

Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses.

J Hepatol 2019 Jul 8. Epub 2019 Jul 8.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research, Hannover, Germany (DZIF), Partner-site Hannover-Braunschweig, Germany; Department of Gastroenterology and Hepatology, Essen University Hospital, Essen, Germany; Integrated Research and Treatment Centre Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.06.025DOI Listing
July 2019

Effects of adenovirus-induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model.

Liver Int 2019 Jun 21. Epub 2019 Jun 21.

Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/liv.14183DOI Listing
June 2019

Treatment of Chronic Hepatitis C: Efficacy, Side Effects and Complications.

Visc Med 2019 Jun 21;35(3):161-170. Epub 2019 May 21.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1159/000500963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616049PMC
June 2019

Second-line chemotherapy in biliary tract cancer: Outcome and prognostic factors.

Liver Int 2019 May 18;39(5):914-923. Epub 2019 Mar 18.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14063DOI Listing
May 2019

Utility of viral kinetics in HCV therapy - It is not over until it is over?

Liver Int 2019 May;39(5):815-817

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.14047DOI Listing
May 2019

Endoscopic biliary drainage in patients with cholangiocarcinoma - self-expanding metal polyethylene stents.

Scand J Gastroenterol 2019 May 24;54(5):640-645. Epub 2019 May 24.

a Department of Gastroenterology, Hepatology and Endocrinology , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/00365521.2019.1614661DOI Listing
May 2019

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

J Hepatol 2019 Apr 13;70(4):593-602. Epub 2018 Nov 13.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany; German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183252
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http://dx.doi.org/10.1016/j.jhep.2018.11.003DOI Listing
April 2019

SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.

J Hepatol 2019 Apr 23;70(4):603-614. Epub 2018 Nov 23.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Center for Infection Research, DZIF, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.012DOI Listing
April 2019

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.

J Hepatol 2019 Apr 22;70(4):722-734. Epub 2018 Dec 22.

Research Group MicroRNA in Liver Regeneration, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183263
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http://dx.doi.org/10.1016/j.jhep.2018.12.016DOI Listing
April 2019

Outcomes of renal dysfunction in patients with acute liver failure.

United European Gastroenterol J 2019 Apr 3;7(3):388-396. Epub 2018 Dec 3.

Division of General Internal Medicine, Nephrology, and Rheumatology, Department of Medicine D, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1177/2050640618817061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466757PMC
April 2019

Recommendations on the Use of Magnetic Resonance Imaging for Collaborative Multicenter Studies in Primary Sclerosing Cholangitis.

Hepatology 2019 Mar 23;69(3):1358-1359. Epub 2019 Feb 23.

Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/hep.30276DOI Listing
March 2019

Shear wave elastography prior to transjugular intrahepatic portosystemic shunt may predict the decrease in hepatic vein pressure gradient.

Abdom Radiol (NY) 2019 Mar;44(3):1127-1134

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00261-018-1795-6DOI Listing
March 2019

An Imaging Biomarker for Assessing Hepatic Function in Patients With Primary Sclerosing Cholangitis.

Clin Gastroenterol Hepatol 2019 01 11;17(1):192-199.e3. Epub 2018 Jul 11.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.05.011DOI Listing
January 2019

Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn's disease.

Eur J Gastroenterol Hepatol 2019 01;31(1):99-108

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover.

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http://dx.doi.org/10.1097/MEG.0000000000001262DOI Listing
January 2019

Different kinetics of liver stiffness using shear wave elastography in patients with chronic hepatitis C infection treated with interferon-free regimens.

Eur J Gastroenterol Hepatol 2019 01;31(1):67-74

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MEG.0000000000001259DOI Listing
January 2019

Novel therapeutic targets in autoimmune hepatitis.

J Autoimmun 2018 12 4;95:34-46. Epub 2018 Nov 4.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
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http://dx.doi.org/10.1016/j.jaut.2018.10.022DOI Listing
December 2018

Editorial: "real world data" of AIH-time to connect!

Aliment Pharmacol Ther 2018 12;48(11-12):1315-1316

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.

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http://dx.doi.org/10.1111/apt.15028DOI Listing
December 2018

Lipid-lowering therapy with PCSK9-inhibitors in the management of cardiovascular high-risk patients: Effectiveness, therapy adherence and safety in a real world cohort.

Cardiol J 2018 23;25(1):32-41. Epub 2017 Nov 23.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.5603/CJ.a2017.0137DOI Listing
November 2018

Transjugular diagnostics in acute liver failure including measurements of hepatocentral venous biomarker gradients.

Hepatol Res 2018 Oct 5;48(11):914-925. Epub 2018 Jun 5.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany.

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http://doi.wiley.com/10.1111/hepr.13185
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http://dx.doi.org/10.1111/hepr.13185DOI Listing
October 2018

Impact of direct-acting antiviral therapy on the need for liver transplantation related to hepatitis C in Germany.

J Hepatol 2018 10 6;69(4):982-984. Epub 2018 Aug 6.

Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg Essen, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Leberstiftungs-GmbH Deutschland, Hannover, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig Site, Germany; Helmholtz Center for Infection Research (HZI), Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.jhep.2018.07.001DOI Listing
October 2018

Dose-dependent impact of proton pump inhibitors on the clinical course of spontaneous bacterial peritonitis.

Liver Int 2018 09 7;38(9):1602-1613. Epub 2018 May 7.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1111/liv.13862DOI Listing
September 2018

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B.

J Hepatol 2018 09 29;69(3):584-593. Epub 2018 Jun 29.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), c/o CRC Hannover, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183205
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http://dx.doi.org/10.1016/j.jhep.2018.05.004DOI Listing
September 2018

Association Between Type 2 Diabetes Mellitus, HbA1c and the Risk for Spontaneous Bacterial Peritonitis in Patients with Decompensated Liver Cirrhosis and Ascites.

Clin Transl Gastroenterol 2018 09 24;9(9):189. Epub 2018 Sep 24.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1038/s41424-018-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155293PMC
September 2018

Clinical characteristics of patients with liver cirrhosis and spontaneous portosystemic shunts detected by ultrasound in a tertiary care and transplantation centre.

Scand J Gastroenterol 2018 Sep 29;53(9):1107-1113. Epub 2018 Sep 29.

a Department of Gastroenterology, Hepatology and Endocrinology , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/00365521.2018.1498913DOI Listing
September 2018

Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis.

J Mol Med (Berl) 2018 08 20;96(8):831-843. Epub 2018 Jun 20.

Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00109-018-1658-1DOI Listing
August 2018

The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities.

Lancet 2018 08 27;392(10148):621-622. Epub 2018 Jul 27.

European Association for the Study of the Liver, Geneva, Switzerland.

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http://dx.doi.org/10.1016/S0140-6736(18)31734-3DOI Listing
August 2018

Autoantibodies against CYP-2C19: A Novel Serum Marker in Pediatric De Novo Autoimmune Hepatitis?

Biomed Res Int 2017 27;2017:3563278. Epub 2017 Nov 27.

Pediatrics, Department of Medicine, Surgery, and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1155/2017/3563278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723963PMC
July 2018

Ethanol sclerotherapy or polidocanol sclerotherapy for symptomatic hepatic cysts.

United European Gastroenterol J 2018 Jul 8;6(6):919-925. Epub 2018 Mar 8.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1177/2050640618764940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047294PMC
July 2018

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity.

Nat Commun 2018 06 11;9(1):2275. Epub 2018 Jun 11.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41467-018-04685-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995831PMC
June 2018

Hepatic T Cell Tolerance Induction in An Inflammatory Environment.

Dig Dis 2018 12;36(2):156-166. Epub 2017 Oct 12.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1159/000481341DOI Listing
May 2018

EASL Recognition Award Recipient 2018: Prof. Mario Mondelli.

Authors:
Michael P Manns

J Hepatol 2018 05;68(5):878-880

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Germany. Electronic address: https://www.mh-hannover.de/gastro.html.

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http://dx.doi.org/10.1016/j.jhep.2018.01.027DOI Listing
May 2018

Unmet needs and new models for future trials in autoimmune hepatitis.

Lancet Gastroenterol Hepatol 2018 05 6;3(5):363-370. Epub 2018 Apr 6.

Departments of Medicine and Surgery, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/S2468-1253(18)30043-8DOI Listing
May 2018

Stomach reduction or gastric bypass as risk factor for treatment failure after DAA therapy for hepatitis C?

J Hepatol 2018 04 22;68(4):851-853. Epub 2017 Nov 22.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research, partner-site Hannover-Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.10.035DOI Listing
April 2018

Hepatitis: No cure for hepatitis B and D without targeting integrated viral DNA?

Nat Rev Gastroenterol Hepatol 2018 04 31;15(4):195-196. Epub 2018 Jan 31.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover; the German Centre for Infection Research (DZIF), partner-site Hannover-Braunschweig; and the Centre for Individualised Infection Medicine (CIIM), Hannover, Germany.

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http://dx.doi.org/10.1038/nrgastro.2017.185DOI Listing
April 2018

Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss.

J Infect Dis 2018 04;217(10):1656-1666

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1093/infdis/jiy097DOI Listing
April 2018

Autoimmune hepatitis.

Nat Rev Dis Primers 2018 04 12;4:18017. Epub 2018 Apr 12.

Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1038/nrdp.2018.17DOI Listing
April 2018

Percutaneous endoscopic gastrostomy with and without jejunal extension in patients with amyotrophic lateral sclerosis.

Eur J Gastroenterol Hepatol 2018 Mar;30(3):257-262

Departments of Gastroenterology, Hepatology and Endocrinology.

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http://dx.doi.org/10.1097/MEG.0000000000001054DOI Listing
March 2018

Budesonide in Autoimmune Hepatitis: The Right Drug at the Right Time for the Right Patient.

Clin Gastroenterol Hepatol 2018 02 8;16(2):186-189. Epub 2017 Nov 8.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.cgh.2017.11.003DOI Listing
February 2018

Cancer vaccines and immunotherapeutic approaches in hepatobiliary and pancreatic cancers.

Hum Vaccin Immunother 2017 12 7;13(12):2931-2952. Epub 2017 Nov 7.

a Department of Gastroenterology , Hepatology and Endocrinology, Hannover Medical School , Hannover , Germany.

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https://www.tandfonline.com/doi/full/10.1080/21645515.2017.1
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http://dx.doi.org/10.1080/21645515.2017.1359362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718787PMC
December 2017

Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis.

Cell Death Dis 2017 12 14;8(12):3219. Epub 2017 Dec 14.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1038/s41419-017-0010-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870592PMC
December 2017

[HBV-infections in Germany - health care costs in a real-life-setting].

Z Gastroenterol 2017 Nov 15;55(11):1103-1112. Epub 2017 Nov 15.

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1055/s-0043-118539DOI Listing
November 2017

Therapy preferences of patients with lung and colon cancer: a discrete choice experiment.

Patient Prefer Adherence 2017 26;11:1647-1656. Epub 2017 Sep 26.

Leibniz University of Hannover, Center for Health Economics Research (CHERH), Hannover, Germany.

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http://dx.doi.org/10.2147/PPA.S138863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630067PMC
September 2017

Interferon-free cure of chronic Hepatitis C is associated with weight gain during long-term follow-up.

Z Gastroenterol 2017 Sep 12;55(9):848-856. Epub 2017 Sep 12.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1055/s-0043-112656DOI Listing
September 2017