Michael Kyba

Michael Kyba

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Michael Kyba

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DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD.

FASEB J 2020 Mar 5;34(3):4573-4590. Epub 2020 Feb 5.

Neuromuscular Research Group, Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1096/fj.201902696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079142PMC
March 2020

Correction to: Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.

Cell Mol Life Sci 2020 Jan 9. Epub 2020 Jan 9.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.

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http://dx.doi.org/10.1007/s00018-019-03443-4DOI Listing
January 2020

Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.

Cell Mol Life Sci 2019 Oct 23. Epub 2019 Oct 23.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.

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http://dx.doi.org/10.1007/s00018-019-03335-7DOI Listing
October 2019

Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies.

Trends Mol Med 2019 Sep;25(9):803-816

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721995PMC
September 2019

Estrogen Regulates the Satellite Cell Compartment in Females.

Cell Rep 2019 07;28(2):368-381.e6

Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655560PMC
July 2019

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.

Autophagy 2018 21;14(4):584-597. Epub 2018 Feb 21.

a Department of Biochemistry , Molecular Biology, and Biophysics , University of Minnesota , Minneapolis, MN , USA.

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http://dx.doi.org/10.1080/15548627.2017.1422851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959323PMC
March 2019

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment.

Proc Natl Acad Sci U S A 2019 03 13;116(10):4346-4351. Epub 2019 Feb 13.

Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455;

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http://dx.doi.org/10.1073/pnas.1808303116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410870PMC
March 2019

Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA.

Cell Rep 2018 12;25(11):2955-2962.e3

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183183
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http://dx.doi.org/10.1016/j.celrep.2018.11.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463520PMC
December 2018

Comment on structural basis of DUX4/IGH-driven transactivation.

Leukemia 2018 09 27;32(9):2090-2092. Epub 2018 Jul 27.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://www.nature.com/articles/s41375-018-0217-7
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http://dx.doi.org/10.1038/s41375-018-0217-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343488PMC
September 2018

Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity.

Cell Stem Cell 2018 Jul;23(1):74-85.e6

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183029
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http://dx.doi.org/10.1016/j.stem.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752207PMC
July 2018

Freeze Injury of the Tibialis Anterior Muscle.

Methods Mol Biol 2016 ;1460:33-41

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Cancer and Cardiovascular Research Building 4-127, 2231 6th St. S.E., Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/978-1-4939-3810-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831515PMC
January 2018

Flow Cytometry and Transplantation-Based Quantitative Assays for Satellite Cell Self-Renewal and Differentiation.

Methods Mol Biol 2016 ;1460:163-79

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Cancer and Cardiovascular Research Building 4-127, 2231 6th St. S.E., Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/978-1-4939-3810-0_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532774PMC
January 2018

The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

J Cell Sci 2017 Nov 21;130(21):3685-3697. Epub 2017 Sep 21.

Lillehei Heart Institute, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55014, USA

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http://dx.doi.org/10.1242/jcs.205427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702055PMC
November 2017

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

Dis Model Mech 2017 10 28;10(10):1211-1216. Epub 2017 Jul 28.

Lillehei Heart Institute, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA

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http://dx.doi.org/10.1242/dmm.030064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665455PMC
October 2017

Pax7 remodels the chromatin landscape in skeletal muscle stem cells.

PLoS One 2017 25;12(4):e0176190. Epub 2017 Apr 25.

Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176190PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404880PMC
September 2017

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.

Nat Commun 2017 09 15;8(1):550. Epub 2017 Sep 15.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1038/s41467-017-00730-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601940PMC
September 2017

Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors.

Stem Cell Reports 2017 07 18;9(1):12-22. Epub 2017 May 18.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-128 CCRB, 2231 6th Street South East, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511038PMC
July 2017

A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.

Nat Commun 2017 06 26;8:15926. Epub 2017 Jun 26.

Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://www.nature.com/doifinder/10.1038/ncomms15926
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http://dx.doi.org/10.1038/ncomms15926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490270PMC
June 2017

Twist of fate for skeletal muscle mesenchymal cells.

Nat Cell Biol 2017 03;19(3):153-154

Lillehei Heart Institute, and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/ncb3482DOI Listing
March 2017

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.

Cell Metab 2017 01 23;25(1):166-181. Epub 2016 Nov 23.

Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226893PMC
January 2017

Modulating the malignancy of Hox proteins.

Authors:
Michael Kyba

Blood 2017 01;129(3):269-270

UNIVERSITY OF MINNESOTA.

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http://dx.doi.org/10.1182/blood-2016-11-751909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248935PMC
January 2017

DNA-binding sequence specificity of DUX4.

Skelet Muscle 2016 28;6. Epub 2016 Jan 28.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455 USA ; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 USA.

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http://dx.doi.org/10.1186/s13395-016-0080-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730607PMC
September 2016

Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.

J Biomol Screen 2016 Aug 31;21(7):680-8. Epub 2016 May 31.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

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http://dx.doi.org/10.1177/1087057116651868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501317PMC
August 2016

Mesoderm, Cooked Up Fast and Served to Order.

Authors:
Michael Kyba

Cell Stem Cell 2016 08;19(2):146-148

Department of Pediatrics and Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909163020
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http://dx.doi.org/10.1016/j.stem.2016.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448393PMC
August 2016

High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice.

PLoS One 2016 15;11(3):e0151467. Epub 2016 Mar 15.

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, 55455, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792399PMC
July 2016

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.

Nucleic Acids Res 2016 06 6;44(11):5161-73. Epub 2016 Mar 6.

Lillehei Heart Institute, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA Department of Pediatrics, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA

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http://dx.doi.org/10.1093/nar/gkw141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914088PMC
June 2016

Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq.

Biochem Biophys Res Commun 2016 06 27;474(3):469-475. Epub 2016 Apr 27.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.04.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873396PMC
June 2016

Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.

J Biol Chem 2016 Apr 14;291(16):8644-52. Epub 2016 Jan 14.

From the Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin Dell Medical School, Austin, Texas 78723,

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http://dx.doi.org/10.1074/jbc.M115.694208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861434PMC
April 2016

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.

Cell Stem Cell 2016 Mar 11;18(3):354-67. Epub 2016 Feb 11.

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular and Cellular Pharmacology Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779406PMC
March 2016

GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.

Exp Hematol 2016 Jan 23;44(1):68-74.e1-10. Epub 2015 Oct 23.

Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.exphem.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5160023PMC
January 2016

Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm.

Stem Cell Reports 2016 Jan;6(1):26-34

Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Lillehei Heart Institute, University of Minnesota, Cancer and Cardiovascular Research Building 4-127, 2231 6th Street Southeast, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719188PMC
January 2016

Pax3-induced expansion enables the genetic correction of dystrophic satellite cells.

Skelet Muscle 2015 26;5:36. Epub 2015 Oct 26.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-128 CCRB, 2231 6th St. SE, Minneapolis, MN 55455 USA.

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http://dx.doi.org/10.1186/s13395-015-0061-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620645PMC
October 2015

Drosophila Cyclin G and epigenetic maintenance of gene expression during development.

Epigenetics Chromatin 2015 7;8:18. Epub 2015 May 7.

Sorbonne Universités, UPMC Univ Paris 06, Institut de Biologie Paris-Seine (IBPS), UMR 7622, Developmental Biology, 9, quai Saint-Bernard, F-75005 Paris, France ; CNRS, IBPS, UMR 7622, Developmental Biology, 9, quai Saint-Bernard, F-75005 Paris, France.

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http://dx.doi.org/10.1186/s13072-015-0008-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438588PMC
May 2015

Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast.

Circ Heart Fail 2015 Jan 24;8(1):156-66. Epub 2014 Nov 24.

From the Cardiovascular Division, Department of Medicine (L.Z., J.G., P.Z., Q.X., S.S.R., J.Z.), Department of Integrative Biology and Physiology, School of Medicine (S.C.W., T.D.O.C.), Stem Cell Institute and Department of Pediatrics (L.X., J.T., M.K.), and Department of Surgery (K.L.), University of Minnesota, Minneapolis, MN; and Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China (J.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303534PMC
January 2015

OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

Blood 2014 Nov 29;124(19):2948-52. Epub 2014 Sep 29.

Department of Pediatrics, Center for Cardiovascular Biology, Emory University School of Medicine, Atlanta, GA; Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL;

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http://dx.doi.org/10.1182/blood-2014-03-556332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224193PMC
November 2014

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.

Stem Cell Reports 2014 Oct 4;3(4):594-605. Epub 2014 Sep 4.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0024
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400242
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http://dx.doi.org/10.1016/j.stemcr.2014.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223713PMC
October 2014

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.

Cell Rep 2014 Sep 28;8(5):1484-96. Epub 2014 Aug 28.

Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA; Department of Pediatrics, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188423PMC
September 2014

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.

Nat Commun 2014 Jul 14;5:4372. Epub 2014 Jul 14.

1] National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, Wisconsin 53715, USA [2] Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53707-7365, USA [3] Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, Wisconsin 53792, USA.

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http://dx.doi.org/10.1038/ncomms5372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107340PMC
July 2014

Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.

Dev Biol 2014 May 26;389(2):208-18. Epub 2014 Feb 26.

Lillehei Heart Institute, Medical School, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099474PMC
May 2014

Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells.

Stem Cells 2013 Dec;31(12):2680-9

Stem Cell Project Group, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1002/stem.1500DOI Listing
December 2013

Expression of the human FSHD-linked DUX4 gene induces neurogenesis during differentiation of murine embryonic stem cells.

Stem Cells Dev 2013 Sep 9;22(17):2440-8. Epub 2013 May 9.

Department of Pediatrics, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1089/scd.2012.0643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749711PMC
September 2013

Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.

Stem Cells Dev 2013 Aug 9;22(15):2211-20. Epub 2013 Apr 9.

Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1089/scd.2012.0611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715789PMC
August 2013

A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation.

Stem Cells 2013 Aug;31(8):1611-20

Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/stem.1402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767774PMC
August 2013

What is a Master Regulator?

J Stem Cell Res Ther 2013 May;3

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4172/2157-7633.1000e114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718559PMC
May 2013

Hemogenic endothelium in a dish.

Authors:
Michael Kyba

Blood 2013 Jan;121(3):417-8

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-12-46
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http://dx.doi.org/10.1182/blood-2012-12-469940DOI Listing
January 2013

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.

Nat Neurosci 2012 Dec 18;15(12):1627-35. Epub 2012 Nov 18.

Université Libre de Bruxelles, Institute for Interdisciplinary Research, ULB Neuroscience Institute, Brussels, Belgium.

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http://dx.doi.org/10.1038/nn.3264DOI Listing
December 2012

Generation of functional thyroid from embryonic stem cells.

Nature 2012 Nov 10;491(7422):66-71. Epub 2012 Oct 10.

Institute of Interdisciplinary Research in Molecular Human Biology (IRIBHM), Université Libre de Bruxelles, 808 route de Lennik, 1070 Brussels, Belgium.

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http://link.springer.com/content/pdf/10.1007%2F978-3-319-192
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http://www.nature.com/doifinder/10.1038/nature11525
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http://dx.doi.org/10.1038/nature11525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687105PMC
November 2012

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

PLoS Biol 2012 28;10(2):e1001268. Epub 2012 Feb 28.

Program in Genes and Development, Center for Stem Cell and Development Biology, Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1371/journal.pbio.1001268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289600PMC
June 2012

A critical role for endoglin in the emergence of blood during embryonic development.

Blood 2012 Jun 24;119(23):5417-28. Epub 2012 Apr 24.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1182/blood-2011-11-391896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369678PMC
June 2012

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.

Nat Cell Biol 2012 Jun 10;14(7):659-65. Epub 2012 Jun 10.

Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1038/ncb2521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389517PMC
June 2012

Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays.

Skelet Muscle 2012 Jun 15;2(1):13. Epub 2012 Jun 15.

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1186/2044-5040-2-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439689PMC
June 2012

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.

J Biol Chem 2012 Jan 5;287(3):2107-18. Epub 2011 Dec 5.

Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M111.322644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265890PMC
January 2012

Functional myogenic engraftment from mouse iPS cells.

Stem Cell Rev Rep 2011 Nov;7(4):948-57

Lillehei Heart Institute, Department of Medicine, University of Minnesota, 4-124 Nils Hasselmo Hall, 312 Church St. S.E., Minneapolis, 55455 MN, USA.

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http://dx.doi.org/10.1007/s12015-011-9258-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465364PMC
November 2011

Embryonic stem cell-based mapping of developmental transcriptional programs.

Nat Methods 2011 Nov 13;8(12):1056-8. Epub 2011 Nov 13.

Departments of Pathology, Neurology and Neuroscience, Center for Motor Neuron Biology and Disease and Columbia Stem Cell Initiative, Columbia University Medical Center, New York, New York, USA.

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http://www.nature.com/articles/nmeth.1775
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http://dx.doi.org/10.1038/nmeth.1775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228994PMC
November 2011

Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.

PLoS One 2011 16;6(5):e19780. Epub 2011 May 16.

Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095625PMC
October 2011

Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells.

BMC Mol Biol 2011 Aug 18;12:37. Epub 2011 Aug 18.

Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1471-2199-12-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167746PMC
August 2011

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Blood 2011 Jul 20;118(1):88-97. Epub 2011 May 20.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1182/blood-2010-12-325019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139390PMC
July 2011

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program.

Nat Commun 2011 Jul 12;2:390. Epub 2011 Jul 12.

Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1038/ncomms1381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622708PMC
July 2011

Gene therapy by allele selection in a mouse model of beta-thalassemia.

J Clin Invest 2011 Feb;121(2):623-7

Center for Molecular and Human Genetics, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1172/JCI45377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026741PMC
February 2011

HoxA3 is an apical regulator of haemogenic endothelium.

Nat Cell Biol 2011 Jan 19;13(1):72-8. Epub 2010 Dec 19.

Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1038/ncb2137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079247PMC
January 2011

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.

PLoS Genet 2010 Oct 28;6(10):e1001181. Epub 2010 Oct 28.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965761PMC
October 2010

The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development.

Stem Cells 2010 Sep;28(9):1518-29

Department of Pediatrics, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1002/stem.484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013318PMC
September 2010