Michael J Eck

Michael J Eck

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Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Nature 2019 Oct 3. Epub 2019 Oct 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1660-yDOI Listing
October 2019

A driving test for oncogenic mutations.

J Biol Chem 2019 Jun;294(24):9390-9391

From the Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1074/jbc.H119.009452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579455PMC
June 2019

Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.

ACS Chem Biol 2019 04 11;14(4):587-593. Epub 2019 Mar 11.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology , Dana-Farber Cancer Institute , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acschembio.8b00722DOI Listing
April 2019

Crystal Structure of the FERM-SH2 Module of Human Jak2.

PLoS One 2016 26;11(5):e0156218. Epub 2016 May 26.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881981PMC
August 2017

Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination.

Biophys J 2017 Aug;113(4):889-899

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567609PMC
August 2017

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.

Cell Rep 2017 07;20(3):549-557

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173088
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http://dx.doi.org/10.1016/j.celrep.2017.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704918PMC
July 2017

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9810-5. Epub 2016 Aug 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1606862113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024598PMC
August 2016

SPLINTS: small-molecule protein ligand interface stabilizers.

Curr Opin Struct Biol 2016 Apr 30;37:115-22. Epub 2016 Jan 30.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland; University of Basel, Petersplatz 10, 4003 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834252PMC
April 2016

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Nat Struct Mol Biol 2015 Dec 9;22(12):983-90. Epub 2015 Nov 9.

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.3117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824005PMC
December 2015

EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors.

Clin Cancer Res 2015 Sep 6;21(17):3913-23. Epub 2015 May 6.

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791951PMC
September 2015

Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.

Structure 2015 Aug 25;23(8):1492-1499. Epub 2015 Jun 25.

Department of Cancer Biology, Dana-Farber Cancer Institute, SM1036, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(15)00218-X.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261500218
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http://dx.doi.org/10.1016/j.str.2015.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578302PMC
August 2015

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Cancer Discov 2014 Dec 24;4(12):1430-47. Epub 2014 Sep 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Genetics, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258125PMC
December 2014

JAK-cytokine receptor recognition, unboxed.

Nat Struct Mol Biol 2014 May;21(5):431-3

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA, and the Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2824DOI Listing
May 2014

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.

Elife 2014 May 20;3:e01763. Epub 2014 May 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States

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https://elifesciences.org/articles/01763
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http://dx.doi.org/10.7554/eLife.01763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059381PMC
May 2014

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Cancer Discov 2014 Apr 20;4(4):452-65. Epub 2014 Jan 20.

Departments of 1Medical Oncology and 2Cancer Biology, Dana-Farber Cancer Institute; 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston; 4Broad Institute of Harvard and MIT, Cambridge; 5MGH Cancer Center, 6Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts; and 7Department of Surgery, Division of Biology and Biomedical Sciences, Washington University, St. Louis, Missouri.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980023PMC
April 2014

Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.

Cancer Res 2013 Nov 24;73(22):6770-9. Epub 2013 Sep 24.

Authors' Affiliations: Departments of Medical Oncology and Cancer Biology; Center for Cancer Genome Discovery, Lowe Center for Thoracic Oncology, and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Departments of Medicine, Brigham and Women's Hospital; Departments of Biological Chemistry and Molecular Pharmacology and Pathology, Harvard Medical School, Boston, Massachusetts; Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea; and The Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903789PMC
November 2013

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.

Nat Struct Mol Biol 2013 Oct 8;20(10):1221-3. Epub 2013 Sep 8.

1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863620PMC
October 2013

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

ACS Chem Biol 2013 Sep 23;8(9):1931-8. Epub 2013 Jul 23.

Howard Hughes Medical Institute and Department of Cellular & Molecular Pharmacology, University of California, San Francisco , San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/cb400376pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938192PMC
September 2013

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.

Proc Natl Acad Sci U S A 2013 Sep 9;110(38):E3595-604. Epub 2013 Sep 9.

Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232.

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http://dx.doi.org/10.1073/pnas.1220050110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780914PMC
September 2013

Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.

Proc Natl Acad Sci U S A 2012 Dec 16;109(50):E3424-33. Epub 2012 Nov 16.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1203035109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528572PMC
December 2012

Cyclic di-GMP sensing via the innate immune signaling protein STING.

Mol Cell 2012 Jun 14;46(6):735-45. Epub 2012 Jun 14.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727651200445
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http://dx.doi.org/10.1016/j.molcel.2012.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697849PMC
June 2012

EGFR in limbo.

Cell 2012 May;149(4):735-7

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2012.04.015DOI Listing
May 2012

Structure and function of the interacting domains of Spire and Fmn-family formins.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11884-9. Epub 2011 Jul 5.

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1105703108
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http://dx.doi.org/10.1073/pnas.1105703108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141961PMC
July 2011

Crystal structure of a coiled-coil domain from human ROCK I.

PLoS One 2011 Mar 21;6(3):e18080. Epub 2011 Mar 21.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018080PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061879PMC
March 2011

The FERM domain: organizing the structure and function of FAK.

Nat Rev Mol Cell Biol 2010 Nov;11(11):802-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/nrm2996DOI Listing
November 2010

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.

Nat Struct Mol Biol 2010 Oct 12;17(10):1175-81. Epub 2010 Sep 12.

School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Korea.

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http://dx.doi.org/10.1038/nsmb.1907DOI Listing
October 2010

Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer.

Biochim Biophys Acta 2010 Mar 22;1804(3):559-66. Epub 2009 Dec 22.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390900368
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http://dx.doi.org/10.1016/j.bbapap.2009.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859716PMC
March 2010

Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.

PLoS One 2008 24;3(11):e3800. Epub 2008 Nov 24.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003800PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582962PMC
June 2009

The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl.

Curr Opin Cell Biol 2009 Apr 11;21(2):288-95. Epub 2009 Feb 11.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ceb.2009.01.014DOI Listing
April 2009

The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.

Mol Cell 2008 Nov;32(4):564-75

Cancer Biology Program, Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628593PMC
November 2008

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.

Proc Natl Acad Sci U S A 2008 Feb 28;105(6):2070-5. Epub 2008 Jan 28.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0709662105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538882PMC
February 2008

Spatial and temporal regulation of focal adhesion kinase activity in living cells.

Mol Cell Biol 2008 Jan 29;28(1):201-14. Epub 2007 Oct 29.

Department of Cell & Developmental Biology, 534 Taylor Hall, CB 7090, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.01324-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223290PMC
January 2008

Mechanism and function of formins in the control of actin assembly.

Annu Rev Biochem 2007 ;76:593-627

Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.75.
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http://dx.doi.org/10.1146/annurev.biochem.75.103004.142647DOI Listing
September 2007

Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly.

J Mol Biol 2007 Jun 5;369(5):1258-69. Epub 2007 Apr 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360700455
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http://dx.doi.org/10.1016/j.jmb.2007.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939941PMC
June 2007

Structural basis for the autoinhibition of focal adhesion kinase.

Cell 2007 Jun;129(6):1177-87

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2007.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077847PMC
June 2007

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Nat Chem Biol 2007 Apr 4;3(4):229-38. Epub 2007 Mar 4.

Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nchembio866DOI Listing
April 2007

Structure of the autoinhibitory switch in formin mDia1.

Structure 2006 Feb;14(2):257-63

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.str.2005.12.003DOI Listing
February 2006

Crystal structure of the FERM domain of focal adhesion kinase.

J Biol Chem 2006 Jan 12;281(1):252-9. Epub 2005 Oct 12.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M509188200DOI Listing
January 2006

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

Blood 2005 Aug 14;106(3):996-1002. Epub 2005 Apr 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2005-02-0707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895152PMC
August 2005

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

N Engl J Med 2005 Feb;352(8):786-92

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMoa044238DOI Listing
February 2005

Structure and regulation of Src family kinases.

Oncogene 2004 Oct;23(48):7918-27

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.onc.1208081DOI Listing
October 2004

FERM domain interaction promotes FAK signaling.

Mol Cell Biol 2004 Jun;24(12):5353-68

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1128/MCB.24.12.5353-5368.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419890PMC
June 2004

SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.

Int Immunol 2004 May 13;16(5):727-36. Epub 2004 Apr 13.

Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/intimm/dxh074DOI Listing
May 2004

Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.

Cell 2004 Mar;116(5):711-23

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00210-7DOI Listing
March 2004

A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin.

Mol Biol Cell 2004 Feb 2;15(2):896-907. Epub 2003 Dec 2.

Department of Biology and The Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.

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http://dx.doi.org/10.1091/mbc.e03-08-0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329402PMC
February 2004

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.

Nat Rev Immunol 2003 Oct;3(10):813-21

Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona 08036, Spain.

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http://www.nature.com/articles/nri1202
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http://dx.doi.org/10.1038/nri1202DOI Listing
October 2003

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

Science 2003 Sep;301(5640):1725-8

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1085643DOI Listing
September 2003

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.

Nat Struct Biol 2003 Jul;10(7):504-12

Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, 41 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nsb936DOI Listing
July 2003

Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine.

Mol Cell 2003 Jul;12(1):75-86

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00271-5DOI Listing
July 2003

Assembling atomic resolution views of the immunological synapse.

Curr Opin Immunol 2003 Jun;15(3):286-93

Department of Pediatrics, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0952-7915(03)00055-4DOI Listing
June 2003

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes.

Structure 2003 May;11(5):569-79

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0969-2126(03)00068-6DOI Listing
May 2003

Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain.

J Biol Chem 2003 Apr 29;278(15):13462-7. Epub 2003 Jan 29.

Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M210483200
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http://dx.doi.org/10.1074/jbc.M210483200DOI Listing
April 2003

SAP couples Fyn to SLAM immune receptors.

Nat Cell Biol 2003 Feb;5(2):155-60

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb920DOI Listing
February 2003

Specificity in signaling by c-Yes.

Front Biosci 2003 Jan 1;8:s185-205. Epub 2003 Jan 1.

Dept. of Microbiology and Immunology and Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown WV 26506-9300, USA.

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http://dx.doi.org/10.2741/1011DOI Listing
January 2003

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.

Proc Natl Acad Sci U S A 2002 Apr;99(8):5367-72

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.082117899
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http://dx.doi.org/10.1073/pnas.082117899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122775PMC
April 2002

Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.

Chem Biol 2002 Jan;9(1):25-33

Department of Cellular and Molecular Pharmacology, Box 0450, University of California, San Francisco 94143-0450, USA.

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January 2002