Michael J Parnham

Michael J Parnham

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Michael J Parnham

Publications by authors named "Michael J Parnham"

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Potential biomarkers for persistent and neuropathic pain therapy.

Pharmacol Ther 2019 Jul 10;199:16-29. Epub 2019 Feb 10.

Institute of Clinical Pharmacology, pharmazentrum frankfurt/ZAFES, Goethe - University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch Translational Medicine & Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193001
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http://dx.doi.org/10.1016/j.pharmthera.2019.02.004DOI Listing
July 2019

Novel Approaches to Persistent Pain Therapy.

Trends Pharmacol Sci 2019 Jun 8;40(6):367-377. Epub 2019 May 8.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, Zentrum für Arzneimittelforschung, Entwicklung, und Sicherheit (ZAFES), University Hospital of Goethe-University, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Translational Medicine and Pharmacology (TMP), Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.04.003DOI Listing
June 2019

Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.

Eur J Pharm Biopharm 2019 Jan 16;134:144-152. Epub 2018 Nov 16.

Fraunhofer Institute for Molecular Biology and Applied Ecology, Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany. Electronic address: http://www.ime.fraunhofer.de.

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https://linkinghub.elsevier.com/retrieve/pii/S09396411183085
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http://dx.doi.org/10.1016/j.ejpb.2018.11.012DOI Listing
January 2019

Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy.

J Control Release 2019 Jan 17;293:63-72. Epub 2018 Nov 17.

Fraunhofer Institute for Molecular Biology and Applied Ecology, Branch for Translational Medicine and Pharmacology, Frankfurt/Main, Germany; Institute of Pharmaceutical Technology, Goethe University, Frankfurt/Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.11.017DOI Listing
January 2019

Ceramides as Novel Disease Biomarkers.

Trends Mol Med 2019 01 23;25(1):20-32. Epub 2018 Nov 23.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S14714914183020
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http://dx.doi.org/10.1016/j.molmed.2018.10.009DOI Listing
January 2019

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

J Mol Med (Berl) 2018 Oct 27;96(10):1131-1144. Epub 2018 Aug 27.

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1007/s00109-018-1689-7DOI Listing
October 2018

The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.

Clin Sci (Lond) 2018 Sep 17;132(17):1963-1976. Epub 2018 Aug 17.

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany

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http://clinsci.org/lookup/doi/10.1042/CS20180506
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http://dx.doi.org/10.1042/CS20180506DOI Listing
September 2018

An in vitro test system for compounds that modulate human inflammatory macrophage polarization.

Eur J Pharmacol 2018 Aug 18;833:328-338. Epub 2018 Jun 18.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.06.017DOI Listing
August 2018

Nrf2, the Master Regulator of Anti-Oxidative Responses.

Int J Mol Sci 2017 Dec 20;18(12). Epub 2017 Dec 20.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.3390/ijms18122772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751370PMC
December 2017

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro.

Mol Immunol 2017 08 7;88:58-68. Epub 2017 Jun 7.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.05.027DOI Listing
August 2017

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

Shock 2017 08;48(2):215-226

*Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany †Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt, Germany ‡Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt, Germany §Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany ||Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1097/SHK.0000000000000842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263038PMC
August 2017

Drugging the pain epigenome.

Nat Rev Neurol 2017 Jul 26;13(7):434-447. Epub 2017 May 26.

Pharmazentrum Frankfurt, Zentrum für Arzneimittelforschung Entwicklung und Sicherheit (ZAFES), Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/nrneurol.2017.68DOI Listing
July 2017

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion.

PLoS One 2016 17;11(10):e0163184. Epub 2016 Oct 17.

Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066982PMC
May 2017

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.

Biochem Pharmacol 2017 Feb 4;125:55-74. Epub 2016 Nov 4.

Aarhus University, Department of Biomedicine & Center for Study and Prevention of Neurodegenerative Inflammation (NEURODIN), Bartholins Allé 6, 8000 Aarhus C, Denmark; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.11.004DOI Listing
February 2017

Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.

Inflamm Res 2017 Jan 28;66(1):1-12. Epub 2016 Sep 28.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00011-016-0988-0DOI Listing
January 2017

R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.

Int J Mol Sci 2016 Dec 30;18(1). Epub 2016 Dec 30.

Pharmazentrum frankfurt, ZAFES, Institute for Clinical Pharmacology, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3390/ijms18010068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297703PMC
December 2016

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

Proc Natl Acad Sci U S A 2016 11 17;113(44):12544-12549. Epub 2016 Oct 17.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES (Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit), University Hospital, Goethe-University, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1073/pnas.1613246113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098623PMC
November 2016

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques.

J Control Release 2016 08 8;235:352-364. Epub 2016 Jun 8.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt (Main), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.06.013DOI Listing
August 2016

Pparγ Expression in T Cells as a Prognostic Marker of Sepsis.

Shock 2016 06;45(6):591-7

*Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt †Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP ‡Department of Anaethesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt §Department of Nephrology, Medical Clinic III, University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1097/SHK.0000000000000568DOI Listing
June 2016

Inverted Perceptual Judgment of Nociceptive Stimuli at Threshold Level following Inconsistent Cues.

PLoS One 2015 6;10(7):e0132069. Epub 2015 Jul 6.

Institute of Clinical Pharmacology, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132069PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493070PMC
April 2016

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.

Eur J Immunol 2016 Mar 22;46(3):570-81. Epub 2016 Jan 22.

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Hospital Frankfurt, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1002/eji.201545782DOI Listing
March 2016

Drug Repurposing for the Development of Novel Analgesics.

Trends Pharmacol Sci 2016 Mar 17;37(3):172-183. Epub 2015 Dec 17.

Institute of Clinical Pharmacology, pharmazentrum Frankfurt/ZAFES, University Hospital of Goethe-University, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project Group Translational Medicine and Pharmacology (TMP), Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.11.006DOI Listing
March 2016

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

Pharmacol Ther 2016 Jan 6;157:43-64. Epub 2015 Nov 6.

Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany; Aarhus University, Department of Biomedicine & Center for Study and Prevention of Neurodegenerative Inflammation (NEURODIN), Bartholins Allé 6, 8000 Aarhus C, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.11.001DOI Listing
January 2016

Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox.

Pharm Res 2015 Dec 28;32(12):3986-98. Epub 2015 Jul 28.

Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt (Main), Germany.

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http://link.springer.com/10.1007/s11095-015-1759-2
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http://dx.doi.org/10.1007/s11095-015-1759-2DOI Listing
December 2015

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.

FASEB J 2015 Dec 19;29(12):5029-43. Epub 2015 Aug 19.

*Fraunhofer Institute for Molecular Biology and Applied Ecology, Project Group Translational Medicine and Pharmacology, Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, and Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany; and Department of Medical Biochemistry and Biophysics, Division of Chemistry 2, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1096/fj.15-275487DOI Listing
December 2015

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture.

Int J Pharm 2015 Aug 26;491(1-2):250-60. Epub 2015 Jun 26.

Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.06.024DOI Listing
August 2015

Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists.

Eur J Pharmacol 2015 May 5;755:16-26. Epub 2015 Mar 5.

Institute of Biochemistry I - Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.02.034DOI Listing
May 2015

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.

EMBO Mol Med 2014 Nov;6(11):1398-422

Institute of Clinical Pharmacology Goethe-University Hospital, Frankfurt am Main, Germany Fraunhofer Institute of Molecular Biology and Applied Ecology Project Group Translational Medicine and Pharmacology (IME-TMP), Frankfurt am Main, Germany

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http://dx.doi.org/10.15252/emmm.201404168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237468PMC
November 2014

Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators.

J Chromatogr A 2014 Sep 29;1360:150-63. Epub 2014 Jul 29.

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2014.07.068DOI Listing
September 2014

Azithromycin: mechanisms of action and their relevance for clinical applications.

Pharmacol Ther 2014 Aug 11;143(2):225-45. Epub 2014 Mar 11.

Respiratory Division, Lung Transplantation Unit, University Hospitals Leuven and Department of Clinical and Experimental Medicine, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.03.003DOI Listing
August 2014

Common non-epigenetic drugs as epigenetic modulators.

Trends Mol Med 2013 Dec 18;19(12):742-53. Epub 2013 Sep 18.

Institute of Clinical Pharmacology, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany; Fraunhofer Institute of Molecular Biology and Applied Ecology - Project Group Translational Medicine and Pharmacology (IME-TMP), Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.08.006DOI Listing
December 2013

The early research and development of ebselen.

Biochem Pharmacol 2013 Nov 5;86(9):1248-53. Epub 2013 Sep 5.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952130053
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http://dx.doi.org/10.1016/j.bcp.2013.08.028DOI Listing
November 2013

Pharmacokinetics of non-intravenous formulations of fentanyl.

Clin Pharmacokinet 2013 Jan;52(1):23-36

Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, J. W. Goethe-University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s40262-012-0016-7DOI Listing
January 2013

Journal status and new developments.

Inflamm Res 2013 Jan;62(1)

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http://dx.doi.org/10.1007/s00011-012-0581-0DOI Listing
January 2013

Azithromycin drives in vitro GM-CSF/IL-4-induced differentiation of human blood monocytes toward dendritic-like cells with regulatory properties.

J Leukoc Biol 2012 Feb 30;91(2):229-43. Epub 2011 Nov 30.

GlaxoSmithKline Research Center Zagreb Ltd. (now Galapagos Research Center Ltd.), Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia.

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http://dx.doi.org/10.1189/jlb.1210655DOI Listing
February 2012

Inflammation research: modern design, more quality science.

Inflamm Res 2011 Jan;60(1)

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http://dx.doi.org/10.1007/s00011-010-0290-5DOI Listing
January 2011

Differential evaluation of excisional non-occluded wound healing in db/db mice.

Toxicol Pathol 2009 Feb 30;37(2):183-92. Epub 2009 Jan 30.

GSK Research Centre Zagreb Ltd., Prilaz baruna Filipovića 29, Zagreb, Croatia.

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http://dx.doi.org/10.1177/0192623308329280DOI Listing
February 2009

Inflammation symptoms and signalling.

Inflamm Res 2008 Sep;57(9):403

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http://link.springer.com/10.1007/s00011-008-0640-8
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http://dx.doi.org/10.1007/s00011-008-0640-8DOI Listing
September 2008

The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics.

Int Immunopharmacol 2007 Dec 30;7(12):1544-51. Epub 2007 Aug 30.

GlaxoSmithKline Research Centre Zagreb Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.

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http://dx.doi.org/10.1016/j.intimp.2007.07.031DOI Listing
December 2007

Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression.

Eur J Pharmacol 2007 Sep 16;570(1-3):212-21. Epub 2007 Jun 16.

PLIVA Research Institute Ltd, Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia.

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http://dx.doi.org/10.1016/j.ejphar.2007.05.072DOI Listing
September 2007

Non-clinical safety studies on biosimilar recombinant human erythropoietin.

Basic Clin Pharmacol Toxicol 2007 Feb;100(2):73-83

PLIVA Research Institute Ltd, Zagreb, Croatia.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00028.xDOI Listing
February 2007

Inflammation 2005 - Seventh World Congress. Respiratory inflammation.

IDrugs 2005 Oct;8(10):783-6

PLIVA Research Institute Ltd, Prilaz baruna Filipovica 25, Zagreb, Croatia.

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October 2005

Inflammation 2005 - Seventh World Congress. Rheumatoid arthritis and cell signaling.

IDrugs 2005 Oct;8(10):786-8

PLIVA Research Institute Ltd, Prilaz baruna Filipovica 25, Zagreb, Croatia.

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October 2005

Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections.

Curr Opin Infect Dis 2005 Apr;18(2):125-31

PLIVA Research Institute Ltd., Zagreb, Croatia.

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April 2005

Antibiotics for asthma?

Pediatr Pulmonol Suppl 2004 ;26:52

PLIVA Research Institute, Prilaz Baruna Filipovica 25, HR-10000 Zagreb, Croatia.

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April 2004