Michael Kapiloff

Michael Kapiloff

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Michael Kapiloff

Michael Kapiloff

Publications by authors named "Michael Kapiloff"

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Compartmentalization of local cAMP signaling in neuronal growth and survival.

Neural Regen Res 2020 Mar;15(3):453-454

Department of Ophthalmology, Byers Eye Institute, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA, USA.

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http://dx.doi.org/10.4103/1673-5374.266055DOI Listing
March 2020

mAKAPβ signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling.

Cell Signal 2019 Nov 9;63:109357. Epub 2019 Jul 9.

Departments of Ophthalmology and Medicine, Stanford Cardiovascular Institute, Stanford University, Palo Alto, CA, USA.

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http://dx.doi.org/10.1016/j.cellsig.2019.109357DOI Listing
November 2019

Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment.

J Neurosci 2019 Jul 16;39(28):5466-5480. Epub 2019 May 16.

Department of Ophthalmology, Byers Eye Institute, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, California 94034,

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http://dx.doi.org/10.1523/JNEUROSCI.2752-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616289PMC
July 2019

Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D.

J Biol Chem 2019 02 6;294(7):2543-2554. Epub 2018 Dec 6.

the Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, Connecticut 06030

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http://dx.doi.org/10.1074/jbc.RA118.005465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378968PMC
February 2019

Calcineurin-AKAP interactions: therapeutic targeting of a pleiotropic enzyme with a little help from its friends.

J Physiol 2018 Nov 29. Epub 2018 Nov 29.

Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1113/JP276756DOI Listing
November 2018

Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.

J Mol Cell Cardiol 2018 05 6;118:13-25. Epub 2018 Mar 6.

Departments of Ophthalmology and Medicine, Stanford Cardiovascular Institute Stanford University, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940533PMC
May 2018

Intracellular compartmentation of cAMP promotes neuroprotection and regeneration of CNS neurons.

Neural Regen Res 2017 Feb;12(2):201-202

Department of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.4103/1673-5374.200797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361496PMC
February 2017

Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation.

Invest Ophthalmol Vis Sci 2016 Sep;57(11):5083-5092

Department of Ophthalmology, University of California San Diego, La Jolla, California, United States 4Byers Eye Institute, Stanford University, Palo Alto, California, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053116PMC
http://dx.doi.org/10.1167/iovs.16-19465DOI Listing
September 2016

RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.

J Mol Cell Cardiol 2016 04 3;93:98-105. Epub 2016 Mar 3.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33101, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846495PMC
April 2016

The cardiac enigma: current conundrums in heart failure research.

F1000Res 2016 18;5. Epub 2016 Jan 18.

Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA.

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http://dx.doi.org/10.12688/f1000research.7278.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754052PMC
February 2016

Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival.

EBioMedicine 2015 Dec 28;2(12):1880-7. Epub 2015 Oct 28.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, United States; Department of Ophthalmology, University of California, San Diego, CA 92093, United States; Byers Eye Institute, Stanford University, Palo Alto, CA 94303, United States.

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http://dx.doi.org/10.1016/j.ebiom.2015.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703706PMC
December 2015

RSK3: A regulator of pathological cardiac remodeling.

IUBMB Life 2015 May 19;67(5):331-7. Epub 2015 May 19.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Division of Cardiology, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.1383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449288PMC
May 2015

mAKAP-a master scaffold for cardiac remodeling.

J Cardiovasc Pharmacol 2015 Mar;65(3):218-25

*Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; and †Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT.

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http://dx.doi.org/10.1097/FJC.0000000000000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355281PMC
March 2015

The role of soluble adenylyl cyclase in neurite outgrowth.

Biochim Biophys Acta 2014 Dec 23;1842(12 Pt B):2561-8. Epub 2014 Jul 23.

Shiley Eye Center, University of California, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262618PMC
December 2014

The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.

Circ Heart Fail 2014 Jul 8;7(4):663-72. Epub 2014 May 8.

From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, FL (M.D.K., J.L., C.L.P., M.G., H.T., J.D., M.S.K.); and Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington (K.D.-K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277867PMC
July 2014

Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains.

J Gen Physiol 2014 Jan;143(1):9-15

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, 2 Department of Pediatrics, and 3 Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33101.

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http://dx.doi.org/10.1085/jgp.201311020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874566PMC
January 2014

p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice.

Am J Physiol Heart Circ Physiol 2013 Oct 2;305(7):H1010-9. Epub 2013 Aug 2.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida; and.

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http://dx.doi.org/10.1152/ajpheart.00237.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798750PMC
October 2013

CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.

J Biomed Sci 2013 Aug 3;20:56. Epub 2013 Aug 3.

Interdisciplinary Stem Cell Institute, Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33101, USA.

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http://dx.doi.org/10.1186/1423-0127-20-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750294PMC
August 2013

Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.

Exp Cell Res 2013 Feb 21;319(4):447-54. Epub 2012 Dec 21.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, United States.

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http://dx.doi.org/10.1016/j.yexcr.2012.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563847PMC
February 2013

Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.

Circ Res 2013 Jan 20;112(1):128-39. Epub 2012 Sep 20.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Department of Pediatrics, University of Miami Leonard M. Miller School of Medicine, R198, P.O. Box 016960, Miami, FL 33101, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.276162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537852PMC
January 2013

Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation.

Cell Signal 2012 Aug 30;24(8):1496-503. Epub 2012 Mar 30.

Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, United States.

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http://dx.doi.org/10.1016/j.cellsig.2012.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362667PMC
August 2012

AKAPs: the architectural underpinnings of local cAMP signaling.

J Mol Cell Cardiol 2012 Feb 11;52(2):351-8. Epub 2011 May 11.

Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168680PMC
February 2012

A-kinase anchoring proteins: scaffolding proteins in the heart.

Am J Physiol Heart Circ Physiol 2011 Nov 19;301(5):H1742-53. Epub 2011 Aug 19.

Département de Pharmacologie et de Toxicologie, Faculté de Biologie et Médecine, Université de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1152/ajpheart.00569.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213966PMC
November 2011

Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes.

J Biol Chem 2011 Jul 5;286(26):23012-21. Epub 2011 May 5.

Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M111.231993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123069PMC
July 2011

The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.

Mol Pharmacol 2011 Mar 13;79(3):533-40. Epub 2010 Dec 13.

Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1124/mol.110.065425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061358PMC
March 2011

Inflammation, stem cells and atherosclerosis genetics.

Curr Opin Mol Ther 2010 Dec;12(6):712-23

University of Miami Leonard M Miller School of Medicine, Department of Medicine, Rosenstiel Medical Science Building, 1600 NW 10th Avenue, Miami, FL 33136, USA.

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December 2010

The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin.

J Mol Cell Cardiol 2010 Feb 31;48(2):387-94. Epub 2009 Oct 31.

Department of Pediatrics and Medicine, University of Miami Miller School of Medicine, Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Miami, FL 33101, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2009.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813376PMC
February 2010

An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

J Biol Chem 2009 Aug 1;284(35):23540-6. Epub 2009 Jul 1.

Department of Medicine, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1074/jbc.M109.030072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749128PMC
August 2009

mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.

Sci Signal 2008 Dec 23;1(51):ra18. Epub 2008 Dec 23.

1Howard Hughes Medical Institute and Vollum Institute, Oregon Health & Science University, 3181 S. W. Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1126/scisignal.2000026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828263PMC
December 2008

Signalosomes as Therapeutic Targets.

Prog Pediatr Cardiol 2008 Apr;25(1):51-56

Cardiac Signal Transduction and Cellular Biology Laboratory, Department of Medicine and Pediatrics, University of Miami Miller School of Medicine, R198, P.O. Box 016960, Miami, FL 33101.

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http://dx.doi.org/10.1016/j.ppedcard.2007.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390861PMC
April 2008

The mAKAP signalosome and cardiac myocyte hypertrophy.

IUBMB Life 2007 Mar;59(3):163-9

Department of Pediatrics, Heart Research Center, Oregon Health & Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1080/15216540701358593DOI Listing
March 2007

The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways.

Eur J Cell Biol 2006 Jul 7;85(7):593-602. Epub 2006 Feb 7.

Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.ejcb.2006.01.007DOI Listing
July 2006

The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling.

J Cell Sci 2005 Dec;118(Pt 23):5637-46

Department of Pediatrics, Heart Research Center, Oregon Health and Science University, NRC5 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1242/jcs.02675DOI Listing
December 2005

Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.

Mol Cell 2005 Dec;20(5):661-72

Howard Hughes Medical Institute and Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.10.013DOI Listing
December 2005

Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.

Exp Cell Res 2005 Feb;303(2):388-99

Department of Pediatrics, Heart Research Center, Oregon Health and Science University, NRC5, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.yexcr.2004.10.009DOI Listing
February 2005

A novel isoform of Cbl-associated protein that binds protein kinase A.

Biochim Biophys Acta 2005 Feb 28;1727(2):145-9. Epub 2004 Dec 28.

Department of Pediatrics, Oregon Health and Science University, NRC5, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, United States.

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http://dx.doi.org/10.1016/j.bbaexp.2004.12.004DOI Listing
February 2005

Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart.

Mol Pharmacol 2002 Aug;62(2):193-9

Department of Pediatrics, Heart Research Center, Oregon Health and Science University, Portland, Oregon 97201, USA.

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http://dx.doi.org/10.1124/mol.62.2.193DOI Listing
August 2002