Michael Laffan

Michael Laffan

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Michael Laffan

Michael Laffan

Publications by authors named "Michael Laffan"

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54Publications

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Patient experience of COPD care: outcomes from the British Lung Foundation Patient Passport.

BMJ Open Respir Res 2019 3;6(1):e000478. Epub 2019 Oct 3.

National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/bmjresp-2019-000478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797266PMC
October 2019

Patterns of breathlessness and associated consulting behaviour: results of an online survey.

Thorax 2019 Aug 8;74(8):814-817. Epub 2019 Apr 8.

National Heart and Lung Institute, Imperial College, London, UK

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http://dx.doi.org/10.1136/thoraxjnl-2018-212950DOI Listing
August 2019

Partial rescue of naturally occurring active site factor X variants through decreased inhibition by tissue factor pathway inhibitor and antithrombin.

J Thromb Haemost 2019 Aug 29. Epub 2019 Aug 29.

Centre for Haematology, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/jth.14627DOI Listing
August 2019

Thrombophilia in non-thrombotic chronic venous disease of the lower limb - a systematic review.

Br J Haematol 2018 12;183(5):703-716

Department of Vascular Surgery, Imperial College London, Charing Cross Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.15692DOI Listing
December 2018

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

N Engl J Med 2017 12 9;377(26):2519-2530. Epub 2017 Dec 9.

From Hampshire Hospitals NHS Foundation Trust, Basingstoke (S.R.), University Hospitals Birmingham NHS Foundation Trust, Edgbaston (W.L.), Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (D.P.), and the Centre for Haemostasis and Thrombosis, St. Thomas' Hospital (B.M.), Imperial College London and NIHR Clinical Research Facility at Imperial College Healthcare NHS Trust (M.L.), and Barts and the London School of Medicine and Dentistry (K.J.P.), London - all in the United Kingdom; and BioMarin Pharmaceutical, Novato (L.W., H.Y., C.V., W.Y.W.), and private consultant, La Jolla (G.F.P.) - both in California.

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http://www.nejm.org/doi/10.1056/NEJMoa1708483
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http://dx.doi.org/10.1056/NEJMoa1708483DOI Listing
December 2017

The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study-Brief Report.

Arterioscler Thromb Vasc Biol 2017 09 6;37(9):1788-1792. Epub 2017 Jul 6.

From the Imperial College Healthcare NHS Trust, London, United Kingdom (D.G., M.A.L.); Department of Clinical Pharmacology and Therapeutics (D.G.), Department of Haematology (M.A.L.), and Department of Population Health and Occupational Disease (C.M.), Imperial College London, United Kingdom; Institute for Biomedicine, Eurac Research, Bolzano, Italy (F.D.G.M.); and Centre for Cardiovascular Genetics (A.P.W.), and Division of Biosciences (S.K.S.S.), University College London, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.117.309757DOI Listing
September 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

Blood 2016 10 23;128(15):1959-1968. Epub 2016 Aug 23.

Haemostasis Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James's Hospital, National Centre for Hereditary Coagulation Disorders, St. James's Hospital, Dublin, Ireland; and Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1182/blood-2016-04-709436DOI Listing
October 2016

A whole genome approach to platelet and bleeding disorders.

Authors:
Michael Laffan

Hamostaseologie 2016 Aug 19;36(3):161-6. Epub 2016 Jan 19.

Mike Laffan, Professor of Haemostasis and Thrombosis, Honorary Consultant in Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, Ducane Road, London W12 ONN, E-mail:

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http://dx.doi.org/10.5482/HAMO-14-11-0056DOI Listing
August 2016

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood 2016 06 15;127(23):2791-803. Epub 2016 Apr 15.

Department of Haematology, University of Cambridge, National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-12-688267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016734PMC
June 2016

Inherited platelet disorders: toward DNA-based diagnosis.

Blood 2016 06 19;127(23):2814-23. Epub 2016 Apr 19.

Department of Haematology, University of Cambridge, Cambridge, United Kingdom; National Health Service Blood and Transplant, Cambridge, United Kingdom; National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge, United Kingdom; and Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2016-03-378588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972611PMC
June 2016

Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study.

Intractable Rare Dis Res 2016 May;5(2):109-13

National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, UK; HHTIC London, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.5582/irdr.2016.01019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869576PMC
May 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/scitranslmed.aad7666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903547PMC
March 2016

Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality.

BMJ 2014 Jul 22;349:g4561. Epub 2014 Jul 22.

Centre for Perioperative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W12 0HS, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106199PMC
http://dx.doi.org/10.1136/bmj.g4561DOI Listing
July 2014

Transfusion for acute upper gastrointestinal bleeding.

N Engl J Med 2013 04;368(14):1362

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http://dx.doi.org/10.1056/NEJMc1301256DOI Listing
April 2013

Clinical phenotype, laboratory features and genotype of 35 patients with heritable dysfibrinogenaemia.

Br J Haematol 2013 Jan 15;160(2):220-7. Epub 2012 Oct 15.

Centre for Haematology, Division of Experimental Medicine, Department of Medicine and Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.12085DOI Listing
January 2013

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions.

Blood 2012 Jul 19;120(1):214-22. Epub 2012 Apr 19.

Department of Haematology, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK.

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http://dx.doi.org/10.1182/blood-2012-02-410050DOI Listing
July 2012

Safety of recombinant activated factor VII in randomized clinical trials.

N Engl J Med 2011 02;364(6):574; author reply 575-6

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http://dx.doi.org/10.1056/NEJMc1013591DOI Listing
February 2011

Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor.

Blood 2010 Jul 23;116(4):640-8. Epub 2010 Apr 23.

Department of Haematology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK.

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http://dx.doi.org/10.1182/blood-2010-02-267450DOI Listing
July 2010

Monitoring heparin anticoagulation in the acute phase response.

Br J Haematol 2010 May 11;149(4):613-9. Epub 2010 Mar 11.

Department of Haematology, Imperial College, and Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08129.xDOI Listing
May 2010

Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis.

Blood 2005 Sep 10;106(6):1988-91. Epub 2005 May 10.

Haematology Dept, Imperial College London, 5th Floor, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-02-07
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http://dx.doi.org/10.1182/blood-2005-02-0792DOI Listing
September 2005

Thrombocythemia and hemoperitoneum after transvaginal oocyte retrieval for in vitro fertilization.

Fertil Steril 2004 Sep;82(3):735-7

IVF Unit, Department of Reproductive Medicine and Science, Hammersmith Hospital, Imperial College School of Medicine, Du Cane Road, London W12 0HS, United Kingdom.

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http://dx.doi.org/10.1016/j.fertnstert.2004.01.044DOI Listing
September 2004

Two novel mutations in severe factor VII deficiency.

Br J Haematol 2004 Jul;126(1):105-10

Haemostasis and Thrombosis, MRC Clinical Sciences Centre, The Faculty of Medicine, Imperial College, Du Cane Road, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2004.04997.xDOI Listing
July 2004

Hunting for the mutation in inherited thrombophilia.

Blood Coagul Fibrinolysis 2004 Mar;15(2):125-7

MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1097/00001721-200403000-00002DOI Listing
March 2004

Recombinant FVIIa in the management of uncontrolled hemorrhage.

Transfusion 2003 Dec;43(12):1711-6

Katherine Dormandy Hemophilia Center, Royal Free and University College Medical School, London.

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http://dx.doi.org/10.1046/j.0041-1132.2003.00577.xDOI Listing
December 2003

Beta-adrenergic receptor polymorphisms in patients with elevated factor VIII levels with venous thrombosis.

Br J Haematol 2003 Oct;123(1):139-41

Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04571.xDOI Listing
October 2003

Dissociation of ABH antigen expression from von Willebrand factor synthesis in endothelial cell lines.

Br J Haematol 2003 Jun;121(6):928-31

Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, Ducane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04366.xDOI Listing
June 2003

Analysis and results of the recombinant factor VIIa extended-use registry.

Blood Coagul Fibrinolysis 2003 Jun;14 Suppl 1:S35-8

The Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital W12 0NN, UK.

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http://dx.doi.org/10.1097/00001721-200306001-00009DOI Listing
June 2003

Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

Blood 2003 Feb 10;101(4):1416-8. Epub 2002 Oct 10.

Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-08-23
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http://dx.doi.org/10.1182/blood-2002-08-2353DOI Listing
February 2003

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy.

Br J Haematol 2002 Aug;118(2):589-94

Haemostasis Research, MRC Clinical Sciences Centre, Faculty of Medicine at Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03617.xDOI Listing
August 2002

Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels.

Arterioscler Thromb Vasc Biol 2002 Feb;22(2):335-41

Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1161/hq0202.103997DOI Listing
February 2002

Genotype at the secretor blood group locus is a determinant of plasma von Willebrand factor level.

Br J Haematol 2002 Feb;116(2):350-6

Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03270.xDOI Listing
February 2002