Michael J O Wakelam

Michael J O Wakelam

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Michael J O Wakelam

Michael J O Wakelam

Publications by authors named "Michael J O Wakelam"

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LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training.

Sci Signal 2019 Jan 8;12(563). Epub 2019 Jan 8.

Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/scisignal.aaw2964DOI Listing
January 2019

CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways.

J Cell Sci 2018 10 29;131(21). Epub 2018 Oct 29.

Institute of Cancer and Genomic Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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http://dx.doi.org/10.1242/jcs.220640DOI Listing
October 2018

Extracellular vesicles: lipids as key components of their biogenesis and functions.

J Lipid Res 2018 08 15;59(8):1316-1324. Epub 2018 May 15.

Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1194/jlr.E086173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071772PMC
August 2018

Phosphatidylinositolphosphate phosphatase activities and cancer.

J Lipid Res 2016 Feb 24;57(2):176-92. Epub 2015 Aug 24.

Signalling Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom

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http://dx.doi.org/10.1194/jlr.R059154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727428PMC
February 2016

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.

Open Biol 2015 Sep;5(9):150093

Division of Cancer Biology, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK

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http://dx.doi.org/10.1098/rsob.150093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593667PMC
September 2015

Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans.

Open Biol 2015 Sep;5(9):150119

The Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK

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http://dx.doi.org/10.1098/rsob.150119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593670PMC
September 2015

The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies.

Biochim Biophys Acta 2014 Aug 24;1841(8):1102-7. Epub 2014 Apr 24.

The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1016/j.bbalip.2014.04.005DOI Listing
August 2014

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.

J Biol Chem 2014 Aug 10;289(31):21276-88. Epub 2014 Jun 10.

From the Medical Research Council-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, United Kingdom and

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http://www.jbc.org/content/289/31/21276.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.582999
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http://dx.doi.org/10.1074/jbc.M114.582999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118089PMC
August 2014

Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4.

J Cell Sci 2014 Jul 29;127(Pt 14):3104-15. Epub 2014 May 29.

Signalling Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK

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http://dx.doi.org/10.1242/jcs.145854DOI Listing
July 2014

Lipidomics in the analysis of malignancy.

Adv Biol Regul 2014 Jan 18;54:93-8. Epub 2013 Nov 18.

The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2013.11.001DOI Listing
January 2014

SnapShot: Lipid kinase and phosphatase reaction pathways.

Cell 2014 Jan;156(1-2):376-376.e1

The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1016/j.cell.2014.01.003DOI Listing
January 2014

SnapShot: lipid kinases and phosphatases.

Cell 2013 Dec;155(7):1654-1654.e1

The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

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http://www.cell.com/pb/assets/raw/journals/research/snapshot
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301537
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http://dx.doi.org/10.1016/j.cell.2013.12.005DOI Listing
December 2013

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.

Obesity (Silver Spring) 2013 Sep 23;21(9):1823-9. Epub 2013 May 23.

Addenbrooke's Hospital, Institute of Metabolic Science, University of Cambridge Metabolic Research Laboratories, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1002/oby.20297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763967PMC
September 2013

Shorthand notation for lipid structures derived from mass spectrometry.

J Lipid Res 2013 Jun 2;54(6):1523-30. Epub 2013 Apr 2.

Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1194/jlr.M033506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646453PMC
June 2013

Methods for analyzing phosphoinositides using mass spectrometry.

Biochim Biophys Acta 2011 Nov 23;1811(11):758-62. Epub 2011 Sep 23.

The Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1016/j.bbalip.2011.09.004DOI Listing
November 2011

Assessment of novel combinations of biomarkers for the detection of colorectal cancer.

Cancer Biomark 2010 ;7(3):123-32

School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/CBM-2010-0155DOI Listing
May 2011

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

Nat Methods 2011 Mar 30;8(3):267-72. Epub 2011 Jan 30.

Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.1564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460242PMC
March 2011

Cross-talk between phospholipase D and MAP kinases activities.

Adv Enzyme Regul 2010 5;50(1):57-61. Epub 2009 Nov 5.

Inositide Laboratory, The Babraham Institute, Babraham, Cambridge CB22 3AT, United Kingdom.

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http://dx.doi.org/10.1016/j.advenzreg.2009.10.032DOI Listing
August 2010

Runx regulation of sphingolipid metabolism and survival signaling.

Cancer Res 2010 Jul 29;70(14):5860-9. Epub 2010 Jun 29.

Molecular Oncology Laboratory, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.

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http://cancerres.aacrjournals.org/content/70/14/5860.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-0726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906707PMC
July 2010

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.

Biochim Biophys Acta 2009 Sep 5;1791(9):856-61. Epub 2009 May 5.

The Inositide Laboratory, the Babraham Institute, Babraham Research Campus, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbalip.2009.04.008DOI Listing
September 2009

Update of the LIPID MAPS comprehensive classification system for lipids.

J Lipid Res 2009 Apr 19;50 Suppl:S9-14. Epub 2008 Dec 19.

San Diego Supercomputer Center, Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0505, USA.

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http://dx.doi.org/10.1194/jlr.R800095-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674711PMC
April 2009

Lipid systems and techniques. Introduction.

Methods Mol Biol 2009 ;462:3-4

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February 2009

Determination of phospholipase D, lysophospholipase D and DG kinase signaling pathways in disease states by mass spectrometry.

Adv Enzyme Regul 2008 7;48:254-60. Epub 2008 Mar 7.

The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.

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http://dx.doi.org/10.1016/j.advenzreg.2008.02.007DOI Listing
December 2008

Proteomic profiling of urine for the detection of colon cancer.

Proteome Sci 2008 Jun 16;6:19. Epub 2008 Jun 16.

Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, UK.

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http://dx.doi.org/10.1186/1477-5956-6-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440369PMC
June 2008

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles.

BMC Cell Biol 2008 May 20;9:25. Epub 2008 May 20.

CR-UK Institute for Cancer Studies, Birmingham University, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1186/1471-2121-9-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2405794PMC
May 2008

Lipidomic analysis of signaling pathways.

Methods Enzymol 2007 ;432:233-46

The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790732010
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http://dx.doi.org/10.1016/S0076-6879(07)32010-7DOI Listing
March 2008

Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18.

Mol Immunol 2007 May 7;44(12):3211-21. Epub 2007 Mar 7.

CRUK Institute for Cancer Studies, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1016/j.molimm.2007.01.033DOI Listing
May 2007

Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation.

J Am Soc Nephrol 2007 Apr 14;18(4):1112-20. Epub 2007 Mar 14.

CR-UK Institute for Cancer Studies, Birmingham University, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1681/ASN.2006090973DOI Listing
April 2007

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion.

Hepatology 2007 Feb;45(2):465-74

Liver Research Group, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.21497DOI Listing
February 2007

Analysis of intact phosphoinositides in biological samples.

J Lipid Res 2006 Jul 21;47(7):1588-96. Epub 2006 Apr 21.

Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1194/jlr.D600004-JLR200DOI Listing
July 2006

Assays to study phospholipase D regulation by inositol phospholipids and ADP-ribosylation factor 6.

Methods Enzymol 2005 ;404:398-410

CR United Kingdom Institute for Cancer Studies, Birmingham University.

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http://dx.doi.org/10.1016/S0076-6879(05)04035-8DOI Listing
March 2006

Diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles.

J Biol Chem 2005 Dec 10;280(50):41171-7. Epub 2005 Oct 10.

Biology Department, Amherst College, Amherst, Massachusetts 01002, USA.

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http://dx.doi.org/10.1074/jbc.M412863200DOI Listing
December 2005

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.

Blood 2005 Sep 2;106(6):2138-46. Epub 2005 Jun 2.

CRUK Institute for Cancer Studies, The Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-02-0471DOI Listing
September 2005

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b.

J Cell Sci 2005 Jul;118(Pt 13):2975-86

CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1242/jcs.02432DOI Listing
July 2005

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.

J Immunol 2005 Apr;174(8):4803-11

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.174.8.4803DOI Listing
April 2005

Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.

J Am Soc Nephrol 2004 Mar;15(3):796-808

Renal Immunobiology, MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1097/01.asn.0000113241.98702.77DOI Listing
March 2004

Phospholipase D.

Biochem Cell Biol 2004 Feb;82(1):225-53

Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7090, USA.

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http://dx.doi.org/10.1139/o03-079DOI Listing
February 2004

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.

J Biol Chem 2004 Jan 27;279(2):1010-9. Epub 2003 Oct 27.

Cancer Research United Kingdom Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M303820200DOI Listing
January 2004

The regulation of phospholipase D by inositol phospholipids and small GTPases.

FEBS Lett 2002 Oct;531(1):62-4

CR UK Institute for Cancer Studies, Birmingham University, B15 2TT, Birmingham, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)03410-5DOI Listing
October 2002

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.

J Biol Chem 2002 Aug 6;277(31):28298-309. Epub 2002 May 6.

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Wolfson Building, Institute of Biomedical and Life Sciences (IBLS), University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M108353200DOI Listing
August 2002

Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway.

Oncogene 2002 Aug;21(37):5765-72

Cancer Research UK Institute for Cancer Studies, Birmingham University, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1038/sj.onc.1205702DOI Listing
August 2002

Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells.

Mol Biol Cell 2002 Apr;13(4):1252-62

Institute for Cancer Studies, Birmingham University, Birmingham, B15 2TA, United Kingdom.

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http://www.molbiolcell.org/doi/10.1091/mbc.01-05-0235
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http://dx.doi.org/10.1091/mbc.01-05-0235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC102266PMC
April 2002