Michael Lehrke

Michael Lehrke

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Michael Lehrke

Michael Lehrke

Publications by authors named "Michael Lehrke"

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Myocardial infarction is sufficient to increase GLP-1 secretion, leading to improved left ventricular contractility and mitochondrial respiratory capacity.

Diabetes Obes Metab 2018 12 16;20(12):2911-2918. Epub 2018 Aug 16.

Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1111/dom.13472DOI Listing
December 2018

Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy.

Diabetes 2018 11 13;67(11):2410-2419. Epub 2018 Aug 13.

Department of Internal Medicine I, University Hospital RWTH Aachen, Aachen, Germany

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http://dx.doi.org/10.2337/db17-1212DOI Listing
November 2018

Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting .

Diabetes 2017 12 29;66(12):3072-3084. Epub 2017 Sep 29.

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, Munich, Germany

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db17
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http://dx.doi.org/10.2337/db17-0313DOI Listing
December 2017

Dermatopontin in Bone Marrow Extracellular Matrix Regulates Adherence but Is Dispensable for Murine Hematopoietic Cell Maintenance.

Stem Cell Reports 2017 09 24;9(3):770-778. Epub 2017 Aug 24.

Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599243PMC
September 2017

Effect of Empagliflozin on the Metabolic Signature of Patients With Type 2 Diabetes Mellitus and Cardiovascular Disease.

Circulation 2017 09;136(10):969-972

From Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Germany (B.A.K., M.L., K.S., C.L., N.M.); Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (A.A., J.A.); Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising, Germany (J.A.); and German Center for Diabetes Research, Neuherberg, Germany (J.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029166DOI Listing
September 2017

Diabetes Mellitus and Heart Failure.

Am J Cardiol 2017 07 30;120(1S):S37-S47. Epub 2017 May 30.

Department of Internal Medicine I, University Hospital Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.05.014DOI Listing
July 2017

Diabetes Mellitus and Heart Failure.

Am J Med 2017 Jun;130(6S):S40-S50

Department of Internal Medicine I, University Hospital Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2017.04.010DOI Listing
June 2017

The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism.

Diabetes Obes Metab 2017 04 22;19(4):496-508. Epub 2017 Feb 22.

Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/dom.12839DOI Listing
April 2017

The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum.

Innate Immun 2016 11 21;22(8):612-619. Epub 2016 Sep 21.

1 Department of Intensive Care and Intermediate Care, University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1177/1753425916667474DOI Listing
November 2016

Arrhythmia causes lipid accumulation and reduced glucose uptake.

Basic Res Cardiol 2015 28;110(4):40. Epub 2015 May 28.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany,

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http://dx.doi.org/10.1007/s00395-015-0497-2DOI Listing
February 2016

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes.

Shock 2015 Dec;44(6):569-77

*Department of Intensive Care and Intermediate Care †Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital Aachen ‡Institute of Biochemistry and Molecular Biology §Department of Medical Statistics, RWTH Aachen University, Aachen, Germany.

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http://pdfs.journals.lww.com/shockjournal/2015/12000/Soluble
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SHK.0000000000000462DOI Listing
December 2015

High-Risk Cardiovascular Patients: Clinical Features, Comorbidities, and Interconnecting Mechanisms.

Front Immunol 2015 23;6:591. Epub 2015 Nov 23.

Department of Internal Medicine I, University Hospital RWTH Aachen , Aachen , Germany.

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http://dx.doi.org/10.3389/fimmu.2015.00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655316PMC
December 2015

PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.

J Mol Cell Cardiol 2015 Apr 30;81:23-33. Epub 2015 Jan 30.

Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany; Department of Cardiology and Angiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828150002
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http://dx.doi.org/10.1016/j.yjmcc.2015.01.015DOI Listing
April 2015

[Prevention of cardiovascular disease in patients with type 2 diabetes].

Dtsch Med Wochenschr 2015 Apr 29;140(9):645-9. Epub 2015 Apr 29.

Medizinische Klinik I, Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin, Uniklinikum Aachen.

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http://dx.doi.org/10.1055/s-0041-101942DOI Listing
April 2015

AAV-mediated gene therapy for atherosclerosis.

Curr Atheroscler Rep 2014 Sep;16(9):434

Department of Cardiology, University Hospital Aachen, Pauwelstr. 30, 52074, Aachen, Germany.

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http://link.springer.com/10.1007/s11883-014-0434-0
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http://dx.doi.org/10.1007/s11883-014-0434-0DOI Listing
September 2014

Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ mice.

Atherosclerosis 2013 Dec 5;231(2):427-35. Epub 2013 Sep 5.

Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstraße 30, D-52074 Aachen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150130050
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http://dx.doi.org/10.1016/j.atherosclerosis.2013.08.033DOI Listing
December 2013

New antidiabetic therapies: innovative strategies for an old problem.

Curr Opin Lipidol 2012 Dec;23(6):569-75

Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOL.0b013e328359b19fDOI Listing
December 2012

Cardiovascular effects of incretin-based therapies.

Rev Diabet Stud 2011 10;8(3):382-91. Epub 2011 Nov 10.

Department of Internal Medicine I, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.1900/RDS.2011.8.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280672PMC
June 2012

BMI and hyperinsulinemia in children.

Clin Biochem 2009 Sep 25;42(13-14):1427-30. Epub 2009 Jun 25.

Institute of Clinical Chemistry, University of Munich, Marchioninistr. 15, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.clinbiochem.2009.06.011DOI Listing
September 2009

Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians.

Clin Endocrinol (Oxf) 2009 May 15;70(5):698-705. Epub 2008 Aug 15.

Cardiovascular Institute, Institute for Translational Medicine and Therapeutics, and Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1111/j.1365-2265.2008.03375.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108432PMC
May 2009

Adipokines and insulin resistance.

Mol Med 2008 Nov-Dec;14(11-12):741-51. Epub 2008 Sep 17.

Department of Internal Medicine II, University of Munich, Munich, Germany.

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http://www.molmed.org/content/pdfstore/741_751.Rabe.00058.PD
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http://dx.doi.org/10.2119/2008-00058.RabeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582855PMC
May 2009

CXCL16 is a surrogate marker of inflammatory bowel disease.

Scand J Gastroenterol 2008 Mar;43(3):283-8

Department of Internal Medicine II, University of Munich, Germany.

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March 2008

Resistin is an inflammatory marker of inflammatory bowel disease in humans.

Eur J Gastroenterol Hepatol 2007 Dec;19(12):1070-4

Department of Internal Medicine II, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1097/MEG.0b013e3282f16251DOI Listing
December 2007

CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans.

J Am Coll Cardiol 2007 Jan 12;49(4):442-9. Epub 2007 Jan 12.

Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jacc.2006.09.034DOI Listing
January 2007

The many faces of PPARgamma.

Cell 2005 Dec;123(6):993-9

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2005.11.026DOI Listing
December 2005

PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1.

J Clin Invest 2005 Aug 7;115(8):2244-56. Epub 2005 Jul 7.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6149, USA.

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http://dx.doi.org/10.1172/JCI24130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172230PMC
August 2005

Gaining weight: the Keystone Symposium on PPAR and LXR.

Genes Dev 2005 Aug;19(15):1737-42

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1341005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182333PMC
August 2005

Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone.

J Clin Endocrinol Metab 2005 Jun 1;90(6):3423-6. Epub 2005 Mar 1.

Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/jc.2005-0287DOI Listing
June 2005

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.

Cell Metab 2005 May;1(5):297-308

Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.04.005DOI Listing
May 2005

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes.

Diabetes 2005 Mar;54(3):603-8

Yale University School of Medicine, Department of Internal Medicine, 300 Cedar St., S263 TAC, P.O. Box 9812, New Haven, CT 06520-8020, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995496PMC
March 2005

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.

Genes Dev 2005 Feb 28;19(4):453-61. Epub 2005 Jan 28.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1263305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548946PMC
February 2005

Resistin is an inflammatory marker of atherosclerosis in humans.

Circulation 2005 Feb 14;111(7):932-9. Epub 2005 Feb 14.

Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pa, USA.

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http://dx.doi.org/10.1161/01.CIR.0000155620.10387.43DOI Listing
February 2005

An inflammatory cascade leading to hyperresistinemia in humans.

PLoS Med 2004 Nov 30;1(2):e45. Epub 2004 Nov 30.

Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1371/journal.pmed.0010045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529430PMC
November 2004

Inflamed about obesity.

Nat Med 2004 Feb;10(2):126-7

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http://dx.doi.org/10.1038/nm0204-126DOI Listing
February 2004

Novel insulin sensitizers: pharmacogenomic aspects.

Pharmacogenomics 2002 Jan;3(1):99-116

Medical Department 2, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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https://www.futuremedicine.com/doi/abs/10.1517/14622416.3.1.
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http://dx.doi.org/10.1517/14622416.3.1.99DOI Listing
January 2002