Michael Lahn

Michael Lahn

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Michael Lahn

Michael Lahn

Publications by authors named "Michael Lahn"

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Novel transforming growth factor beta receptor I kinase inhibitor galunisertib (LY2157299) in advanced hepatocellular carcinoma.

Liver Int 2019 Aug 3;39(8):1468-1477. Epub 2019 Jun 3.

National Institute of Gastroenterology, Research Instituts "S. De Bellis" Research Hospital, Castellana Grotte, Bari, Italy.

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http://dx.doi.org/10.1111/liv.14113DOI Listing
August 2019

Phase 1b study of galunisertib in combination with gemcitabine in Japanese patients with metastatic or locally advanced pancreatic cancer.

Cancer Chemother Pharmacol 2017 Jun 27;79(6):1169-1177. Epub 2017 Apr 27.

National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-017-3313-xDOI Listing
June 2017

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma.

Neuro Oncol 2016 08 21;18(8):1146-56. Epub 2016 Feb 21.

Medical Oncology Department, Bellaria-Maggiore Hospitals, Azienda USL - IRCCS Institute of Neurological Sciences, Bologna, Italy (A.A.B.); Hôpital Avicenne, Paris 13 University, Bobigny, France (A.F.C.); University of California San Diego Health System, La Jolla, California (S.K.); Hospital Universitario 12 de Octubre, Madrid, Spain (J.M.S.-S.); Department of Oncology, Royal North Shore Hospital, St Leonards, Australia (H.R.W.); CHU Hôspital De La Timone, Rue Saint Pierre, France (O.C.); Austin Hospital, Heidelberg, Australia (L.C.); Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Frankfurt, Germany (J.P.S.); Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany (D.C.); Antwerp University Hospital, Edegem, Belgium (P.S.); Medical Oncology, Vall d'Hebron University Hospital and Universitat Autònoma de Barcelona, Barcelona, Spain (J.R.); Eli Lilly and Company, Erl Wood, England (A.C., C.S., I.G., C.M.); Eli Lilly and Company, Indianapolis, Indiana (S.C.G., D.D., M.M.L.); Neurology Clinic, University of Heidelberg, Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1093/neuonc/now009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933481PMC
August 2016

Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis.

Oncoimmunology 2016 May 29;5(5):e1123366. Epub 2015 Dec 29.

Department of Molecular & Radiation Oncology, German Cancer Research Center (DKFZ), 280 INF, Heidelberg, Germany; Department of Radiation Oncology, University Hospital Center, 400 INF, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2015.1123366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910723PMC
May 2016

Why are we failing to implement imaging studies with radiolabelled new molecular entities in early oncology drug development?

ScientificWorldJournal 2014 18;2014:269605. Epub 2014 Aug 18.

Early Phase Oncology Clinical Investigation, Eli Lilly Corporate Center, Building 31/4, 893 S. Delaware Street, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1155/2014/269605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151371PMC
May 2015

Evaluation of antitumor activity using change in tumor size of the survivin antisense oligonucleotide LY2181308 in combination with docetaxel for second-line treatment of patients with non-small-cell lung cancer: a randomized open-label phase II study.

J Thorac Oncol 2014 Nov;9(11):1704-8

*Cedars-Sinai Medical Center, Los Angeles, California; †The Lung Cancer Group, The Christie and University Hospital of South Manchester, Manchester, United Kingdom; ‡Memorial Cancer Centre of Oncology and Institute Department of Lung Cancer and Chest Tumours, Warsaw, Poland; §Poznań University of Medical Sciences, Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznań, Poland; ‖Karmanos Cancer Center, Detroit, Michigan; ¶Lung Cancer Unit, IRCCS AOU San Martino IST, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy; #Gemeinschaftspraxis für Haematologie, Onkologie und Palliativmedizin, Münster, Germany; **Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida; ††St. Vincentius-Kliniken gAG - Med. Klinik Abt. 2, Karlsruhe, Germany; ‡‡Sheffield Experimental Cancer Medicine Centre, Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Sheffield, United Kingdom; §§Internal Medicine, Karmanos Cancer Institute, Detroit, Michigan; ‖‖Eli Lilly and Company, Windlesham, United Kingdom; ¶¶Eli Lilly and Company, Basingstoke, Hampshire, United Kingdom; ##Eli Lilly and Company, Indianapolis, Indiana; and ***Department of Oncology, University of Oxford, Cancer and Haematology Center, Churchill Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1097/JTO.0000000000000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340255PMC
November 2014

Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation.

Strahlenther Onkol 2014 Oct 27;190(11):1037-45. Epub 2014 May 27.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany,

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http://link.springer.com/content/pdf/10.1007/s00066-014-0686
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http://link.springer.com/10.1007/s00066-014-0686-1
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http://dx.doi.org/10.1007/s00066-014-0686-1DOI Listing
October 2014

Transforming growth factor-β as a therapeutic target in hepatocellular carcinoma.

Cancer Res 2014 Apr 17;74(7):1890-4. Epub 2014 Mar 17.

Authors' Affiliations: Department of Biomedical Science and Human Oncology, University of Bari Medical School, Bari; Department of Internal Medicine, University of Modena and Reggio, Modena, Italy; and Early Phase Clinical Investigation, Eli Lilly and Company, Indianapolis, Indiana.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0243DOI Listing
April 2014

In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography.

J Oncol 2009 27;2009:596560. Epub 2009 May 27.

Section of Pediatric Hematology & Oncology, Herman B Wells Center for Pediatric Research, Indiana University Simon Cancer Center, 1044 West Walnut Street R4 321, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1155/2009/596560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688651PMC
July 2013

Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma.

Oncoimmunology 2012 Sep;1(6):943-945

Departments of Translational Radiation Oncology, German Cancer Research Center (DKFZ); Heidelberg, Germany ; Department of Radiation Oncology; University Hospital Center; Heidelberg, Germany ; Department of Oncology; Tongji Hospital, Tongji Medical College; Huazhong University of Science and Technology; Wuhan, China.

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http://dx.doi.org/10.4161/onci.19789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489753PMC
September 2012

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.

Cancer Res 2011 Dec 17;71(23):7155-67. Epub 2011 Oct 17.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1212DOI Listing
December 2011

Inhibiting TGF-β signaling in hepatocellular carcinoma.

Biochim Biophys Acta 2011 Apr 1;1815(2):214-23. Epub 2010 Dec 1.

Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine; University of Bari Medical School, Bari, Italy.

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http://dx.doi.org/10.1016/j.bbcan.2010.11.004DOI Listing
April 2011

Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer.

Int J Colorectal Dis 2009 Jun 10;24(6):641-5. Epub 2009 Mar 10.

Danish Colorectal Cancer Group South, Vejle Hospital, 7100, Vejle, Denmark.

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http://dx.doi.org/10.1007/s00384-009-0680-8DOI Listing
June 2009

Safety of multi-targeted kinase inhibitors as monotherapy treatment of cancer: a systematic review of the literature.

Curr Drug Saf 2009 May;4(2):143-54

United BioSource Corporation, 101 Station Landing, Medford, MA 02155, USA.

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http://dx.doi.org/10.2174/157488609788173026DOI Listing
May 2009

Reduction of HLA-DR+ lymphocytes after treatment with enzastaurin in patients with metastatic thyroid cancer.

Chemotherapy 2008 31;54(4):268-73. Epub 2008 Jul 31.

Klinikum Nurnberg Nord, Medizinische Klinik 5, Onkologie und Hämatologie, Nürnberg, Germany.

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http://dx.doi.org/10.1159/000149717DOI Listing
January 2009

Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 Mitogen-activated protein kinases for treatment of cancer. A systematic review of the literature.

Med Oncol 2008 19;25(3):323-30. Epub 2008 Jan 19.

United BioSource Corporation (formerly MetaWorks, Inc.), 101 Station Landing, Medford, MA 02155, USA.

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http://dx.doi.org/10.1007/s12032-008-9039-1DOI Listing
December 2008

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice.

Eur J Cancer 2008 Jan 26;44(1):142-50. Epub 2007 Nov 26.

Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1016/j.ejca.2007.10.008DOI Listing
January 2008

Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer.

Clin Cancer Res 2007 Aug;13(15 Pt 2):s4641-6

M. D. Anderson Cancer Center, Houston, University of Texas, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0538DOI Listing
August 2007

Randomized clinical trial of morphine in acute abdominal pain.

Ann Emerg Med 2006 Aug;48(2):150-60, 160.e1-4

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10463, USA.

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http://dx.doi.org/10.1016/j.annemergmed.2005.11.020DOI Listing
August 2006

The role of protein kinase C-alpha in hematologic malignancies.

Acta Haematol 2006 ;115(1-2):1-8

Division of Oncology Product Development, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1159/000089458DOI Listing
February 2006

Distribution and leukocyte contacts of gammadelta T cells in the lung.

J Leukoc Biol 2005 Nov 4;78(5):1086-96. Epub 2005 Oct 4.

Departments of Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1189/jlb.0505244DOI Listing
November 2005

Concordance between capnography and arterial blood gas measurements of carbon dioxide in acute asthma.

Ann Emerg Med 2005 Oct;46(4):323-7

Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.annemergmed.2004.12.005DOI Listing
October 2005

TGF-beta inhibitors for the treatment of cancer.

Expert Opin Investig Drugs 2005 Jun;14(6):629-43

Eli Lilly & Company Research Laboratories, Therapeutic Area Oncology, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1517/13543784.14.6.629DOI Listing
June 2005

Protein kinase C alpha expression in breast and ovarian cancer.

Oncology 2004 ;67(1):1-10

Divison of Oncology Product Development, Lilly Research Laboratories, Eli Lilly, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1159/000080279DOI Listing
October 2004

Randomized clinical trial of intramuscular vs oral methylprednisolone in the treatment of asthma exacerbations following discharge from an emergency department.

Chest 2004 Aug;126(2):362-8

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th St, Bronx, NY 10467, USA.

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http://dx.doi.org/10.1378/chest.126.2.362DOI Listing
August 2004

The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen.

Curr Pharm Des 2004 ;10(16):1923-36

Department of Medicine, AK St. Georg, Lohmühlenstrasse 5, D-20099 Hamburg, FR-Germany.

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http://dx.doi.org/10.2174/1381612043384376DOI Listing
July 2004

Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.

Int Arch Allergy Immunol 2004 May 25;134(1):49-55. Epub 2004 Mar 25.

Department of Immunology, National Jewish Medical and Research Center, Denver, Colo, USA.

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http://dx.doi.org/10.1159/000077533DOI Listing
May 2004

The role of protein kinase C-alpha (PKC-alpha) in melanoma.

Melanoma Res 2004 Apr;14(2):85-9

Divison of Oncology Product Development, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1097/00008390-200404000-00002DOI Listing
April 2004

The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review).

Oncol Rep 2004 Feb;11(2):515-22

Eli Lilly and Company, Oncology Product Development, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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February 2004

Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation.

J Leukoc Biol 2004 Jan 2;75(1):68-75. Epub 2003 Oct 2.

Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1189/jlb.0703326DOI Listing
January 2004

Targeting protein kinase C-alpha (PKC-alpha) in cancer with the phosphorothioate antisense oligonucleotide aprinocarsen.

Ann N Y Acad Sci 2003 Dec;1002:263-70

Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1196/annals.1281.029DOI Listing
December 2003

Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue.

Immunology 2003 Oct;110(2):225-33

Departments of BioRTP, Infectious Disease, and Cardiovascular Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783033PMC
http://dx.doi.org/10.1046/j.1365-2567.2003.01724.xDOI Listing
October 2003

Increased blood lead levels in severe smoke inhalation.

Am J Emerg Med 2003 Oct;21(6):458-60

Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, New York 10467, USA.

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http://dx.doi.org/10.1016/s0735-6757(03)00105-0DOI Listing
October 2003

Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer.

Semin Oncol 2003 Apr;30(2 Suppl 3):30-3

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46225, USA.

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http://dx.doi.org/10.1053/sonc.2003.37273DOI Listing
April 2003

Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells.

J Immunol 2002 Oct;169(8):4190-7

Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.169.8.4190DOI Listing
October 2002

MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness.

Proc Natl Acad Sci U S A 2002 Jun 17;99(13):8850-5. Epub 2002 Jun 17.

Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1073/pnas.132519299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124387PMC
June 2002

Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner.

J Allergy Clin Immunol 2002 May;109(5):810-6

Division of Cell Biology, the Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA.

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http://dx.doi.org/10.1067/mai.2002.123531DOI Listing
May 2002