Publications by authors named "Michael Jeltsch"

40Publications

Investigation on the role of biallelic variants in VEGF-C found in a patient affected by Milroy-like lymphedema.

Mol Genet Genomic Med 2020 Sep 26;8(9):e1389. Epub 2020 Jun 26.

Department of Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/mgg3.1389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507552PMC
September 2020

Key molecules in lymphatic development, function, and identification.

Ann Anat 2018 Sep 26;219:25-34. Epub 2018 May 26.

Translational Cancer Biology Research Program, University of Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.aanat.2018.05.003DOI Listing
September 2018

Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels.

Front Bioeng Biotechnol 2018 12;6. Epub 2018 Feb 12.

Translational Cancer Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.3389/fbioe.2018.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816233PMC
February 2018

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.

Sci Rep 2017 07 7;7(1):4916. Epub 2017 Jul 7.

Translational Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, PO Box 63, Haartmaninkatu 8, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1038/s41598-017-04982-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501841PMC
July 2017

Factors regulating the substrate specificity of cytosolic phospholipase A-alpha in vitro.

Biochim Biophys Acta 2016 Nov 1;1861(11):1597-1604. Epub 2016 Jul 1.

Faculty of Medicine, Department of Biochemistry and Developmental Biology, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.06.022DOI Listing
November 2016

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.

Circ Res 2016 07 25;119(2):210-21. Epub 2016 May 25.

From the VA San Diego Healthcare System, Medical and Research Sections, La Jolla, CA (S.C.J., X.Y., R.E., M.M.F.); Division of Pulmonary and Critical Care, Department of Medicine, University of California San Diego, La Jolla (S.C.J., X.Y., R.E., M.M.F.); Marine Drug Research Institute, Huaihai Institute of Technology, Lianyungang, China (X.Y.); Translational Cancer Biology Research Program, Institute of Biomedicine (M.J.) and Helsinki University Central Hospital (K.A.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, La Jolla (J.R.B., M.S.); Biomatrix Center, New York University (S.A.W.-A.); and Translational Cancer Biology Research Program, Wihuri Research Institute, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938725PMC
July 2016

Lymphatic Vessels in Regenerative Medicine and Tissue Engineering.

Tissue Eng Part B Rev 2016 10 27;22(5):395-407. Epub 2016 Jun 27.

1 Ludwig Boltzmann Institute for Experimental and Clinical Traumatology , Vienna, Austria .

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http://dx.doi.org/10.1089/ten.TEB.2016.0034DOI Listing
October 2016

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Circ Res 2015 May 26;116(10):1660-9. Epub 2015 Mar 26.

From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304949DOI Listing
May 2015

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Circulation 2014 May 19;129(19):1962-71. Epub 2014 Feb 19.

Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002779DOI Listing
May 2014

Receptor tyrosine kinase-mediated angiogenesis.

Cold Spring Harb Perspect Biol 2013 Sep 1;5(9). Epub 2013 Sep 1.

Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1101/cshperspect.a009183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753715PMC
September 2013

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12960-5. Epub 2013 Jul 22.

Translational Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1301415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740881PMC
August 2013

The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.

Sci Signal 2013 Jul 2;6(282):ra52. Epub 2013 Jul 2.

Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scisignal.2003905DOI Listing
July 2013

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Blood 2011 Feb 8;117(5):1507-15. Epub 2010 Dec 8.

Molecular Cancer Biology Program, Research Programs Unit, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2010-08-301549DOI Listing
February 2011

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Cancer Cell 2010 Dec 2;18(6):630-40. Epub 2010 Dec 2.

Institute for Molecular Medicine Finland, Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ccr.2010.11.001DOI Listing
December 2010

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.

Circulation 2010 Oct 11;122(17):1725-33. Epub 2010 Oct 11.

Molecular/Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.957332DOI Listing
October 2010

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Proc Natl Acad Sci U S A 2010 Feb;107(6):2425-30

Molecular Cancer Biology Program, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, PO Box 63, University of Helsinki, Haartmaninkatu 8, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.0914318107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823880PMC
February 2010

Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.

Circ Res 2009 Jun 14;104(11):1302-12. Epub 2009 May 14.

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.197830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776655PMC
June 2009

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.

Cancer Res 2008 Jun;68(12):4754-62

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5809DOI Listing
June 2008

Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.

Circ Res 2007 May 3;100(10):1460-7. Epub 2007 May 3.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/01.RES.0000269042.58594.f6DOI Listing
May 2007

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.

Circ Res 2007 May 3;100(10):1468-75. Epub 2007 May 3.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, the Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1161/01.RES.0000269043.51272.6dDOI Listing
May 2007

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.

FASEB J 2006 Jul;20(9):1462-72

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P.O.B. 63, FI-00014 University of Helsinki, Helsinki, Finland.

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http://www.fasebj.org/doi/10.1096/fj.05-5646com
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http://dx.doi.org/10.1096/fj.05-5646comDOI Listing
July 2006

Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns.

J Biol Chem 2006 Apr 27;281(17):12187-95. Epub 2006 Feb 27.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, P.O. Box 63 (Haartmaninkatu 8), University of Helsinki, Helsinki 00014, Finland.

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http://dx.doi.org/10.1074/jbc.M511593200DOI Listing
April 2006

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.

Cancer Res 2005 Jun;65(11):4739-46

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4576DOI Listing
June 2005

Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis.

Am J Respir Crit Care Med 2005 Jun 18;171(12):1421-9. Epub 2005 Mar 18.

Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki/Helsinki University Central Hospital, Helsinki, Finland.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200408-1001O
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http://dx.doi.org/10.1164/rccm.200408-1001OCDOI Listing
June 2005

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Nat Immunol 2004 Jan 23;5(1):74-80. Epub 2003 Nov 23.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland.

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http://www.nature.com/articles/ni1013
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http://dx.doi.org/10.1038/ni1013DOI Listing
January 2004

Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

FASEB J 2003 Nov;17(14):2006-13

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1096/fj.03-0179comDOI Listing
November 2003

Genesis and pathogenesis of lymphatic vessels.

Cell Tissue Res 2003 Oct 27;314(1):69-84. Epub 2003 Aug 27.

Molecular and Cancer Biology Laboratory, Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, Postbox 63, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00441-003-0777-2DOI Listing
October 2003