Michael L Fitzgerald

Michael L Fitzgerald

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Michael L Fitzgerald

Michael L Fitzgerald

Publications by authors named "Michael L Fitzgerald"

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Healthy aging with HIV: The role of self-management support.

Patient Educ Couns 2019 08 21;102(8):1565-1569. Epub 2019 Feb 21.

C.T. Lamont Primary Health Care Research Centre, Bruyère Research Institute, 43 Bruyère St, Ottawa, ON, K1N 5C8, Canada; Department of Family Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada; Institute of Clinical and Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pec.2019.02.019DOI Listing
August 2019

Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal.

J Exp Biol 2018 07 9;221(Pt 13). Epub 2018 Jul 9.

Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA

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http://dx.doi.org/10.1242/jeb.178491DOI Listing
July 2018

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Cell 2018 01;172(1-2):162-175.e14

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324559PMC
January 2018

HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Antiretroviral Therapy.

J Clin Endocrinol Metab 2017 11;102(11):4250-4259

Lipid Metabolism Unit/Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/jc.2017-01334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673269PMC
November 2017

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Sci Transl Med 2016 Apr;8(333):333ra50

Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany. German Center of Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7489 Trondheim, Norway. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad6100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878149PMC
April 2016

HIV infection induces structural and functional changes in high density lipoproteins.

Atherosclerosis 2015 Nov 29;243(1):19-29. Epub 2015 Aug 29.

Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609619PMC
November 2015

LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.

Biochemistry 2015 Nov 9;54(46):6931-41. Epub 2015 Nov 9.

Lipid Metabolism Unit, Massachusetts General Hospital (MGH), Center for Computational & Integrative Biology (CCIB), Richard B. Simches Research Center , 185 Cambridge Street, 7th Floor #7150, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b00894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874254PMC
November 2015

Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.

J Pharmacol Exp Ther 2015 Sep 30;354(3):376-83. Epub 2015 Jun 30.

George Washington University School of Medicine and Health Sciences, Washington, DC (A.R., L.D., T.P., S.K., D.S.R., M.B.); Baker International Diabetes Institute, Heart and Diabetes Institute, Melbourne, Victoria, Australia (D.S.); and Harvard Medical School, Lipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts (M.L.F.)

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22448
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http://dx.doi.org/10.1124/jpet.115.224485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538872PMC
September 2015

Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice.

J Nutr Biochem 2015 Jun 4;26(6):585-95. Epub 2015 Feb 4.

Department of Biology, University of Copenhagen, Copenhagen, Denmark; National Institute of Nutrition and Seafood Research, Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2014.12.005DOI Listing
June 2015

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

J Lipid Res 2014 Mar 30;55(3):493-503. Epub 2013 Nov 30.

Lipid Metabolism Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1194/jlr.M044941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934733PMC
March 2014

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

Nat Immunol 2014 Feb 8;15(2):152-60. Epub 2013 Dec 8.

1] Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, Bonn, Germany. [2] Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany. [4].

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http://dx.doi.org/10.1038/ni.2784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009731PMC
February 2014

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Atherosclerosis 2011 Aug 23;217(2):407-14. Epub 2011 Jun 23.

Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150110055
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http://dx.doi.org/10.1016/j.atherosclerosis.2011.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150192PMC
August 2011

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

J Lipid Res 2010 Sep 22;51(9):2591-9. Epub 2010 May 22.

Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1194/jlr.M006049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918442PMC
September 2010

Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.

Biochemistry 2010 Sep;49(38):8338-49

Lipid Metabolism Unit, Center for Computational and Integrative Biology, Richard B. Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, 7th Floor #7150, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1021/bi100466qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943568PMC
September 2010

ABC transporters, atherosclerosis and inflammation.

Atherosclerosis 2010 Aug 21;211(2):361-70. Epub 2010 Jan 21.

Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2010.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888932PMC
August 2010

MiR-33 contributes to the regulation of cholesterol homeostasis.

Science 2010 Jun 13;328(5985):1570-3. Epub 2010 May 13.

Department of Medicine, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1189862
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http://dx.doi.org/10.1126/science.1189862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114628PMC
June 2010

Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.

J Biol Chem 2009 Sep 10;284(37):24881-90. Epub 2009 Jul 10.

Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M109.014365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757191PMC
September 2009

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.

J Biol Chem 2008 Dec 27;283(52):36624-35. Epub 2008 Oct 27.

Lipid Metabolism Unit, Department of Medicine, Center for Computational & Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807377200
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http://dx.doi.org/10.1074/jbc.M807377200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605993PMC
December 2008

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Biochemistry 2008 Jun 17;47(23):6138-47. Epub 2008 May 17.

Lipid Metabolism Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1021/bi800182tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504083PMC
June 2008

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.

J Lipid Res 2007 Mar 1;48(3):621-32. Epub 2006 Dec 1.

Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1194/jlr.M600449-JLR200DOI Listing
March 2007

Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression.

Arterioscler Thromb Vasc Biol 2006 Jan 27;26(1):157-62. Epub 2005 Oct 27.

Department of Medicine, University of Illinois, Chicago, IL 60612, USA.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000193627.12
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http://dx.doi.org/10.1161/01.ATV.0000193627.12516.1dDOI Listing
January 2006

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

J Biol Chem 2005 Nov 28;280(47):39653-64. Epub 2005 Sep 28.

Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M510187200
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http://dx.doi.org/10.1074/jbc.M510187200DOI Listing
November 2005

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.

J Biol Chem 2004 Nov 3;279(46):48477-85. Epub 2004 Sep 3.

Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M409848200
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http://dx.doi.org/10.1074/jbc.M409848200DOI Listing
November 2004

Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells.

Cancer Res 2004 Nov;64(21):7682-5

Ben May Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2647DOI Listing
November 2004

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.

J Lipid Res 2004 Jul 21;45(7):1256-65. Epub 2004 Apr 21.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1194/jlr.M300358-JLR200DOI Listing
July 2004

Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.

Biochemistry 2004 Feb;43(7):2126-39

Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 715 Albany Street W509, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1021/bi035813pDOI Listing
February 2004

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.

J Biol Chem 2002 Dec 15;277(50):48508-13. Epub 2002 Oct 15.

Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA.

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http://dx.doi.org/10.1074/jbc.M209085200DOI Listing
December 2002

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.

J Biol Chem 2002 Sep 25;277(36):33178-87. Epub 2002 Jun 25.

Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M204996200DOI Listing
September 2002

Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.

J Mol Med (Berl) 2002 May 7;80(5):271-81. Epub 2002 Mar 7.

Lipid Metabolism Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s00109-001-0318-yDOI Listing
May 2002