Michael J Ziller

Michael J Ziller

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Michael J Ziller

Michael J Ziller

Publications by authors named "Michael J Ziller"

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29Publications

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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.

Cell Rep 2019 04;27(3):708-718.e10

Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525305PMC
April 2019

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Cell Stem Cell 2018 04 15;22(4):559-574.e9. Epub 2018 Mar 15.

The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535433PMC
April 2018

Targeted bisulfite sequencing of the dynamic DNA methylome.

Epigenetics Chromatin 2016 3;9:55. Epub 2016 Dec 3.

Broad Institute of MIT and Harvard, Cambridge, MA 02142 USA ; Harvard Stem Cell Institute, Cambridge, MA 02138 USA ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138 USA ; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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http://dx.doi.org/10.1186/s13072-016-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135789PMC
January 2018

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Cell 2016 11;167(5):1310-1322.e17

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)31466-0.pdf
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http://www.cell.com/cms/attachment/2072756198/2068594890/mmc
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http://dx.doi.org/10.1016/j.cell.2016.10.045DOI Listing
November 2016

Saturation analysis for whole-genome bisulfite sequencing data.

Nat Biotechnol 2016 07 27;34(7):691-693. Epub 2016 Jun 27.

Medical Genomics, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/nbt.3524DOI Listing
July 2016

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome.

Dev Cell 2015 Dec;35(6):750-8

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691283PMC
December 2015

Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.

Cell Stem Cell 2015 Oct 30;17(4):462-70. Epub 2015 Jul 30.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592414PMC
October 2015

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.

Cell 2015 Jul;162(2):412-424

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511597PMC
July 2015

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Nat Genet 2015 May 30;47(5):469-78. Epub 2015 Mar 30.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414868PMC
May 2015

Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing.

Nat Methods 2015 Mar 2;12(3):230-2, 1 p following 232. Epub 2014 Nov 2.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [4] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344394PMC
March 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Transcription factor binding dynamics during human ES cell differentiation.

Nature 2015 Feb;518(7539):344-9

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature14233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499331PMC
February 2015

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

Cancer Cell 2014 Dec;26(6):813-825

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302418PMC
December 2014

Universality of protein reentrant condensation in solution induced by multivalent metal ions.

Proteins 2010 Dec 24;78(16):3450-7. Epub 2010 Sep 24.

Institut für Angewandte Physik, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 10, Tübingen 72076, Germany.

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http://dx.doi.org/10.1002/prot.22852DOI Listing
December 2010