Publications by authors named "Michael L Stromyer"

4 Publications

  • Page 1 of 1

Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Bioorg Med Chem 2021 Jan 28;30:115893. Epub 2020 Nov 28.

Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA. Electronic address:

A series of novel bis-imidazolium salts was synthesized, characterized, and evaluated in vitro against a panel of non-small cell lung cancer (NSCLC) cells. Two imidazolium cores were connected with alkyl chains of varying lengths to develop a structure activity relationship (SAR). Increasing the length of the connecting alkyl chain was shown to correlate to an increase in the anti-proliferative activity. The National Cancer Institute's NCI-60 human tumor cell line screen confirmed this trend. The compound containing a decyl linker chain, 10, was chosen for further in vivo toxicity studies with C578BL/6 mice. The compound was well tolerated by the mice and all of the animals survived and gained weight over the course of the study.
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http://dx.doi.org/10.1016/j.bmc.2020.115893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903221PMC
January 2021

Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.

Eur J Med Chem 2020 Jan 31;185:111832. Epub 2019 Oct 31.

Molecular Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA. Electronic address:

Imidazolium salts have shown great promise as anticancer materials. A new imidazolium salt (TPP1), with a triphenylphosphonium substituent, has been synthesized and evaluated for in vitro and in vivo cytotoxicity against bladder cancer. TPP1 was determined to have a GI ranging from 200 to 250 μM over a period of 1 h and the ability to effectively inhibit bladder cancer. TPP1 induces apoptosis, and it appears to act as a direct mitochondrial toxin. TPP1 was applied intravesically to a bladder cancer mouse model based on the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Cancer selectivity of TPP1 was demonstrated, as BBN-induced tumors exhibited apoptosis but normal adjacent urothelium did not. These results suggest that TPP1 may be a promising intravesical agent for the treatment of bladder cancer.
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http://dx.doi.org/10.1016/j.ejmech.2019.111832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224591PMC
January 2020

Synthesis and Characterization of Cobalt(II) ,'-Diphenylazodioxide Complexes.

ACS Omega 2018 Nov 27;3(11):16021-16027. Epub 2018 Nov 27.

Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44114, United States.

Removal of chloride from CoCl with TlPF in acetonitrile, followed by addition of excess nitrosobenzene, yielded the eight-coordinate cobalt(II) complex salt [Co{Ph(O)NN(O)Ph}](PF), shown by single-crystal X-ray analysis to have a distorted tetragonal geometry. The analogous treatment of the bipyridyl complex Co(bpy)Cl yielded the mixed-ligand cobalt(II) complex salt [Co(bpy){Ph(O)NN(O)Ph}](PF), whose single-crystal X-ray structure displays a trigonal prismatic geometry, similar to that of the iron(II) cation in the previously known complex salt [Fe{Ph(O)NN(O)Ph}](FeCl). The use of TlPF to generate solvated metal complex cations from chloride salts or chlorido complexes, followed by the addition of nitrosobenzene, is shown to be a useful synthetic strategy for the preparation of azodioxide complex cations with the noncoordinating, diamagnetic PF counteranion. Coordination number appears to be more important than electron count in determining the geometry and metal-ligand bond distances of diphenylazodioxide complexes.
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http://dx.doi.org/10.1021/acsomega.8b01200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643636PMC
November 2018

Crystal structures of [Ln(NO3)3(μ2-bpydo)2], where Ln = Ce, Pr or Nd, and bpydo = 4,4'-bi-pyridine N,N'-dioxide: layered coordination networks containing 4(4) grids.

Acta Crystallogr E Crystallogr Commun 2016 Jan 1;72(Pt 1):25-30. Epub 2016 Jan 1.

Department of Chemistry Mathematics and Physics, Clarion University, 840 Wood Street, Clarion, PA 16214, USA.

Three isostructural coordination networks of Ce, Pr, and Nd nitrate with 4,4'-bi-pyridine N,N'-dioxide (bpydo) are reported, namely poly[[tris-(nitrato-κ(2) O,O')cerium(III)]-bis-(μ2-4,4'-bi-pyridine N,N'-dioxide-κ(2) N:N')], [Ce(NO3)3(C10H8N2O2)2], poly[[tris-(nitrato-κ(2) O,O')praeseodymium(III)]-bis-(μ2-4,4'-bi-pyridine N,N'-dioxide-κ(2) N:N')], [Pr(NO3)3(C10H8N2O2)2], and poly[[tris(nitrato-κ(2) O,O')neodymium(III)]-bis-(μ2-4,4'-bi-pyridine N,N'-dioxide-κ(2) N:N'], [Nd(NO3)3(C10H8N2O2)2]. All three compounds are isostructural to the previously reported La analogue. The asymmetric unit of [Ln(NO3)3(μ2-bpydo)2] contains one lanthanide cation, two bpydo ligands, and three nitrate anions. Both bpydo ligands act as end-to-end μ2-bridges and display nearly ideal cis and gauche conformations, respectively. The bpydo ligands link the ten-coordinate Ln (III) cations, forming inter-digitating 4(4) grid-like layers extending parallel to (-101), where inter-digitation of layers is promoted by C-H⋯O inter-actions between nitrate anions and bpydo ligands. The inter-digitated layers are linked to sets of neighboring layers via further C-H⋯O and π-π inter-actions.
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http://dx.doi.org/10.1107/S205698901502318XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704766PMC
January 2016