Michael J McConnell

Michael J McConnell

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Michael J McConnell

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Where are we with monoclonal antibodies for multidrug-resistant infections?

Drug Discov Today 2019 May 8;24(5):1132-1138. Epub 2019 Mar 8.

Antimicrobial Resistance and Hospital Acquired Infections Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.03.002DOI Listing
May 2019

Imaging Flow Cytometry Quantifies Neural Genome Dynamics.

Cytometry A 2019 May 7. Epub 2019 May 7.

Department of Biochemistry & Molecular Genetics, University of Virginia School of Medicine, Neuroscience Graduate Program, Charlottesville, Virginia, 22908.

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http://dx.doi.org/10.1002/cyto.a.23783DOI Listing
May 2019

The effect of rho kinase inhibition on morphological and electrophysiological maturity in iPSC-derived neurons.

Cell Tissue Res 2019 Mar 8;375(3):641-654. Epub 2018 Nov 8.

Department of Biochemistry and Molecular Genetics and Neuroscience, Centers for Brain Immunology and Glia, Public Health Genomics, and Children's Health Research, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA.

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http://dx.doi.org/10.1007/s00441-018-2942-7DOI Listing
March 2019

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex.

Cell Rep 2019 Jan;26(4):825-835.e7

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Brain Immunology and Glia, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Child Health Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.107DOI Listing
January 2019

Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii.

Virulence 2018 12;9(1):930-942

a Clinical Unit of Infectious Diseases, Clinical Microbiology and Preventive Medicine; Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC /University of Seville , Seville , Spain.

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http://dx.doi.org/10.1080/21505594.2018.1460187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955468PMC
December 2018

Peptidoglycan recycling contributes to intrinsic resistance to fosfomycin in Acinetobacter baumannii.

J Antimicrob Chemother 2018 Nov;73(11):2960-2968

Clinical Unit of Infectious Diseases, Clinical Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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http://dx.doi.org/10.1093/jac/dky289DOI Listing
November 2018

Improved molecular karyotyping in glioblastoma.

Mutat Res 2018 09 8;811:16-26. Epub 2018 Jul 8.

Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA, United States; Department of Neuroscience, University of Virginia, School of Medicine, Charlottesville, VA, United States; Center for Public Health Genomics, University of Virginia, School of Medicine, Charlottesville, VA, United States; Center for Brain Immunology and Glia, University of Virginia, School of Medicine, Charlottesville, VA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2018.06.002DOI Listing
September 2018

Immunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection.

Vaccine 2018 07 7;36(29):4153-4156. Epub 2018 Jun 7.

Clinical Unit of Infectious Diseases, Clinical Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, 41013 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2018.05.113DOI Listing
July 2018

Pharmacological reactivation of inactive X-linked in cerebral cortical neurons of living mice.

Proc Natl Acad Sci U S A 2018 07 16;115(31):7991-7996. Epub 2018 Jul 16.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908;

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http://dx.doi.org/10.1073/pnas.1803792115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077728PMC
July 2018

Single-cell analysis of diversity in human stem cell-derived neurons.

Cell Tissue Res 2018 01 29;371(1):171-179. Epub 2017 Nov 29.

Department of Biochemistry and Molecular Genetics, Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1007/s00441-017-2728-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260820PMC
January 2018

Using bacterial genomes and essential genes for the development of new antibiotics.

Biochem Pharmacol 2017 06 8;134:74-86. Epub 2016 Dec 8.

Biomedical Institute of Seville, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411290PMC
June 2017

Rapid Detection of Antibiotic Resistance in Gram-Negative Bacteria Through Assessment of Changes in Cellular Morphology.

Microb Drug Resist 2017 Mar 3;23(2):157-162. Epub 2016 Jun 3.

4 Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospitals Virgen del Rocío and Virgen Macarena, Seville, Spain .

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http://dx.doi.org/10.1089/mdr.2016.0023DOI Listing
March 2017

Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii.

Antimicrob Agents Chemother 2016 08 22;60(8):5076-9. Epub 2016 Jul 22.

Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Seville, Spain

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http://dx.doi.org/10.1128/AAC.00407-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958213PMC
August 2016

Impaired growth under iron-limiting conditions associated with the acquisition of colistin resistance in Acinetobacter baumannii.

Int J Antimicrob Agents 2016 Jun 22;47(6):473-7. Epub 2016 Apr 22.

Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville 41013, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09248579163005
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http://dx.doi.org/10.1016/j.ijantimicag.2016.03.010DOI Listing
June 2016

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis.

ACS Chem Biol 2016 05 14;11(5):1428-37. Epub 2016 Mar 14.

Department of Radiation Oncology, University of Pittsburgh , Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1021/acschembio.5b00909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488269PMC
May 2016

Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design.

Drug Discov Today 2016 Apr 11;21(4):674-81. Epub 2016 Mar 11.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.03.005DOI Listing
April 2016

Identifying targets for antibiotic development using omics technologies.

Drug Discov Today 2016 Mar 12;21(3):465-72. Epub 2015 Dec 12.

Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.11.014DOI Listing
March 2016

Vaccines for Antibiotic-Resistant Bacteria: Possibility or Pipe Dream?

Trends Pharmacol Sci 2016 Feb 10;37(2):143-152. Epub 2015 Nov 10.

Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.10.003DOI Listing
February 2016

Single neuron transcriptome analysis can reveal more than cell type classification: Does it matter if every neuron is unique?

Bioessays 2016 Feb 8;38(2):157-61. Epub 2016 Jan 8.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.

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http://dx.doi.org/10.1002/bies.201500097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852373PMC
February 2016

Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii.

Int J Antimicrob Agents 2015 Dec 7;46(6):696-702. Epub 2015 Sep 7.

Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, 41013 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2015.07.017DOI Listing
December 2015

First steps towards a vaccine against Acinetobacter baumannii.

Curr Pharm Biotechnol 2013 ;14(10):897-902

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Hospital Universitario Virgen del Rocio/Instituto de Biomedicina de Sevilla, Avenida Manuel Siurot s/n, 41013 Sevilla, Spain.

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September 2014

Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae.

J Proteomics 2014 Jun 24;106:46-60. Epub 2014 Apr 24.

Departamento de Bioquímica y Biología Molecular, Universidad de Córdoba, Campus de Excelencia Internacional CeiA3, Córdoba, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.04.023DOI Listing
June 2014

Considerations for the development of a prophylactic vaccine for Acinetobacter baumannii.

Vaccine 2014 May 1;32(22):2534-6. Epub 2013 Nov 1.

Biomedical Institute of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2013.10.064DOI Listing
May 2014

Activity of host antimicrobials against multidrug-resistant Acinetobacter baumannii acquiring colistin resistance through loss of lipopolysaccharide.

Antimicrob Agents Chemother 2014 May 24;58(5):2972-5. Epub 2014 Feb 24.

Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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http://dx.doi.org/10.1128/AAC.02642-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993257PMC
May 2014

Progress on the development of rapid methods for antimicrobial susceptibility testing.

J Antimicrob Chemother 2013 Dec 30;68(12):2710-7. Epub 2013 Jun 30.

Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Avenida Manuel Siurot s/n 41013, Seville, Spain.

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http://dx.doi.org/10.1093/jac/dkt253DOI Listing
December 2013

Colistin resistance in a clinical Acinetobacter baumannii strain appearing after colistin treatment: effect on virulence and bacterial fitness.

Antimicrob Agents Chemother 2013 Sep 8;57(9):4587-9. Epub 2013 Jul 8.

Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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http://dx.doi.org/10.1128/AAC.00543-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754302PMC
September 2013

Rapid detection of antibiotic resistance in Acinetobacter baumannii using quantitative real-time PCR.

J Antimicrob Chemother 2013 Jul 23;68(7):1572-5. Epub 2013 Feb 23.

Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Biomedical Institute of Seville, University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1093/jac/dkt057DOI Listing
July 2013

Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models.

FEMS Microbiol Rev 2013 Mar 18;37(2):130-55. Epub 2012 Jun 18.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1111/j.1574-6976.2012.00344.xDOI Listing
March 2013

Emerging therapies for multidrug resistant Acinetobacter baumannii.

Trends Microbiol 2013 Mar 11;21(3):157-63. Epub 2013 Jan 11.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013, Sevilla, Spain.

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http://dx.doi.org/10.1016/j.tim.2012.12.002DOI Listing
March 2013

Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells.

PLoS One 2012 13;7(4):e33073. Epub 2012 Apr 13.

Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326023PMC
August 2012

Quantitative real-time PCR for detection of Acinetobacter baumannii colonization in the hospital environment.

J Clin Microbiol 2012 Apr 1;50(4):1412-4. Epub 2012 Feb 1.

Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Institute of Biomedicine of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1128/JCM.06566-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318517PMC
April 2012

Improved viral suppression after treatment optimization in HIV-infected patients with persistent low-level viremia.

J Acquir Immune Defic Syndr 2011 Dec;58(5):446-9

Unit of Infectious Diseases, Microbiology and Preventive Medicine, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain.

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http://dx.doi.org/10.1097/QAI.0b013e3182364513DOI Listing
December 2011

Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii.

Vaccine 2011 Aug 14;29(34):5705-10. Epub 2011 Jun 14.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X110086
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http://dx.doi.org/10.1016/j.vaccine.2011.06.001DOI Listing
August 2011

Expression, purification, and refolding of biologically active Acinetobacter baumannii OmpA from Escherichia coli inclusion bodies.

Protein Expr Purif 2011 May 3;77(1):98-103. Epub 2010 Dec 3.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.pep.2010.11.019DOI Listing
May 2011

Acinetobacter baumannii-induced lung cell death: role of inflammation, oxidative stress and cytosolic calcium.

Microb Pathog 2011 May 1;50(5):224-32. Epub 2011 Feb 1.

Service of Infectious Diseases, Institute of Biomedicine of Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, Av. Manuel Siurot s/n, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.micpath.2011.01.008DOI Listing
May 2011

Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development.

Theory Biosci 2011 Mar 8;130(1):31-43. Epub 2010 Sep 8.

Department of Mathematical Sciences, Clemson University, Clemson, SC 29634-0975, USA.

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http://dx.doi.org/10.1007/s12064-010-0107-7DOI Listing
March 2011

Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

J Infect Dis 2011 Feb 7;203(4):545-8. Epub 2011 Jan 7.

Servicio de Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Seville, Sevilla, Spain.

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http://dx.doi.org/10.1093/infdis/jiq086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071218PMC
February 2011

Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii.

Infect Immun 2011 Jan 25;79(1):518-26. Epub 2010 Oct 25.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Hospitales Universitarios Virgen del Rocío, Edificio Laboratorio Anexo Caracola, Avenida Manuel Siurot s/n, 41013 Seville, Spain.

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http://dx.doi.org/10.1128/IAI.00741-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019872PMC
January 2011

Active and passive immunization against Acinetobacter baumannii using an inactivated whole cell vaccine.

Vaccine 2010 Dec 18;29(1):1-5. Epub 2010 Nov 18.

Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.vaccine.2010.10.052DOI Listing
December 2010

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

Trends Neurosci 2010 Aug 12;33(8):345-54. Epub 2010 May 12.

Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1016/j.tins.2010.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916067PMC
August 2010

Mathematical modeling supports substantial mouse neural progenitor cell death.

Neural Dev 2009 Jul 14;4:28. Epub 2009 Jul 14.

Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/1749-8104-4-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729736PMC
July 2009

H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.

Proc Natl Acad Sci U S A 2009 Apr 3;106(16):6784-9. Epub 2009 Apr 3.

Bio-X and Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902018106
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http://dx.doi.org/10.1073/pnas.0902018106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672503PMC
April 2009

Adenovirus-based prime-boost immunization for rapid vaccination against anthrax.

Mol Ther 2007 Jan;15(1):203-10

Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/sj.mt.6300034DOI Listing
January 2007

Characterization of a permissive epitope insertion site in adenovirus hexon.

J Virol 2006 Jun;80(11):5361-70

University of Michigan Medical School, 6304 Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0942, USA.

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http://dx.doi.org/10.1128/JVI.00256-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472126PMC
June 2006

Cytokine response and survival of mice immunized with an adenovirus expressing Bacillus anthracis protective antigen domain 4.

Infect Immun 2006 Feb;74(2):1009-15

Department of Microbiology and Immunololgy, University of Michigan Medical School, 6304 Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0942, USA.

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http://dx.doi.org/10.1128/IAI.74.2.1009-1015.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360362PMC
February 2006

Constitutional aneuploidy in the normal human brain.

J Neurosci 2005 Mar;25(9):2176-80

Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4560-04.2005DOI Listing
March 2005

Biology of adenovirus and its use as a vector for gene therapy.

Hum Gene Ther 2004 Nov;15(11):1022-33

Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1089/hum.2004.15.1022DOI Listing
November 2004

Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells.

J Neurosci 2003 Nov;23(32):10454-62

Biomedical Sciences, School of Medicine, University of California, San Diego, California 92093, USA.

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http://www.scripps.edu/chun/PDFs/Yang%20J%20Neurosci%202003.
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November 2003

Alteration of gene expression by chromosome loss in the postnatal mouse brain.

J Neurosci 2003 Jul;23(13):5599-606

Neuroscience Program, Department of Pharmacology, University of California, San Diego, San Diego, California 92093, USA.

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July 2003