Michael J Hayman

Michael J Hayman

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Michael J Hayman

Michael J Hayman

Publications by authors named "Michael J Hayman"

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A phosphoarray platform is capable of personalizing kinase inhibitor therapy in head and neck cancers.

Int J Cancer 2018 01 4;142(1):156-164. Epub 2017 Oct 4.

Department of Microbiology and Molecular Genetics, Stony Brook University, Stony Brook, NY, 11794.

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http://dx.doi.org/10.1002/ijc.31045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765765PMC
January 2018

Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L.

Theranostics 2016 28;6(6):808-16. Epub 2016 Mar 28.

1. Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, New York, USA;

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http://dx.doi.org/10.7150/thno.13826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860889PMC
October 2017

KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.

Oncotarget 2017 Mar;8(11):17995-18009

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.18632/oncotarget.14929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392302PMC
March 2017

A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma.

Mol Cancer Res 2016 08 23;14(8):740-52. Epub 2016 May 23.

Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, New York. Division of Pediatric Hematology/Oncology, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987210PMC
August 2016

The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A.

J Cell Biochem 2016 Feb;117(2):334-43

Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile.

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http://dx.doi.org/10.1002/jcb.25275DOI Listing
February 2016

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells.

Oncotarget 2015 Jun;6(18):15814-27

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599239PMC
http://dx.doi.org/10.18632/oncotarget.4538DOI Listing
June 2015

Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease.

Nat Commun 2013 ;4:2735

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5222, USA.

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http://www.nature.com/articles/ncomms3735
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http://dx.doi.org/10.1038/ncomms3735DOI Listing
June 2014

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas.

Proc Natl Acad Sci U S A 2014 Mar 18;111(9):3466-71. Epub 2014 Feb 18.

Departments of Molecular Genetics and Microbiology and Pathology, Stony Brook University, Stony Brook, NY 11794.

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http://dx.doi.org/10.1073/pnas.1319911111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948305PMC
March 2014

Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.

J Cell Physiol 2012 Jan;227(1):278-87

Programa de Genética Humana, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://doi.wiley.com/10.1002/jcp.22733
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http://dx.doi.org/10.1002/jcp.22733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138863PMC
January 2012

Identification of Ski as a target for Aurora A kinase.

Biochem Biophys Res Commun 2011 Jun 12;409(3):539-43. Epub 2011 May 12.

Programa de Genética Humana, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbrc.2011.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132191PMC
June 2011

Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer.

Cancer Invest 2010 Dec 27;28(10):1054-62. Epub 2010 Sep 27.

Division of Pediatric Hematology/Oncology, Stony Brook University, Stony Brook, New York 11794-8111, USA.

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http://dx.doi.org/10.3109/07357907.2010.512602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983479PMC
December 2010

The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.

Biochem Biophys Res Commun 2010 Sep 4;399(4):623-8. Epub 2010 Aug 4.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.07.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940706PMC
September 2010

RON-expressing MCF-10A breast epithelial cells exhibit alterations of hyaluronan expression, promoting RON-mediated early adhesion events.

Biochem Biophys Res Commun 2010 Jan 21;391(4):1604-9. Epub 2009 Dec 21.

Stony Brook University, Department of Molecular Genetic & Microbiology, 130 Life Sciences Building, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.080DOI Listing
January 2010

The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.

Biochem Biophys Res Commun 2009 May 31;383(1):119-24. Epub 2009 Mar 31.

Department of Molecular Genetics and Microbiology, SUNY at Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.03.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695671PMC
May 2009

Annexin II binds to SHP2 and this interaction is regulated by HSP70 levels.

Biochem Biophys Res Commun 2007 May 19;356(4):906-11. Epub 2007 Mar 19.

Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034505PMC
May 2007

HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway.

Biochem Biophys Res Commun 2006 Dec 3;351(4):979-85. Epub 2006 Nov 3.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698467PMC
December 2006

Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.

Biochim Biophys Acta 2006 Jan 20;1763(1):45-56. Epub 2005 Dec 20.

Department of Biochemistry and Molecular Pharmacology and The Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506-9142, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2005.11.013DOI Listing
January 2006

An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family.

J Gen Physiol 2005 Jul 13;126(1):41-53. Epub 2005 Jun 13.

Department of Physiology and Biophysics, HSC, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1085/jgp.200509274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266615PMC
July 2005

The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis.

Oncogene 2005 Jun;24(27):4321-9

Department of Molecular Genetics and Microbiology, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1038/sj.onc.1208631DOI Listing
June 2005

The C terminus of RON tyrosine kinase plays an autoinhibitory role.

J Biol Chem 2005 Mar 4;280(10):8893-900. Epub 2005 Jan 4.

Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1074/jbc.M412623200DOI Listing
March 2005

Ski negatively regulates erythroid differentiation through its interaction with GATA1.

Mol Cell Biol 2004 Dec;24(23):10118-25

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1128/MCB.24.23.10118-10125.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529047PMC
December 2004

The human Ski-interacting protein functionally substitutes for the yeast PRP45 gene.

Biochem Biophys Res Commun 2004 Jul;319(4):1105-9

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.096DOI Listing
July 2004

Differential effects of the Ski-interacting protein (SKIP) on differentiation induced by transforming growth factor-beta1 and bone morphogenetic protein-2 in C2C12 cells.

Exp Cell Res 2004 Jun;296(2):163-72

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.yexcr.2004.01.025DOI Listing
June 2004

Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.

Mol Cell Biol 2003 Nov;23(21):7875-86

Department of Molecular Genetics and Microbiology, Health Sciences Center, Stony Brook University, Stony Brook, New York 11794-5222, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC207628PMC
http://dx.doi.org/10.1128/mcb.23.21.7875-7886.2003DOI Listing
November 2003

The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.

Oncogene 2003 Oct;22(44):6909-18

Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1038/sj.onc.1206798DOI Listing
October 2003

Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase.

Oncogene 2003 Sep;22(41):6311-8

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1038/sj.onc.1206742DOI Listing
September 2003

Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling.

J Biol Chem 2003 Aug 11;278(35):32489-92. Epub 2003 Jul 11.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5222, USA.

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http://dx.doi.org/10.1074/jbc.C300276200DOI Listing
August 2003

Signal-dependent N-CoR requirement for repression by the Ski oncoprotein.

J Biol Chem 2003 Jul 25;278(27):24858-64. Epub 2003 Apr 25.

Department of Molecular Genetics and Microbiology, Stony Brook University, New York 11794-5222, USA.

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http://dx.doi.org/10.1074/jbc.M303447200DOI Listing
July 2003

Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.

J Biol Chem 2003 Apr 11;278(16):13952-8. Epub 2003 Feb 11.

Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, 11794-5222, USA.

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http://dx.doi.org/10.1074/jbc.M210670200DOI Listing
April 2003