Michael M Meagher

Michael M Meagher

UNVERIFIED PROFILE

Are you Michael M Meagher?   Register this Author

Register author
Michael M Meagher

Michael M Meagher

Publications by authors named "Michael M Meagher"

Are you Michael M Meagher?   Register this Author

28Publications

340Reads

-Profile Views

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1815408
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019

Highly Sensitive SDS Capillary Gel Electrophoresis with Sample Stacking Requiring Only Nanograms of Adeno-Associated Virus Capsid Proteins.

Methods Mol Biol 2019 ;1972:263-270

Department of Therapeutics Production and Quality, St. Jude Children's Research Hospital, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9213-3_19DOI Listing
January 2019

Sample Stacking Provides Three Orders of Magnitude Sensitivity Enhancement in SDS Capillary Gel Electrophoresis of Adeno-Associated Virus Capsid Proteins.

Anal Chem 2017 03 9;89(6):3285-3292. Epub 2017 Mar 9.

Department of Therapeutics Production and Quality, St. Jude Children's Research Hospital , Memphis, Tennessee 38105, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b02933DOI Listing
March 2017

Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

Hum Gene Ther Methods 2016 06;27(3):112-21

Department of Therapeutics Production & Quality, St. Jude Children's Research Hospital , Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hgtb.2016.021DOI Listing
June 2016

Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector.

Mol Ther Methods Clin Dev 2016 30;3:16015. Epub 2016 Mar 30.

Department of Therapeutics Production & Quality, St. Jude Children's Research Hospital , Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtm.2016.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813606PMC
April 2016

Safety and immunogenicity of an intranasal Sendai virus-based human parainfluenza virus type 1 vaccine in 3- to 6-year-old children.

Clin Vaccine Immunol 2015 Mar 31;22(3):298-303. Epub 2014 Dec 31.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/CVI.00618-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340902PMC
March 2015

Process development and cGMP manufacturing of a recombinant ricin vaccine: an effective and stable recombinant ricin A-chain vaccine-RVEc™.

Biotechnol Prog 2011 Jul 31;27(4):1036-47. Epub 2011 May 31.

University of Nebraska-Lincoln Biological Process Development Facility, College of Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0668, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/btpr.631DOI Listing
July 2011

Isolation of Pichia pastoris PIR genes and their utilization for cell surface display and recombinant protein secretion.

Yeast 2011 Mar 22;28(3):213-26. Epub 2010 Dec 22.

Biological Process Development Facility, Department of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE 68588, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/yea.1832
Publisher Site
http://dx.doi.org/10.1002/yea.1832DOI Listing
March 2011

Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate.

Microb Cell Fact 2010 Nov 23;9:93. Epub 2010 Nov 23.

Unit for Molecular Glycobiology, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1475-2859-9-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004841PMC
November 2010

Rational design and optimization of fed-batch and continuous fermentations.

Methods Mol Biol 2007 ;389:43-64

Xoma Ltd., Berkey, CA.,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-456-8_4DOI Listing
December 2007

Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) Protein (Na-ASP1).

Methods Mol Biol 2007 ;389:65-76

Department of Chemical Engineering, University of Nebraska, Lincoln, NE. USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-456-8_5DOI Listing
December 2007

Purification of the N- and C-terminal subdomains of recombinant heavy chain fragment C of botulinum neurotoxin serotype C.

Methods Mol Biol 2007 ;389:77-98

Department of Chemical Engineering, University of Nebraska, Lincoln, NE, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-456-8_6DOI Listing
December 2007

Protection with recombinant Clostridium botulinum C1 and D binding domain subunit (Hc) vaccines against C and D neurotoxins.

Vaccine 2007 May 16;25(21):4273-82. Epub 2007 Mar 16.

Integrated Toxicology Division, United States Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2007.02.081DOI Listing
May 2007

Developement of serum-free media in CHO-DG44 cells using a central composite statistical design.

Cytotechnology 2007 May 5;54(1):57-68. Epub 2007 Jun 5.

Department of Chemical Engineering, University of Nebraska, 207 Othmer Hall, 820 North 16th Street, Lincoln, NE, 68588, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10616-007-9074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267511PMC
May 2007

Glycerophosphate as a phosphorus source in a defined medium for Pichia pastoris fermentation.

Appl Microbiol Biotechnol 2006 Aug;72(1):139-144

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, NE, 68588, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00253-005-0238-9DOI Listing
August 2006

Enhancement of protein secretion in Pichia pastoris by overexpression of protein disulfide isomerase.

Biotechnol Bioeng 2006 Mar;93(4):771-8

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska, Lincoln, 207P Othmer Hall, Nebraska 68588-0643, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bit.20762DOI Listing
March 2006

Purification and scale-up of a recombinant heavy chain fragment C of botulinum neurotoxin serotype E in Pichia pastoris GS115.

Protein Expr Purif 2006 Feb 20;45(2):359-67. Epub 2005 Sep 20.

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0466, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2005.08.015DOI Listing
February 2006

Maximization of production of secreted recombinant proteins in Pichia pastoris fed-batch fermentation.

Biotechnol Prog 2005 Mar-Apr;21(2):386-93

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, Nebraska 68588-0643, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bp049811nDOI Listing
July 2005

Crystallization and preliminary X-ray analysis of Na-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasite Necator americanus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Apr 24;61(Pt 4):391-4. Epub 2005 Mar 24.

Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1744309105007748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952415PMC
April 2005

Causes of proteolytic degradation of secreted recombinant proteins produced in methylotrophic yeast Pichia pastoris: case study with recombinant ovine interferon-tau.

Biotechnol Bioeng 2005 Jan;89(1):102-12

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, NE, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bit.20318DOI Listing
January 2005

Optimization of cell density and dilution rate in Pichia pastoris continuous fermentations for production of recombinant proteins.

J Ind Microbiol Biotechnol 2004 Aug 15;31(7):330-4. Epub 2004 Jul 15.

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, 207 Othmer Hall, Lincoln, NE 68588-0643, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-004-0155-4DOI Listing
August 2004

Improved production of recombinant ovine interferon-tau by mut(+) strain of Pichia pastoris using an optimized methanol feed profile.

Biotechnol Prog 2003 May-Jun;19(3):794-802

Biological Process Development Facility, Department of Chemical Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68583, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bp025744qDOI Listing
May 2004

Detection of non-host viable contaminants in Pichia pastoris cultures and fermentation broths.

J Ind Microbiol Biotechnol 2003 Nov 6;30(11):643-50. Epub 2003 Nov 6.

Department of Chemical Engineering, University of Nebraska, Lincoln, NE 68683, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-003-0089-2DOI Listing
November 2003

Design of methanol Feed control in Pichia pastoris fermentations based upon a growth model.

Biotechnol Prog 2002 Nov-Dec;18(6):1392-9

Department of Chemical Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0919, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bp025516wDOI Listing
July 2003

Pichia pastoris fermentation with mixed-feeds of glycerol and methanol: growth kinetics and production improvement.

J Ind Microbiol Biotechnol 2003 Apr 2;30(4):210-5. Epub 2003 Apr 2.

Department of Chemical Engineering, University of Nebraska-Lincoln, 207M Othmer Hall, Lincoln, NE 68583-0919, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-003-0035-3DOI Listing
April 2003