Michael Karin

Michael Karin

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Michael Karin

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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation.

Cell Mol Gastroenterol Hepatol 2019 Oct 10. Epub 2019 Oct 10.

Department Rheumatology, San Diego, California; Department of Medicine, Autonomous University of Barcelona, Plaça Cívica, Bellaterra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.10.002DOI Listing
October 2019

Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries.

Am J Physiol Regul Integr Comp Physiol 2019 Oct 16. Epub 2019 Oct 16.

Department of Pediatrics, University of California, San Diego, United States.

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http://dx.doi.org/10.1152/ajpregu.00056.2019DOI Listing
October 2019

The Immunobiology of Hepatocellular Carcinoma in Humans and Mice: Basic Concepts and Therapeutic Implications.

J Hepatol 2019 Aug 23. Epub 2019 Aug 23.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193048
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http://dx.doi.org/10.1016/j.jhep.2019.08.014DOI Listing
August 2019

Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach.

Mol Cancer Res 2019 Jul 9;17(7):1493-1502. Epub 2019 Apr 9.

Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1045DOI Listing
July 2019

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation.

Immunity 2019 07;51(1):15-26

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640850PMC
July 2019

The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer.

Cancer Cell 2019 May;35(5):714-720

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193016
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http://dx.doi.org/10.1016/j.ccell.2019.04.001DOI Listing
May 2019

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Cell Metab 2019 01 15;29(1):18-26. Epub 2018 Nov 15.

Department of Pharmacology, University of California San Diego, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183064
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http://dx.doi.org/10.1016/j.cmet.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326872PMC
January 2019

Publisher Correction: The gut-liver axis and the intersection with the microbiome.

Nat Rev Gastroenterol Hepatol 2018 12;15(12):785

Department of Pediatrics, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1038/s41575-018-0031-8DOI Listing
December 2018

Author Correction: Inflammation-induced IgA cells dismantle anti-liver cancer immunity.

Nature 2018 09;561(7721):E1

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, California, 92093, USA.

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http://dx.doi.org/10.1038/s41586-018-0304-yDOI Listing
September 2018

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Cell 2018 09 13;175(1):133-145.e15. Epub 2018 Sep 13.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183103
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http://dx.doi.org/10.1016/j.cell.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159928PMC
September 2018

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Nature 2018 08 25;560(7717):198-203. Epub 2018 Jul 25.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.

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http://www.nature.com/articles/s41586-018-0372-z
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http://dx.doi.org/10.1038/s41586-018-0372-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329306PMC
August 2018

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.

J Hepatol 2018 07 2;69(1):79-88. Epub 2018 Mar 2.

Department of Pathology, and Division of Biological Sciences, Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183013
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http://dx.doi.org/10.1016/j.jhep.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008184PMC
July 2018

The gut-liver axis and the intersection with the microbiome.

Nat Rev Gastroenterol Hepatol 2018 07;15(7):397-411

Department of Pediatrics, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1038/s41575-018-0011-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319369PMC
July 2018

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.

Cancer Cell 2018 06;33(6):1061-1077.e6

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA; Department of Pathology, University of California San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA; Moores Cancer Center, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005359PMC
June 2018

New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance.

Authors:
Michael Karin

Precis Clin Med 2018 Jun 4;1(1):21-28. Epub 2018 Jun 4.

Laboratory of Gene Regulation and Signal Transduction, UC San Diego School of Medicine, Department of Pharmacology, 9500 Gilman Drive, La Jolla, CA, USA.

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http://dx.doi.org/10.1093/pcmedi/pby005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333043PMC
June 2018

NF-κB, inflammation, immunity and cancer: coming of age.

Nat Rev Immunol 2018 05 22;18(5):309-324. Epub 2018 Jan 22.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nri.2017.142DOI Listing
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.

Proc Natl Acad Sci U S A 2018 01 8;115(4):E812-E821. Epub 2018 Jan 8.

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702;

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http://dx.doi.org/10.1073/pnas.1717520115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789942PMC
January 2018

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.

Cancer Cell 2017 Dec 16;32(6):824-839.e8. Epub 2017 Nov 16.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730340PMC
December 2017

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Nature 2017 11 8;551(7680):340-345. Epub 2017 Nov 8.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature24302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884449PMC
November 2017

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Diabetologia 2017 10 20;60(10):2021-2032. Epub 2017 Jul 20.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8.

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http://dx.doi.org/10.1007/s00125-017-4345-9DOI Listing
October 2017

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.

PLoS One 2017 10;12(8):e0181052. Epub 2017 Aug 10.

Southern California Research Center for ALPD and Cirrhosis of the University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181052PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552280PMC
October 2017

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.

Nat Immunol 2017 Jul;18(8):861-869

Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/ni.3772DOI Listing
July 2017

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Proc Natl Acad Sci U S A 2017 02 6;114(8):E1432-E1440. Epub 2017 Feb 6.

Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1700232114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338369PMC
February 2017

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases.

Clin Exp Rheumatol 2016 Jul-Aug;34(4 Suppl 98):12-6. Epub 2016 Jul 21.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology; and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.

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December 2016

Targeting Inflammation in Cancer Prevention and Therapy.

Cancer Prev Res (Phila) 2016 Dec 10;9(12):895-905. Epub 2016 Nov 10.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142754PMC
December 2016

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction.

Cell 2016 11;167(4):1052-1066.e18

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908236PMC
November 2016

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.

Cancer Cell 2016 10;30(4):595-609

Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081228PMC
http://dx.doi.org/10.1016/j.ccell.2016.09.004DOI Listing
October 2016

p62 in Cancer: Signaling Adaptor Beyond Autophagy.

Cell 2016 Oct;167(3):606-609

Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163131
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http://dx.doi.org/10.1016/j.cell.2016.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114003PMC
October 2016

p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.

FEBS Lett 2016 08 6;590(15):2375-97. Epub 2016 Aug 6.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/1873-3468.12301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983218PMC
August 2016

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment.

Cell 2016 Jul;166(2):288-298

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947210PMC
July 2016

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.

Carcinogenesis 2016 06 4;37(6):541-6. Epub 2016 May 4.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology.

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http://dx.doi.org/10.1093/carcin/bgw060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876993PMC
June 2016

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.

Cancer Cell 2016 06 19;29(6):935-948. Epub 2016 May 19.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907799PMC
June 2016

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Sci Signal 2016 06 7;9(431):re5. Epub 2016 Jun 7.

Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, La Jolla, CA 92093-0723, USA.

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http://dx.doi.org/10.1126/scisignal.aaf2885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902175PMC
June 2016

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

Cell Rep 2016 06 16;16(1):120-132. Epub 2016 Jun 16.

Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, 691 Preston Building, 2220 Pierce Ave., Nashville, TN 37232, USA; U.S. Department of Veterans Affairs, Washington, DC 20420, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 USA.

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http://dx.doi.org/10.1016/j.celrep.2016.05.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927403PMC
June 2016

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis.

Cell Metab 2016 05;23(5):759-61

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.018DOI Listing
May 2016

Tumor-Elicited Inflammation and Colorectal Cancer.

Adv Cancer Res 2015 28;128:173-96. Epub 2015 May 28.

Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, California, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2015.04.014DOI Listing
April 2016

Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling.

J Immunol 2016 Mar 20;196(5):2368-76. Epub 2016 Jan 20.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1501724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761524PMC
March 2016

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Cell 2016 Feb;164(5):896-910

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769378PMC
February 2016

Obesity and Cancer: The Oil that Feeds the Flame.

Cell Metab 2016 Jan;23(1):48-62

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0723, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.12.015DOI Listing
January 2016

Reparative inflammation takes charge of tissue regeneration.

Nature 2016 Jan;529(7586):307-15

Princess Máxima Center and Hubrecht Institute, Uppsalalaan 8, 3584 CR Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nature17039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228603PMC
January 2016

The IL-23 to IL-17 cascade inflammation-related cancers.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S87-90. Epub 2015 Oct 12.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, UCSD School of Medicine, La Jolla, CA, USA.

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December 2015

Analysis of NF-κB activation in mouse intestinal epithelial cells.

Methods Mol Biol 2015 ;1280:593-606

Department of Pharmacology, UC San Diego School of Medicine, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2422-6_35DOI Listing
November 2015

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.

Proc Natl Acad Sci U S A 2015 Nov 28;112(45):E6166-74. Epub 2015 Oct 28.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, University of California, San Diego (UCSD) School of Medicine, La Jolla CA 92093-0636;

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http://dx.doi.org/10.1073/pnas.1519384112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653219PMC
November 2015

Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA.

Proc Natl Acad Sci U S A 2015 Nov 9;112(47):14670-5. Epub 2015 Nov 9.

Institute for Genomic Medicine and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92328; Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital and Sichuan University, Chengdu 610041, China; Veterans Administration Healthcare System, San Diego, CA 92161

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http://dx.doi.org/10.1073/pnas.1518151112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664371PMC
November 2015

Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.

Nat Commun 2015 Oct 12;6:8428. Epub 2015 Oct 12.

The Vontz Center for Molecular Studies, Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1038/ncomms9428DOI Listing
October 2015

Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.

Cytokine Growth Factor Rev 2015 Aug 20;26(4):389-403. Epub 2015 Jun 20.

First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.

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http://dx.doi.org/10.1016/j.cytogfr.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526340PMC
August 2015

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.

Cell 2015 Aug;162(4):766-79

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545590PMC
August 2015

Emerging roles of Lys63-linked polyubiquitylation in immune responses.

Immunol Rev 2015 Jul;266(1):161-74

Laboratory of Signal Transduction and Gene Regulation, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://doi.wiley.com/10.1111/imr.12310
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http://dx.doi.org/10.1111/imr.12310DOI Listing
July 2015

Immune Infiltration and Prostate Cancer.

Front Oncol 2015 8;5:128. Epub 2015 Jul 8.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine , La Jolla, CA , USA ; Laboratory of Gene Regulation and Signal Transduction, Department of Pathology, University of California San Diego School of Medicine , La Jolla, CA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495337PMC
July 2015

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Genes Dev 2015 Jun;29(12):1271-84

Department of Pharmacology, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA;

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http://dx.doi.org/10.1101/gad.262816.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495398PMC
June 2015

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.

Nature 2015 May 29;521(7550):94-8. Epub 2015 Apr 29.

1] Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, San Diego, California 92093, USA [2] Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, California 92093, USA.

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http://dx.doi.org/10.1038/nature14395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501632PMC
May 2015

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Nature 2015 Mar 25;519(7541):57-62. Epub 2015 Feb 25.

1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [3] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature14228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447318PMC
March 2015

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.

Sci Rep 2015 Mar 30;5:9502. Epub 2015 Mar 30.

Department of Molecular &Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1038/srep09502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377584PMC
March 2015

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.

FASEB J 2015 Feb 3;29(2):408-17. Epub 2014 Nov 3.

Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York, USA;

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http://dx.doi.org/10.1096/fj.14-258814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314228PMC
February 2015

Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.

Cancer Res 2014 Dec 21;74(24):7274-84. Epub 2014 Oct 21.

Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349570PMC
December 2014

The commonly used antimicrobial additive triclosan is a liver tumor promoter.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):17200-5. Epub 2014 Nov 17.

Laboratory of Environmental Toxicology, Departments of Chemistry & Biochemistry and Pharmacology, and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1419119111
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http://dx.doi.org/10.1073/pnas.1419119111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260592PMC
December 2014

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

Immunity 2014 Dec 25;41(6):1052-63. Epub 2014 Nov 25.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613140043
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http://dx.doi.org/10.1016/j.immuni.2014.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272447PMC
December 2014

New Approaches for Studying Alcoholic Liver Disease.

Curr Pathobiol Rep 2014 Dec 14;2(4):171-183. Epub 2014 Sep 14.

Department of Surgery, UC San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s40139-014-0053-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648354PMC
December 2014

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14776-81. Epub 2014 Sep 29.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, and Moores Cancer Center, School of Medicine, University of California, San Diego, La Jolla, CA, 92093

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http://www.pnas.org/cgi/doi/10.1073/pnas.1416498111
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http://dx.doi.org/10.1073/pnas.1416498111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205637PMC
October 2014

Whipping NF-κB to Submission via GADD45 and MKK7.

Authors:
Michael Karin

Cancer Cell 2014 Oct;26(4):447-9

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.09.012DOI Listing
October 2014

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.

Cancer Cell 2014 Sep 14;26(3):331-343. Epub 2014 Aug 14.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; Department of Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165611PMC
September 2014

The therapeutic value of targeting inflammation in gastrointestinal cancers.

Trends Pharmacol Sci 2014 Jul 28;35(7):349-57. Epub 2014 May 28.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0723, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2014.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108072PMC
July 2014

Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.

Cell Metab 2014 Jul 5;20(1):133-44. Epub 2014 Jun 5.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079758PMC
July 2014

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.

Nat Commun 2014 Jul 29;5:4513. Epub 2014 Jul 29.

State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing 100850, China.

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http://dx.doi.org/10.1038/ncomms5513DOI Listing
July 2014

Critical role for IL-1β in DNA damage-induced mucositis.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):E702-11. Epub 2014 Jan 27.

Lautenberg Centre for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1073/pnas.1322691111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926043PMC
February 2014

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer.

Semin Immunol 2014 Feb 16;26(1):54-74. Epub 2014 Feb 16.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; UC San Diego Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.01.001DOI Listing
February 2014

NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.

Cell Metab 2014 Jan;19(1):6-7

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA; Moores UCSD Cancer Center, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947913PMC
January 2014

Tumor infiltrating B-cells are increased in prostate cancer tissue.

J Transl Med 2014 Jan 30;12:30. Epub 2014 Jan 30.

Department of Urology and Department of Surgery, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1186/1479-5876-12-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914187PMC
January 2014

Common flora and intestine: A carcinogenic marriage.

Cell Logist 2013 Jan 15;3(1):e24975. Epub 2013 May 15.

Laboratory of Gene Regulation and Signal Transduction; Department of Pharmacology and Pathology; School of Medicine; University of California, San Diego; La Jolla, CA USA.

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http://dx.doi.org/10.4161/cl.24975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906427PMC
January 2013