Michael J Witty

Michael J Witty

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Michael J Witty

Michael J Witty

Publications by authors named "Michael J Witty"

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21Publications

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The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

PLoS Pathog 2018 09 25;14(9):e1007315. Epub 2018 Sep 25.

Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1007315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173450PMC
September 2018

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.

J Med Chem 2015 Sep 8;58(18):7572-9. Epub 2015 Sep 8.

Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch, Cape Town 7701, South Africa.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01156DOI Listing
September 2015

Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries.

J Med Chem 2013 Oct 30;56(20):7750-4. Epub 2013 Aug 30.

Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1021/jm400279yDOI Listing
October 2013

Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.

Future Med Chem 2012 Dec;4(18):2265-77

Department of Chemistry, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa.

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http://dx.doi.org/10.4155/fmc.12.176DOI Listing
December 2012

Novel orally active antimalarial thiazoles.

J Med Chem 2011 Nov 11;54(21):7713-9. Epub 2011 Oct 11.

Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1021/jm201108kDOI Listing
November 2011

Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.

Bioorg Med Chem Lett 2009 Jan 18;19(2):481-4. Epub 2008 Nov 18.

Department of Chemistry, University of Cape Town, P/B Rondebosch 7700, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.047DOI Listing
January 2009

Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity.

Bioorg Med Chem Lett 2009 Jan 3;19(2):401-5. Epub 2008 Dec 3.

University of Cape Town, Department of Chemistry, P/B Rondebosch 7700, Cape Town, South Africa; Department of Chemistry, Pfizer Global R&D, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.098DOI Listing
January 2009

Mission possible.

Nature 2007 Sep;449(7159):166-9

Pfizer Global Research and Development, Sandwich, UK.

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http://dx.doi.org/10.1038/449166aDOI Listing
September 2007